CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Migraines No side effects I am aware of. Took for two years, weaned of for 2 years for alternate treatment. Back on for approx 3 years. F 60 3 years
60
3/9/2016
 1  Fibromyalgia Extreme pain in my arms and legs. Could not stay awake, never felt rested. Numbness, mood swings. Terrible drug do NOT take. Hopefully this drug is off the market by now. F 67 2 months
60 1X day
3/9/2016
 1  anxiety/depression When taking a higher dose, (up to 90mg per dr. prescription) Flu-like sypmtoms, headache, coughing, coughing up stringlike mucos. Difficulty swallowing, difficult digestion of food. Constipation. When attempting withdrawal, brain zaps, leg cramps. severe stomach bloat, dehydration, severe dizziness when moving my head, Now attempting to level at 30mg. Experiencing all symptoms off and on. debilitating. Some days cannot function at all and am bed-ridden. Waiting for capsules with beads so I can taper at 2%. This med is evil, makes a person feel and be treated by Drs as if they are crazy. It is poison and should be taken off the market. F 59 18 months
30 1X day
2/21/2016
 5  Depression Tension headaches, nausea, jittery feeling Immediate relief from depression on the second afternoon. Side effects also getting better. Completely worth it to feel better! F 14 3 days
20mg
2/20/2016
 1  depression Almost immediate change in cognitive and visual perceptions Spaced, foggy thinking,altered perceptions of routine actions ie Walking felt new,talking seemed to echo within my head , anxious thoughts, extreme fatigue slept on and off for last three days since starting on 30mg only taken for 2 days . I have completely abstained from alcohol and all illegal and prescribed medications for 13 odd years before making the decision to try an anti D as my life situation is spiraling due to depression unemployment ,relationship breakdowns both intimate and family. Id had starter box for 6 months and just finally took one to see if i would feel something for the better shift. I immediately felt completely out of it ,akin to the first rush of an lsd tab, racing thoughts , mentally numb and foggy. It was in this state i picked my son up from school Even though i thought i presented normally he immediately asked " whats wrong dad you sound weird?" That's all the red flags i needed not continue down this path. If i hadnt had over a decade living with depression and anxiety non medicated i would possibly be enjoying the mental fog and body stone but i cant stand feeling this drugged. its like cymbalta immediately added itself as a complete thinking and feeling system to my brain . 3 days ago i knew i was depressed and needing to make changes to get some form of joy or happiness into my bleak mindset. I now know for me alone i prefer that than this chemical straight jacket state. I was on anti depressants for 8 years til 13 years ago They sure helped me feel better about my insane life and drinking /drugging for a while so they did "work"on one level then.. I just can't go back to feeling drugged and be ok about finding my peace of mind there.. M 49 2 days
30
2/20/2016
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 1  Anxiety and pain After taking it 1 day, I got very sick .. Diarrhea and upset stomach lasted 2or 3 days. Stopped taking it May try again after the shock wears off M 72 1 days
30
2/20/2016
 1  fibromyalgia Fog, loss of ambition, tired, depressed, Trigeminal Neuralgia, weight gain I was put on Cymbalta to help with Fibro pain. It does help deep muscle pain, and helped with brain zaps I had for many years from going off of Lexipro. But the party ended when I gained 30 pounds almost overnight when it was increased from 30 to 60. I've never been so lost in my life. I have no ambition to do anything. Everything I once loved to do is too hard for me to concentrate. I tried to get off it once before, and I couldn't handle all the pain; plus my zaps were horrific. Terrible dreams. And my muscle pain was 100 times worse. When I went on this my doctor told me "not to read the indications and trust her." WTF? Be very careful before going on this drug. I've taken others for depression and anxiety and didn't have these problems, other than some weight gain. F 62 1 years
60 2X day
2/15/2016
