CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Depression, Anxiety, Fybromyalgia Upset stomach and Nausea. Stomach Pain. Loss of appetite. It does tend to make me kind of un emotional. The 2 most important things that doctors do not tell you about Cymbalta are 1.) It is extremely addictive & if you miss a dosage or run out (or stop) you come off it hard. The withdraw is very very rough. It makes me bed ridden and very sick. 2.) Cymbalta has extreme interactions with many other drugs so be carful what you take with Cymbalta. Always read the pamphlet the pharmacist gives you & research it on the internet when prescribed a new medicine. A doctor didn't look into the drug reactions and put me on Depakote. I ended up deathly ill in the hospital with Serotonin Syndrome. However, I still take Cymbalta. I've been taking it for years, since before there was a Generic available. I had incredibly horrible pain throughout my body, it would keep me up screaming night after night. Cymbalta changed my life as far as that is concerned. However, the effectiveness for my depression and anxiety has decreased in the last year & I've had to be put on Xanax and Adderall to compensate. This is often a common effect of any medication used for psychiatric disorders. I know a lot of people have had some bad experiences with Cymbalta - but it has really helped me. F 27 4 years
90 MG 1X day
8/8/2015
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 5  Musculoskeletal pain due to hemochr Side effects were quite severe for the first 10 days (mood swings, nausea, diarrhea, nervousness) but after that almost nothing I have found cymbalta has helped me with pain significantly and almost no side effects after the first week or so. I read so many bas reviews of this drug, I just wanted to offer a positive one. F 39 6 weeks
60 mg
8/6/2015
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 4  Depression anxiety fibromyalgia Decreased appetite tiredness Took almost all my pain away but does leave me rather flat feeling F 34 1 months
90
8/5/2015
 5  Depression None Long story short, Cymbalta has saved my life. I am finally starting to feel like my old self again, and I am able to go outside of the house and enjoy the things I used to. Took me from deep depression to my normal, happy self again, and NOT in a manic way, just normal!!!! F 53 2 weeks
60mg
8/2/2015
 1  Depression and anxiety Waking up throughout the night to an electric shock-like feeling. Waking up to a pool of sweat and having strange dreams that felt indistinguishable from reality. Shivers/jittery feeling throughout the day and feeling like my heart was beating out of control. Pain radiating through left arm. Other unexplained aches and pains throughout the body, but mostly in my left arm/shoulder. The worst part of this drug is the withdrawal symptoms. Oversleeping (>10 hours) and feeling sleepy ALL THE TIME. No amount of sleep helps me feel rested. Extreme irritability. Headaches. Nausea. Though it did help my mood and lack of energy I had experienced with depression, I regressed back to having depressed episodes and anxiety attacks within a couple months. My doc prescribed 60 mg of Cymbalta, but told me to start at 30 mg for a week. I experienced the described symptoms on only 30 mg. I tried 60 mg of Cymbalta for a week and felt like it was going to kill me. My doctor looked at me like I was crazy when I told her this. She said 30 mg shouldn't be doing anything for me. F 24 6 months
30 mg 1X day
7/30/2015
 1   I was prescribed this medication to help with my diabetic nerve pain in my feet and some mild anxiety...it took away my nerve pain but replaced it with extreme sweating tingling warm sensations. I went from mild anxiety to extreme panic attacks. Could not feel normal mentally and thought I was going crazy until I realized it was the cymbalta doing it to me! Once stopped it took days to get out of my system before I could feel like myself again but the damage was done for me at work. This medication is DANGEROUS! It almost ruined my career. I dont normaly comment on stuff but I want to warn people of the dangerous reaction they might have to it! M 43
1X day
7/30/2015
 1  5 Scoliosis surgeries, Anxiety,etc. Arms/legs felt like they were on fire. Cold sweats. Sleepless restless nights. Anxiety got worse. Paranoia. Crazy dreams. Vomiting. Worsened back pain. Headaches. Blurry vision. Constant yawning with gagging. Lack of appetite. Jitters and twitches. Shivering when not cold. Sensitivity to light. Worsened depression. Everything tasted weird like chemicals. Electricity/tingly feeling in hands and feet. Eyes felt like someone was holding them open, pupils super dilated. Uncomfortable feeling overall in my own skin, couldn't move without the pain all over my body worsening... I have had 5 Scoliosis surgeries in the past 8 years, the last two were this April 2015, in the same week, Emergency surgeries, I had rods (hardware) in my back, one of the screws got loose and moved into my spinal canal pinching my spinal cord. I almost ended up paralyzed, or like my surgeon said, I could have died if it cut my spinal cord. Throughout my surgeries they have removed 3 rib bones and a piece of my hip