CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  neuropathic pain post-chemo/depress nausea, headache, excess sweating, insomnia This SNRI is not for everyone, certainly not for me. Side effects are too marked to continue this. F 56 1 days
10/11/2009
 1  depression/anxiety med helped for a while, but I gained about 30lbs in the midsection. I was always thin and fit before. was taking it for multiple failed fertility treatment's and devastating experience with failed IVF. became pregnant surprisingly (by natural means). my md stopped the 60mg cymbalta cold turkey and switched me to lexapro. I had to be hospitalized within a day for severe vomiting, & electrolyte imbalances. I felt terribly anxious and had heart palpitations I didn't understand. I had waited 7 years for a baby. At 12 1/2 weeks pregnant....after all that suffering, the baby died. DO Not stop this medication cold turkey. They make a 20mg capsule. then you can open it and remove some beads. my life will never be the same again. F 38 2 days
10/9/2009
 5  anxiety, mild depression I did experience some night sweats while on the medication. I did not experience a loss of sexual drive and did not lose/gain weight. Took 20 mg a day. Cymbalta completely changed my life. I am 25 years old and have suffered from anxiety and depressive episodes since 16. After much consultation with my doctor, we decided that cymbalta would be the best choice. I still get mildly sad sometimes or nervous but only for short periods and I am usually able to just stop thinking negative (which I could never do before). I have been happier in the past 2 years than I can ever remember. I even stopped taking it for 4 months and was not a terrible experience. I did not quit instantaneously and went for about 2 months taking less and less each week. I don't think the medicine numbs your feelings and taking a relatively small dose may really help someone experiencing multiple side effects. I have taken 20 mg. a day the entire time. M 25 2 years
10/7/2009
 3  Fibromyalgia/Depression Nausea, diarrhea, upset stomach, dry mouth, sleepiness I have only been on 30mg for 4 days and have the extreme runs. Upset stomach and no appetite. Pain in minimal though and I feel less anxious and depressed. F 38 4 days
10/5/2009
 1  fibromyalgia Terrible side effects! Debilitating leg pain close to needing walker or wheelchair. Bouts of panic. Insomnia. Anti-social behavior. Vivid dreams. Initially nearly bit my tongue off during my sleep on several occasions. It's dangerous stuff. You can't tell me otherwise. I took myself off after my doctor brushed off my rremarks regarding side effects I was experiencing. I never asked for this stuff. She simply put me on it because she notice that "fibromyalgia" was noted on my chart some years prior to seeing her. This drug robbed me of quality life for nearly two years. The leg pain was both muscle and ligament related. At times I would nearly fall down when my muscles would give out unexpectedly. At other times one leg would become rigid and I was unable to straighten it out. At times I could not turn over in bed. Eventually my entire spine became sore and stiff and I had to sleep on ice packs. My doctor blamed this on arthritis. I took myself off the drug and found a new doctor. After 8 days I am pain free! F 61 20 months
10/4/2009
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 1  Depression I couldn't really tell it was making any difference in my depression, so the dr continued to up my dosage. Now, trying to taper myself off this crazy stuff after years of taking it daily, I am experiencing the following: Dizziness, Nausea (now I know what projectile vomiting is!), vomiting, light-headedness... and this has been going on (only when I don't take any) for three months now. It has gotten to where I count the tiny balls that make up the capsule and reduce the amount of tiny balls by 5 every few days and make new dosages by putting "new dosage" in emptied vitamin capsules. Absolute HELL trying to get off this stuff! F 45 3 years
10/3/2009
