CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  Fibromyalgia More pain in my neck than usual and a lot of shifting bones, that grate. It has almost been a week but I am not sure I can tolerate MORE pain to see if it will help? Admittedly the comments about this drug concern me, if this is a good thing why does it do so much damage coming off of it? And it doesnt seem like there are many fibro patients that are benefiting from it at all. F 32 6 days
10/27/2009
 2  anxiety, depression, & fibro extreme nausea, headache, inability to concentrate, insomnia The nausea could be for a week or two my doctor told me...but I don't know if I can take it. I'm so sick. No vomiting, but a feeling of the worst case of motion sickness ever. Does it go away. I just want to feel better. F 46 4 days
10/25/2009
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 4  Depression and anxiety When I first started Cymbalta (30mg) I had a major decrease in my appetite and a lot of trouble sleeping. By week three I felt better and was feeling less stressed and happier. I was without Cymbalta for about 4 days, and I felt horrible. I was very dizzy and sick to my stomach. I am fearful that it will be a difficult withdrawal process when the time comes to stop the medication. F 36 3 days
10/23/2009
 3  Depression, Fibro Pain, Anxiety Only major side effect was inability to achieve orgasm which I personally found intolerable. Really worked great on my general pain & depression. Had it not been for the one side effect, I'd likely have continued it indefinitely for Fibro Pain & Depression. F 37 3.5 weeks
10/23/2009
 1  Depression/Anxiety/Nerve Pain Imsomnia, fatigue, moodiness, no energy, no appetite Severe Imsomnia; cannot sleep for more than one hour, feels like out of body experience when I'm sleeping. Vivid dreams, some disturbing. Very tired during the day, moody from lack of energy, no motivation. It's been hell! I am going to stop taking it after 7 days. I was told to give it two weeks, but I cannot take another night without sleep. I have a spinal cord injury and have severe pain and Cymbalta hasn't made any difference in relieving the pain. I feel my depression and anxiety is worse because of bad side effects. I was hoping Imsomnia problem would go away after few days, but it's getting worse. This drug is not for me! F 40 7 days
10/23/2009
 4  Major Depression/ Dysautonomia Vivid dreams, waking up at night some times, will sweat a little more, loss of appetite I am taking 20 mg once a day for depression and dysautonomia. My mood has improved already, to early to tell on the dysautonomia (or re-balancing of the autonomic nervous system)I have been experiencing neurocardiogenic syncope for years which did not stop fully with a pacemaker and cardiac meds so we are trying cymbalta. I have noticed no change in libido but orgasm takes a little longer which my wife seems to like! A welcome side effect is that 30 years of migraine and chronic daily headache has stopped since starting cymbalta I hope the drug is the cause, time will tell as nothing else has ever worked for me. I have found with my cardiac meds a loss of appetite as with the cymbalta, so I eat 5 or 6 small meals through out the day which helps me to be healthier and keeps my weight normal. eg: healthy protein bars/yogurt/nuts/peanut butter sandwich and lots of fluids M 41 20 days
10/21/2009
 3  anxiety/depression take naps mid noon at work, no orgasms, dizziness, nausea, been on it for 4 months (90 mgs) and stopped for 4 days because I thought the side effects sucked. big mistake. back on it now. I can drink a 12 pack of beer no sweat! this stuff has it's ups and downs, like most meds. I wish it weren't so expensive (I have to buy 60+30 each month for the 90 mg.,$$$$$) have only freaked out a few times when around lots of people, so I guess it works. M 38 4 months
10/19/2009
 1  depression, leg pain, migraines Was on it for about 2 months. Would have panic attacks, night sweats, headaches, etc. It was horrible being on it. Started to reduce my dose to 30mg last week. Had to take the whole week off due to the withdrawal side effects. Will go back to Wellbutrin. F 27 2 months
10/19/2009
 1  depression related to chronic pain extreme dizziness, diarrhea, extreme "brain zaps" trying to come off the drug very difficult coming off the drug. Very expensive...$300.00 without insurance. M 51 1 years
10/18/2009
 1  "anxious depression' Decreased libido with no chance of orgasm, but at least I was dizzy, nauseaous, and gained 25 lbs. Oh, and did I mention the doctor said this is the medication with the least effect on libido, and of course, it doesn't affect your weight.? On 60mg for 1 year, and over all felt better...until I tried coming off the drug. It's been 6 weeks and I am still sensitive to motion. During the first 4 weeks I was very sensitive to light, sound, and my fuse was very short. This was supposed to clear my head, not make it spin. F 42 1 years
10/18/2009
