CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  depression & pain from empty nose s forgetful; initially had to stick to strict time schedule, but now at almost 2 years on it, no longer have to be as strict. It saved my life; prior to being on it, I was depressed and non-functioning --sort of a zombie state--felt like I was dying (difficulty breathing from empty nose syndrome) yet didn't care. Cymbalta almost eliminated my chest pain and gave me a desire to live again. I did experience a couple of awful nightmares and hallucination in the beginning and cut back the dose from 30 mg to about 23 mg. [Am concerned about 29 yr old woman who wrote in on 4/17/09 and said she was losing her hair from stress--has she had her thyroid checked? For years I was treated for depression and also lost hair-- and it turned out that I was hypothyroid and needed thyroid hormone pills.] F 67 18 months
6/16/2009
 4  Fibromyalgia I experienced migraines daily, trouble sleeping, racing heartbeat, loss of appetite, disorientation and floating feeling. Although I could not tolerate the side effects of this medication, my fibromyalgia symptoms improved by 90% during the short time I was on the medication. I was disappointed that I could not continue with it. Seeing a new doctor who put me on a mood stabilizer and is hopeful I will be able to return to the Cymbalta soon. F 42 6 days
6/14/2009
 2  Anxiety & Depression -Night sweating. And I'm not talking a little sweat. I'm talking drenched head to toe all night long, I even sleep on towels and change my clothes in the middle of the night. -When I finally am able to pull myself out of bed after a sleepless night I feel cloudy and tingly. -I feel hungry all the time especially for sweets….starting to notice weight gain. -Has done little for my depression and anxiety -My muscles are SO tired. Going to the gym, or even walking up stairs for that matter are a ridiculous painful challenge. I started at 30mg and 6 weeks later my Dr upped it to 60mg when my depression/anxiety was not going away. I am now in week 9/10 and am ready to ask my Dr to switch meds. This is more miserable when I was feeling before the meds. F 31 9 weeks
6/12/2009
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 1  wife has stage 4 lung cancer my doctor gave me cymbalta 30 mg. 1 a day said would help with my depresion . I had thoughts of killing myself and couldnt eat or sleep,or talk to anyone wanted to stay in bed all day long. 1 week of this cured me this med.is SHIT dont take it . the goverment should ban this drug very dangerious, I never In my life wanted to kill my self M 55 4 weeks
6/11/2009
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 3  Major depressive disorder/anxiety Hypotension?, night sweats, excessive yawning, spontaneous orgasms, vivid dreams At 30mg, I was yawning about twice every minute, these were "big yawns" and on top of that I would occassionaly experience an orgasm from the yawns. However I felt no difference in my depression and was increased to 60mg. At 60mg I still had excessive yawning and when I'd wake up in the morning, I'd feel floaty and tingly, I assume this was hypotension. At this dose my anxiety was better but no change in severe depression. I was increased to 90mg and still had hypotension in the morning but the yawning went away. Still no significant change in my depression or suicidal ideation. My doctor increased me to 120mg even though there's no evidence to indicate this dosage works. I finaly felt better but started having hypotension everyday, more vivid dreams and would wake up drenched in sweat. I just went to my doctor today and he's switching to me to Pristiq with no withdrawal time. I'm supposed to take the first dose tomorrow. F 29 6 months
6/9/2009
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 3  Depression, anxiety Brain zaps, feeling very sleepy, feel like my eyes are wide open but my mind is tired, dry mouth, loss of appetite I'm on 30 MG. Is this normal to feel this way? I feel like my anxiousness and annoyance with minor things have gone away in a matter of days but the side effects are not good...any advice?? F 25 4 days
6/9/2009
