CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Fibro/depression WEIGHT GAIN!!, constpation, stomach problems( digestion) The Dr's say it doesnt cause weight gain but I was on nothing before Cymbalta & I have gained 24 lbs in 2.5 years. My stomach is distented alot , constpation & now hemmoriods due to the constipation F 34 2.5 years
2/26/2009
 1  peripheral neuropathy & fibromyalgi Severe stomach pain, headache and open gating of pain in all areas of my body for first 48 hours or so. Pain lasted so long I had suicidal thoughts. Effects of loss of appetite and extra pain sensitivity lasted over a month. This is not a good drug. Try anything else. F 56 1 days
2/26/2009
 5  clinical depression extreme sweating when am physically exerted,e.g. gardening. Never experienced this type of sweating. whole scalp is sopping and perspiration runs down face. Was on luvox before and never had any problems of this type. Have no appetite yet unable to shed even a few pounds. constipation, lack of energy, wanting to nap all the time. F 64 8 months
2/25/2009
 1  major depression, neuropathy Personality change,suicidal thoughts and actions, impulsiveness, frequent electric shock-like "heart jolts" that radiate out, worsening of depression as time passed, super hot flushing that emerged even though I've been surgically menopaused 19 years and take HRT. Cymbalta helped my depression in the first months, but as time went by, I became someone else- agressive, impulsive, extremely angry. The depression became far worse and thoughts of suicide emerged. That and the impulsiveness it brought about has led me to several instances of both wreckless and suicidal behavior. I spent 5 months reducing my dose by 5 beads a day, and got off completely 2 weeks ago. I had tried by 10 beads a day prior and had to go back on. And I'm still having problems with the effects Cymbalta has caused, still having thoughts of suicide as recently as 3 days ago. Yesterday was the first day I felt somewhat like my former pre-depression self, but I know I'll probably swing back and forth for awhile. Be extremely careful if you take this drug. I believe it works for some, but not others. Just know it will be hard to get off of; take it very slowly. F 49 1.5 years
2/25/2009
 5  severe anxiety wicked sick dreams, night sweating, increased sex drive it usually brings out the best side of me EXCEPT when i miss a dose or two, its like a bad hangover times ten... i enter depression and cant get out of bed. F 21 2 years
2/23/2009
 5  fibromyalgia When I first started taking the medication the side effects that bothered me the most was for weeks i had no desire to eat and felt nausea. that went away. immediately , my pain went away due to my medical condition. I have a family of 5! 3 kids including a set of twins! I would not be able to survive without this medication. the other downfall is that it is very difficult to have an orgasm!!! I plan on talking to my dr. about this issue and she said she would be able to put me on something along w/ cymbalta if this did happen. I have yet to do that. I would die without this drug. It has saved me. I wake up every morning and can;t wait to take my happy pain free medication. I can't say enough about this medication. F 35 2 years
2/23/2009
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 1  General pain, mild depression Extreme nausea, diarrhea, dizziness, inability to concentrate, drowsiness, anxiety I only too 1 dose of 30mg, and within about 2 hours I was curled up in fetal position from nausea. I spent the whole night back and forth from the bathroom to bed, with diarrhea and dry heaves. The next day I felt completely out of it and was not able to function, so I spent my entire Sunday in bed. It is now two days later, and I'm still barely able to function! F 30 1 days
2/23/2009
 3  depression and fibromyalgia None except for swelling of hands and feet. Could not get my shoes on or my rings off. Helped with depression but no lessen in pain from fibro. My doctor took me off of cymbalta and am now on effexor. Have urinated a lot and my rings come off now and can wear shoes again. No withdrawal symptoms at all. Feel very good now. F 57 5 weeks
2/22/2009
 3  depression lethargy, increased need for sleep, extreme night sweats, daytime sweating, vivid dreams with violent behavior upon waking I have struggled with depression for 30 years without seeking couseling or medication. After severe period of anxiety and depression, got very good initial results from 60mg. after no help from Lexapro. Assumed extra need for sleep was just "catching up" from sleep deprivation over previous months. Now getting worried because the vivid and often pleasant dreams have twice ended with me striking my wife who was cuddled up close to me. Last night I dreamt Will Farrell was clowning around in his typical movie character and throwing things around the RV in which I was actually sleeping. In the dream I jokingly threatened to punch him if he did not stop throwing stuff around. I asked if he preferred a right or a left. He chose a left and I struck him. My wife's outcry woke me as I had just knocked her on top of her head, jamming my own left thumb severely. This is not me! I adore my wife and would never hurt her. This behavior has to be caused by Cymbalta. Reading many other comme M 58 2 months
2/21/2009
 1  depression/anxiety vivid nightmares, apathy, bladder spasms, increased anxiety, weight gain..100 pounds, blurry vision, headaches, body tremors, night sweats, dizziness, fluid retention, tachycardia, hypertension, confusion this is by far the WORST ad i have ever taken. i am trying to do a slow taper, and i mean very slow and the withdrawal is HELL! it increased my anxiety and did nothing for my depression but i became so apathetic i didn't even care how horrible my life had become. M 31 18 months
2/21/2009
