CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Depression and Anxiety I had insomnia problems before Cymbalta, the insomnia is maybe a bit worse now but I seem to have more energy during the day. I've tried a lot of different anti-depressants over the past 15 years (Prozac, Effexor, etc, etc) and for me Cymbalta has been the best one. After 2 years at 60mg my depression has just started getting a bit worse again so I'm thinking of aasking the Doc to increase my dosage to 90mg per day M 52 2 years
60mg 1X day
1/1/2013
 1  Depression, social anxiety disorder Insomnia, constipation, WORSENING depression, complete sexual dysfunction I call it Cymcrapta. I wouldn't wish it on my worst enemy. Withdrawal was horrific too. Did nothing to help ANY of my symptoms M 18 2 months
90 1X day
1/1/2013
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 4  IBS Heartburn, insomnia, tired but bursts of energy, delayed orgasm but not to bad This drug has been wonderful for my IBS. I am taking otc med for my insomnia so that's not so bad. The heartburn is getting bad and keeping me up at night-not sure how to remedy that but overall I really like this drug so far. Hope it continues to be a good one for me. Not many drugs have helped my IBS and these side effects are ones I can live with. F 37 3 weeks
30mg 1X day
12/29/2012
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 5  Major Depression First day was bad - dizziness, felt 'stoned', but it went away in a day. I had dry mouth, and night terrors for about 3 weeks, but they both went away. Positive side effects more than out weight the first adjusting period. I sleep like a rock, I feel great all the time now, I have more energy than I have had in years. The first week is going to suck. I ended up taking a week off of work, but it is totally worth it. I have not felt this great in a long time. I can finally sleep, drive a car without crying, concentrate on the future and make rational choices again. I have lost about 30 lbs (a good thing for me) and I'm finally interested in life again. Take the time to get through the first few weeks and you won't regret it. F 27 6 months
60 mg 1X day
12/8/2012
 4  anxiety, pain, depression Heavy GI illness for 2 weeks, helps with anxiety and depression. Still dealing with chronic pain. Find that it takes 2-3 days to recover after a workout. I taker 30mg in am then 60mg @ night. Tried 60mg in morning and couldn't keep my eyes open. M 39 2 years
90mg
12/4/2012
 3  Pain/Depression A bit of insomnia. Unable to have an orgasm. It worked well for depression, but I don't have major depression. It's more related to pain and this drug did not do much for the pain. I found the sexual side effects difficult to deal with and when I asked my doctor had no other ideas other than "to fake it"- how professional... I'm looking for a better doctor. F 36 2 months
60 MG 1X day
11/29/2012
 3  Anxiety Nightmares, night sweats, dizziness, insomnia & low energy level I had little to no side effects using this medication while smoking marijuana (1 joint a day) for the past 2.5 years, however I have recently quit smoking (60 days) and am having HORRIBLE side effects. Wondering if anyone else has found that marijuana use has eased side effects? Thanking you for any input. F 42 2.5 years
60 MG 1X day
11/29/2012
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 5  Fibromyalgia Weight gain, a slight bubble personality I was put on cymbalta to try to help with my migraines and fibromyalgia pains. It did not help at all with my numbness or problems sleeping, but I thought I would taper off because I was still feeling numb. The first three days I was more my moody, impatient self... but I realized it kind of kept me in this weird bubble. Within three days my double vision returned and a constant head pressure. Now, about a week and a half off, I am in so much pain I can barely type this because my hand hurts. I forgot how much pain I was in before. I am miserable. Cymbalta may be the worst drug made but it made me a functioning happy person and I am getting right back on it. F 28 9 months
60 2X day
11/19/2012
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 5  Depression/anxiety No bad side effects what so ever... Initially I was given Cipralex along with a Ativan to control my initial anxiety due to a horrible gambling addiction I was recovering from which caused me so much pain and suffering I was wishing I would die. I hated my life and what I had done. Although the Cipralex helped me with my anxiety at first, I was sleepy all day, gained almost 30 pounds + my libido was non existent. My doc then gave me Wellbutrin which made me feel better as I lost most of the weight, then headed on 30 mg of Cymbalta gradually increasing into 60 mg. I feel great, I'm able to work 2 jobs + able to be a better father and husband. I hear that the withdrawal symptoms a eye nasty but thus far I have no plans of getting off. I get my blood tested once a month or so to make sure my liver is ok. As matter of fact my doc said that my overall blood work has improved. I've read many horror stories about this med, so I guess it affects people differently. I guess nobody can say if any med is good or not until you try it. M 38 3 months
60 1X day
11/18/2012
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 1  Chiari Malformation 2cm Herniation My experience was horrible. I reconnected with a childhood friend who is a pharmacist (and has been for 40 years). He told me that Cymbalta is one of the most dangerous medications on the market that he can not believe that it was approved by the FDA. Everytime he fills it he has a very sick feeling that he has done harm. THAT should tell you something! Wish I had spoken to him BEFORE I took this nightmare drug and the withdrawal was unspeakable! Vile drug! F 65 6 months
60mg 1X day
11/17/2012
