CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  
2/17/2006
 5  Depression and anxiety Loss of appetite and weight (5 lbs. in a month). I didn't really have any negative side effects, or if I did, they were very mild (slight "loosening of the stools", which was good because I tend to be, uh, constipated all the time...a little sleepy in the afternoon in the first few weeks...dry mouth in the first week). I consider the appetite supression/weight loss and anti-constipating effect to be *good* side effects! Cymbalta helped my life. I went from having explosive mood swings, to being more easygoing and stable. The Cymbalta is also taking care of more personal and specific issues that I feel a little embarrassed writing about. I feel less needy and fearful of abandonment. F 22 1 months
2/16/2006
 2  depression, fibromyalgia Racing heartbeat, inability to get a deep breath much of the time, headaches, weight gain of 4 lbs. in 4 wks., sleeplessness if taken at night. No reduction in fibromyalgia pain or elevation in mood, although I was taking only 30 mg/day. F 53 4 weeks
2/15/2006
 5  Major Depression , PTSD This med is a godsend. As a positive side effect, it has greatly decreased the back pain from a back injury I experienced 4 years ago. I've had some horrible things happen to me in my life that manifested in depression and PTSD. I don't feel like giving up anymore and even though i come close to bottom some days, I am able to pick myself up and get things done that need to get done. I sufferered horribly from sex harr and gender discrimination in a male dominated field that I loved (and still do). I filed and won a Federal EEOC charge but the process took the life out of me. I've been trying to talk myself into believing that it's not worth it..I should forget about re-entering the field because of my prior bouts of depression and PTSD..I am not as strong mentally as I feel. My psychiatrist tells me that I shouldn't stress myself anymore as I could go off the deep end again. :( A person shouldn't continue to suffer .. get help.. help is out there. Cymbalta is helping me. Good luck to everybody!!!!! F 53 1 years
2/13/2006
 5  anxiety I started on 30mg and that was the difficult stage - many side effects including major sweating, fatigue, headache, nausea. I also felt that I could hear every beat of my heart and I could not sleep at night. Then started on 60mg and things began to change, less sweating, nausea went away but was still having difficulty sleeping. My doctor advised me to take meds in the am to help and it definitely has even though I have tossing and turning nights every once in a while. All other side effects mentioned have gone away. I had taken Prozac for about 2 years for anxiety and felt that it was time for a change because I couldn't feel it helping my situation. My doctor recommended Cymbalta and even though the transition was extremely difficult, I hung in there for 6-8 weeks and now I feel wonderful. It is a great drug for me because it has given me self-confidence and my anxiety level is at an all time low. I also have not noticed a significant weight gain which was important to me. I understand Cymbalta doesn't work for some but if you are willing to give it a try it could really be the one for you. F 38 5 months
2/13/2006
 5  depression, neuropathy For the first two weeks I was very nauseous. After the two weeks the neuropathy pain subsided and had a loss of appetite which was a good thing for me. I continue to lose weight right now I have lost thirty pounds in about 8 months. My mood is better I now get excited about things that are good. I do have sleeplessness but, I am willing to deal with that in exchange for the pain, weightlose and the feeling of happiness. In the past I have taken zoloft which I could not tell that it helped with the depression. My Doctor which me to cymbalta because of the neuropathy pain I was having. I feel this drug has been a great help to me. F 42 8 months
2/4/2006
 4  depression, neuropathy For the first two weeks I was very nauseous. After the two weeks the neuropathy pain subsided and had a loss of appetite which was a good thing for me. I continue to lose weight right now I have lost thirty pounds in about 8 months. My mood is better I now get excited about things that are good. I do have sleeplessness but, I am willing to deal with that in exchange for the pain, weightlose and the feeling of happiness. 8 months F 42
2/4/2006
 1  anxiety Increased heart rate and blood pressure. M 38 6 weeks
2/3/2006
 1  Depression Crying spells, sluggishnish in the mornings when before I got up no problem and no appetitie. Weakness in legs. F 44 6 days
2/3/2006
 4  depression, migrains, ptsd,anxiety, first night no sleep, second night same thing, but with a headache, ibuprofrin worked to rid the headache. not sure what i feel yet. dry mouth. bloated , no apatite.gas. i feel ok one moment then not another, just need time to see. i am afraid of weight gain and hair loss, loss of libido etc.clonzapam helps the anxiety and trazadone helps me sleep. i almost feel as if i need to take this drug in the morning rather than at night, as i get tired in the afternoon and awake all darn night., F 26 5 days
1/30/2006
 1  Bi-polar depression Weight gain, fatigue, lack of libido, significant short-term memory loss and overall flakiness - wore my bedroom slippers to work one day. This drug seemed to work for quite a while and the short term memory loss seemed to increase over time. Now I can hardly function without taking copious notes about everything - I just can't remember. F 37 18 months
1/30/2006
 1  depression loss of appetite,major nauseua,dizziness,memory loss,fuzzy brain, heart arrhythmia This drug should not be prescribed for elderly patients because the withdrawel is quite severe from what I've read for any age but going through it myself has been hell. Wouldn't recommend it to my worst enemy except for my psychiatrist who should take it to experience the symptoms before she recommends such a drug!!!!! F 82 2 days
