CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  Depression Mild Constipation(went away after 3 weeks) decreased libido (still in effect). Increased sweats (went away after 4 weeks). I now blackout when drinking hard alcohol (never happened before), also prone to emotional outbursts and crying when drinking hard alcohol. Okay with beer. I like this drug alot, most of the side-effects have gone away, except for decreased libido (but not really a problem since mine was over-active before) and the fact I can no longer drink hard alcohol. Has helped tremendously in getting rid of persistent negative thoughts. Most symptoms of depression are gone, some still remain, but i've only been on it for 4 months so far. M 25 4 months
3/21/2007
 2  severe depression Triggered extreme rapid cycling. The good thing I can say about this med is that it helped determine for sure that I have bipolar disorder. I went into severe rapid cycling, mania, hypomania, severe suicidal depression ... it was terrible. I am coming off it now and already see a difference. DO NOT TAKE IF YOU ARE BIPOLAR WITHOUT DISCUSSING THIS WITH A PSYCHIATRIST!!! F 22 3 months
3/21/2007
 4  depression Increased sweating, occational night sweats, mild constipation, difficulty to orgasm. So far so good. I can live with the minimal side effects I am experiencing as long as it continues to help me feel better emotionally. It does scare me to read all of the horrible side effects most are experiencing though. F 32 6 weeks
3/20/2007
 1  anxiety/MILD DEPRESSION Constipation, sexual dysfunctions, bloating, irritable bowl, weight gain (YIKES!!!), sluggish/numb feeling, uncontrollable hunger especially for carbs and sweets!!! WHATEVER YOU DO...DON'T DO IT!!!Been trying to come off for about 3 months now. After 3 tries at different SSRI's this was supposed to be the golden pill. BULL!!Should have used my better judgement and went the natural way. Don't care what the med. prof. says, no taper will work! First was told to quite cold turkey, thought I was going to kill someone or myself(not because of mental dysfunction, but because I felt so HORRIBLE). Brain zaps, dizzy, wierd feeling like eyes were going to pop out, ringing in ears, wooshing in head, nausea, tiredness, overall feeling of being drunk and hung over at the same time! Have tried the suggested taper program--same outcome, even tried using empty casings to make my own lower doses tapering for 3 weeks from 20mg to 2.5mg. OK until 0MG--same outcome! Now 2 weeks of living in pure HELL, I have desperately found that pseudoephedrin is in same family and will ease the symptoms, but now am addicted to pseudophed every 4 hours!! If anyone have any a F 38 7 days
3/20/2007
 1  Depression None at all. I didn't notice any effects at all. I also know a number of other people who have also been recently prescribed Cymbalta and they have told me they have had no effect. This seems to me like a pointless drug that is currently being heavily prescribed because it was recently approved. But if it helps some people, great. M 30 2 months
3/19/2007
 1  
3/18/2007
 3  Depression Extreme itchiness including eyes, inside ears, inside nose, down throat and all over skin. No rash. No hives. Itching stopped with discontinuing medication. Medication was starting to improve mood. F 54 1 weeks
3/17/2007
 2  Complex Regional pain syndrome severe Constipation, Urine retention, no libio, It seemed to numb all my bodily functions. F 37
3/15/2007
 1  depression Cymbalta initially made me feel agitated. My doctor thought that perhaps I was under medicated, so he increased my dose. I then started to feel manic. I had hot and cold chills while taking this medicine; I felt like I had the flu the whole time I took it. I also lost my ability to have an orgasm! I stopped taking this medication and now am back to normal, orgasm and all. I was told that this drug was great, that many people were doing well on it, but sadly, it did not work well for me. F 40 28 days
3/15/2007
 5  neuropothy initial- sleepiness, lightheadedness, loss of appitite. coming off of this is a NIGHTMARE, i would recommend weening yourself down off of it, cold turkey will make you seriously want to kill someone. this is my second time being perscribed cymbalta, the first time i stopped taking it ONLY because my insurance no longer covered it. let me tell you, for me--this drug is HEAVENSENT. i was miserable before i started taking it, excrutiating pain down my left hip and leg, tried everything--this was the ONLY thing that worked and it started working immediately. i've been on it again now for 3 days and i can say that the worst part of this drug is coming off of it or going onto it. if you stick it out--things get SO MUCH BETTER. F 25 4 months
3/14/2007
 5  low back pain constipation I was in a bad car accident and hurt my low back (L-5) and had undergone all kinds of injections, etc to get out of pain. My dr suggested Cymbalta. I was on in for 6 weeks and told my dr it was "a miracle drug." It was the first time I was out of pain in 4 years. Then, just as quickly, the pain came back. My dr said that he had other patients who had experienced the same response. Those of you on it for a month or so, good luck, I hope that it keeps you out of pain. I wish that it still worked for me. F 49 4 months
