CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Moderate Depression, Severe Anxiety Night sweats, constipation, taking longer to climax during sexual intercourse I am glad that I started Cymbalta before I came to this site. I have only been on Cymbalta for 10 days but I am already starting to feel so much better...I've gone years and years being depressed, sometimes severe sometimes moderately. The disheartening thing is that the people who are most likely to post on sites like this are the few that have had bad side effects. However, remember that everyone is different and out of ALL those taking this medication only 20-30% end up with severe side effects if any at all. Every person physiologically is different and processes meds such as Cymbalta differently. There is a balance...there are many who are taking this medication and have not had any side effects at all and even the ones that have, it has been worth the side effects. I am hoping that my experience with this med continues and that it gets more effective as time goes on. M 32 10 days
60 1X day
7/18/2010
 5  depression and anxiety initially, had stomach pains and some tiredness. some sexual side effects, constipation. this is my second pass at cymbalta. the first time, the side effects were more severe and included brain zaps and a feeling of being amped up. now, after being on it for 4 months, this second time is so much better. i don't have any of the brain zaps anymore and i don't get tired or to amped up. i take it in the early evening as i find this works best for my system. i have had two long lasting side effects. the first is constipation. i now take benefiber three times a day and this really helps out tremendously. just with each meal. benefiber comes in "to go" packages so it's easy when i go traveling or eat out. the second side effect is the sexual one. although i do have the desire and can achieve an erection, it is difficult for me to orgasm. i used to be able to do it easily but now, it takes real effort and all the planets have to be aligned, if you catch my drift. also, the amount of semen that comes out has diminished. i try to reach orgasm, but if i don't, i am not discouraged, and maybe that is the cymbalta working to not make me depressed, i'm not sure. PLEASE, if you are a male and have had similar experiences, please contact me, i'd like to discuss this with someone who has the same side effects as me and find out possible solutions, etc. overall, i really do like cymbalta and don't see myself getting off of it any time soon. M 41 3 months
30mg 1X day
7/16/2010
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 3  Major depression I get brain buzzes, headaches, and cannot sleep. Major Depression has been helped but still have anxiety and panic attacks and days when I feel just simply not motivated. Not sure on this one M 42 6 months
120 1X day
7/13/2010
 3  depression/anxiety stomach pain, loose stools/diarrhea This medication helped my depression somewhat but the constant upset stomach has been too much for me. F 30 120 days
60 1X day
7/12/2010
 3  depression at first none felt great after approx i week got this foggy feeling, always tired, have a not care to do any thing attitude this is my second time on this first time quit cold turkey not to may problems other than those silly brain zaps. this will be my second and last time taking after one day i feel 100% better hopefully tommorw will be the same M 43 30 days
30mg 1X day
7/10/2010
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 4  Major Depression Initially; dizziness, brain zaps, weight loss, nausea. These dissipated after a couple of months. Now I have night sweats and my body temperature has increased. My weight has stablised and I am seven pounds heavier than I used to be, but I have a decreased appetite. As others have said, the withdrawals happen very quickly - I get pins and needles in my face and tongue (how bizzarre!) within hours of missing a dose. I have found that this has helped my depression and anxiety very much. I no longer have suicidal thoughts (which i had lived with for fifteen years), I no longer am extremely anxious and negative. It has not helped my hypersomnia - I can still sleep for up to 14 hours a day. Am looking at changing my meds (I also take a small dose of Lamictal every day) as I am very unmotivated and slightly depressed at the moment but I think t could be to do with my life circumstances which aren't great right now. F 34 2.5 years
60 1X day
7/7/2010
 4  depression/fatigue due to MS Daytime sleepiness. Primary Care Physician suggested taking it at night. I began taking Cymbalta late in the afternoon and there seems to be improvement. I have MS and the fatigue/depression for the past year have been at times almost unbearable. Neurologist didn't seem to care about my quality of life. I finally was able to get my primary care doctor to prescribe Cymbalta. F 68 18 days
60 mg 1X day
7/2/2010
