CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Depression Nausea; sweating; loss of libido; loss of appetite This worked for a while and then appeared to stop working so well. I'm currently coming off the drug which is resulting in insomnia, vivid dreams and a bit of a lack of inhibition. This appears to be the general trend for me- the drug alleviates depression temporarily and then the depression returns and the drug appears to have less effect so, after coming off the drug and those associated effects, I feel better. F 35 2 months
60 MG 1X day
10/24/2010
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 5  GAD As soon as I started this medicine I felt like the old me, even my spouse was like WOW. That was 2 years ago. Now I am in my 4th week of weaning myself off because my doctors answer to my problems was to up the mg I was taking to 60mg. I have developed high blood pressure to the point they said I could have a stroke. I am a healthy 37 year old, we eat good and are active. I never had this problem before but high blood pressure is a side effect. I thought my depression and moodiness was bad, but now it's out of control. I cry sometimes for hours just because? My eye's hurt, my eye balls..I can't find where that is a withdrawl effect but how long can withdrawl really take? Dry mouth is terrible. The dentist is worried about what it is doing to my mouth & gums. Not to metion I could care less about sex. Like anything else in life, only you and your doctor can make the right choices but I really think the side effects are not worth it. I was very happy for almost 2 years, I would not trade them with my family for anything. BUT be prepared withdrawl is hard. F 37 2 years
30 1X day
10/22/2010
 1  Fibromyalgia Initially: Hyper, dizzy, disoriented. Later that day: Panic attacks, hypervigilance, insomnia, heart palpitations, chest pain, intense muscle spasms, loss of motor control, slurring or speech, severe hand and leg tremors. I understand that it takes some time to adjust to Cymbalta, and I have read some of the other comments about how if you've only taken it for a short time you are not qualified to truly review the drug, but I have to ask: If a drug requires that much suffering to adjust to it, should you really be taking it? At what point are you clearly just reacting to the drug? My body clearly did NOT want this. The day started out ok. I took the Cymbalta at 9am and went to a meeting. By lunchtime, my co-workers were making comments that I "had too much coffee". I was indeed hyper but couldn't control it. I was annoying to MYSELF! But, I did feel quite happy. I was a little dizzy but nothing I couldn't handle, and I did manage to drive myself home. By 7pm, I started having crazy thoughts- like suicidal. I have NEVER had any sort or mental illness and I've never had any issues with clinical depression, and here I was having suicidal thoughts and panic attacks. My husband returned home and looked at me strangely and asked me what I was "on". I told him I didn't feel right and he asked if I was drunk and said I was slurring. Soon after, my hands and legs started shaking and I couldn't control it. A friend of mine brought me to the ER and they kept me for observation and said I was having a severe reaction to the Cymbalta. Needless to say I didn't take any more pills!I think every person is truly unique and your mileage may vary, but use your head: your doc doesn't know ever M 36 1 days
20mg 1X day
10/22/2010
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 1  Bi-polar, anxiety I have brain zaps, dizziness, fear, anxiety attacks, constipation, vertigo, suicidal thoughts, and so many more Cymbalta is an EVIL drug and should be outlawed! Doctors should be forced to try it before prescribing this to their patients! I weaned off with the help of Prozac but felt so awful even after tried other meds.I had brain zaps, dizziness, fear, anxiety attacks, constipation, vertigo, suicidal thoughts, and so many more. Got so depressed and had suicidal thoughts so I told the doctor to just put me back on it. I hate this drug and feel that after years of taking it I can no longer function without it no matter what meds I try. I hate my doctor! Please do not take this drug! Tell your doctor HELL NO! F 35 7 years
60mg 1X day
10/21/2010
