Average Rating: 2.7 (2701 Ratings)

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 Type: Rx Drug

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

 1  Anxiety, depression I took one dose and the next day I felt like my head was full of cotton. I was drowsy all day and nearly fell asleep while making dinner. I would not have been able to drive anywhere. I was also constipated, which is extremely rare for me. No appetite. I have not taken any additional doses. F 44 1 days
60 MG 1X D
 2  Depression Fatigue, dry mouth, weight gain Trying to come off of this drug is hell F 39 4 weeks
 1  Depression Headaches, sore neck, suicide thoughts THIS DRUG IS DANGEROUS. I took this drug in the morning and after 2 hours I had severe headaches and stiff neck. I rarely get headaches. After another 2 hours I couldn't talk and had to leave work. Driving home I had severe suicide thoughts. Was thinking I would drive out onto the highway and drive in front of a truck. Thankfully my home is only 3 min from work and is between the highway and work and I was able to make it home. This is the only time I have had suicide thoughts in my life. M 62 1 days
40 1X D
 1  Depression fibromyalgia Weight gain, unable to self care, insomnia, no sex drive, socially dysfunctional, suicidal ideology, zombie .. easier to just kill myself because it has taken my life anyway Symptoms are not obvious especially if combined with other drugs so you don't notice it poisoning your body. It's like my body is telling me it's full of poison but I'm not listening because my brain is so tired and pain is so bad all I do is sleep F 57 6 years
60 1X D
 5  Depression/anxiety Nausea and insomnia for a few days Works extremely well with aripiprazole 5mg. The constant negative and worried thinking has gone. I feel peaceful and even joyful M 43 3 weeks
60 1X D
 1  General Anxiety Disorder I experienced every bad side effect that is advertised within 2 hrs of first dose. Didn't sleep for two days. Couldn't go too work. Horrible experience. Almost had my wife take me to ER that night, it was soooo BAD! M 44 1 days
60mg 1X D
 1  Nerve pain, Anxiety Flu like symptoms Panic attacks Nausea Muscle pain Shakes Tremors Heart palpitations Dry mouth Brain fog Eyesight changes Dizziness Electric shock headaches in the font of my head Ever have that feeling when you are sleeping and you "fall down the stairs"Ě, you jerk awake abruptly and you can't breathe? I was constantly falling down the stairs in my sleep and was being jerked awake. I'm 3 days I had terrible mood swings and all I wanted to do was sleep. Nausea was horrid, everytime I went to eat I had to force myself. I've taken different nerve pain medication, but this by far was the worst. Never again. F 40 3 days
20 1X D
 3  Fibromyalgia, osteoarthritis & pttd This really did help my pain. But the side effects were getting worse eg. Constantly feeling too hot all the time, sweating, constipation, no sex drive, sensitivity to sun light & frequent migraines. Been off the drug a week now, I decided to go cold turkey whilst off work for a different reason. Been feeling dizzy most days, not all day it comes & goes. I am now back to going to the toilet regularly which is good. I am also not sweating as much as before & able to cool down more which confirms to me that this medication was causing this. I was put on Clonidine 6 months ago to control the sweating/ feeling overheated. I am now off this med as I no longer need it. This was my main side effect it was horrendous. My joints have been sore all over but I've started supplements for this to help. I would be very cautious with this medication. There is a list full of side effects that for me started subtlety but increased over time until I got to the point of weighing up the side effects compared to the pain which it was prescribed for, I opted to come off & seek a more natural root. F 45 1 years
30mg 1X D
 5  Anxiety, Depression, Nerve pain Had no side effects and feel more like myself than I have in years!!! Scares me to see all the dissatisfaction with this drug when it seems to be helping me so much. F 61 13 days
60mg. 1X D
 4  Anxiety and depression This is a good drug and works rapidly to treat symptoms of anxiety, depression and panic attacks. I would recommend it. I donít trust any other antidepressants following bad experiences with them. It does cause a bit of weight gain, but that is a minor issue given how effective the drug is. Iím grateful this drug exists. M 44 2 years
 1  Depression, Anxiety It started out as tremors and then moved to mild dystonia., my tongue would twitch and my head would jerk back. The doctors thought it may have been repressed tourettes and told me to continue taking it so I did. It quickly developed into three hour episodes of completely losing control of my body and has caused some of the most traumatic experiences of my life. I had to keep letting my mom know that I was conscious and wasn't seizing thought these episodes. After weening off of it, I developed ibs and still have tremors and tics. Nothing full blown like the episodes I had, but just the tounge twitch and head jerk when I get stressed. Even though I'm no longer on this medication, I can still feel the imprint that it left of me. If you develop tremors or tics while taking this medicine try to ween off of it asap. Medicine is always different for everyone, but I wouldn't recommend this one. F 18 3 weeks
90 mg 1X D
 5  Depression Sexual disfunction Withdrawal symptoms I experienced were: brain zap, brain fog, anxiety, vivid nightmares. M 29 10 months
 1  PTSD Related Symptoms F 41 1 years
60 1X D

