CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  major depression Initially had some increased sweating and fogginess. During switch from Zoloft, there were some really bad days. It seemed that there were moments that showed promise and others that were very dark. Initial weight loss. Despite the fact that I now weigh more than ever before in my life, I am feeling so good otherwise that I will take chubby and happy any day oever thin and miserable. I have my whole life back and Cymbalta had a lot to do with it. No sex problems, sweating is gone. I do have trouble deciding when I am no longer hungry. Cymbalta saved my life. F 47 8 months
1/12/2007
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 3  Menopause - Miled Depression Weight gain, teeth grinding/clenching & anti orgasmic I have been taken off of Cymbalta because it caused me to grind my teeth so bad that I was in a lot of pain. I think I wore the bottom of my teeth off! I also gained weight. I did have withdrawl headaches but nothing to bad. F 49 4 months
1/10/2007
 1  PTSD, impulse control, irritability Nightmares, sleeplessness, weight gain, diminished sex drive I am trying to quit since the drug started giving me depression that I did not have before and I am having very unpleasant withrawal side effects: dizziness and bad rash every 48 or so hours AFTER NOT taking the drug. It does not go away and no alternative medications (like antihistamines or anti itch herbals) help. I still have to take Ambien on the day I don't take Cymbalta because I can't fall asleep without it. By the way, I am taking 20 mg every other evening and this is the smallest doze you can find. I am going to try to divide a capsule in half in attempt to taper it off and see what happens. F 42 3 days
1/10/2007
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 1  Depression Horrible insomnia, highly depressive and suicidal feelings, inability to orgasm, loss of energy, exhaustion I took this medicine for about a month, and during that month I did not sleep more than 5 hours a night... I woke up at least 5 or 6 times every night. It was horrible. I felt weak and exhausted and unable to keep up with normal days. I took so many short naps, but nothing helped. My feelings of depression, which Cymbalta was supossed to fix, were increased and I found myself contemplating sucidial or destructive actions a lot. I talked to my doctor and he IMMEDIABTLY suggested I come off of it... Another thing that bothered me, well a lot, was I was unable to orgasm... at all... I have since changed medicines and am able to once again, so I totally blame that effect on the drug. Overall, the drug gave me a bad feeling. I would not suggest this to anyone else, especially if you are switching from another medication. F 19 1 months
1/10/2007
 1  Neuropathic pain No side effects, but also didn't help with pain at all. Moved from 30 to 60 mg, then back down to 30. Since there was no relief of pain, at the next office visit the doctor told me to stop taking the Cymbalta. The WITHDRAWAL is TERRIBLE! DO NOT plan on being even reasonably human during this withdrawal!!! Withdrawal causes jerking muscles, headache, dizziness, confusion and nausea. Fatigue and muscle weakness were so bad that I had to be propped up in bed for several days. Had I known the withdrawal symptoms were so bad, I would never had taken the drup in the first place! F 53 3 months
1/10/2007
 5  Severe Depression (PPD),anxiety... First few days had a cloudy mind (took around 5 pm). I was on 30 mg for a month then went up to 60 mg. I take in the mornings now and usually get stomach cramps about 30 min. after I take it-but lasts for 10 min. Nothing worse than bad menstral cramping really. Night waking and sweats here and there but not sure if it's the medicine really. Loss of appetite also but not too severe. My anxiety is nearly GONE. Depression GONE! I go out and DO THINGS NOW!!!! I had a vomit phobia before and I dealt w/ my two kids and husband throwing up this month and I didn't freak out or run away. I think CYMPBALTA has SAVED MY LIFE!! REALLY! I love it and I was the kind of person that was against anti depressants. I forced myself to stick w/ this and I have NO REGRETS! I'm HAPPY! I LOVE LIFE!!!!!!! F 32 3 months
1/9/2007
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 5  migrane prevention constipation, dry mouth, loss of appitite, increase sex drive, teeth grinding, hard to fall asleep and wake up alot during the night It's too early to tell if the medicine will prevent my migranes but so far it has given me more engry. Which is awesome b/c my other meds made me tired all day. The constipation went away after one week. I already grined my teeth but it has increased since taking cymbalta. My sex drive has actually increased but harder to orgasm. Hopefully my migranes will become fewer or not at all. F 25 2 weeks
1/8/2007
 5  Fibromyalgia dry mouth, increased sweating It's like a miracle drug for me! Very little pain if any, more alert, more energy, increased sex drive, No more IBS, decreased appetite and some weight loss. I love this drug. I just wish it worked for everybody! F 46 3 months
1/8/2007