 4  GAD, OCD. insomnia (treated with low dose Risperdal), costipation, mild drowsiness, delayed eiaculation. cymbalta day by day let me know what is really GAD. a destroying disorder that does not allow u to life free. i take it in combination with Risperdal, as said, and Bupropion 100 mg daily. M 24 1 months
60 mg 1X day
10/20/2010
 3  Depression Sexual side effects, needing less sleep, dry mouth. I know that most of the posts on this site for Cymbalta are negative, but I feel that this one really helped me. It's nice to feel like me again, my husband even commented that I was back to the girl that he first met instead of being so sad. I only need 4-6 hours of sleep on Cymbalta when I was really depressed I could sleep all night and day with no issues. I have had crazy dry mouth but I can live with that and the sexual side effects to feel like myself again. I think this one for me is a real life saver. F 24 4 weeks
60 mg 1X day
10/20/2010
 2  bipolar frequent sweats, mental confusion, high blood pressure, high cholesterol, high sugar. also taking 60 mg vyvanse. hard to know whether one, the other, or the combination. severe constipation; periodic shortness of breath, chest tightening. major insomnia such that Ativan has become ineffective. spacey. problem focusing. horrible muscular skeletal pain. intensified insecurity, interference with work performance. extremely forgetful. worsened short term memory. like being in a mini straight jacket (description of physical sensation) not right for me. very serious medications with major side effects downplayed unfortunately for too long. F 58 1 years
60 mg 1X day
10/19/2010
 2  Anxiety, depression Chest pain, heart palpitations, rapid heart rate, high blood pressure, nausea. Was taken to the ER for major chest pain, admitted overnight for observation and spent tens of thousands of $'s on heart scans, etc. Stopped taking and switched to another similar medication. Experienced constant nausea, dizziness, heart palpitations, "brain zaps" (feeling of an electrical pulse in my head when I turn my head or move my eyes), constant ringing in my ears, mood swings, irritability, increased anxiety and much more. Would not recommend this medication to anybody! Have felt awful for 2 weeks so far and have been told by others that these symptoms may last for months to come. M 32 9 months
60 MG 1X day
10/18/2010
 4  depression, severe anxiety, and MS F 40 6 days
30mg 1X day
10/17/2010
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Patient History
 1  Depression, migraines Nausea, dizzy, forgetfulness, insomnia, stomach turning Two days in a row I wake up after 4hrs of sleep or less. I'm very queezy at work and forget what I was supposed to be doing. I work nights and am a single mom. My dr is insistant that I take something for everything I am going through. I cant be on something with these kinds of side affects. Glad I found this site explains why I cant sleep. Bad medicine in my book. Why does something that supposed to help you have so many faults? F 31 3 days
30mg 1X day
10/17/2010
Email
 4  depression and chronic nerve pain At first, dizziness, nausea, headache, bruxism. I solved most of the headaches with a night toothguard for the bruxism (I dreamed I was eating so I figured out I was grinding my teeth, which I never did before. Now, only slight yawning and vivid dreams (I like this). Slight sexual side effects. I'm sad to hear so many bad comments because it has really been a miracle drug for me. I guess it goes to show it's all about your own body chemistry. From about 2 hours after I started taking it, I felt so much better, for both depression and pain! I have tried 10+ other anti-d's and none worked well and all had worse side effects, including one that increased the depression. Cymbalta is almost a miracle for me! (By *almost* I mean I still have some depression and some pain, but it is greatly alleviated.) I am nervous about ever having to go off it tho because I fear withdrawals. F 38 6 months
60mg 1X day
10/16/2010
Email
 1  depression,anxiety lost feelings of joy,could not focus,weight loss,no cares for anything I used to love.deep,scary thoughts never have had them before Cant wait to get of and get my life back.This drug was awful for me.Beware,do your research first F 37 6 months
60 1X day
10/15/2010
