CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  Depression Some night sweats, initial nausea-only lasted a few days. This drug has changed my life, and the turnaround was immediate. I went from years of depression and had tried Paxil, Wellbutrin, and a number of other drugs that I simply could not tolerate. My doctor augments this with 25 mg of Traozodone for sleep. I sleep for the first time in 30 years and wake up feeling great. I am positive, optomistic and am never "Blue". I can have a sad moment over something that is truly sad. I don't ever sweat the small stuff and am doing great. I highly recommend this. For the first time I am living, loving, and enjoying life--not just sitting at the sidelines watching it go by. F 45 6 months
8/24/2008
 1  Depression/Anxiety Extreme fatigue, dizziness, feeling detached, nausea, headaches, lethargy I only took it once and I felt really awful. I took it before bed and slept all night. When I woke up I didn't feel well but figured it was normal. When I stood, though, I was really off-balance and it didn't go away. The longer I stood, the more my stomach started to hurt. I could barely go to the bathroom and get back to bed before feeling like my entire body was shaking and falling apart. I slept all day and all the next night. It took days for the effects to fade completely. My doctor put me on Lexapro instead. F 20 1 times
8/24/2008
 5  Fibromyalgia extreme sweating from morning to night; blurred vision at times. Either jittery feeling or tired feeling depending on time of day taken. Taken in a.m., hungry after six hours; taken in p.m. appetite depressed next day, so usually try and take in p.m. I am one of the extremely lucky ones, I guess: I can still cry at sad things and I have much STRONGER orgasms! No loss of libido. The main thing is after only about five days the pain from fibromyalgia--toes, feet, neck--ALL GONE! I only take 30 mg a day and sometime only every other day. F 57 3 months
8/23/2008
 5  depression/anxiety Sweating, nausea at first, headaches if I missed a dose I've read all the negative and positive. Cymbalta, like other antidepressants, does not work for everyone but I have had a great experience. I was on it for about 3 months and had to go off. Had NO difficulty with discontinuing the med other than headaches the first few days. I feel more able to focus, less anxiety, and increased sense of wellbeing when taking it. I restarted the med a few months ago and other than a few days of nausea, had no adjustment problems. I would highly recommend Cymbalta. Positive benefit - decreased appetite helped me lose and keep off 15 pounds. F 39 9 months
8/18/2008
 5  Major Depression Night sweats -- especially during my period. Itchy palms. Occasional dizziness. No other side effects to speak of. I have taken Cymbalta now for three years and it's changed my life. I've had fantastic results. I can navigate challenges professionally and personally that I could not have managed nearly as well before due to chronic depression. Other than some uncomfortable night sweats during my period, side effects for me have been negligible. I had previously used Prozac and Wellbutrin. The former killed my libido. The latter simply did not work. With Cymbalta, I am liberated from depression for the first time in my life -- in my 40s. I feel very lucky to have found it. F 47 3 years
8/17/2008
 4  treatment resistant depression constipation, slight stomach upset and jittery for the first few days on 30mg After 20 years of clinical depression and trying everything from elavil,pamelor,prozac,paxil,lexapro,remeron and others I can't remember, this is the first med that has actually helped me. I resisted trying it because of the many negative comments, but I have an excellent psychopharm and I'm very impressed with the results so far. I feel good,focused,almost cheerful and am going to stick at 40mg in the am. I actually lost weight and have energy, but am sleeping better at night. For me, it's by far the best and I was about to give up hope. F 50 4 weeks
8/17/2008
 5  Depression & Anxiety None I can pinpoint to the drug. I read a lot before agreeing to take Cymbalta. I held off for several months because of experiences like many mentioned here. I finally felt dealing with the depression was worth the risk. I started on 30mg and have increased to 60mg. Within days I felt the drug work. It has been tremendously helpful with no side effects of any consequence. Maybe some mild neausea, but I'm not even sure the meds was the cause. I do worry about withdrawing. I take other meds that have horror stories (benzos & prozac). But, I'm not sure of the alternative. So far these meds have saved my life, and so far (knock on wood) none have had bad side effects. I didn't go into this lightly, I've done talk therapy as well for many years. I've have good psychiatrists not just GP's. Without the meds I would be house bound at best. Instead I am a CEO of a company. I believe all the horror stories and it's awful. But I think it's important to know that on the other hand, for some of us this F 41 3 months
8/14/2008
 5  for depression and anxiety attacks Some fatigue about an hour after taking it definitely take with food a lot of sweating in the beginnig but went away I feel great at work very happy more optimistic F 37 1 months
8/14/2008
 5  Irritable bowel syndrome/depression NONE!!! My doctor prescribed Cymbalta at first for my extreme Irritable Bowel Syndrome. I found it to be a life-saver!! I went from being able to eat practically nothing without horrible pain to anything, including raw veggies, beans, etc. with NO PAIN! I then noticed that I was able to focus on my work much better (also have been diagnosed with ADHD, but was treating previously non-medically with just exercise, healthy diet, adequate sleep, etc.) About 9 months after starting the Cymbalta my father passed away and I became very depressed, so my doctor increased my dosage, which helped in just a couple of weeks. I now stay at 60 mg, b/c it makes me feel so much better. CYMBALTA IS A WONDERFUL Rx TO ME - A LIFESAVER! F 36 2 years
8/13/2008
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 4  Fibromyalgia nausea for the first 3 days, also if not taken early in the day insomnia Works extremely well. I have not been on it for very long at all but the effects have been dramatic. I truly cannot believe I resisted this for so long. F 34 7 days
8/13/2008