 2  multiple sclerosis and depression sweating, weight gain, increased compulsive behavior, felt flatlined, not emotional, stole most of my emotional pleasure, loss of libido it took more than a month to get off of it, that was a horrible experience. rushing sound in my ears, sounded as if I was standing inside of a waterfall. vision and brain not in sync, I would turn my head when changing my field of vision but the picture would appear much later. F 55 2 years
10/17/2009
 3  Depression, fibromyalisia Mid day sleepiness. The worst was the excessive sweating, I would soak through layers of clothes and would have to change every hour even with the mildest movement such as grocery shopping. If it hadn't been for the cold sweats I loved the results. It took six years to figure out it was the cymbalta wasn't worth having the cold sweats which agrivated the fibromyalsia. I would rather be suicidal. F 46 6 years
10/16/2009
 5  depresion None so far, and I have been taking the same dose for almot 2 years. M 46 2 years
10/15/2009
 4  Depression, Anxiety aorgasmia, decreased libido, weight gain, concentration, focus, short term memory issues, mania As with all SSRIs and SNRIs, your results may vary. I have found it astoundingly useful as a mood elevator/anti-anxiety drug (my mood changed within two hours of the first dose, though my understanding is this is abnormal). The major side effects have been libido and energy decrease to the point of total inability to complete tasks. Presumably this is due to sensitivity to the product on my part. In short, it did what it was supposed to do quite effectively, but at a rather high cost. Am now taking Vyvanase to combat the cognitive problems. M 48 2 years
10/15/2009
 1  depression, severe menstrual pain 30mg: confusion, frightened, muscle tightness, jaw clenching, uncontrollable facial frowning (strange, I know), irritable, freezing feeling (cold flashes), insomnia, felt myself stop breathing while sleeping which woke me up, polluted/unclean feeling (this is very hard to describe) I would never again take this medication nor would I ever recommend this to anyone else. There are some who suffer mild side effects but there are more who suffer more. I hate the idea of how this drug is "thought to work", not knowing how this medication works or even long term effects. F 31 1 days
10/15/2009
 3  menopause/hotflashes No side effects...yet. I'm a little confused as to why my doc would prescribe this drug for menopause. He said his nurse is going through the same symptoms I am going through and sent her in to talk with me. She had a full hysterectomy just like me and swears cymbalta works for her. Anyone with some advise??? Oh by the way...I have no depression or any other pain problems. F 47 1 days
10/14/2009
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 4  depression, neuropathy hot sweats, regular powerful muscle aches, loss of sexual libdo, 40 lbs weight gain I don't know if its worth it M 48 3 years
10/13/2009
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 5  depression anxiety,and possible FM I felt a little nausea the first day. I have a hot flash type of feeling the first few hours after taking it. I sweat a little more and my sex drive has decreased somewhat. I feel amazing on cymbalta!!! I could tell a difference the first day. By the second week when I went to the 60 mg I felt like a different person. I have fewer panic attacks. I don't get mad as easily as I did at my kids. I actually get up and do house work after dinner instead of lay on the couch. My 8 hour work day goes by so much better. I highly recomment it to anyone. My side effects are/were so mild if you are depressed this drug is worth trying. Of course I haven't had to try to get off of it yet. That might be a different story! F 31 1 months
10/12/2009
 5  Depression / Fibro Pain The first few days were hard- nausea, horrible headaches, insomnia, i just felt 'ill'. Was gonna stop taking it but decided to give it a week.Inability to climax. My fibro was getting so painful, but cymbalta stopped it in its tracks-i would not have belived a non opoid could be so good. Im not in that bleak depressive place either, im 'ok'. Still get the odd headache and need a bit extra sleep. In 2 mths ive lost 17lbs, the only 'problem' is the orgasm thing, but ill accept the trade off. Would be very happy to lose the other 15 lbs meds have put on me with this med! F 39 2 months
10/11/2009
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 3  anxiety, mild depression vivid nightmares, insomnia, very low sex drive, delayed orgasm I started taking Cymbalta because I had adverse reactions to Wellbutrin. I feel like my eratic emotions are more in check but I am concerned about my low sex drive and nightmares. I had night terrors on Wellbutrin too which is one reason I made the switch to Cymbalta. I am becoming increasingly concerned about taking this medication after reading other peoples comments. F 27 18 days
10/11/2009

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