 4  Depression and anxiety Feel mildly nauseous. Also tired a lot of the time but this could be the depression rather than the side effect of the medication. This worked significantly better than SSRI, which made me feel poisoned. My depression has improved and while I am not motivated and feel sleepy a lot of the time, the horrible darkness has gone and I have more and more good days when I feel like my normal self. F 50 1 months
30 1X D
 4  Depression and anxiety Feel slightly nauseous and sleepy though the latter might be due to the depression itself I feel much more like myself. Although I am not motivated yet the horrible darkness has gone and I have a lot of good days F 50 1 months
30 1X D
 1  Fybromyalgia and depression At first I found that it really helped my pain. Which I found unbelievable really. As nothing else worked. The longer I've been on it the more side effects I've been having. Dry mouth and dizzy n sick is the worst. I've been weening myself of them for about 3 months now. I wake up dizzy n sick go to bed dizzy n sick. I feel like I get heart palpitations and my head n neck feel like I've an elephant sat on me. I'm in agony with my fybro again. So it does prove they do help for my nerve pain. But I cannot cope with all these other symptoms on top of pain. Hopefully once I stop or rather if I stop feeling so Ill from this horrendous tablets n side effects. I am going to seek help with a herbalist. And try natural tinctures ect. I literay think comming off an alchol addiction I once had was less traumatic than these so called legal tablets. Great for nerve pain. For a while.until your body gets used to it. But cymbalta definitely gave me more problems on top of everything. Low sex drive, dizzy, sick, weak, palpitations, shaky and the list goes on. And it's even worse trying to come off the rubbish. F 32 2 years
90mg 1X D
 3  Depression Terrible constipation and have headache on and off but in last week everyday and today a bad frontal headache where I can't bend forward. I feel it has helped a few ms symptoms such as the electric shocks, also I'm not sure how effective it is being with my depression I think I'm on an even keel but do still feel uninterested in things etc. F 44 5 days
60mg 1X D
 1  Pain, disc degeneration etc Shaky and jerky, horrible stomach pain (like a hole was burning through it) and nausea for days, headache with burning sensation in front of my brain, face and hands turned red with burning sensations on top of hands and feet, etc I was first tried on gabapentin with ďcatastrophic resultsĒ- looked like I had Parkinsonís and ended up in ER three times, shaking so violently, once felt like something popped in my neck and was burning down my neck, could barely walk and talk. After taking only ONE cymbalta this started again, along with horrible stomach pain and nausea for days, like a hangover on steroids. Felt like Iíd been poisoned. I donít know why my body reacted so horribly to these meds, but the worst part is the doctorís attitudes towards me - I cry in pain more days than not, canít work since these meds as pain is worse, and Iím scared feeling my docs are going to kill me with meds! F 50 1 days
 1  Depression Anxiety Headache nausea diarrhea frequent urinating shaky feels like a had 20 Red Bull's pupils are so dilated feels like eye bulging out of my head restless legs no sleep your sleeping but awake. Horrible never again F 40 1 days
1 1X D
 1  Anxiety, Fibromyalgia Increased anxiety, constipation, scary brain fog, drugged feeling, grinding teeth all day, very tired, no motivation. Was not warned about the difficulty in discontinuation. Terrible to withdrawal from! F 58 8 weeks
90 mg 1X D

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   (Sources: U.S. Centers for Medicare Services, FDA)