 3  Major Depression, Social Phobia,GAD INTENSE HOT FLASHES, PROFUSE SWEATING, particularly severe with stress and when too hungry - can get to the point of soaking, dripping sweat, soaked clothes, bed, chair, car seat, total embarrassment, happens worst at most inappropriate times. No one seems to understand why this happens, so embarrassing, even family mystified. It seems only a VERY TOXIC drug would have this side effect. Now, after 9 months, constant dull (sinus) headache, constant insomnia, caffeine intolerant (1 cup coffee = heart pounding, headache, agitation, uncomfortable for rest of day), 3 months ago weight started increasing, now 40 pounds heavier! Isolating, fuzzy headed, poorer concentration now 9 months after switching to Cymbalta, time to switch back or on to another SSNRI/SNRI or hopefully, maybe, something better!?! Effexor was on a similar uncomfort scale to Cymbalta for me, increased blood pressure, hot flashes/heat, sweating. Cymbalta, however, has decreased ability to orgasm much less than Effexor or Zoloft, Paxil caused much worse (totally intolerable) headaches. Cymbalta has helped with depression, but I've had better success with much less, unpleasant side effects from other medications, and soon I will be switching back. PLEASE - be careful with Cymbalta and all other SSNRIs/SSRIs, report all side effects, withdraw VERY SLOWLY - dizziness, "brain zaps", blackouts are inevitable result of withdrawing too quickly from all of this class, ONE MUST SHAVE PILLS DOWN BY CRUMBS IN DECREASING DOSE OVER LONG PERIOD OF TIME WHEN WITHDRAWING, A MG. AT A TIME - IF THIS IS NOT FOLLOWED CLOSELY, DANGEROUS AND UNPLEASANT WITHDRAWAL SYNDROME (SEROTONIN SYNDROME) RESULTS, AS SO MANY OF US HAVE REPORTED AND ARE FAMILIAR WITH!!! Please be careful, good luck, and good health. M 36 9 months
1/6/2007
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 4  back pain ,mild depression I just posted, so I won't repeat - I found this one cymbalta.com - I think paresthesia is what covers the "brain shocks" people describe on withdrawal Discontinuation of Treatment with Cymbalta — Discontinuation symptoms have been systematically evaluated in patients taking Cymbalta. Following abrupt discontinuation in MDD placebo-controlled clinical trials of up to 9-weeks duration, the following symptoms occurred at a rate greater than or equal to 2% and at a significantly higher rate in Cymbalta-treated patients compared to those discontinuing from placebo: dizziness; nausea; headache; paresthesia; vomiting; irritability; and nightmare. F 26 4 days
1/5/2007
 4  back pain, mild depression loss of appetite, diarreah, nausia, feeling wired at night, trouble falling asleep first 2 days, bad taste in my mouth and urge to yawn all the time even though I felt pretty wired and alert. I feel good, but the more I read about the withdrawal symptoms, the more scared I am. I called my dr. today to find out more about BRAIN ZAPS, and am waiting to hear back. My mood has improved, I feel good- relaxed, even tempered and am not dwelling on things like usually, and today my back pain is improved, I feel less nautious when I take in the AM with food. My doc recommended taking for a year. . . but I'm not up for that if the withdrawal symptoms are as bad as I've read. F 26 4 days
1/5/2007
 5  OCD and Anxiety Jaw clenching, shaking from the inside out, stuttering(this has been reported to the FDA), weight loss, high energy, loss of appetite, high sex drive. Cymbalta works wonders for me. It starts working immediately. Most of the side effects don't bother me. It lets me think clearly, I dont get near as offended by random comments and I have more patiens with my husband and kids. Overall I love it. F 27 1 years
1/3/2007
 5  Severe Depression Near complete relief from 20 years of depression after just a few weeks at 60mg. Prior to Cymbalta I could not find joy in anything. Tried Paxil, Wellbutrin, Zoloft, Effexor and Lexapro before finding Cymbalta. Nothing before had worked and after only a few weeks I'm feeling much, much better - thoughts of suicide have disappeared completely. With this drug I have experienced loss of appetite, night tremors, sleeplessness, dizziness, blurred vision, headache, fatigue, and difficulty with orgasm, but all to such a minor degree that they do not outweigh the benefits. My head is so clear of negative thoughts I can't believe what I have been missing all these years. If you've tried all of the other depression meds with no relief then give Cymbalta a chance. I didn't even realize the extent of the physical pain I was in until after a few weeks on this medication. Now considering an increase to 90mg daily to see if additional relief is possible. Insurance will cover to 120mg daily w M 45 6 weeks
1/2/2007
 5  Anxiety Complete loss of libido and sexual function. Total impotence. The impotence and loss of sex drive turned out to be permanent. Even one year off the drug, nothing has come back. I can't have a girlfriend any more. See here for more details: ssri-side-effects.com M 30 6 weeks
1/2/2007
