CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  Depression, anxiety, insomnia First few months dramatic decrease in sex drive and ability to have orgasm and ejaculation. Worked like a truth drug telling people exactly what I thought about them and everything else but very calmly and to the point. Increased desire to consume alcohol. No other side effects and the sex drive/performance issues leveled out to normal after a few months. The blatant honesty side effect was surprising at work, home, and with friends but was liberating for me personally. Way more social and easily engaged in conversation with friends and total strangers. Discontinuing this drug has been a big challenge for the past month. This is the worst side effect of all since life was really good while I was taking it. M 47 1.5 years
30 mg 1X day
8/28/2010
 3  Depression - extremely suicidal Inabailty to orgasm, insomnia, migraine headaches, jaw clenching, feeling 'wired' and speedy. I found the drug very effective at lifting my mood and removing depression. I also found it made me feel more empathetic and connected to people, something i had not felt for a very long time. I found that once the initial start up dose of 30mg was increased to 60 mg, I suffered from migraines for a period of time. Eventually these went away. Also i found it very difficult to orgasm. This actually became worse the longer I was on the medication, and in some ways the only way to have orgasm was to stop taking the medication for a day, then wait till the next day to have orgasm. I also began to find it really hard to sleep, and also felt too racy and speedy. I have recently stopped taking cymbalta - even though the +ve on mood and disposition were very good, I found not being able to orgasm, sleep etc were making me want to stop taking the drug. Since stopping, I definately am struggling again with mood, and disposition... I may try another type of anti_depressant... I'm not sure yet though. M 35 5 days
60 1X day
8/28/2010
Email
 4  Depression Constipation, vivid dreams and restless sleep patterns Overall this med helped me with my energy levels and fatigue. I know longer feel tired in the afternoons, I no longer cry at the drop of a hat and I feel alert and focused. Prior to taking this, I was a trembling, sappy mess who could not think about holding a job. Now I am on my second interview thanks to Cymbalta F 44 40 days
60 1X day
8/27/2010
 3  GAO Nausea, dry mouth, loss of appetite Has already started helping with my anxiety. Involved in very stressful situation last night and felt very calm throughout. I weighed myself and have already lost one pound in just 2 days from loss of appetite. It's the weekend though, so I'm concerned about the nausea during work hours. M 39 3 days
30 1X day
8/22/2010
Email
 3  Neuropathy pain & depression Increased depression, lethargy, fatigue, sugar cravings, night sweats Initially, I felt that my depression worsened- even though my nerve pain lessened. It has been a difficult summer so I questioned how much of it was the medication vs. situational depression. It is always important to look at the big picture and not jump to conclusions about what may/may not be a side effect. I was strongly encouraged to try to ride out the side effects, as a nurse, I know that these improve or disappate in time. The night sweats decreased, the fatigue continues- but I also work night shift and wonder if I am just getting burnt out. I initially started with 60mg, but intended to titrate off the medication, so I slowly reduced my doseage to 30mg- where I currently remain. I am feeling better and am beginning to feel like perhaps I should continue and see how things go. I also am on Wellbutrin for depression. I am not sexually active, but think if George Clooney showed up... I might not care much. I strongly encourage anyone trying this medication to not go off it without talking with your doctor about how to do so safely. Also, please give it a chance to work, there will likely be side effects to most medications you try- but your body needs a chance to adapt to it and this can take 2-4 wks. As I said, I am stablizing- it has helped my nerve pain, I am using the Neurontin I was on only once daily now for trigeminal nerve pain from a crushing blow. For now, my plan is to give it another month and see how I feel. If there is any weight gain wh F 41 30 days
30mg 1X day
8/22/2010
 5   Dry Mouth: Tolerable. Loose Stool: Also tolerable. Decreased Appetite: Tolerable and Grateful! It's Day 4. I didn't realize I had GAD. I thought BEING ANXIOUS WAS NORMAL. In the past year, I've lost a family member, gotten engaged, moved to fiancee, lost two friendships, and have had two family members in the hospital 4 over 25 days with major medical life threatening problems. I have been to 7 doctor appts since April certain I have "a condition". My thoughts, every day, were centered around "when they find a diagnosis.." That thought process led to Sweating, Acting Out, and Severe TMJ with Bruxism. My Doctor prescribed Cymbalta for day and Xanax for night to deal with the teeth clenching. I already feel NORMAL. I can sit and focus on my job. I can now sit and focus on what family and friends are saying. My mind is quiet. AGAIN, I DIDN'T KNOW I HAD ANXIETY UNTIL I TOOK THIS CYMBALTA. I just thought I was a TYPE A, High Strung, Colorful Character. ALL I CAN SAY IS ...WHAT A RELIEF... Doc gave me 60mg for the next week. I am going to call him and tell him 30mg is just fine. GIVE IT A CHANCE. F 43 4 days