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 3  fibromialgia dry mouth, feel "floaty", if that makes any sense... also had the feeling of a knot in my throat, or something that kinda made me feel nauseous i have been taking 30mg once daily for my fibromialgia pain... after about an hour of taking my first pill, i started feeling "floaty"... don't know how else to describe it. i also had very bad dry mouth, no matter how much water i drank. after about the 4th day, i stopped feeling floaty and do not get dry mouth anymore. it seems to be helping BARELY with my pain... i think i need to be on a higher dose. i think i will give it about another week so it has time to build up in my system, and if it's still not helping that much, i will ask my doctor for a higher dose. M 27 1 weeks
6/8/2009
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 4  Anxiety/Panic Attacks At first had hot flashes and sweating. Within the first 2 weeks had some middle of the night insomnia. But within a week that went away. After taking several different medications over the past 2 years (lexapro, paxil, zoloft, celexa) this is the only one that actually was able to balance me out. I am not a zombie I can think clearly I am not ruled by my anxiety. I would recommend giving this medication a try if you have been unsuccessful with others and waiting a good 6 weeks before changing. It truly takes awhile to feel the benefits but well worth it. F 37 3 months
6/7/2009
 5  Depression/ anxeity none. it saved my life. I had severe anxeity and manic depression. I'm am happy to say i am free now. Im 21 and i have tried all the depression meds out there. this is the FIRST medication that has worked 100%.IT SAVED MY LIFE. BUT PLEASE DO REMEMBER YOU HAVE TO FIND THE RIGHT MEDICATION THAT WORKS FOR YOU. IT TOOK ME 7 YEARS TO FIND. F 21 1 years
6/6/2009
 3  norepinephrine reuptake Nausea, loss of appetite, severe pressure in head It is hard to determine whether or not this is helping due to the side effects. I have noticed that it takes the edge of a bit and I don't seem so overwhelmed with adrenaline all the time. M 27
6/6/2009
 3  neurological pain & depression Dizziness/Nausea/Vomiting/Diarrhea Cymbalta has been the only pain medication that has helped to relieve severe neurological pain I have had for almost 7 years. Unfortunately the side effects were so bad after 6 weeks that I had to stop using it. What good is the relief of the neurological pain if your head is stuck over the toilet most of the day because of the nausea? For the last week I took Cymbalta, I had chronic diarrhea. The other major size effect was the dizziness. The last day I took it my world was literally spinning around me. I was laying down trying to watch TV and it was like chasing the TV all over the wall to try and see the image. When I first took the med I had an episode where I was crashing into the walls trying to make it to my bedroom because of how dizzy the Cymbalta made me. It worked wonders for the pain though, and I really feel bad that I cannot continue on it because of the side effects I experienced. I would rather cope with the neurological pain than live through the side effects. M 52 6 weeks
6/5/2009
 1  armpits nerve pain EXTREME FATIGUE,mental fogginess,pain irritatingly dulled but present,dizziness, body felt heavy, chest tightness I tried lyrica for armpit nerve pain and only stopped because of my quick and steady weight gain. My family doctor suggested cymbalta. The 7 days I was on cymbalta were absolute mental and physical imprisonment. To come off I took a flerixil and xanax instead of the cymbalta last night. This morning the fatigue and dizziness are gone. I never felt the need to post any comments about medications before, but this medication is absolutely BRUTAl on the mind and body. I would prefer the weight gain of lyrica. In the past I took zoloft without any problems, so I was hoping for pain relief and improve mental attitude. Your body and mind will tell you very quickly if this is the right medication for you. Don't wait several weeks. Trust your instincts about this med. F 66 7 days
6/3/2009
 1  Depression Terrible! Anxiety, depression stayed and weight gain. Don't believe those commercials on TV. I would rather be depressed than go through that experience again! Thank goodness there are others out there that work much better! F 40 1 months
6/3/2009
 4  anxiety and depression INCREDIBLE nausea for the first few days, dilated pupils, blurred vision, forgetfullnes, UP and DOWN, constipation, tired eyes, teeth clenching/grinding, irritable, occasional brain fog, picking/scratching myself When i first took it i went to bed and then couldn't get to sleep, everything was spinning around i couldn't move and felt so nauseous but it was weird cos i had this sense of happiness. I thought if this is how it makes me feel i will put up with any amount of side effects cos i had never felt like that before. Well now i've been on it for 5 weeks and i still feel good!!! I had like a week where i was hypo and then the whole of the next week i was super low but i think it's balanced out now. Also i have only had one anxiety attack since i've been taking them and it only lasted for 5 minutes. F 23 5 weeks