 2  Depression, peripheral Neuropathy Tired. Always tired. The first 6 months on Cymbalta were crazy. The pain in my legs subsided but I couldn't achieve an orgasim for almost the whole 6 months. Now that I've been taking 60mg for about 2 years I'm emotionally flat. Easy to shrug off anything important. Pain in my legs came back a year ago worse than ever. I ran out of pills on Tuesday. The mail order pharmacy was too slow to get the order out. Today's Friday. Started getting a headache Wednesday, didn't think anything of it. My ears started ringing loudly yesterday and today it hurts to look at the computer screen. Funny thing is when I got out of bed this morning the first thing I noticed was that the pain in the bottoms of my feet was gone. Funny reading about the brain zaps. I wouldn't have known to describe them that way. It's like a rush of blood being sprayed towards my ears from the inside. Colors are more vivid. More detail. I just got my shipment today and I don't think I am going to take it anymore. M 50 2 years
10/2/2009
 1  Depression, Anxiety Could not urinate for two days. Absolutely went from good sex drive to none whatsoever. No orgasm for a month after taking it. Side effects were much worse that what I was trying to treat. My depression became worse that before the med was started. Anxiety increased a lot. My work involves traveling with others and could not uninate for two days. Developed urinary track infection. DRUG SHOULD BE OUTLAWED. I tried to continue taking after one month of Dr samples. Guess what ,Blue Cross denied prescription and had to quit cold turkey. Depression continued to worsen and am lucky to be here today. Stay away from this drug. A patent drug being pushed to Drs by phamacuticals regardless of the results. I will be suprised if you see this drug around in five years. Thank God I made it off and still alive. M 54 30 days
9/30/2009
 3   initial nausea which went away after 1 week. moodiness and agitation at 30mg, stabalized mood at 60mg, but much fatigue and 20 lbs weight gain, back to 30 mg, agitation and moodiness, brain fog, back to 60 mg, better mood, but much fatigue and weight gained back that lost at 30 mg. Taking Cymbalta for peripheral nueropathy and body aches due to a spinal arthritis and possible fybromyalgia. Amazingly, Cymbalta cured? my virtigo and insomnia. First time in years I was able to sleep through the night and dream, incredibly detailed dreams btw. Pain deminished, but then returned after two years on drug. Back to where I started w/ pain and numbness, but still sleeping well and no vertigo/dizziness. Some blurry vision off and on. Prior to Cymbalta I was always very cold, excruciatingly cold when temp was under 50 degrees F. Would like to go off Cymbalta because of fatigue and return of pain and stiffness, but can not risk return of insomnia and vertigo. Sweat alot, but feels good not to be soooooo cold. Reduced to 30 mg, but even though there was no return of vertigo or insomnia, I could not handle the irratic mood swings and brain fog. Now back at 60 mg, I am always so tired and sleep hours dueing the day, lack of motivation, can no longer multi-task and often can not finish what I started. F 47 2 years
9/29/2009
 3  Depression & nerve pain (MS) Drastic drop in libido, profuse sweating, decreased appetite I really don't know what to do. I was switched to Cymbalta from Pristiq for cost reasons because I have no insurance. I have MS and all my meds are very expensive, so my MD signed me up for an assistance plan and Cymbalta is on it. The decreased libido is a major problem because I truly love my husband of 14 years, but I have a VERY difficult time being interested on an intimate level. I also cannot deal with the sweating. I sweat so profusely that it has become embarrassing. I have taken Lexapro successfully in the past and I am thinking about trying that again, regardless of the cost. F 33 2 months
9/29/2009
 3  bi-polar/depression dry mouth, constipation, irritable..more than usual, and sometimes mean, cramping in feet or legs, almost no sex drive (really bad), some nightmares. I have been on cymbalta for a few months now. I am only on 30mg, and have recently noticed I have been very irritable, and short with my husband and kids. Of course they helped point it out. I would say my depression is better, but I am just not very nice right now. As of today my dr. told me not to take it for about 4-5 days and then let him know how I feel. From reading other entries I am assuming I will be experiencing some terrible side effects by doing that...i'll have to call tomorrow and see if I should expect to feel bad. IE: headaches, and etc. F 40 5 months
9/29/2009
