CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  Depression I have been taking Cymbalta for about 3 years, I was taking Prozac and felt it was time for a change. But I am having trouble here lately with terrible headaches, everyday! I am wanting to get off of it. It seemed to have worked quite well at first and now it seems useless. Does anyone fill the same way? F 47 3 years
11/12/2009
 3  migraine, mild depression Nausea for first 2 weeks or so, complete loss of sex drive for a year on meds- for 1st 6-8 months or so any thought of sex or physical contact disgusted me from what once was a high-above average sex drive, inability to orgasm for 1st year, difficulty achieving orgrasm still, but it is possible (about half the time), Complete loss of appetite (got down to 90 lbs while on it (was originally 100 lbs)) It did help with my depression. I am only on 30 mgs. My body couldn't handle being on 60mg (the no sex drive as a newly wed and weight loss was just too much). Weight loss obviously is not typical (according to other reviews) but I am a 100 lb, petite girl to begin with. It made no difference on my migraines, in fact, it might have made them worse. I am beginning to slowly taper off by taking one every other day, but am concerned with the side effects. After one week, my only withdrawl symptom has been migraine (which was why I was on it to begin with) F 25 1.5 years
11/10/2009
 5  depression, hypothyroidism Nothing major. I upped the dose after one week instead of two. A little trouble sleeping, but since I have major fatigue, that is fine with me. I am much more awake in the mornings. Feeling great, no depression symptoms in switching over from Lexapro/Wellbutrin. I think a lot of the "side effects" people are listing are symptoms of their medical conditions and not this drug.It is treating my depression fine, with hardly any side effects. Also, I have a back injury which causes chronic mild pain, and it is feeling a lot better. I can stretch further than I used to be able to without the pain. Seems like an appetite suppressant to me. Hardly hungry at all. F 38 4 weeks
11/9/2009
 1  depression, anxiety Serious headaches. Neck and shoulder pain. Got to where I could hardly move my neck. I switched from Lexapro to Cymbalta because Cymbalta isn't supposed to have a negative effect on your libido. I wanted my sex drive back. But this has been horrible. I've been in so much pain, I had to stop taking it. Going back to Lexapro immediately. F 36 10 days
11/9/2009
 1  chronic fibromyalgia pain First week a marked decrease in pain,and it was all downhill from there. Exhaustion, hyper-sweats, dizziness, constant suicidal thoughts. Then slow withdrawal with a rapid escalation of constant and severe pain. Five weeks off it and I am pretty much incapacited by agonizing unbearable pain everywhere in my body. My life is hell on earth and I am unable to perform the daily life tasks so basic to life. Cymbalta is killing my life and perhaps my poor crippled body. We who have experienced these permanent effects must unite to get this drug off market. I am afraid. In three months I have lost 50% of what little mobility I had. I went to: www.AttorneyLink.us today to ask for free legal help. Please something has to be done to stop Eli Lilly now. I am a former professional female 65 years old and I have to attempt to stop the Lilly drug company from destroying lives. They made billions off this dangerous drug in the past year. F 65
11/9/2009
 1  Fibromyalga, bipolar stroke type symptoms heavy heavy eyes massive slurred speach loss of control neck up had pass out episodes alot for 2.5 months the longer i took (60mg) the med the worse the episodes got first day no cymbalta no episode 4 days now no cymbalta was satisfied with med for the pain but very very dissatisfied that it caused such a side effect that my kids were at risk cause durin an episode there was no way anyone could have gotten me awake enough to be of any good. first day no cymbalta no episode 4 days now no cymbalta, and no episodes, and even though it worked great for fibro myalga i will never take it again not dure but i read people had horrible withdrwals from med i did not (yet) im awake and livly now but in severe pain from the fibromyalga but the stroke type symptomes have quit (hopefully for good it has only been 4 days) F 40 3 months
11/9/2009