 1  Anxiety/depression I felt better while on medication but didn't want to feel dependent on a pill which is how I knew I was ready to come off. DO NOT TAKE!!! The withdrawal from coming off this drug is not worth the benefit. There are plenty of other meds that don't have the withdrawal side effects of this one! I have a very stressful job and I felt I needed help after holding a baby while he died. Yes I was depressed. The medication did help but now that I'm off I still have withdrawal symptoms a month later! The first week of withdrawal was hell. Brain shivers, insomnia, dizziness, Flu-like symptoms, and many others were just the start. Yes I did taper off of it but it didn't matter. Just don't take it! F 27
60mg 1X day
10/14/2010
 1  Fibromyalgia Vomitting, dizzy, legs very weak could not stand, could not drive. Completely out of it and could not do anything but sleep. Took it at night but could not function until 4:00 the next day. Try to go to work but had to turn around and go home. This drug is very dangerous in my opinion. Do not recommend this drug to anyone. F 45 1 days
60 MG 1X day
10/12/2010
 1  Depression Severe nausea, bad taste in mouth, upset stomach, severe dizziness, night sweats, vivid dreams/nightmares My doctor weaned me off Lexapro and put me onto 20 mg of cymbalta a day. The pharmacy filled the 60 mg and I took it for 4 days without noticing I was taking 60 mg. I started to feel extremely ill (nauseous, dizzy, confused) and looked at the bottle closer and saw it was 60 mg. I guess thats why my nausea was so extreme, since I didnt wean myself on it. I started taking the 20 mg's and still felt the severe nausea. I stopped taking it altogether because my dizziness and nausea were so bad I almost went to the hospital a few times. It's been hard just getting through the day without having to keep laying down. My doctor said you cant do anything about the nausea/dizziness because its the brain thats effected and you just have to wait it out. I do not recommend this to anyone. I may go back to Lexapro or consider not taking anything at all for the time being. I havent taken it in almost a week and I still feel the severe dizziness. I never want to feel like this again. F 24 1 weeks
20 mg 1X day
10/9/2010
 1  depression nausea, extreme tiredness, lack of appetite,constipation, abdominal pain, constant bouts of crying Symptoms got worse as I increased dose F 43 1 months
90mg 1X day
10/4/2010
 5  panic attack/PTSD When I fist started taking it I had dry mouth, 1 really bad headache, sleepiness, occasional nightmares and night sweats. After taking this for about a month I was able to start driving again. All my symptoms disappeared except for the night sweats, which were occasional and the sleepiness. for the sleepiness I adjusted when I took my pill. I started taking in the afternoon and I was able to wake up easier and was not sleepy during the day. At first I did not have the nightmares, those came later. The dreams were very real and frightening, nothing like I had ever had before. I also started to have some weight gain and that is the reason I weened myself off of it. I started taking it about every other day, then after awhile I went to every 2 days, this is when it got tough. I could do this for a couple of days and then on the 3rd day I would get really nauseated and vomit. Once I threw up I was fine. I went ahead and pushed through it and this only lasted 2 to 3 days more once a day. After that I was fine and I am still fine. The night sweats and nightmares have stopped. I have never experienced anything like the withdrawl I went through it was crazy, but like I said I only had the symptoms once a day for about an hour or so and once I threw up I was fine and went about my day. Taking this allowed me to get my confidence back for driving. F 38 1 years
30mg 1X day
10/3/2010
 4  Anxiety,Pain Sweaty F 34 4 days
60 mg 1X day
9/29/2010
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 5  depression headaches and migraines, constipation, slight memory loss/forgetfulness, upset stomach almost every day. F 22 1 years
60 Mg 1X day
9/28/2010
Email
 3  Depression Crazy and vivid Dreams, dry mouth at night, needing to urinate frequently during night, insomnia. These side effects are freaking me out so although the crazy dreams are actually quite amusing I am going to take myself off of this now and maybe try going back onto Lexapro. I do hate the numbness that all these meds make you feel but then I guess it is better to be numb than depressed and I am hopeing the psycho therepy will help me manage it. F 31 30 days
60mg 1X day
9/28/2010

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