CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  bipolar yawning, yawning, yawning. Jaw seems to be sleepy, like I need to stretch my mouth and mandibles to 'awaken' them. (?). Lots of energy. Nocturnal emission. I sweat easily now, before I did not. Tad of urinary incontinence: I go, and then seconds later couple drops more need to come out. Nocturnal emission, is not only nocturnal, but at any moment of the day after urinating. Orgasm: what is that? Erection is fine, but it is a marathon to reach the end (great calorie burner). I have felt a change in my mood. I was on Lexapro and I was having severe mood swings. Cymbalta has stablized me. It is like there is this bottom floor and upper ceiling, that do not allow me to be either happy or go way down into depression. Not great to be on medication but I need it and I have felt a positive change. In control. There is a light at the end of the tunnel feeling. M 36 2 months
7/13/2006
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 1  Depression Headache, blurred vision, dilated pupils, weight gain, inorgasma, difficulty sleeping and concentrating I wouldn't recommend this medication to my worst enemy. More drug testing and analysis of side effects needs to be done before these drugs are made available to the public. In addition, this drug company is charging so much money for this drug! F 35 2 months
7/12/2006
 2  Depression/anxiety I lost all desire to eat for a short while and then I became really hungry. No specific side effects beyond that really. I felt like I wasn't taking an antidepressant at all. I was back to mood swings, insomnia, inability to sleep when I should, but no problems sleeping when I shouldn't, I thought I was headed back to that freaking crazy depressive garbage that lead me to antidepressants in the first place. I usually feel positive effects immediately, but not with this one. I couldn't concentrate, couldn't motivate myself to do my job and chores, etc. Felt in a funk...back to depression...back to crying craziness and feeling like a psycho. Doc switched me to yet another one. Guess we'll see. F 36 4 weeks
7/11/2006
 1  Neuropathy, Slight Depression Horrible Insomnia, Shakiness, Electric Shocks up spine, Bleeding in GI Tract This was a horrible drug for me. The side effects were TERRIBLE. The Insomnia was so bad I would not sleep at all 3-4 nights of the week the remaining nights I would only be able to sleep a maximum of 2-4 hours total in a day. They tried to g ive me ambien even with ambien I could not sleep it was horrible. I also would shake uncontrollable with my hands and I am an artist full time and I Could not deal with this. When I would set down 3-4 sometimes 5 times a day I would feel this puls up my spine starting at the base that felt like strong very hard electric pulses almost like a buzzing electrical post. The most severe side effect I had starting a bout 3 weeks to 4 weeks in was bleeding intermittantly in my GI tract. I felt like a zombie most the time. The only thing this drug helped me with was road rage and aggitation towards coworkers. The only reason it helped was because i couldnt not focus enough on either task to care. Once I started weening myself off of this drug at about a m F 30 1 months
7/11/2006
 3  Moderate depression CYMBALTA PATIENTS: This is a serious medication. My side effects were sexual disfunction, including anorgasmia and partial loss of pleasurable sensation and stimulation of erect penis; jitters, jaw clenching, teeth grinding, and a sense of being slightly dazed. Having said that, I actually felt emotionally very well in the days immediatley following discontinuing this medication. My doc prescribed Cymbalta 30mg/day for moderate depression. Within two days of taking Cymbalta, I immediately noticed onset of sexual dysfunction, including anorgasmia and partial loss of pleasureable sensation and stimulation of erect penis. The sexual side effects alone were reason enough for me to immediately discontinue using Cymbalta. SSRI's and SSNRI's are known to cause long-term or permanent sexual dysfunction for some patients. Note: Not all patients have the same side effects profile with Cymbalta; I am merely speaking of my personal experience. M 45 2 days
7/10/2006
 2  Fibromyalgia/Depression Very Sleepy throughout the day,nauseous,pain actually got worse,could not sleep good at night, WITHDRAWEL EFFECTS ONLY AFTER TAKING FOR 10 DAYS!!Please take heed,vomiting,muscle twitches,anxiety,bad thumping headache PLEASE F 30 10 days
7/10/2006
 5  clinical depression Extreme weight gain and constant yawning I believe this is the best anti depressant out there. The positives far outweigh the side effects. I would rather be heavy and in my right mind, than thin and suicidal. Cymbalta is AWESOME! I totally recommend this drug. __^..^__ F 36 3 years
7/7/2006
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 3  anxiety, depression, MS pain Panic out of dead sleep, sudden nite sweat with drop in BP like I was going to faint, severe abdominal cramps/diarrhea with liteheadedness mood is "upgraded" to medium and stable, works well for my pain, some muscle tightness, palpitaions--but nothing as bad as Effexor (seizure) or Paxil (unable to stand up). I'll stay on the 60 mgs for another week at a time. BTW--Taking Provigil helps with the sleepiness. F 58 2 weeks
7/2/2006
