CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2744 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Fibromyalgia incredible drowsiness, brain "zaps", in a fog I took 30mg for only one day, and that was enough for me. Three hours later I had to leave work (not sure how I got home!) and go to bed. I slept all day and was still exhausted. That night, I had some real funky stuff happen when I went to bed... seemed like I was "charged" and was having what I hear others describe as brain zaps. I just didn't feel right and felt like I couldn't focus on anything, and felt like I was in a worse fog than Fibromyalgia ever caused. It took about two days to feel "normal" again. The one positive thing was that it did stop some severe spasming I was having, but it was definitely not worth it and I definitely will never take it again. F 26 1 days
9/22/2007
 4  Depression/Anxiety In the first couple of weeks the only side effects I experienced were yawning(could not stop) and dry mouth. both of these subsided after about 3-4 weeks. Now, after about 3 months or so, I have gained about 15-20 lbs since being on Cymbalta. My jaw also hurts alot from clenching my teeth all the time. I'm not sure if these are direct side effects from the drug but I have been experiencing them. Overall, a good experience. I would rather have the side effects than feel the way I did before. F 24 3 months
9/21/2007
 5  Severe depression-anxiety-stress At first, starting with the 30 mg, the side effects were awful. Severe dizziness, diarrhea, so bad I went to the ER. After a few days staying on the medicine, these went away. Then graduated to the 60 mg. the effects came back less severe for a couple days. Now if I miss one pill, I get foggy headed, ringing in my ears, light headed, but after I take my missed dose, about 2 hours and these go away. After a bout with severe chest pains, causing me to have a arteriogram, my doctor put me on Cymbalta for the severe depression, anxiety and stress. So far, I have had to stop taking it 1 time and that is when the real problematic side effects kicked in. Major crying, of course the depression, anxiety came back. My doctor put me back on it immediately. My friends at work even stated that if I can't afford to get it refilled, let them know and they would be glad to pay for it. They don't like me when I don't have my Cymbalta. (My HAPPY PILL) This is a wonder drug for me. It hasn't solved all my problems, but it has helped me tremendously!! F 41 2.5 years
9/20/2007
 5  Major depression and anxiety Dry mouth, night sweats, nausea, waking up in the middle of the night and having trouble falling back asleep. The benefits from taking Cymbalta greatly outweigh the yucky side effects. For sleeping issues I am taking Trazodone which is helping a lot. The nausea is steadily decreasing. Mentally I feel better than I have in a long time. I do not have crying spells, my anxiety is gone, I am not feeling hopeless, motivation is back and best of all I feel happy. This drug may not be for everyone but I definitely have benefited from it. F 33 3 weeks
9/20/2007
 4  Concentration, slight depression Hypomania. Slight bladder pain when running. Higher heart rate when running. Exstreme loss of apetite (probably due to hypomania). Good for me, because I have Zyprexa and I gained 20kg) It is great, but I am slightly hypomanic, so that maybe doesnt count. It is a strong drug for major depresive disorder I am probably going to take just 15mg (split the capsule and fill another one). I can finally feel like a normal human being not thinking I am very bad and have no qualities whatsoever. I stabilise with Omega 3 in the evening to fall a sleep and of course Zyprexa. Allmost no side effects whatsoever. I am actually bipolar with psychosis and I dont want to take moodstabilasers, because I cant read when taking them. Good luck to all. M 24 6 days
9/18/2007
