CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Depression Anxiety Neropathy The incessive body jerking! It works so well for my Depression and Panic disorder and Neuropathy pain. But the body jerking makes me want to jump out of a window. I fear staying on it but what else can I do.... F 45 2 years
60
2/17/2015
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 1  generalized pain Did not do much for the pain, but made me not care about that or anything else. Increasing the dose to 90mg caused extreme anxiety and racing heart. Caused extreme social withdrawal, no sense of self preservation, no emotional responses, inability to think clearly, and a feeling of being removed from myself and the environment. Withdrawal symptoms were unpleasant and still ongoing. Now prone to anxiety attacks and zoning out with no memory. The pain is easier to deal with than the side effects of this drug. I would rather feel, even pain, than feel nothing at all. This drug creates zombies. F 55 1 years
60mg 1X day
2/15/2015
 1  nerve damage After only 3 hours of first dose I had extreme diarrhea, stomach pain, severe brain fog, blurry vision, headache, jaw clenching, couldn't sleep even though I felt exhausted. I flushed this crap. F 62 1 days
30
2/15/2015
 1  Anxiety, conversion disorder, pain This drug destroyed me. It took away my pain and anxiety. The anxiety so much so, that I had no fight or flight response. I constantly wanted to take risks which is 100% not my personality. I ended up putting myself in a lot of danger and being raped because I could not feel unsafe on that drug. Once my doctor assured me that this was a dangerous side effect of the drug and took me off, the withdrawal was worse than coming off of street drugs. I was violently ill, bounced back and forth between suicidal, manic and dissociation, and could not function in life. The weining the doctors suggested only made withdrawal worse and drawn out. This drug is the devil in capsule for, in my opinion. F 22 1 years
60mg
2/13/2015
 4  fibermyaliga i had been taking cymbalta since 2007 for depression at 30mg then 60mg. have been living with the fibermyaliga pain for over 10 years. went to see rheumatoloist, after going to all pressure points of my body, which just about brought me off the table, he increased my dosage to 120mg to be taken in the morning. took about 3weeks, but i do not hurt. the pain is gone. this has really worked for me. i have had some weight gain, i can handle that, but the pain was getting too much for me. so i am one that would say that cymbalta is a good drug. F 70
120mg 1X day
2/11/2015
 2  depression,aniexty,and pain I agree that it isnt really effective for me either. I feel sluggish,unmotivated,and still have depression,aniexty and pain. I need something that helps me with all those things. I was on Lexapro for 4yrs and it stopped working. I also, agree that if I stop taking the Cymbalta I feel those "brain zings" and fuziness,that is withdraw symptoms. If I dont take the medicine at the same time every day or forget a day, I will expreience withdraw and its horrible! I am going to go to a psychotrist to see if there is something else that will help me. F 34 3 months
60 mg
2/11/2015
 2  Fibro/acute anxiety First MONTH was awful! Couldn't keep anything down, or it ran straight through me. Headaches like I had never had, even worse than migraines if that's possible. Extreme rage over nothing. 4 months later, headaches still hit with no warning. Either I "feel" nothing or I'm on the extreme far ends of the emotional spectrum. During the day I sleep, productivity way down, can't sleep at night. Joint pain is better, but muscle, lower back, and spasms have tripled. I've seen good reviews and had hoped this would finally help. I hate it. But I can't stop taking it. When I've tried (slowly taking every other day) I get diarrhea, brain zaps, and this weird sensation that my lips are going numb and I'll get these scary tingles that start on the side of my head and run through the left side of my body. Will "pulse" it only hits for 3 seconds but will hit every minute or two. The headaches are the worst though. At least with migraines there are warnings. This feels like those super intense headaches that hit right above your eye and lasts for a second or two, but these do not go away for hours. They are devastating. F 28 6 months
30mg 1X day
2/6/2015
 4  Fibromyalgia, Depression Decreased libido. F 52 2 years
60mg
2/3/2015
 5  depression and chronic pain No side effects!!! A miracle drug. No more pain. My mood was so much better. More energy. Could not continue to afford it. Fast forward 3 years later. Depressed. Pain. No energy. Started taking cymbalta again..not the same. Too many bad side effects! NOT THE SAME!!!!!! What happened?? In 2007 I started taking cymbalta and it changed my life. For the first time in a long time I felt normal. In 2012 tried it again, made me sick. Don't know what is different about it but it's not the same. Now I would rate it terrible!!! F 65 2 months
30mg.