30mg 1X day
8/21/2010
 4  fibromayalgia runny nose,hot flashes, extreme sweating ,weight loss,gas,dry mouth,vaginal irritation,ejaculation problems i went on cymbalta five weeks ago as a tryout.my doctor gave it to me to take together with amitripyline at nights.after the second dosage i felt a relief.the horrible pain was gone.my mind could focus properly,i felt energetic. i was happy. by the end of week number one i began to have dry mouth and i got an infection in my vagina.the doctor took me off it ,but the withdrawal was so bad with so much pain that he put me back on it.right now i am five weeks in and my life is a living hell. i am always thirsty,have a bad taste in my mouth ,sweating all the time, passing gas all over the place, i have had some weight loss, loss of appetite and my sex life is suffering. i also have internal body heat.i want to be free of this drug but it helped so well with the pain,and i don't want it back. withdrawal symtoms are worst. please if Dr.says cymbalta to you say no.it is like a satan. F 26 5 weeks
60 mg 1X day
8/20/2010
Email
 4  Depression/Fibromyalgia Dry mouth, fatigue, dizziness and nausea for the first week I'm very sensitive to medications and originally reacted very badly to a 30MG dose of Cymbalta. When I was switched to the smallest dose possible, I did much better. The physical side effects were the worst the first two weeks, but psychologically I felt a change from day one. It's not a miracle worker and does not take away all my pain, especially on a low dose, but it helps me mentally balance so that I can focus on healing and managing my pain. Forgetting a dose does have side effects like nausea and dizziness and a major brain fog, even on the lowest dose - don't forget doses and wean yourself off slowly if you're trying to quit! :) F 20 6 months
20 MG 1X day
8/20/2010
 3  Anxiety/Eating Disorder Reduced anxiety, some weight loss, memory loss, confusion, nausea, decreased appetite I told my doctor that I would not take anything that was linked to weight gain, and that i would do my own research to find out. After reading Cymbalta and no connection to weight gain I agreed to take it. At first I was happy with it. It has significantly reduced my anxiety to a level where I can now function, however after reading everyone elses comments, I'm begining to wonder whether my recent weight gain could be attributed to this drug. Overall, its done what it has meant to for me; reduced my crippling anxiety F 26 4 weeks
60 1X day
8/19/2010
 1  Fibromyalgia/Back Pain Excessive sweating/Hair thinning/Insomnia I called Eli Lilly about the hair thinning since it is not listed as a side effect. Also, reported to the FDA. All online now, only takes a few minutes and includes prepaid postage. I am so tired of drugs that I try helping me with pain but then have such horrible side effects! The FDA needs to hear about it. Eli Lily stated that they don't have to report anything under 5%. Anyone else having hair loss problems as a side effect should also call the company and report it to the FDA. F 48 4 months
40mg 1X day
8/19/2010
 4  anxiety dry mouth, sleepiness started to not work as well after 4 years M 52 4 years
90 1X day
8/18/2010
 1  Severe depression Four broken teeth due to grinding/clamping of my jaw. In June 2010 I suffered a detached retina and have very little vision in my right eye. Only now that i am starting to feel better have I realised that this drug may be responsilble for these side effects. now suffering from stomach cramps, constant nausea and insomnia whilst trying to come off this horrid drug. F 44 18 months
60MG 1X day
8/17/2010
 5  nueropathy after chemo; depession constipation but helped w/ additional fiber; some weight gain This drug helped the severe leg and muscle pain immediately! I was depressed and overwhelmed during my cancer treatments, and the 2nd round of chemo caused pain that prevented sleep - or any real rest. I feel so much better now, sleep easily, can focus at work,am happy and able to deal with my situation. Comparing how I feel now to a year ago is night & day. And, the weight gain is probably because I enjoy eating again. It's been amazing! F 61 11 months
60mg 1X day
8/15/2010
 4  Depression Fibromyalgia at start dry mouth& metallic taste; started clinching jaws which causes headache, tooth and gum pain & neck pain. The dry mouth is very insignificant compared to depression. For those people who do not understand why anyone would take these drugs with all the side effects YOU HAVE NEVER SUFFERED REAL DEPRESSION. It is necessary to find one with fewest side effects and everyone is different. What can you live with?? I am assuming the Cymbalta is the cause of the clinching. I had the same thing with Lexapro along with some other things. M 68 2 months
1X day
8/15/2010