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 2  Depression Initial side effects: insomnia, headaches, spaced out, constipation, dry mouth. Persistent effects: lowered motivation, loss of sexual interest and function. This is the second time I have tried Duloxetine. First trial was for 5 weeks and was unsatisfactory. This second trial has been much the same. For a while it seemed like I was improving, but over the last week or so I have sunk back to how I was before beginning the drug. In fact I am worse because this drug, like most serotonin dominant drugs, saps what little motivation I have left. I just have no interest or desire to do anything and this is much worse than before starting. The drug also failed to alleviate my bad memory and other cognitive impairment problems. There seems like no point continuing any more. I would like to give it a couple more weeks but am really sick of the way it makes me feel. I should point out that most drugs don't seem to work for me any more. M 34 6 weeks
60mg 1X day
2/12/2016
 4  GAD Depression It's only been a week so hopefully the mild side effects I'm having will subside. Mostly cold chills, and stomach upset. Eating something really helps with the stomach upset. Decreased appetite, not a bad thing. One night of severe insomnia and headache, (had a few drinks, birthday) not advised to drink when first starting didn't know this. If I had, I wouldn't have had any drinks. So far improved my symptoms,we shall see. F 42 7 days
60mg
2/1/2016
 1  Clinical Depression Started out as "best thing since sliced bread", but brain zaps began. Been slowly weaning from it and it looks like it's going to take a while.Fish Oil (Omegas?) Seem to help with withdrawals.If talking helps then I'd love to hear from anyone. Email below here somewhere, I guess. Been on numerous SSRI's for over 10 years. This SNRI started off great, 30mg once a day for a week or so then up to 30mg 2 times a day. Nearly a month ago I noticed the "brain zaps", I guess. More like my brain was turned into ultra fine steel wool and I could hear and feel my steps at times. I could hear my eyes blink, or a squishy sound in my ears (like someone squeezing steel wool inside my ears). The sounds came along with the "mild electric jolt" feeling too, from toes to head often. Generic form I have are 6 small white pills inside the blue and white capsule. Dropped from 60mg to 30mg for several weeks. Then began removing 3 of the small white pills to take 15mg for a few weeks. Was going to remove one more to go to 10mg then one more later to take 5mg for a few weeks. As John, the Duke, Wayne says at one point in McClintock, "Ya-ta-hey". I guess it's Comanche for something, but it seems appropriate for this time. I'm on day 2 of NO Generic Cymbalta. Didn't drop it by 5's as planned. Yesterday was a good day. Today is much vertigo, zaps, steel wool sounds that come and go. Have also been having the WEIRDEST dreams. I wake up and go right back to the dream, like for a freaking commercial break! Dreams seem to go ALL night. I have sleep apnea (5'7", 160 pounds), and use my CPAP, but I'm still tired, I assume, from the dreams. Not really nightmares, like as for many I read about. Take vitamins, have for years, but also 4,000 mcg of Fish M 56 6 months
30mg 2xday
1/28/2016
 5  Foot Pain, Joint pain loss of appitite, nausea This drug has been a life saver. I have had severe foot pain for 3 years. Have seen many doctors, had food injections, started on methotrexate, etc. Since starting Cymbalta, I can get out of bed without holding onto something in severe pain. I can now actually work on my feet all day and come home and go for a walk with the dog. I can wear any shoe now without all the different orthotics in them. I feel like I have my life back and can finally start exercising again to get rid of all the weight I gained while being inactive due to the pain. I am grateful my primary doctor put me on this medication. F 49 14 days
1X day
1/27/2016
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 1  Neuropathy Sensation of 'hearing my eyes move.dizziness. nausea. Vertigo. Leg pain. Tiredness. Unable to get out of bed.memory loss.alternating constipation and diarrhoea/diarrhea. Very disappointed in this drug and am trying to slowly discontinue using it. I don't think it helped anyway I have been dizzy and nauseated for three weeks now and am really afraid to take any more of it in case it just prolongs the agony. F 72 3 months
30mg
1/25/2016
 5  Fibromyalgia None known. Tried to see if I could get off of drug, but found that my foot pain was so bad that I could barely function. This is one of the several drugs I take to lead a semi productive life and still able to work full time. Quality of life is still somewhat impaired, but I must keep working for at least 10 more years & realize work gives me purpose to get out of bed at this time of my life. M 49 10 years
90 1X day
1/15/2016