 5  fibromyalgia & Depression Dry mouth and Constipation I have been on Cymbalta since Febuary 2009 and I love it... I haven't felt this good in 2 years... I have lost 72lbs since starting it and my Fibromyagia is doing great... I can deal with the side affects when the out come is so wonderful... F 41 7 months
9/27/2009
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 5  Anxiety Day 1 = vomited & had to go home from work. Day 2-3 = felt very high. Day 4-7 = slept 12+ hours per night. Day 1-30 = couldn't orgasm. Day 30+ = body twitches similar to those on Zyban. After first 2 weeks felt the positive effects. Has had a very positive effect on me and has helped me achieve balance - no more erratic behaviour, no more black dog. Generally pretty damn happy. No sexual side effects after initial issues. Can achieve sleep without taking a sleep aid for the first time in years. After initial concerns - I am really happy with Cymbalta. It's been fantastic for me. F 40 3 months
9/22/2009
 5  bipolar for the first few weeks a bit of nausea, nervousness, fatigue/sleeplessness, difficulty reaching orgasm. My temper is perhaps a bit worse. More recently (after about 1 year) night sweats. This medication has been great for me. I tried zoloft years ago but it made me feel emotionally numb. Cymbalta makes me feel more energetic and positive in general. Libido still a bit lower, but it's worth it to get rid of the depression. F 27 14 months
9/22/2009
 3  Depression and anxiety extreme dry mouth at first - could not drink enough water. Hypersomnia - could sleep in excess of 12 hrs per day. Stomach discomfort - started as constipation, then switched to diarrhea when dose was upped from 30mg to 60mg. have seen some improvement in mood, but still lack interest in things I use to love; lack motivation; still isolate/withdraw. F 40 2 months
9/22/2009
 3  depression with fibromyalgia Weight gain (30+ pounds without changing eating habits), uninterested in sex, have days where I cry for no reason, especially right before my period. F 44 8 months
9/22/2009
 1  depression, fibromyalgia unable to have orgasm, loss of all emotion, insomnia, forgetfulness, loss of appetite which I don't need. not worth the loss of sex drive or ability to have an orgasm, ever! Did nothing for my fibromyalgia- Lyrica works so much better. F 39 4 days
9/20/2009
 1  Depression Nausea, diarrhea, anxiety, agitation, bad dry mouth, difficulty urinating. My physician prescribed me Cymbalta because Lexapro was at highest dose (20 mg) and not working. I was put on 60 mg. and have been in my own hell ever since. I am now 3 weeks into trying to get off it. Went down to 30 mg. for two weeks and am now off it completely. I have been having terrible side effects ever since. Constant rining in my ears,vertigo,"brain zaps" that I can only explain as a shock to my brain, agitation, sudden crying, terrible taste in my mouth, headache, sweats, foot cramps, diarrhea and stomache pain, nausea. I feel worse than I ever have in my life! I can hardly get my work done, I freak out when driving because my brain is zapping so often. Those who are trying to come off Cymbalta should be very careful. Better yet never start it in the first place. F 47 4 months
9/19/2009
 2  depression/ anxiety Blurred vision, horrible nightmares, night sweats, itchy hands, leg cramps, forgetfulness, sugar/carb cravings, weight gain, delayed orgasm,not able to really urinate with any real "Ahhhh" feeling. Honestly,I was blaming my problems on menopause,especially the sweats.As far as I know,men don't have menopause and I've noticed they have a lot of my same symptoms.I guess I've got to move on.If getting off Cymbalta is anything like getting off Paxil, I'm in BIG trouble. F 46 1 years
9/18/2009
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 2  Depression/anxiety fatigue, diarrhea, severe night sweats, nausia I would take my pill in the morning right after I ate breakfast around 8:30. At 10:30 I would have a morning snack (carrots, fruit, etc) within minutes of eating my snack I was keeled over sitting on the toilet with severe diarrhea and my stomache felt like it was in a HUGE knot. Took about an hour to go away. That happened everytime I ate with in 2-3 hours of taking it. I was on 60 mg. I thought eventually it would go away after I got used to the meds...NOPE one year later I'm just getting off it. F 28 1 years
9/17/2009

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