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 1  anxiety/depression I took the med for 3 weeks. The first week was terrible with daily migraines but I was told that was just the transition period. By week 3: insomnia, foggy feeling all daily, daily migranes, dry mouth, numbness in legs, stomach pain, nightmares when sleep was possible, hopeless feelings, feeling "off" and not understanding what was wrong, crying spells. I almost passed out while shopping for my daughter's birthday cake and could not stop sweating. I had to drive home w/all the windows down (even though it was only 45 degrees that morning). I was so scared...my daughter was with me....I just prayed that we would make it home and could not put up the windows because I needed air so much. I stopped the medicine that day! Withdrawal is HELL...it has been almost 2 weeks and the HELL continues. I saw my dr who wanted to put me on a low dose to help w/withdrawal but I refused...I never want that drug in my body again. Everyday, I wake up thinking that this is the day that I will feel better...but it never is. The migranes are so severe, the dizziness is insane, I am constantly in slow motion, I cry almost all the time. I CANNOT UNDERSTAND HOW SUCH A DRUG WAS EVER ALLOWED ON THE MARKET. The drug company obviously did not have people in mind and did not disclose the proper information. I cannot believe that doctors would prescribe this to their patients if they truly new all the terrible side effects. I believe this medicine should be taken off the market. F 39 3 weeks
11/9/2009
 3  Anxiety/Depression/Pain Nausea, Dizziness, muscle spasms, decrease/increase in appetite, irritability,sleepiness, difficulty or inability to orgasm. Migraines, jaw-clenching. It certainly helped to elevate my mood and make me less anxious bu the side effects are rather distracting, especially the Dizziness and Nausea and I have no energy. My pain seems to have gotten worse but it's only been three weeks so I hope that will get better. The difficulty/inability to orgasm is particularly irritating. I feel like my parts are almost numb and I seriously would probably not be able to orgasm at all if I didn't use a vibrator. I have no idea how I could naturally get one! Yet I still have sexual urges which makes it even more frustrating when I want to do it and can't enjoy it as much. I hope the side-effects will level out in time so I can fully enjoy life again! F 25 3 weeks
11/7/2009
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 1  ANXIETY WEIGHT GAIN, BRAIN ZAPS, BRIEF THOUGHTS OF SUICIDE THIS DRUG SHOULD BE REMOVED FROM THE MARKET AS IT DESTROYS THE LIVER! M 39 1 years
11/7/2009
 1  pain from Parkinson's Horrible nightmares, excessive and ongoing sweating, shortness of breath, rapid heart rate (felt like pounding in my throat), sleeping through whole days. Mental - didn't feel like myself; minimal emotions, manic talking, especially during the evening. Have endangered friendships because of this, as I am sure it came across as very strange behavior. This drug is a DRUG. I lived through the 60s, and have no desire to revisit it. After 3 months up to 40 mg, I called my neurologist and began weaning myself off if it, 10 mg. a week, thanks to the info. on this website. I will be totally off it by tomorrow, but last night I woke up twice soaked with sweat and still have shortness of breath. No pain is worth this. I have a sense of myself back, and will never touch this drug again. F 65 3 months
11/7/2009
 1  anxiety weening from 60 nto 30 mg and then off it has been a week i am on 30 mg now and am so scared to go offf becsause I WANT TO DIE I FEEL SEVERE MUSCLE SORENESS HEADACHES LIKE I HAVE NEVER HAD WEIGHT LOSS LOSS OF INTREST IN EVERYTHING THIS IS HORRIBLE AND MY DR IS USELESS, MORE CONCERNED ABOUT HIS HAIR RHAN MY SIDE EFFECTS. WITHDRAWL HELL IF YOU START NEVER STOP I WOULD TAKE 2O ANXIETY ATTAKS RAATHER THAN GO THREW THIS WITHDRAWL AGAIN F 25 2 years
11/7/2009
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 3  Anxiety,depression I have been on it for 3 days. I have tried lexapro got allergic reaction. Zoloft made me feel like I was in a dream world and very weird. I am scared of with draul but I spoke to my dr. And he said don't believe everything u hear. I'm sure this drug has helped lots of people they are just not posting because they now have a life. And for the people that say they gained weight should watch what they eat. It is a proven fact this drug does not cause weight gain. As far as withdraw, we just need to ween off super slow. Any drug is going to give side effects. I just hope I finally found something. I'm afraid of taking meds. F 26 3 days