 1  hyperparathyroid Anxiety , night sweats, dry mouth, lack of concentration. I didn't want to stay at work. Tired , fatigue Getting off this med is the worst.. brain zaps, vomiting. I was in bed for a week I couldn't read or write. Constant dizziness and brain zaps I fell broke my ankle. Nightmares. So many others things. This is poison. It took months to get my brain back to normal. Hopeless feeling F 43 2 years
60
1/14/2016
 2  Depression & Anxiety, Joint Pain Very Tired, the feeling of just Not wanting to do anything at all,just feeling BLA and the insane feeling of being so HOT on and off all day it's crazy it's freezing outside and I'm out there in a tank top my neighbors probley think I'm nuts..Did NOT help with my joint pain actually I feel worse I know every medication effects people differently but this definitely isn't for me.. Hopefully it works for someone else.. Good luck.. Definitely would not recommend it.. Sucks didn't help at ALL.. F 40 1 months
30mg
1/11/2016
 1  Depression Brain zaps,dizziness, couldn't sleep,u name it I had!Taking cymbalta was the worse day of my life!! F 36 9 months
60mg
1/7/2016
 3  Major Depression Not sure if side effects were from this medicine or others (Niasin and Zetia for high cholesterol), but I had dry mouth. I was still depressed, and I don't know if it was working. When I forgot to take a dose on time, I had nausea. I went through a difficult divorce and had a lot of other big changes in my life (moving to different house, starting a new business, money issues), but I was still very depressed so I didn't think meds were helping. I stopped taking Cymbalta when I had skipped a dose and was too busy to deal with the nausea. I didn't really intend to stop taking it, but I didn't want to deal with the nausea so I just never took it again. Didn't notice any difference for at least a month. But then I went through more stress, moved again, downsized my business, had staffing problems, no family or close friends nearby, etc. Two months after stopping med, I had extreme memory and disorientation problems. That is getting better because I don't have as much on my mind now, but I can't concentrate, am very lonely and depressed and confused. I have a lot of bad crying jags and feelings of homelessness and fear of the future. I might go back on it, but when I moved 4 months ago, I never finished unpacking and now I can't find my meds so I would need to get a new prescription, but it is so hard to get an apt to see a Dr. I am just generally confused and can't make decisions. I feel like there is no one I can depend on, and no one would notice if I disappeared. F 58 3 years
60 mg 1X day
1/5/2016
 1  Fibromyalgia The amount of pain this offset over the years is not worth the horrible side affects of trying to stop taking it. Its been over 3 weeks of feeling like my head is inflating and deflating, my eyes feel like they are spinning. I have the dreaded "brain zaps". I alternate between rage, depression and crying my eyes out. I have trouble concentrating and my ears are ringing. My short term memory has failed. I can barely drive. I tried decreasing my dose for a week and the side affects hit me full on, so not wanting to extend this for longer, I stopped entirely. I am worried about keeping my job, my relationship and my sanity (maybe even my life). From other patient experiences, it seems this could go on for weeks. The manufacturer should be honest when you start taking the drug about how severe this withdrawal can be and what percentage of individuals have these symptoms. They also need to research how they can help people get off of it, maybe a step down package of 10 F 49 4 years
60 MG 1X day
12/29/2015
 5  Nerve,joint,PTSD post car crash Have had some dry mouth/throat but no other side effects. This medicine has helped TREMENDOUSLY. I was rear-ended while parked and had numberous fractures, spine damage, nerve damage, and severe PTSD. My dr put me on neurontin first but I ended up in the ER. Second day of neurontin, my vision became so blurry I could not see and my blood pressure was off the charts. I was very worried about more nasty side effects with cymbalta. As far as I'm concerned, this medicine is a Godsend. After about 5 days, I felt the best I've been since my car accident six months ago. It's expensive but for me it's awesome! F 38 2 weeks
60
12/26/2015
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 1  Nerve pain and depression Headache hard time concentrating very sleepy nausea memory problems dry mouth Would not recommend F 60 1 days
30
12/21/2015

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