CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Major depression/Bipolar decreased appetite, fatigue, maybe a little "foggy" It's only been four days, but I'm not experiencing anything negative with this drug. Not feeling much happier, but I know it takes a couple weeks for the drug to kick in completely. Due to my depression, I am always fatigued so that part doesn't bother me. And I'm 50 pounds overweight, so I'm not complaining about the decreased appetite! I'm taking 30 mg each morning, I'm sure I'll be posting again in a week or two. F 28 4 days
3/16/2008
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 5  depression was very sick at the beginging, it kicked in after 14 days,started on 30mgs I upped it to 60mg after 1.5 years... Gave me back my life.was on it 3 years.I came off it cold turkey when I found out I was pregnant, had a miscarriage..took 8 weeks to get back to normal came down with a bang. Lost weight on this drug F 40 3 days
3/15/2008
 5  MDD/depression due to chronic pain flatulence, loose stools, and a really good reaction in evey day life. it rocks. check out the BLTC Good Drug Guide. it is a blockbuster that will need augmentation with a stronger DRI in order to reach its fullest potential with my unique chemistry. bottom line is--- it works with at least 4 weeks to get used to the new blueprint... i highly recommend it if you are in chronic pain or EVEN- feeding off of the exogenous opoid. Love. M 36 10 weeks
3/15/2008
 5  depression anxiety minor headaches, extreme horniness, weight loss, happiness , clear thoughts, motivation. helping me tremendously. I recommend trying it and staying on it. F 37 90 days
3/14/2008
 1  Depression I felt as though my brain was in a very altered state. I felt as though my visual sense was extremely heightened. I had to close my eyes to shut-off the visual stimulus. At times I felt as though my physical movements (hand moving) was not in sync with my brain. I have never felt that horrible. I took my first dose this morning around 8:00 am and by around 11:00 my head was hurting. Then things got progressively worse from 11:00 am to 1:30 pm. It was a frightening experience. I called a collegue (I was at work) to meet me in a restroom because I thought I was going to pass out and I needed to explain to her what I had taken. I figured someone should know what I took if I passed out. I will never take that medication ever again. I left work as soon as I felt a bit better but drove slowly. I called my doctor once I got home and left her a message. I'm going to plead that she not prescribe it to anyone else! I came online to see what I could find and was shocked to read so many postings that sounded similar to what I experienced. Eli Lilly really needs to pull this medication off the market. F 35 1 days
3/14/2008
 3  depression foggy headed, dialated pupils, insomnia, fatigue, black outs, hot feeling, hot skin, extreme sweating and night sweats, strange long dreams I started on 60mg. Even though at first (1 week) I experienced wired feelings, it worked very well. After about 3 weeks I felt as if it quit working. I was constantly on the couch tired and content doing nothing. My Dr. upped the dosage to 90mg. I have dizzy spells, hot flashes and extreme night sweats. I am no longer depressed but I am still unmotivated to clean and can't stand the hot feelings and sweating. Worst side effect... if I drink alcohol, I completely black out after 3 drinks and can't recall the evening. My husband tells me I am awake and hallucinate carrying on conversations with people who aren't there. Overall, I am thankful that this drug has brought me out of thoughts of dying but I think I'm ready to try something else. This is my first antidepressant. F 33 4 months
3/13/2008
 1  fibromyalgia nausea, dizziness, palpatations and the WORST muscle pain I have ever had !! Doctors are irresponsible if they don't tell you the possible interactions with Migraine medications. I thought my head and heart were going to explode. They also should warn you of the bad side effects when you are trying to come off the medication. I have never had such a bad experience. I was on the 60 mg dose and it worked for awhile. I am no longer bentifiting from it and am trying to get off it. I will never do that again and now will reley on all natural products. F 58 8 days
3/12/2008
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 5  depression. ADD. OCD none horribly expensive. MY copay was $400.00 after ins. for 90days. Having to quit it for the cost too much now that pay percentage not small copay F 59 3 years
3/10/2008
 4  Depression, Anxiety weight gain, excessive sleepiness, heartburn Was on welbutrin and lexapro before, and cymbalta is much more effective with much less side effects. It hasn't 'cured' my depression, but I feel much better on it then off it. The side effects aren't great, but pretty mild. I have gained some weight, but I was pretty skinny to start and watching my diet has stopped any excess gain. The sleepiness is a bigger problem, make sure to take this at night, but I still can sleep 10hr and be tired the next day. The heartburn has just started cropping up, seems if I have an empty stomach when I take it I get heartburn. So take it before bed, but soon after dinner. Though its not recommend to drink with this drug, I have had no problem with weekend drinking aside from the expected effects of the alcohol. M 20 1 years
3/10/2008
 1  Fibromyalgia/ Major Depression Nausia in the beginning. I had to come off of it because it didn't ever help for pain and I had a sudden major depression on it. After upping it I went back on Effexor. Cymbalta is a weak antidepressant for major depression. I was actually debilitated when Cymbalta just stopped working. I was crying and a mess. It was the longest 2 weeks until I got back on Effexor. I'm glad I wasn't suicidal!!! F 45 12 months