 1  Fibromyalgia Blurred vision, diarrea,constipation, indigestion THIS DRUG NEEDS TO BE TAKEN OFF THE MARKET! In the begining I thought I had experinced a miracle the chronic pain I had experienced for the past 8 years was 75% gone so I managed the bowel problems with immodium or fiber, and ate alot of tums. Ignored the vision problems I was so grateful for the relief from the pain. About 7 months into it I started becoming very drowsy,started drinking ten to twelve cups of coffee a day to stay awake. My mood started getting very dark and I suddenly found NOTHING funny, I was angry all of the time. Instead of mumbleing under my breath at other drivers I would scream at them, would tell clerks in stores they were stupid... then the pain started coming back. I not only spoke with my physician but with a pharmacist I have known as a personal friend for twenty years they both agreed that this was a complete personality change for me. The pharmacist told me that this DRUG works by shutting down your brain. hence my need for the caffeine. F 62 9 months
2/21/2009
 1  mild depression,anxiety,chronic pai I feel like I have been drugged. Its a zoombified high.I took 1 dose and have had diahrea,dry mouth,catatonic feeling. my 6 year old had to take care of me. The side effects outweigh the benefits.Extreme heart palpations and the feeling of "bugging out". Will never take again. F 45 1 days
2/21/2009
 1  Depression High pulse, high BP,shortness of breath, severe headaches, yawning, diarhea, swelling, loss of sleep, light sensitivity, mood swings I was on the "drug" for one year prior to all the headaches and blood pressure issues began asked my MD to take me off, myMD was not convienced it was the problem after several ER visits and BP and headaches became worse the shortness of breath and fluid retention began. I took myself off the "drug" and went to see a cardiologist and he diagnosed me with Cymbalta Poisoning. After I took myself off the "drug" the brain shocks become worse. I am now taking Atenolol for my pulse that now runs around 120 a minute. Prior to Cymbalta my BP was 120/68 and my pulse ran around 60-80. F 31 1 years
2/17/2009
 1  depression,anxiety brain zaps,excellerated heart rate,bad dreams,night sweating, tingling of hands and feet,weight gain (feeling hungry all the time) Please be carefull with missing a dose with this drug!I missed 3 to 4 days and I tried to kill myself...ended up in the hospital for 5 days.I was only on 60mg.I just went down to 30 and it has been an awfull week.Irratability,severe depression,crying a lot,dramatic mood swings.I really want to get off this stuff...it's too scary! F 33 1 years
2/17/2009
 5  Severe depression dizziness, erectile dysfunction, constipation, high and low sex drive M 47 2 years
2/16/2009
 2  Anxiety/ Depression Dry Mouth, watery eyes, blurred vision, sleepiness, yawning (excessive), loss of appetite, extreme night sweats, and vivid "nightmares" just to name a few. I've been taking this medication for almost three months and although it has helped with my anxiety and depression the negative side effects outweigh the benefits. Mostly the loss of appetite and night sweats-most nights I wake up soaking wet. Then there is a decrease in sex drive, longer time to climax and when I do it's not as intense. It's scary because I don't want to live with depression and anxiety, but I don't want to be a tired, indifferent, skinny zombie that can't-or rather doesn't have the desire to please her man. F 29 3 months
2/16/2009
 2  Depession Lots of anxiety not sure about taking it anymore M 57 10 days
2/14/2009
 1   Aweful diarrhea, reflux, Feeling of beeing stoned, yawning +- 300 times per day, tired eyes, flat emotions, dulled senses, extreme tiredness, vivid dreams, ringning ears and "charged feeling" in my head, reduced general pain, slow reflexes My pdoc put me on this stuff for serious anxiety and mild but chronic depression. First day I take it im tired and groggy within half an hour. this feeling eventaully develops into a pleasant feeling much like being STONED on marijuana. Im in lectures and yawning furiously. I cant stop yawning, my eyes are watering i want to go to sleep. I cant get any reading done, im so bombed. call my pdoc, he says take it at night. i do. get tired right away and fall alseep. i wake up at 5am feeling like im staring though my eyes from a control room in a distant galaxy. I just lie there with blurred vision, not knowing what to make of this feeling, it fast becomes extreme anxiety. My ears are ringing and i get up and stumbles around in panic. get back to bed but with my lamp on because i feel uncomfortable because of a heavy feeling of darkness. wake up late, im lethargic and late for class. spend the day at uni basically stoned. social anxiety a minimum. dont really care what i say or do, who i lo M 27 2 days
2/14/2009
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 1  Depression, Moody, Sad WEIGHT GAIN, Abdominal cramping (GI symptoms), FATIGUE, headaches, diarrhea then constipation, water retention I work in the medical field and truly wish I would have done more research instead of just trying the newest drug that hit the market.My dr recommended Cymbalta and said that he's heard great things from his patients that have been on this med. I even looked it up in the Physicians Desk Reference (PDR) before agreeing to take it. Everything seemed to be positive. NO WAY!! I have since been to a Nature Path, Gastrointerologist, Allergist and Immunologist, as well as the Gynocologist that I work for, to try to figure out what has been causing my abd pain and excessive weight gain (40+ lbs). Not one of them mentioned that it may be the Cybalta because the PDR states "weight loss". Total crap. I've been on this for 2 yrs and am in the process of coming off- enduring the same 'brain zaps' and moodiness everyone else mentions.Take my advise... don't start this med!! I have no idea when I'll get back to 'normal'. My weight at 140 lbs made me sad... but now I'm really depressed at F 35 2 years
2/13/2009
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 4  Long term Depression Brain zaps if miss a dose; dry mouth I have been on this drug for 5.5 years. I took huge levels of other antidepressants without the results I have gotten from cymbalta. I am nervous being on it so long and the brain jolt effect however It is the longest I have gone in my life without a depressive cycle. I usually spent half of each year depressed since I was a child and am 38 now and have not had a majopr depression since I started the cymbalta. I do have a few nerological things going on but they have not been connected to the cymbalta. I am afraid of to go off due to how hard it is and then wonder if I did would I be depressed again? so for now I think it is best to stay on. F 38 5.5 years
2/12/2009

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