 3  Depression, Fibro pain Extreme nausea, memory loss, lack of clear thinking, highs and lows of depression, some help with pain I'm truly confused with this medication! It helps my depression quite well, but for some reason I get these terrible lows and have suicidal thoughts. I BARELY notice its effectiveness with my Fibro and MS pain, so although I'm on such a high dose (120mg daily) I still have to take 800mg Ibuprofen and Oxycodone daily as well. My memory is totally shot, which could very well be from my illnesses period. I've notice a very high increase in my sexual desires and have made some extremely terrible decisions which does not fit my personality at all. Has anyone else experienced the latter in particular? Being sick is so frustrating. You can never find the proper balance... Lots of hot sweats at night, very unusual dreams. I'm not sure if this med truly works or not due to the crazy affects my illnesses give me in the first place, and then add aaaall the meds I'm on. It's a never ending battle. F 29 2 years
120mg
11/13/2012
 2  for fibromyalgia pain I and my sister experienced development of glaucoma, unbearable withdrawal symptoms like insomnia, brain glitches, brain fog, irritability, taking 6 months to taper from 60 mg to 30 mg. Another 4 months and I am down to about 20 grains, however much that is - have to open capsule and count little grains Even thought it initially halted my FM pain, I would strongly advise against taking Cymbalta F 59 6 days
60 1X day
11/2/2012
 1  RSD Spaced out, heart related issues, shortness of breath, developed sleep apnea, among many other issues Horrible drug, my doctor put me on it because of my RSD both for pain and he thought I was depressed?? We didn't share that "depressed opinion"........probably more like "kick back" from the drug company but that's only my opinion! I was also taking Lyrica and other medications for pain as RSD is very painful. My opinion was TOO MUCH DRUGS........the human body couldn't handle it all...........!! They have a "PILL" for everything these days.........makes you wonder!! I came to a point that I decided I wasn't taking this medication any longer as I felt it served no useful purpose. That's when the good part came, you have to initially take this medication in a very subscribed manner to get on it as well as off it. It is very indicative of Niacin.......you get the heart palpitations along with the flushing only 100 times worst..........you think you're going to die any minute! Stopped the drug, suffer for several months from the withdrawl symptoms but totally relieved all the side effects including the apnea!! Would not recommend this drug to my worst enemy!!! Another pharmaceutical money maker $$$$$$$$$$$$$!!! M 58 2 years
1X day
10/29/2012
 3  Fibromyalgia & depression To be honest, it is hard for me to distinguish the side effects of this drug since I take some other medications as well (e.g. Lyrica). However, I have experienced dramatic weight gain. Also, I am sleepy all the time. This might be a combination of the Lyrica and Cymbalta together. I'm not sure. I tried to stop taking Cymbalta, but reverted to having worse pain and very depressed. This condition sucks regardless. I guess it is better to take this med and not be in so much pain all the time. F 49 2 years
90 mg 1X day
10/23/2012
 5  low back pain, fibro, arthritis This drug has been a miracle for me. Ater taking Lyrica and several anti-depressants with major side affects (also on Norco for 2 years), Cymbalta has allowed me to a live an almost normal life. Started out with 30 mg once a day and six nuerontins, slowly weaned off the nuerontin and dr upped Cymbalta to 30 mg one day/60 next day alternting every other day, I can now exercise, do most chores around the house. Still have difficulty sitting for more than half an hour but will take it over previous agonizing pain. Have noticed some Vertigo lately but no sure if related to Cymbalta or something else going on. Didnt have this problem for past year and a half. Felt immediate results....less pain after taking for several days and attitude change to positive instead of dreading getting up in the morning. Started to see weight loss after lowering Nuerontin and dosage upage of Cymbalta. Nice to see since Ive gained over 18 lbs since on Nuerontin and not able to exercise due to pain. F 54 2 years
30/60 1X day
10/22/2012
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 1  MS and Ovarian Cancer Pain Sick to my stomach. Headache, anxiety and felt bloated all the time. I would also have bouts of sweating. Gave it a month and then stopped using it. I was given this to take daily. I have Lortab for serious pain but this was to help in between with daily pain I suffer with. I do not use Lortab very much and this was to be something that would sort of help me daily. This drug was terrible. Would NOT advise taking it. It did nothing for pain. It mostly just made me sick. Quick after giving it a solid 30 day try. When I don't want to use the Lortab. I do much better taking Motrin or an older medication called Ketoprofen. F 38 30 days
60 1X day
10/20/2012
 1   I took one Pill Tuesday evening. I felt Stoned, Drunk, Confussed, Dizzy, my Heart is fluttering and I keep having sharp pain in Back and Legs, short of Breath. It is Thursday and still feeling the effects from 1 pill F 40 1 days
30 MH
10/18/2012
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 1  Pain Gradually increasing pain in the abdomen. Passing red blood , which got worse over time. Weakness. Symptoms resolved approximately 1 week after discontinuation of Cymbalta. M 47 30 days
20MG 2X day
10/16/2012
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 1  Anxiety I took one pill on a Saturday and soon felt stoned out of my mind. Had no strength to get up or do anything but sleep. I very nearly slept an entire weekend away. My knees and hip both hurt afterward. These plagued me until Monday afternoon. Sticking with ativan as needed and seeing a therapist. Will never touch that medicine again. F 40 1 days
30mg
10/16/2012
 1  Depression/Back pain Nausea, Brain zaps, SEVERE WEIGHT GAIN 60lbs This drug is HELL. If I missed a dose by a few hours, the side effects would start. Brain fog and brain zaps are horrible!! Even more difficult to stop the drug. It's like they want you to be addicted, so you can stay a lifelong customer! It did absolutely nothing for pain. It worked wonders for my depression at first, but since I gained so much weight I was more depressed than when I started. You just keep gaining no matter what you do! As soon as I got off cymbalta I lost 30lbs instantly without doing anything. F 29 18 months
60mg 1X day
10/13/2012
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