 1  Chronic Pain HAIR LOSS STARTED UP AFTER 5 MONTHS AND HAS BECOME A MAJOR PROBLEM. OTHER SYMPTOMS HAVE GOTTEN WORSE: SUGAR CRAVINGS, EXCESSIVE SWEATING, JITTERY/ANXIOUS This drug worked wonders for my pain from Fibromyalgia and chronic pain that occured after surgery. It lifted my depressiona and make me a happier person-for 5 months. Then major side effects started occuring as stated. Also, the anxiety is now interfering with my life. Scared to come off of it because of the prior pain yet cannot handle these side effects. Every time I put my hand through my hair, I have a hand full of hair to throw out. Finding my hair everywhere. That is also very scary. F 56 6 months
30mg 1X day
8/14/2010
 4  Depression Bad breath, Weight loss, Feel drauzy, Increased sexual lust, Cold sweats F 24 2 months
30 1X day
8/13/2010
 1  depression anxiety Horrible sweating,feelings of tremendous heat.Numb and prickling hands,horrible taste in mouth.Feeling sick-headachy and nauseous all the time.Heart racing.Pounding all over.Can't sleep.Strange feelings that I can't describe.Mental confusion and loss of memory. Cymbalta does control anxiety a lot,and depression to a very small extent,but I can't keep taking this drug due to awful side effects. F 60 3 months
20-30mg 1X day
8/12/2010
Email
 5  severe refractory depression weight loss, anorexigenic, dry mouth (most notable the first few days), "speedy" feeling (dissipated after two days) This medication literally saved my life. I've battled with PPD and major depression since first getting pregnant 4 years ago, which took a sharp turn for the worse within weeks after giving birth. I've tried every SSRI and SNRI on the market, with no (or negative) results. I finally gave up the search for an anti-depressant almost 2 years ago, and dealt with the resulting problems as they presented. I confessed to our family physician that I was experience severe bouts of anger (I went so far as to throw a lit cigarette at my husband the day before because he wouldn't "leave me alone) and I've never experienced anger like that before -- I am the most passive, peaceful person on the planet. My physician suggested depression, at which I baulked -- I figured it was anxiety, or stress, or just "life catching up with me." My physician smiled and told me to give it a try; at the very least, he said, it would help curb my anxiety and reduce the incidence of my panic attacks, something I've dealth with, unmedicated, since I was 8 years old. I took the prescription, but decided not to fill it. My husband, who is vehemently opposed to "mind-altering" medications, was the one who finally prompted me to try Cymbalta when he came across the prescription four days later. I was very hesitant, but I figured I'd take it once to appease him and be done with it. I took my first pill just before we went to bed that night, and within an hour, I noticed the first po F 26 2 weeks
60 MG 1X day
8/11/2010
Email
 2  Depression Heart racing, vivid dreams and/or nightmares every single night, total loss of interest in sex, difficulty concentrating/focusing, weight gain/impossible to lose weight, and my head feels strange - hard to describe like sort of light-headedness. Also, tiredness and lack of motivation. I was on lexapro for years and it worked just great - I am switching back. Cymbalta didn't even relieve my depression symptoms fully and I am not increasing my dosage because the side effects bother me. F 36 4 months
30 MG 1X day
8/11/2010
 5  Major Depression, PMDD, Anxiety First Month: Insomnia, Constipation, Nausea, Exhaustion, Severe Withdrawal with missed dose. Side effects have relented a bit into the second month. This drug is horrible at first, but you HAVE to stick with it. I know it's hard. You CANNOT miss a dose or you will be sicker than you've ever been in withdrawal. I can't even begin to describe how awful it is. Constipation was really bad in first month, now it comes and goes. I've increased my fiber through my diet -lots of fresh fruit and veggies, that seems to help. Nausea is pretty much gone, and my sleep pattern seems to be normalizing now. For the first few weeks I was on it I had intense dreams, some of them unpleasant. If I was able to finally get to sleep, the sleep was not good. That has also subsided. This drug has saved my life. After 2 months I am feeling mentally normal again. I am slowly getting my life back from severe depression. This is a hard drug to stick with, I was REALLY sick at first. It really does get better. Just DON'T miss a dose. 24 hours after missing a dose the withdrawal is really intense and you are really sick until about 3 hours after you take a dose. I've suffered with PMDD for years, and I always know when I am about to start when the PMDD starts up. I can get so depressed right before my period that I would be downright suicidal, cry uncontrollably, have passive aggressive tendencies, and that is gone. This month I did not even know I was about to start! I don't know how I will ever get off this drug when the time comes, because of the withdrawals. For now it has drastically changed my life for the better, so I will just have to cross that bridge when I get there. F 33 60 days
30 mg 1X day
8/10/2010

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