 4  panic disorder and depression Weight gain,high blood pressure, lack of orgasim, sleeping during day, awake at night I had taken Cymbalta about 2 years ago. It was the only medicine that literally stopped my panic attacks and lifted my depression. However I experienced very high blood pressure and was placed on blood pressure meds, not knowing the Cymbalta was the reason. However after about 3 months, my blood pressure went back down. Not as it usually was, but I was able to stop the high blood pressure meds. I was on 60 mgs. Gained 30 pounds which cause a great depression in me as I was always glad I was able to keep my shape. It seemed to stop working so I went off it. I found out after going off it, that I was worse. Maybe it was the holidays that were approaching. I lost my son a few years ago and holidays are not good anymore. I tried Wellbutrin. Wow, great med that decreased my smoking to less than a pack a day from 2 packs a day. I was losing weight but could not handle the high anxiety. Shaking so bad I could not hold a glass. I had to stop it. The doctor and I discussed start F 54 3 days
12/29/2006
 1  My Neurologist suggested taking it A friend of mine and I were prescribed Cymbalta around the same time. (This fact probably coincided with a marketing campaign designed to line physicians' pocket books with hundred dollar bills for every Cymbalta RX they wrote). BOTH MY FRIEND AND I HAD THE VERY SAME SIDE EFFECTS!!!!! The side effects were HORRIBLE! We both: felt like hurting someone---hitting, injuring, beating up somone, etc. Neither one of us are like that AT ALL! Also, Cymbalta made us both feel like ZOMBIES! Cymbalta sneaks up on you and you don't even know that your whole world has changed almost over night. Cymbalta makes you go insane! Believe me....you don't EVER want to take this drug! You will sit and stare like a madman or madwoman. You will lose the "will" to do anything----- and you have violent thoughts constantly going through your head. This medicine sneaks up on you---without you even knowing it. It makes you totally PSYCHO. THE SAME EXACT REACTION happened to a friend of mine! I warned her about Cymbalta. But when she got on the medication, she forgot about my warning and she completely wigged out,just like me! She is about 40 yrs old & I am 53. Cymbalta is a DRUG with a bunch of marketing HYPE! Don't let a physician try to give you a sample of this poison...or you'll be sorry! The physicians probably get a kickback from the Pharm Co to push this awful mixture of chemicals! I think that all Physicians who prescribe this medication must first themselves take it for a minimum of 6 months! I guarantee you, if they did, they would no longer be practicing medicine---they would be practicing how to make tatoos in a prison cell! I sure would like to slip Cymbalta in my former doctors' coffee cup every day! The only "hard" thing he would have anymore would be his ass---from sitting on it all day, F 53 2 months
12/29/2006
 4  DEPRESSION inorgasmia, early morning awakening have tried a number of ssri's. i felt physically better the first day of taking the medication but began to experience sleep disturbances. noted about day 4 and since the feeling of restlessness. sex drive went capuoi which is hard. no pun intended. i still have depressed thoughts so i think that the norepinephrine reuptake is more effective for the physical symptoms than the ssri is for the depression M 40 40 days
12/28/2006
 4  GAD and Depression I was so tired the first few days I started this I stayed home from work for two days because I couldn't stay awake. I slept for hours and hours. The first few days I would yawn constantly, it was a weird fake yawn but I felt compelled to do it. Also the first couple of nights while sleeping I would clench my jaw to the point when I woke up and started with the yawning it hurt. My pupils are huge were co-workers and friends have noticed and asked "What are you on?" Currently I'm still very tired all the time, I'm constantly trying to figure out how I can fit naps into my day, or sleep in longer in the morning, going to bed earlier. I used to be very active (anxiety) I could never sit still, I hated to sit down and watch a TV show or Movie. Now I rather stay in on the weekends and watch TV and nap. This was kind of nice at 1st but now I'm getting worried. I'm tired all the time, I can nap during the day but at night I wake up almost every hour tossing and turning and bad nigh Aside from being tired all the time and conspiring to sneak in naps through out the day, Cymbalta has helped greatly with my GAD and depression. My anxiety was on the verge of ruining my relationship with my boyfriend of 3 years but now things are great. I feel very secure, like a weight has been lifted off my shoulders. I'm independent and free from my repetitive and negative thought process. It's very refreshing. I do have a harder time reaching orgasm but I find intercourse to feel 100 times better. I just hope the tiredness goes away and that soon I will sleep at night. F 29 1 months
12/27/2006
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 1   M
12/24/2006
 4  baby blues didnt love life anymore the only side effects i experienced so far have been upset stomach which lasted about 3 days and more frequent urination. I was taking Lexapro and was extremely tired all the time it was an effort to do common things. also had delayed orgasm which has not been a problem since starting the cymbalta This has worked well for me and has given me back my life Im currently taking 30 mg of cymbalta and have noticed a slight increase in appetite but nothing that is too crazy. Nice to hear others out there have similar side effects and positives . M 28 3 months
12/23/2006
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