2/2/2015
 3  Scoliosis{Spine} pain Occasional headaches,and I have gained over 25 lbs!!!!ARGH!!! BUT! It is a miracle for the pain.Not sure its worth it tho,if the weight gain continues to be an issue.. Not sure the pain numbing is worth the amazing weight gain... F 54 5 months
30 mg 1X day
1/28/2015
 4  Fibromtalga, cfs,pain, depression I have been taken cymbalta for yrs. Tried to change to a different med, could not it got put back on cymbalta. Then I was changed duloxetine the gentic brand of cymbalta and I just dont feel right. I can NOT fond if there is a differents between them, but my insurance did the same saying there is no different. Can anyone help me on this? Ty F 57 10 years
120mgs
1/19/2015
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 2  Fibromyalgia 8 pound weight gain, horrible clenching of my teeth Improved my mood but had no effect on my pain. F 46 21 days
60 mg 1X day
1/19/2015
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 1  fibromyalga Did not help with pain. Made me feel like a zombie. Had shocks going through my brain. Been off for a year and still having withdrawal symptoms. Still have the shocks in my head and shakes. M 56 1 years
30
1/16/2015
 4  Depression Lots of side effects but it works. Now the weight issue. I lost weight at the start (some 7 years ago). Last few yes regained 7 lb and almost impossible to get it off even with dieting. If you take this drug for a long time.. Without continuos excersise, you will gain some weight. Also causes restless legs and some insomnia. Am off now and on a month of viibryd. Good effects but also, I put on 2 pounds overnight without eating more than 1000 calories a day. Next stop.. Wellbutrin Good drug; lots of weird side effects M 62 1 years
60
1/10/2015
 1  anxiety,depression,fibromyalgia I was taking at night but it made me to irritable to sleep .I started taking it today during the day. It still makes me very irritable. Will this go away or maybe just stop taking it ? Its acting more like a stimulate in my system. Dr says stay on it for 2 weeks then see him again . I'm not sure I can handle it that long. Also headaches everytime I take it. He also gave me ambien for sleep but at even 10mg I'm miserable and can't sleep F 54 3 days
60mg
1/7/2015
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 3  Bipolar 1, GAD, PTSD I thought my psych was going to stop this back in December, but instead he doubled the dose. And simultaneously cut the Risperidone dose in half (?due to Parkinsonian-like side fx). This has helped me to a degree. I feel less depressed at top-level cognitive functioning but no less depressed at a more deep-seated level of consciousness. There is persistent anergia++ and this is possibly worse (certainly no better). Sexual dysfunction/libido remains poor and unchanged. On the plus side, I can converse much better at dinner parties and the bipolar babble has settled. Net result of increased Cymbalta = slight improvement as regards depression but nil elsewhere except maybe helps my anxiety a bit. M 56 4 months
60 2X day
1/4/2015
 2  bipolar 1 , chronic pain, fibromyag Nervousness, night sweats, jerking of arms, palpitations, anxiety, difficult concentrating, insomia Pharmacist thought I was having serotonin syndrome, since old med still on board. After weeks and Dr calling in nerve med and muscle jerks started I stopped and went back on old symptoms went away. Did seen to help with pain some F 54 6 weeks
60mg
1/3/2015
 4  Depression,social anxiety Sexual dysfunction, somnolence, fatigue, insomnia, loose stool. Worked amazingly well for anxiety and depression when combined with clonazepam. I felt better than I had felt in years. Sad to say the side effects were just too much to bear. I have 2 other close relatives on Cymbalta and they are having a good response. I wonder if response to this med. depends upon genetics. Stopping wasn't too much of a problem, but I was quickly put on another antidepressant which may have helped. M 54 3 years
60 1X day
12/28/2014
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 1  Neuropathy Felt stupid , couldn't function properly ,couldn't eat right This drug sucks tried to come off it cold turkey and couldn't even function worse then when I was on it I saw my dr and she she said to break open the capsules and take out a little bit at at a time. Still don't feel well F 51 1 days
60 mg
12/28/2014
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 1  fibromyalgia Very fast Heart rate and high blood pressure, full body shaking, jerking limbs requiring duloxetine to be stopped and a 6 night stay in hospital. Postural hypotension, nausea, anorexia and black-outs with loss of muscle tone . Pain reduction by day 3 leading to improved mobility. By day 14 pain was increasing and occasionally my mobility was stiff. Day 54 my blood pressure and heart rate were high. Day 55 I felt unwell and my heart rate was 148. On arrival at A\E I collapsed and was rushed into resus where my heart rate was 175 and blood pressure 174/104. I was given oxygen, cannulated and given diazepam for total body jerking and spasms. I was so frightened. I was diagnosed as having a severe adverse reaction to duloxetine. I was admitted and the duloxetine stopped. The jerking continued for several days and I collapsed on several occasions. Whilst in hospital I felt suddenly drained of all energy and fell onto my bed unable to move for almost an hour. The medics agreed to allow me home providing I had someone at home with me. I had further episodes of collapse whilst remaining conscious/ losing consciousness and unable to move my legs and hold my head up. One of these occurred at the gp surgery and another I phoned for an ambulance. Neither the gp I had grown to trust nor the ambulance crew believed me. I was shouted at and told to move. Each time I became hysterical. I had further episodes of difficulty breathing, chest pain for which I spent hours in A\E. By day 11 my energy and appetite have started to return but this episode has affected my trust and destroyed the relationship I had in my gp. F 54 55 days
60mg 1X day
12/27/2014
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