bone to fuse my spine. Through the everyday pain and struggle, I have suffered through severe depression, anxiety, and lots of pain. My doctor thought, let's try a medication that deals with all 3 of those things. So she prescribed Cymbalta... I had high hopes,since she seemed like it was such an amazing medication that I'd probably end up all smiles, lollipops and kittens with the sun shining out of my ass... Nope, a whole lot of nope, I went Through hell with this medication, I thought I was dying, it puts you through the worst hell imaginable, I kept wishing i could just rush myself to the hospital and flush it all out of my system. It made everything worse, I could not Function, I would never recommend Cymbalta to anyone unless you have a death wish... Good luck to anyone about to take it,I know a lot of people's systems are different. I saw more negative outcomes on this medication on this page than i saw any good feedback. I ignored all the negative posts... Big mistake, because now I'm one of those that has to add to them... F 23 1 months
30mg
7/24/2015
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 1  depression went through hell don't take F 70 1 weeks
7/22/2015
 1  depression/anxiety/adhd emotionless, sleeping 14+ hours per day, worsening anxiety, inability to focus, zero sex drive, extreme fatigue, low blood pressure, seratonin syndrome. interacted with visine which irritated/burned my face. had an extreme reaction the second week of use. Spent the night in bed, low temp (6 degrees below normal), confusion, tremors, shaking, extreme paranoia, anxiety. DO NOT TAKE THIS. it almost killed me, and worsened ALL of my symptoms including giving me new problems. F 24 21 days
30mg, 60mg 1X day
7/20/2015
 1  For Pain, Anxiety, Depression, Ect. Anger,Rage,Delusions,Brain Zaps,Blackouts, Memory loss, Destroyed Relationship, And a DUI! I was prescribed this horrible drug in hopes of sciatic pain relief, and Anxiety issues. I was told by a Doctor that this is like a wonder drug that helps people in many areas and that works with past addiction issues and severe pain and Anxiety! I was seriously miss informed!It took away my sex life, caused so many problems between my girlfriend and me and wasn't helping in the least with anything at all.It was instead making everything so much worse! So I stopped! I was already having opiate withdrawals and wasn't pleasant to be around. But this evil pill made me even more mean but I had no idea that I was! I forgot so much about this time of my life! But what I do know now is that I'm a single guy who's fighting a DUI but can't remember hardly anything about the insodent! I'm really scared and haven't taken this Evil drug in almost a year. Nobody believes me about this drug because of my past! I don't even remember if I drank that day or not! All I remember about that day is waking up and hitting a mailbox! I found out that they shouldn't have prescribed me those medications together! I have never had a DUI before! I could have hurt someone! How is this drug still legal????? M 44 3 months
2 25 mg pd
7/16/2015
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 4  bipolar major depressive episode weight gain, sluggishness, sleepiness, restless legs, rashes, slow healing wounds. What a strange drug. I just say at the outset that it definitely helped the depression and seeing as that was making me suicidal I can offset the multiple side effects against that. But it's after the depression passed that I realised how it had wrecked my physical bod somewhat. Weight gain was appalling and by the time came when I realised it had done all it could for the depression I was feeling very "zonked", a sign with me that it's time to reduce meds because the episode is gone. The thing is, nobody should be just placed on an anti depressant forever. You are not ALWAYS depressed, it is a reaction to something happening in your life where your mind cannot handle it. My psych was great, we reduced it quite quickly with a few, not many, initial anxiety days where my biochemistry got used to being without and now, six months down the line I feel a lot better, am losing weight and feeling like my old self. Would I take it again? Maybe. If the depression was threatening my life once more. F 42 2.5 years
60mg to 20 1X day
7/8/2015
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 1  Back Pain Withdrawal symptoms are horrific. The first time I tried to withdraw which may have had something to do with the fact that my doctor wasn't aware of how to ween me off, I experienced elevated blood pressure, debilitating brain zaps, severe depression,gastrointestinal distress, sinus issues, abnormality of gait, lack of appetite. Over the last year I had weened myself down to about 10mg but had not been able to go below that because I would begin to experience withdrawal symptoms. I experienced some debilitating back pain and decided maybe I needed to start it again. Once starting it again at 20 mg this past Thursday my pain has subsided but I'm experiencing some depression and a severe lack of motivation. I'm so torn about my feelings about this drug because it works for pain but I don't understand the depression causing aspect if it is a anti-depressant. I also have no appetite and am nauseated. If I recall correctly I remember this being a side effect when I originally started taking it. F 51 9 years