1/29/2006
 2  Pre PMS Well I was on it for about 2 months .. the only thing I got from this drug was uncuntrolable urges for sweets. I have gained 10# so far... The first time I took the drug I did feel something(heart paplatations..) but not want I needed. Still had the feelings of emptyness and cry very easelie. Felt like people were laughing and talking about me. I felt more from the drug comeing of it... On days I don't work I can sleep till 3:00pm. And the days I do work I come home around 4:00pm and sleep till 6:00pm just to get up to make supper for hubby. Don't go anywhere no desire. Brain sizzle sensations. Hard to explain. Foggy thinking. On my 7th day of detox'g from it. 6 days and up took every other day now on the every 3 days. I have 4 pills left I am go'g to try and open caps and split the littles balls in them to taper down even slower. 42 60 days
1/28/2006
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 4  chronic pain (vulvodynia) Severe stomach pain for the first 5-7 days at 30mg. Slight stomach pain for the first 3-5 days at 60mg. At first, I couldn't tell if it was working; it took a couple of months to be completely effective. Since I began taking Cymbalta, I have had an 80% reduction in the amountof time I am in pain, and when I do have pain, it is much less severe. I was also able to stop taking my migraine preventative (Topamax) and am experiencing less anxiety. F 27 8 months
1/26/2006
 1  depression and neuropathy extreme nausea, migraines, lethargy, loss of libido, flu-like symptoms I'm going to go cold turkey today. I hate this drug. F 51 2 months
1/24/2006
 1  DEPRESSION/IMPATIENCE ANORGASMIA; NO SEX DRIVE; APATHY NAUSEA AND EXTREME FATIGUE WHEN WITHDRAWING F 40 8 days
1/22/2006
 1  depression I was prescribed lithium and cytomel in addition to Cymbalta 60 mg. I experienced increased induced depression. My physician took me off the lithium and cytomel thinking that was the problem. Wrong! I have lived with depression for over 40 years, but it's the lethargy, feeling lazy, not motivated decreased concentration, and oh yes weight gain that I am experiencing from Cymbalta. There's nothing like weight gain to make me depressed. 25 lbs. I told my dr. about constipation and he just dismissed my complaint. I getting to be an expert with soap suds enemas because I am such a zombie I can't remember when my last BM was. When I have my own familiar worst depression, I have never gone three days without showering, and then it took me until 9 p.m. to psych myself to take the shower. I don't remember when the last time I washed my hair. I stop answering the phone. My daughter who lives out of state called police, my circle of friends, my son (who lives in the same city I do) to c I do not go out of the house and although my suicidal thoughts have decreased a little, if I had the energy I think I would be buried by now. F 59 3 months
1/17/2006
 5  Depression, Fibromyalgia, PMS Nausea, dry mouth, bad taste in mouth, anorgasmia, shakiness, sleep disturbance, loss of appetite, weight loss, mild constipation, increased sweating, drowsiness. All except for the change in appetite, weight loss and sleep disturbance stopped after the first 2 weeks. The very second day I took this I felt so comfortable. My fibro pain has gone and only seems to surface quite mildly when my hormones cycle one way or another. By the third day I noticed that my mood, despite the side effects, had evened off to a relaxed medium! What a relief, there are no words (except maybe rebirth) to adequately describe what Cymbalta is doing for me. I FEEL YOUNG AGAIN. I had intense endometriosis pain with every cycle, and experienced 2 cycles on Cymbalta with no abnormal pain-- quite like when I was a teenager. My relationships have started to glow again (my husband is so happy, and I love being a mother again) and I feel more social than ever and more realistic and accepting of deep-seeded childhood trauma. The only downsides have been decreased interest in sex and the sleep disturbances. My neurotransmitters function the way they are supposed to-- when my stomach is full, my brain actually gets the message! Also, my Primary RAYNAUD'S disease, a chronic condition for 9 years, has almost completely disappeared. I lost 2 years to fibro and depression. I now have my life back. F 32 45 days
1/15/2006
 2  depression with pain (migraines) shaky, weak, felt like I was going to faint if I stood at all. "Cold" sweat, flu-like symptoms 30mg. Wasn't taking anything else. My pdoc was pretty shocked with these side effects. F 31 1 days
1/11/2006
 5  dep 2* chronic pain I get dozens of sudden dizzy spells that last a minute or two each if I stop taking it for more than 48hrs. They last for about two weeks but other than that there doesn't seem to be any other withdrawal effects for me (I went cold turkey to see what would happen because of all the horror stories I had heard about going off of Cymbalta). Fluoxetine (Prozac) was the only anti-depressant I had been able to tolerate until I took Cymbalta (it doesn't mess with my norepinephrine levels like Effexor does which Cymbalta is chemically related to). It ups my mood and I actually have a libido again, and unlike the fluoxetine it doesn't cause me horrible dry mouth (my teeth are in bad shape from 10 years of fluoxetine). I have tried everything out there from tricyclics to SSRI's to MAO's to trazadone for depression with disasterous results (dysphoria, priapism, increased depression, paranoia, psychosis, etc.) I can't even take cyclobenzaprine (flexiril) because it is too closely related to the tricyclic anti-depressants. So Cymbalta has been a Wonderful thing for me. M 38 11 months
1/10/2006
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