11/4/2009
 1  depression/ anxiety Flu-Like Symptoms (Alternating between cold chills and hot sweats, sore throat, body fatigue), headaches, insomia. There were brief moments when I felt good but the bad outweighed the good... I swear this med is a virus in a pill. Upon calling my doctor, she said these flu-symptom side effects are quite common at start-up in a lot of people but I couldn't take it anymore. M 29 4 days
11/3/2009
 2  depression anxiety dry mouth, irritabilty, can't breathe! Haven't even thought of sex. Eating more. So tired I can't stay awake during the day. I am afraid I am dying sometimes I sleep so much and can't breathe! F 52 1 months
11/1/2009
 1  Depression/anxiety After 2 weeks I had terrible acid reflux which I NEVER had before, constipation, stomach ache 24/7, then rectal bleeding which scared the heck out of me. Got off the drug immediately. Because of the bleeding I had to go for a colonoscopy and have my stomach biopsied which showed it cause the lining of my stomach was inflammed. It took me 2 weeks to be weaned off the medication and I felt awful all over like I had the flu. I was only on 20MG and it worked mentally but to this day, my gastro-intestinal system is screwed up. I do have to say, I was taking Advil and noticed on TV now there are now warnings about taking over the counter pain relievers with this medication. F 54 6 days
10/31/2009
 1  fibro pain and depression extreme stomach illness/cramping and nausea /diarhea for HOURS after first dose felt like I had severe food poisoning!I spent hours doubled over in the bathroom. Agony! Now its 3 AM and I am extremly agitated, frowning ( weird I know)and cant sleep. Heart is also acting erratic and head is pounding. I will NOT take a 2nd dose F 55 1 days
10/30/2009
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 5  Depression I have not noticed any side effects and I have been on Cymbalta for about a year or more. I have Fibromyalgia also, but never noticed any improvement with the pain. For those of you that are wanting to stop taking Cymbalta, NEVER quit a medication cold turkey. Get instructions from your pharmacist or your doctor on how to take yourself off a medication. F 64 1 years
10/29/2009
 3  Major Depression Disorder/GAD I have gained 30 lbs since I began taking this. I have never been overweight before. Also, oddly my cholesterol has jumped up over 50 points in the last year. Which can be a side effect of Cymbalta. Very sleepy all the time. Hard time focusing and if I miss dose look out... I become very irritable, not to mention I experience brain zaps similar to paxil withdrawal. Having been involved in a lawsuit with glaxosmithkline due to the effects of paxil withdrawal I am very concerned about stopping this drug. However, I am not willing to be a depressed huge woman either. The drug has helped with the depression, however the side effects are awful. If you think giving a depressed woman who has never had a weight problem, an extra 30 lbs to carry around is a good idea you would be mistaken. So mostly the weight issue is a big deal. I swear the drug makes me very, very hungry. It is quite bizarre. Also, I also just seem mostly numb which is pretty scary. I dont like feeling like that. F 30 3 days
10/29/2009
 5  Nerve pain after stroke, depression dry mouth, loss of appetite This drug started working right away. I have had problems with my knees for 3 years and never out of pain. I had a stroke that affects the nerve pathways giving the perception of pain on my left side. That is gone too. Also my depression is gone. I am no longer irritable or sad. I feel like myself again after what seems like forever. I know not each drug is for everyone but for me this has been better than anything for me! F 44 9 days
10/28/2009
 5  major depression extreme ongoing and continual nausea, delayed orgasm, numb hands & feet been on 120mg for 12 months, from being suicidal am now back at work full time, feeling normal again other than the side effects. M 38 12 months
10/27/2009

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