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 3  Depress, chronic pain, neuropathy At first I had extreme dizziness with zombie like feeling when taken in the morning, then I tried taking it at night with good response. After 2 weeks, I started having severe gas pain, less desire for sex, constipation, and vivid dreams with talking in my sleep. I had no emotions, good or bad. I started with the 30mg for 1 week and it didn't work at all for the depression but I wanted to stay of the narcotics. The dose was increased to 60mg and it started to work for the chronic pain ( spinal stenosis from 2 back surgeries and hip replacement). Then it hit. I was getting short temper, irritable, and had no affect. I visited my family members after being on it for 4 weeks and it was so embarrassing with the gas (SBD - silent but / and deadly!) I couldn't predict it and and it was going 24/7. I tried antiflatulants with no response. There was some constipation but I did go. The most starting side effect was I kept waking up dreaming and realizing I was talking in my sleep. As the way my significant other stated it - when I go to sleep, the talking begins. This went on for days and days. After awhile, the insomnia began. I would sleep for 2-3 hours, wake up and stay wide awake for the rest of the night. I searched the professional side effects listed post marketing a F 52 1 months
9/18/2007
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 5  Anxity weight loss, loss of appitite,& increased sweating overall I feel much better and do not let things bother me as much. F 38 6 months
9/17/2007
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 3  depression loss of appetite, trouble sleeping. It has only been two days and I realize you have to give the meds a couple of weeks to really begin to work. I feel a bit like I am speeding and I was verbally sort of aggressive today. Like when you've had too much to drink and you say things you normally wouldn't say. But, I am awake. Prior to taking this medicine I just wanted to sleep all the time and not talk to anyone. F 36 2 days
9/17/2007
 1  Depression Dizziness, nausea, headache, buzzing noise in head. DO NOT TAKE THIS DRUG. IT IS POISON. After taking 30 mg a day for 3 weeks, I stopped. I HAVE NEVER felt so awful as I do today. Started cying and laughing hysterically. Head is so mucked up I can barely move or think. Called doc and he said it's withdrawal. WTF, is this heroine or something? Withdrawal? I've stopped other SSRI's in the past and never experienced anything. This is bullshit. Do not take this poison. F 57 3 weeks
9/17/2007
 1  Anxiety & Depression OMG only been on it 2 days and its horrible.I feel like i am speeding and paranoid when i drive. Please be careful this is a VERY powerful drug. I also have teeth grinding, hands shaking, my eyes look wired and my mouth urrrg i have no taste buds left dry and burning yuk. And after reading about the side effects of coming off i think i will stop now. I have had all the usual anti-depressants in the past but got myself off them all for the last 4 years and was taking a natural herb Holy Basil and that's it i am going back to that and my would rather stick to my lorazepam just 1mg a day takes all the fear and anxiety away. I only went on because of my life situation but no way i would rather take the above stuff than Cymbalta any day. F 38 2 days
9/16/2007
 1  foot neuropathy after foot surgery Extreme nausea, tiredness, dizziness, flat mood, headache, dry mouth, abdominal pain, loss of libido and ability to orgasm I am trying to taper off the medication, and am experiencing a constant headache. F 53 2 months
9/15/2007
 1  depression/anxiety/fibromyalgia Works great at first. BUT DON'T DO IT!!!! EVER!!!! Eventually, I was no longer myself. Agressive, angry outburts, worse depression than before, worse anxiety, worse insomnia. Withdrawal is hell. Tapering may not help. If your psychiatrist or prescriber is not helpful with withdrawal symptoms, seek help from someone immediately DON'T DO IT! F 27 2 years
9/13/2007
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 4  severe headache menopause, anxiety Only bad thing is muscle spasms in my back...My doc started me out with 30 mg for first week and then 60 mg after. During this time I was going off Remeron. At 2.5 weeks got horrible cramps in back that kept me from sleeping. They have gradually decreased to random times mostly when awake. I take a very low dose os Seroquel to sleep at night 50-75 mg. Great as far as relieving headache and returning attention and focus. I love the meds except for spasms. I do not have the crazy hunger like I did with Remeron. F 53 5 weeks
9/12/2007