3/14/2007
 4  depression/anxiety Do NOT suddenly stop taking this med. The withdrawal period is miserable. Brain zaps and severe personality changes - taper off slowly with help from a doctor. I tried to take myself off of it when my Rx expired, bad idea. But it did stop my emotional outbursts and crying spells. F 32 2 years
3/14/2007
Email
 4  pain in muscles after taking lipito
3/14/2007
 2  motor peripheral neuropathy took 60 mg dose after breakfast, then the horror begins; severe chest pain at first, sat down wrote a goodbye note, well the chest pain passed then was cold sweats, chills, sick feeling all day, finally was able to eat something, tried to sleep it off. No Good, head felt like it had a gyroscope gone crazy inside, was not able to sleep the entire night, wanted to go outside and run around in circles, but was unable to due to foot/ankle pain swelling etc. I guess I just can't tolerate Cymbalta or another possibility it was stored at improper temparature. a sample bottle that was by my PC Physician, Now after 2 years I am going to try Lyrica, I hope the chest pain doesn't return. M 50 1 days
3/13/2007
 5  anxiety / depression no side effects still have my libado! F 42 6 months
3/12/2007
 1  Generalized Anxiety Disorder Nausea, depression, night sweats, excess sleep, panic attacks, severe anxiety, general inability to function followed by negative personality changes that friends and loved ones noticed after a few days. My psychiatrist and MD both wanted to get me off of xanax because of habituation and dosage creep, I'm up to 4mg+ per day after 3 years of using it. FDA recently approved Cymbalta for GAD so my MD put me on a 30mg trial dose to see how I handled it, along with my (habituated) xanax dose. The idea was to let the Cymbalta do it's thing for a while then taper off the xanax. The result was an abject disaster on every possible level. I don't suffer from depression, and I'm glad that this helps people who do. The side effects were far worse and much broader than described in their clinical trials. Basically, the first few days I felt extremely toxic physically, then when the brain chemistry changes started to kick in, my anxiety level was off the hook to the point of nearly complete dysfunction. I lost a week of my life to this stuff, just two weeks after it was officially approved by the FDA for exactly the problem I have - GAD. I've been off it for two days now and I finally feel li M 44 7 days
3/11/2007
 1  Generalized Anxiety Disorder Nausea, depression, night sweats, excess sleep, panic attacks, severe anxiety, general inability to function followed by negative personality changes that friends and loved ones noticed after a few days. My psychiatrist and MD both wanted to get me off of xanax because of habituation and dosage creep, I'm up to 4mg+ per day after 3 years of using it. FDA recently approved Cymbalta for GAD so my MD put me on a 30mg trial dose to see how I handled it, along with my (habituated) xanax dose. The idea was to let the Cymbalta do it's thing for a while then taper off the xanax. The result was an abject disaster on every possible level. I don't suffer from depression, and I'm glad that this helps people who do. The side effects were far worse and much broader than described in their clinical trials. Basically, the first few days I felt extremely toxic physically, then when the brain chemistry changes started to kick in, my anxiety level was off the hook to the point of nearly complete dysfunction. I lost a week of my life to this stuff, just two weeks after it was officially approved by the FDA for exactly the problem I have - GAD. I've been off it for two days now and I finally feel li M 44 7 days
3/11/2007
 5  for fibromyalgia pain It kept me awake at night if I took it before bed. I now take it after I wake up in the morning, and I'm sleeping fine. I'm amazed how well it has reduced my daily pain level. I have no other side effects. I take 30 mg. per day. F 44 45 days
3/7/2007
 4  Major Depression and anxiety Night sweats, drowsiness I have been on Cymbalta now for 3 weeks. Started at 30mg for 2 weeks, then upped to 60 mg for 6 days and 120 mg for the last 2 days. Medicine seems to be kicking in over the last 2 days. I have been able to go without taking any Xanax for anxiety for 2 days. Also, my mood has been better. I hope this works - have been in my current episode of depression for 5 months now. Have tried 3 different medications and nothing has worked. Am cautiously optimistic about Cymbalta. If it keeps working, I will be back in a week to give it a full5 instead of just a 4 rating!? M 40 21 days
3/7/2007
 3  Depression Emotionally numb, wasn't happy or sad. No libido at all, was unable to orgasm from sex. F 27 6 months
3/7/2007

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