60mg 1X day
7/5/2015
Email
 4  Major depression Weight gain and fluctuation The drug works well. It does slow metabolism. You initially lose some weight.. Then if you don't watch food intake and carbs... You will gain weight over a period of years. It also fluctuates up or down even if you hardly eat but eat starch and do not sweat or excersise moderately. The long term effects, if you do not maintain a low food intake and SOME excersise will most often cause a gain of 3 to 10 pounds M 62 7 years
60
7/3/2015
Email
 1  Fibromyalgia Cymbalta is the devil! I tried to get off of it and almost died! Severe nausea room spinning, vivid daytime helucinations. It was like the devil himself crawled into my brain and took it over. Severe rage! suicidal thoughts and actions. Powerful bursts of electricity in your brain. (Brain Zaps) I felt as if the devil took control of me and my body. Horrendous night terrors were I ripped at my skin and torn lesions with my nails. I had to tape mittens on my hands. Nose bleeds. My eyes turned yellow and bloodshot. Vomiting blood/ blood in urine and stool. Violent muscle twitches. Extreme agonizing headaches that would last for days. It got so bad I had to go to the phych ward and call my priest to do an excersim after I tried to blow off my head with a shotgun to make the voices stop. CYMBALTA IS THE SATAN! Please don't take the devils pill these drug doctors are doing the devils work! M 30 1 months
120mg
6/30/2015
 1  neuotopy pain nausea intestinal cramps. extreme anxiety. ringing in ears loud! heart races. pounds out of my chest. cinching of my mouth. mucscle twitchig intense. irritable. mean. aggitated. ended up in er with hlrrible stomache cramps and dehydration and high blood pressure. it was a borrible experience! i only took one 30 mlg pill. thjs is the third day off and am still having jaw clinching and somexanxiety. but the worst is over .now i am extremely tired. this drug is ppison! i took the generic brand. i wonder if the origional brand is better. i have read there is a difference. i still have .erve pin.i also felt like i was loosing my mind. like nothing was real. whoever makes this generic kind. got somethibg wrong and it needs to be banned. whoever makes this money from cymbalta needs to know its a killer to many. and revisit the drug. i am wonderig on this cite. how many of us are talking about the generic. are the only good comments talking about the brand name? i would lime to know. i would rather pay 200 a month and get nerve pain relief. but i will never touch the generic again! it has cost me a week in bed and a triop to the er. F 57 1 days
6/26/2015
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 4  pain anxiety and substantial weight gain even with minimal calorie intake (1250 per day) and exercise (30-45 min aerobic), increased BP It helps with pain associated with RA and post surgical abdominal adhesions F 49 12 years
60 1X day
6/21/2015
 2  Pain and antidepressant Extreme vertigo and dizziness heartburn aND acid reflux mood swings and depression The higher dose is making the symptoms worse. going to get doctor to wean me off F 52 6 months
120
6/19/2015
 1  Depression Was not going to review until I read another reviewer comment...side effects people are posting must be their imagination. Bullcrap!! This drug is DANGEROUS. My side effects ... High blood pressure, reflux, lethargic, blurred vision, short term memory loss and just a feeling of worthless. I decided to stop this drug when I lost my Primary Doctor and was unable to get it filled before I could find a new one. Then the real hell began...withdrawal! I went cold turkey before reading how dangerous that is!! I didn't sleep for a week and when I did the night terrors were terrifying!! Could not eat, nausea,extreme vertigo, brain zaps, mood swings. It took over a month to feel somewhat normal again. I found a support group on Facebook...Cymbalta Hurts Worse, and found out that my side effects were normal and many had it far worse than me. It has been 4 months since I stopped and I still have bouts of short term memory loss, night terrors. I did find my pain has increased (was taking for depression but found out it helped for pain relief) but I'd rather deal with extra pain than take this EVIL DRUG again. F 47 5 years
60 mg
6/18/2015
 1  Fibromyalgia headache, diarrhea horrible horrible side effects after only three days taking this drug! I would rather deal with the pain than poison my body. F 72 3 days
30
6/15/2015
 1  Anxiety Horrible withdrawal symptoms. Stopped cold turkey-wanted to be drug free. Unable to work for the first week or drive a car, vertigo, sweats, itching, dizziness, joint pain. Second week severe vertigo eased up but still dizzy and "electric shocks" in extremities. Now in week three with dizziness and electric shocks beginning to be able to function. Had I been warned of the severe withdrawal symptoms from this drug I would not have taken it. F 57 7 years
60 1X day
6/14/2015

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