3/7/2008
 4  Headaches, Anxiety During the first few weeks: dry mouth, nasuea During the first few months: persistent fatigue This medicine has really helped to control my chronic daily headaches. It has also significantly improved my anxiety. I was really struggling for a while with fatigue, but I've learned to manage it. I try to get at least 8 hours of sleep each night (I do wake up a bit becasue of my daugheter but I always go right back to sleep). I usually take a nap one day a weekend. If I sit still for long, I will get drowsy and want to go to sleep - so I try to keep active. There's never any shortage of stuff to do around the house and I don't feel tired while I'm actually going....it's only when I stop. I do still have daily headaches, but they're now more of a 2-3 rather than a 6-7, so I call that a huge improvement. I hope this drug can help you too. F 36 10 months
3/5/2008
 1  depression & neurothy weight gain big time. Loss of appitite and weight gain, dry mouth,bad dreames,night sweats,joint pain,cramps,constipation,. M 54 7 years
3/5/2008
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 5  anxiety I have had night sweats horribly, but I have read on alot of sites that they subside!!!! It has helped me a great deal. I have only been taking it for a month. This is the 3rd differnt med. I am on. I took lexapro, then effexor and this seems to be helping out much better. I was on 30mg for a week and now I am on 60 mg. M 25 4 weeks
3/3/2008
 1  Depression Anxiety I lasted less than a week on this - caused severe anxiety. F 33 1 weeks
3/3/2008
 1  depresion Worsening depression-- My family and friends noticed that my behavior was much more manageable before I went on Cymbalta. After I started, I had to force myself out of bed in the mornings. Suicidal thoughts-- I've never been suicidal, but after I started the medication, I thought about suicide and death nonstop. Panic attacks-- I'm 19 and have never had a panic attack or anything close. I had six in the month I was on Cymbalta, one of which caused me to have to go to the emergency room. F 19 1 months
3/3/2008
 2  Depression Nausea, dizzy, fatigue, Started with 60mg/day, wow, too much, went to 30mg/day,not as bad, but after I have read about withdrawl try to stop taking it I'm thinking of stopping now. Since the prescription cost $232.00 though I don't want to waste it. All in all it sounds like a pretty scary way to trade-in depression. M 52 7 days
3/2/2008
 5  Depression and pain Little nauseaus first couple of days. I already had all the gastro symptoms and hot flashes others have mentioned. Unfortunately, those symptoms have not improved. I am experiencing hair loss and am wondering what the cause may be-could be Cymbalta, could be my age/hormones, a vitamin I might need, winter. 30 mg worked initially then abruptly seemed to stop working after about 6 weeks/now on 60 mg. I am happy to say I have not felt this good for years and years. Fibro pain greatly reduced, energy up, sleep and dreaming wonderful after many years of not much of either. I am very enthused and interested in my life again. Coming off Cymbalta does sound scary, but I am trying to just enjoy feeling well for now, will cross that bridge down the road. I am trying some different approaches to the thinning hair and hope I can solve it. F 61 3 months
2/29/2008
 5  FIBROMYALGIA I DID NOT HAVE ANY SIDE EFFECTS UNTIL I MISSED 3 DAYS OF MEDS. THEN I BECAME HIGHLY IRRITATED AND IRATE BUT ONCE I STARTED THE MED BACK I FEEL GREAT. I REALLLY LIKE THIS MEDICATION IT SUPRESSES MY APPETITE AND HELPS WITH MY FIBROMYALGIA PAIN AND DEPRESSION. GREAT MED. I JUST WITH IT DID NOT COST SO MUCH. F 42 1.5 days
2/28/2008
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 5  Depression, Fybromyalgia First two weeks headache, dizzy, nausea, no appetite....switched to taking it at bedtime and most side effects went away. (Because I slept through them.) A little foggy at times; yawning. I was hesitant to take this med because of some of the negative things I read about. I do not take any other meds. I knew there would be a period of adjustment and some side effects and was prepared for the worst. I was on Lexapro a few years ago and the adjustment period was a painful 7 or 8 weeks. Within 2 weeks on Cymbalta, I feel better than I ever really expected. The side effects were initially uncomfortable but experimenting with the time I took the dose helped tons! I don't think I'll need a stronger dose than the 30mg. I can understand why a higher dose could make you feel whacked-out. The number of people who try it for a few days and give up are suprising. I recently learned that consuming more than a a few cocktails while on it can cause some pain. Two glasses of wine are probably my maximum from this point forward. I am motivated to get back to the gym and work out....which can only help me further. I wish everyone the best who needs to take an anti-depressant.....don't be F 34 6 weeks
2/28/2008
 5  Depression Some nausea (occasionally at the beginning) and difficulty to reach orgasm (first four weeks or so). These all went away completely after about a month on Cymbalta. Fantastic. It has been a great medicine for me. Only problem has been weaning off it as the abstinence effects are quite uncomfortable. I've been on a reduction mode for about 18 months. Currently take 30mg 3 times a week down from 60mg daily. M 35 2.5 years
2/27/2008

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