 1  seizures, major depression, anxiety Extreme lethargy and "brain freeze" migraine headaches This drug was HORRIBLE!! I was not able to awaken - slept for 18-22 hrs. daily for wks. SEVERE withdrawal migraine; vicodin didn't help relieve pain, injections of ativan and dilaudid @ ER helped. Finally, in desperation, tried accupuncture and got relief! Have always been a 'mainstream med' person, but am becoming a bit more open to alternatives. At any rate, this med. is NOT for everyone! Subsequently was prescribed effexor; side effects have been different, but just as debilitating! However, have wonderful physician working with me and am hopeful! F 50 4 weeks
7/1/2006
 4  Depression Insomnia at night, drowsiness during the day, difficult to orgasm I'm taking 60mg and it has helped with my depression. It has also made it nearly impossible to orgasm, which really bothers my. I also have a big problem with insomnia on this medication, whether I take it at night or in the morning. I like that this med does not cause weight gain like Lexapro did for me, but I hope these side effects go away soon. F 21 6 weeks
6/26/2006
 2  anti anxiety nausea,diarrhea,moodiness F 27 2 weeks
6/26/2006
 5  Major Depression Sexual side effects: some difficulty getting and keeping erection, significant difficulty achieving orgasm. I've tried a variety of anti-depressants, and Cymbalta has been by far the most effective for me. I feel happy and productive for the first time in several years. The sexual stuff is bothering me, though. I have a new girlfriend and want to be great in bed. Viagra solves the erection issue, but the no orgasm is really a drag. Not sure what to do about that.... M 47 4 months
6/25/2006
 1  depression nonstop headache, constipation, racing thoughts, insomnia, annoying muscle twitches at night, and an all-around lack of well being. Bad Drug! F 53 2 weeks
6/25/2006
 1  depression nonstop headache, constipation, racing thoughts, insomnia, annoying muscle twitches at night, and an all-around lack of well being. Bad Drug! F 53 2 weeks
6/25/2006
 1  Depression insominia,increased sweating, vomiting, INABILITY TO DRIVE, decreased appetite, terrible thoughts I took this drug for maybe a week. I lost about 10 lbs due to decreased appetite and vomiting. I felt like a zombie. I could not remember what I had done 10 minutes ago. I was also unable to drive and I was thinking terrible thoughts.. stuff i never thought of before. crazy.. Be careful with this drug. I experienced withdrawl eeffects only after being on it a week! F 18 7 days
6/24/2006
 4  Fibromyalgia, depression Brain buzz if even an hour late taking dosage, weight LOSS of 10 lbs, insomnia (I take Ambien for it), increased energy, decreased pain, Cymbalta brought on jaw grinding which I never had a problem with before, spasms in my feet and decreased libido. Pretty emotionally void. I started on 60mg but I was wired so the Dr. decreased the dosage to 30mg, which has worked wonders for me. It particularly helps with my fibro pain and has given me my energy back. I would NOT recommend taking an opiate with Cymbalta; I took Darvocet and it quickly got less effective so I took more and more often-got addicted-NOT good! I am off Darvocet now, which I did cold turkey (thank GOD!) and I have much better days. After reading the ratings here, I hope I never have to go off Cymbalta-the withdrawal sounds like hell. F 50 2 years
6/23/2006
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 5  Depression Easy bruising, gums bleeding ALOT, teeth grinding, insomnia at first, vivid dreams... BUT WORTH ALL OF THIS! This is an awesome drug. I have to say that I have been on it once before, and was very happy with it. I got off bc we're trying to get pregnant. So I switched to Wellbut. XL and it gave me HORRIBLE headaches (common side effect). So decided that I will stop cym as soon I learn I'm preg. This med has help so much with my anger/frustration and overall feeling about myself. BTW withdrawl is not as bad as others say! This is a wonderful med. I hope it helps others as much as it has me. F 26 6 days
6/17/2006
 4  depression/anxiety/stress nausea at the beginning, sleeplessness, now I am gaining a lot of weight People around me have definetly noticed a positive improvement in my mood and I myself feel better (beats Paxil - do not EVER take that stuff!) I am concerned though that I have gained 19 pounds in the last three months (have been taking this for about 6). It all seems to be centered in my stomach area, which is getting bigger by the day, despite not changing anything about my regular diet/exercise habits. F 30 6 months
6/17/2006
 4  depression headaches and nausea almost gone now This is my second entry. I am coming off of effexor and and now down to 150 mg effexor and 40 mg of cymbalta. I notice my mood is ok, my thoughts are clear and most of all I am not as tired which is the main reason I wanted to get off effexor. M 35 17 days
6/9/2006
 5  Anxiety & Depression Could not sleep the first week 30mg - it gave me an abudance of energy and lifted my mood. Lost 15lbs in two weeks which is always a good thing. I am much happier and the stress and anxiety is in control. This drug has been great for me as I have taken others and could not function from day to day as other anti-depressants made me sub-human or sleep 14hours of a 24hour day. Just find the one that is right for you F 37 6 days
6/8/2006

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