 2  major depression and anxiety heart palpitations, chronic constipation, legs weak and heavy, trembling, crying jags, irritability, once or twice a "rage" reaction, very low self esteem, feeling unsafe and insecure, unhappy and scared I'm in the middle of weaning from Effexor XR and adding Cymbalta, since becoming more depressed and anxious recently. I have been taking antidepressants for 17 years. Now I take Paxil CR, Trazadone for sleep, Xanax XR and Effexor XR every day. My doctor recommended switching the Eff to Cymbalta, because of this deeper, developing depression. I've been having side effects of the new drug since Day 1, but they became much, much worse as I changed dosages. I believe I moved right into a bad crash and withdrawal. I had so many of the frightening effects alot of you mentioned. I immediately reversed the process, and, boy, do I feel more level, within 2 days. I'm going back to Effexor XR, although my doctor told me today to continue the process with the Cymbalta! Ugh! He also increased the Xanax dosage slightly. Frankly, I've had more luck with Xanax added to my regimen than with trying other meds like Zoloft, Wellbutrin, Prozac. For me, I find it has a milder, generalized calming effec F 60 6 weeks
8/12/2008
 1  anxiety hyperactivity, insomnia, extreme tremors, stuttering and speech impairment I have no family history of health problems of any kind, not even in my extended family, not even heart disease or diabetes or anything. I've never spent a day in the hospital and have always been healthy except for the occasional cold. I began taking Wellbutrin during my junior year of college after being extremely stressed and unable to relax. I was taking half of a regular dosage and took it for about two years. Because of a change in my insurance, my doctor suggested Cymbalta as a cheaper alternative since he received samples for free. I finished my last Wellbutrin pill on a Sunday morning. The next morning (Monday) I took one dose of the Cymbalta. That night I was unable to sleep. I began having tremors mainly in my arms and legs. I also began to stutter when I tried to speak. Some words were difficult to get out entirely, every other word I stammered out. After visiting the hospital twice that day with the same symptoms, each visit having been sent home with atavan and F 22 1 times
8/11/2008
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 1  depression/anxiety SEVERE headaches, extreme sweating, tired all the time, no real emotions I didn't associate some of my side effects to cymbalta until I stopped taking it 5 days ago and I couldn't be happier. The headaches (or I should say 5 month migraine) was the worst part. On top of that, all I wanted to do is lay down and go to sleep. I think it made the depression feel worse because I had less energy while taking this than I had before. This didn't help me. F 31 5 months
8/8/2008
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 5  GAD, Panic My stomach was a bit queezy for the first couple days but that's it. After reading all the negative comments I was hesitant to try Cymbalta, in fact I almost didn't take it. But after quite a lot of convincing, I started to take it. I am glad I did because it's really helped me without making me feel less like myself. F 28 2 years
8/7/2008
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 1  anxiety and depression anxiety got much worse, many side affects like nausea, headache, diziness,very weird feeling in my head. After stopping cymbalt depression got worse, suicide thoughts, numb feeling. be carefull when you decide to take this medicine F 45 6 weeks
8/7/2008
 3  
8/5/2008
 5  depression/anxiety dry mouth, constipation, weight loss then gained weight back (only 10 lbs), blurrred vision, eratic sleep patterns, sweating at night, vivid dreams, very increased sexual drive- but hard to climax, sometimes very sleepy Other than all the side effects- which I have learned to overlook- I find that they change around-I feel great. I still have some bad days now and then- but I know that they will become less. I don't worry about things like I used to. In fact sometimes I don't give a shit anymore on things that used to drive me crazy with worry. My sex drive increased but the climaxing is so hard if I am able to. I have more energy. I feel much differnet and my advice is to deal with the side effects and see how you feel over all. I wake up a lot at night and have bad sweating...but when I lost my job due to a layoff and did not worry about my future. I knew that this medicine was working. I am much calmer and laugh like I have never before. So give this medicine a shot. It may not be for everyone. Back in the 90's I tried everything and NOTHING worked. So I gave up and dealt with the depresion and anxiety on my own. I was okay unitl my divorce (he was a party dude- not a family man) and then I went d F 40 4 months
8/2/2008
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 3  fibromyalgia None yet, just started and am here trying to learn how others fared. F 51 0 days
7/31/2008
 1  Depression dizziness,heart palpitations,restless leg syndrome,emotional imbalance,weight gain The benefits of this medication (very brief relief from depression) do not out weigh the cost. Most troubling for me was the weight gain that came out of no where. So frustrating. This did not help with depression. I am happy to report that after being off of it for six months, I am back to my normal weight. Don't let the doctors fool you-This medication will make you gain. Getting off of it is no walk in the park either. It took me nearly a month of very gradual tapering and still I experienced alot of dizziness,weakness and lethargy. Quite a price to pay for only a brief period of relief. I would explore just about any other option before embarking on the cymbalta band wagon. I have gone back to prozac. I don't know why I ever stopped. F 45 2 years
7/27/2008
 5  depression & anxiety When first starting... Goosebumps and chills intermittently, fatigue and sleepiness, slight intermittent feeling of dizziness, urinary hesitancy, decreased appetite with slight weight loss. I started taking Cymbalta in March "08". It has been a success story for me. I feel very well and am enjoying life. My experiences with side effects are minimal and were only when first starting and adjusting to it. Goosebumps and chills intermittently, fatigue and sleepiness, slight intermittent feeling of dizziness, urinary hesitancy, decreased appetite with slight weight loss. None of these symptoms were distressing and abated after about 6-8 weeks. Now it's just a daily med I take and is no big deal. I have missed a dose occasionally and have not had any problems but I never would allow myself to miss two days doses as I know what paxil did to me with that experience. It has helped me so much that I don't contemplate going off of it. It doesn't make me feel addicted like paxil did. Why try stopping what has made such a positive difference to my health and well-being?...just to be miserable? Blessings to all of you. F 52
7/25/2008

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