6/1/2009
 5  fibromyalgia & depression night sweats and nightmares I've been on this for 5 weeks and I love it! It makes a noticible difference in my daily life regarding pain level, tiredness and lethargy and fogginess. No more muscle spasms or tingliness in my limbs. My only complaint it the nightmares, which have stopped the last few days so I'm thinking they're probably gone. I love this med! F 34 5 weeks
5/31/2009
 2  depression/pain drug was great for 2 months, then went off it b/c of weird symptoms; muscle pain (new), weird brain zaps (yes, typical ssri symptom but this was the worst brain zap episode ever! lasted 3 weeks while tapering slowly off the drug. also, severe dizziness, disassociation between my body and my brain (seemed like it took my brain a few seconds to realize my body had moved...very weird and disconcerting) avoid this drug. w/ the brain zaps and dizziness upon tapering down to go off god knows what it's doing to the neurons long term. if you taper, try to use another ssri at the same time to minimize brain zap effect. F 43 2 months
5/31/2009
 4  Anxiety, Fibromyalgia Fatigue and overall sleepiness. Vivid nightmares. Withdrawal symptoms if not taken promptly on time (brain jolts, night sweats, prolonged coma-like sleep). Possible IBS-like symptoms and GI upset. I love Cymbalta. It is my miracle drug. It has restored my quality of life and I am now able to live as a normal person without being crippled by anxiety. There are side effects of course but for me they are nothing compared to anxiety and fibro pain. F 21 4 years
5/29/2009
 1  depression brain zaps, fogginess, headaches, insomnia my brain does not connect well with my body or my mouth, I get confused about mostly everything, I am a college graduate who can no longer read more then a page or two and forget all of what I read. I burn things when I cook because I cant stay on task anymore. I walk away and it is out of sight out of mind. bath water overflowing, forgetting my dog outside for a long time(never happened before cymbalta) we can call it BC. Get in the car and not have a clue as to why or where you might be going. I cant be positive about anything anymore because I dont remember more then a few minutes back attention span of a gnat. PS this took me 2 hours and a lot of assistance to write. My family has been very suppotive I would be soooo lost with out them (no really) F 47 3 years
5/29/2009
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 1  Anxiety, depression, bi-polar Night sweats, 30 lb. weight gain, worse depressive episodes than pre-medication, panic attacks, alcoholism, dissociation, psychotic episodes when increasing dosage, extreme withdrawal syptoms: brain zaps, nausea, vomiting, diarrhea. Avoid Cymbalta at all costs! Felt great for the first two months, the next two years were a nightmare of horrible depression (worse than being un-medicated), psychotic episodes brought on by increasing dosage from 60 to 90 mg, alcoholism (which had never even been remotely a problem), and went from 155 lbs. athletic and fit, to 193 lbs. and severely depressed to where I did not leave the house for four months if I wasn't working. Withdrawal symptoms are horrible, but after switching to B-complex, Omega 3's, Melatonin (to sleep), and 5-htp, I feel much, much better. No more horrifying nightmares either. M 26 2 years
5/29/2009
 3  depression, anger, anxiety nausea, vomiting, shakiness (tremors in hands), loss of concentration, zombie-like, low energy, slowed reactions and thinking I only took it once and I am dying for it to get out of my system. The symptoms from the depression got a little better the first few hours, but then I felt sad again. When it was time for bed, I didn't feel sleepy so I just laid there, but then I had temporarily lost all energy and concentration - it was like my mind went blank, and i couldn't even get my body to react to anything. Then I got a sudden urge to get up and ran to the bathroom to vomit like crazy. All day I've felt fatigued, nauseous, and my hands won't stop trembling... I can't even control them long enough to hold something. F 25 1 days
5/28/2009

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