 5  Moderate to Severe Depression During first two weeks of use only: 1)Nausea: I experienced a dull nausea almost constantly and had very little appetite (which led to small weight loss) 2)Feeling of being extra alert with a touch of jittery-ness (like having an extra cup of coffee) 3)Slight and occasional dizziness 4)Reduced sex drive I began Cymbalta about 2.5 years ago after weaning myself off of Zoloft, which I had taken for 1.5 years with some success and significant weight gain. As mentioned, I initially experienced typical side effects, especially the nausea. This was difficult at first and really cut my appetite. But after two weeks, the nausea and the other side effects (even the sexual ones!) were all but gone. Fast foward 1.5 years: Cymbalta (60 mg daily) worked very well in alleviating my depression and anxiety, and I felt more like "myself" that I had on the Zoloft. Zoloft sometimes made me feel disconnected from the world and my emtions, as if there was a film or fog between me & my sense of reality. Cymbalta, for whatever reason, did not have this effect. It also kept my mood much more stable. This is not to say I did not have lows, but they were more manageable; it was like I was able to pause on the way down, reevaluate, and often pull myself back up. Now: About 9 months ago, I chang 25 2.5 years
9/11/2007
 4  depression, anxiety, headaches Constipation, increase in acne, weight lose Was taking Celexa and it seemed to just stop working. I was also having severe headaches and an insatiable appetite while taking Celexa. Even though I dieted like crazy and worked out like a weight lifter I could not loose any weight. After starting on Cymbalta, I almost instantly dropped 10 lbs. I am still loosing about a lb a week, because my appetite seems to be normal. I do not over eat and I have been eating what ever I want, but in smaller amounts and feel satisfied, that was not the case before. I do not have any problems sleeping, but have noticed an increase in the vividness of my dreams. I am happy with this drug because I do not have the ever-present headache and am able to loose weight. F 40 6 days
9/8/2007
 2  Anxiety & Depression It's around 5am and I just had a case of vomiting. Obviously I'm experiencing Nausea, NO sleep, Weakness in limbs... I have M.S. and am currently on other medications as well. (i.e., Ibuprofin, Avonex Injection once per week, Lexapro. There were some other comments that stated it might take a couple of weeks to adjust within my system...unfortunately I can't do that to my body again. Does anyone have any advice? Thank you in advance, jm M 42 2 days
9/7/2007
 1  Depression Insomnia, confusion, itchy skin, digestive problems, worse depression, etc. Upon discontinuing med, TERRIBLE WITHDRAWAL SYMPTOMS (anger, sadness, confusion, brain zaps, dizziness, more). WARNING!! Withdrawal from this med was HELL--DO NOT TAKE IT! My Mom took this med for depression for several months with NO improvement. She tried to come off from it and just could not handle the withdrawal; she acted "out in a fog" for several days before unexpectedly COMMITTING SUICIDE with one of my Dad's guns. BEWARE, this stuff is POISON!! F 44 1 months
9/7/2007
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 5  Depression, Anxiety First week - Nausea, dizziness, no appetite. First month - sleeplessness. After that, just teeth grinding. I take a low dose of klonapin for that. Sexually, I'm stronger then ever. I know there are a lot of nay sayers out there. I work with my doctor and trust him very much. I've suffered from GAD for quite a long time, and this drug works wonders. Things that I would obsess over before no longer are a concern. The only issues I have, not really side effects, is that its a little harder to get out of bed in the morning, and some constipation. They are not side effects that ruin my life or change it in anyway, so I didn't mention them. M 24 1 years
9/6/2007
 1  Depression Brain zaps; grinding my teeth; night sweats; constant shaking of my hands and limbs; not being able to stop my Head going into tremours; insomnia; constant fatigue; headaches; hair falling out; forgetfulness; sore jaw etc - you name it I got them all badly ! I think it is the worst thing I have ever taken - for almost a year I have tried to take it hinking it would help or blaming my body for the effects and now I have come to realise it is this drug / poison. I think people should be warned and that surely after all the blogs about Cymbalata that are negative that the Testing results of this drug should be investigated. Some blogs have hundreds of negative comments - something doesn't smell right - how did this pass clinical trials ? I am now trying to wean off it am in my second week of hell. F 33 11 months
9/5/2007
 5  moderate depression & anxiety the first 2 weeks I was fatigued & constipated. Less sexual side effects than effexor or zoloft and I feel great! Less mood swings. F 49 30 days
9/4/2007

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