 2  Fibromyalgia INITIAL: Nausea, constipation, diarrhea, dry mouth, dizziness MONTH TWO: All of the above PLUS,headache, decreased libido, back pain, night sweats, hot flashes, flushing, heartburn, insomnia, constant yawning, blurred vision. MONTH THREE: All of the above,PLUS, profuse sweating, stiff neck, joint stiffness, weight gain (10 lbs. in 6 weeks), difficulty passing urine, extreme itching, difficulty reaching orgasm, cold sores, pins & needles in hands and feet. WITHDRAWAL SYMPTOMS: All of the above,PLUS,restless legs, chills, crying, fatigue & restlessness at the same time, eyes aching & itching, heart palpitations, multiple intense violent nightmares throughout the night, feeling drugged or hung over, flu-like symptoms, extreme flatulence, difficulty swallowing, difficulty concentrating or focusing, extreme thirst, pressure in the head, shortness of breath, itching & ringing in ears, loss of balance. Initial side effects were worth living with because my pain had decreased substantially. As time went on the side effects increased & became worse. Then i developed an itch in my breast that became so intense it began to blister. I experienced 3 weeks of hell going thru tests (mammogram, ultrasound, MRI & biopsy) to confirm it wasn't inflammatory breast cancer. I finally made the connection when reading another patient's comments with the same symptoms. I have been weaning off this drug over 3 weeks and still feel horrible. I wish I had found this site earlier. I would never have taken this terrible drug. F 52 3 months
60 MG 1X day
6/28/2010
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 5  Severe Depression Dry skin, dry/cracked lips, hair loss decreased libido with difficult climax. I was falling deep into depression and was suicidal after a separation and immediately noticed a change within the first few hours after taking my first dose. This medication not only gave me my life back but showed me what I had been missing my whole life. I have several food allergies and many of them affect my mood. I was very unsure at first but now I realize it was the best thing I could have done at the time. without it i could have hurt myself or someone else. Be very careful with taking doses regularly because the side affects are severe. I was unable to take mine for days and was very frightened (something very wrong)the whole time without it especially when trying to sleep. This is a powerful drug and not for everyone but in my case it worked like a miracle. My family is in health care and I was raised learning about medicine. My feelings are that this drug is a double sided sword. The side affects can be controlled if you are careful and smart. If you will be gone TAKE EXTRA WITH YOU and have more just in case you run out. My lips were dry for a year after taking it. Sometimes less is better I have read. M 32 6 months
25mg /50 2X day
6/27/2010
 4  Depression & nerve pain Constipation and bloating, trying to deal with this because I don't want to stop taking it. Big problem is feeling like I have an earache all the time.. Been on Cymbalta for approx. 6 months. Really helpful with depression, but I have had the bloating etc that everyone talks about. Trying to deal with that. Weight gain, which I hate!! Has anyone had the feeling like you have an earache all the time?? This is driving me nuts. F 61 6 months
30mg 1X day
6/25/2010
 4  Anxiety, Depression At first dry mouth, then weight gain. Some difficulty paying attention to things, but that might just be my personality. I went on after suffering from severe panic attacks for 2 months. I took it for 18 months and had a huge reduction in the panic attacks. I'm about to work my way off of it, with the help of a doctor. F 26 18 months
60 1X day
6/24/2010
 2  chronic depression insomnia, severe headache, hyperactivity Noticed a change after first dose. Increased energy and motivation. Decrease in anxiety and obsessive worrying. Great in this respect, exactly what I was looking for. However, insomnia was a huge problem. Slept about two or three hours a night at most. Became extremely physically tired, but could not fall asleep. Severe headache that would not go away with over the counter meds. If not for the insomnia and headache, I feel Cymbalta would have been very beneficial to me. Very disappointing. I was directed by my doctor to stop taking it, and was prescribed something else. The headache and insomnia stopped within a day or so after I stopped taking it. I did not have any problems with withdrawal, probably due to immediately starting another med. F 46 4 days
30 mg 1X day
6/22/2010
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 3  Depression/Anxiety/Social Anxiety At first, dizzy, nausia, night sweats,insomnia,creepy (for lack of a better term) feeling, decreased sex drive. All but the night sweats, insomnia and decreased sex drive went away pretty early on, within the first month. The side effects of skipped doses are aweful. Feels like pins and needles in my feet and dizzy even when missing only one dose. I take 60mg in the am, 30 mg in the pm. Have had a total lifestyle change since I first started taking it, divorced, kids away at college, better diet, regular exercise, but the depression and anxiety is back big time with a new symptom, freaky dreams, and cymbalta isn't helping anymore. I want to change meds but I am terrified of the effects of even cutting the dosage down. I don't want to increase it because I am almost at the max daily dose (120mg) as it is. I would have never started taking it if I had known of the lasting side effects and the effects of coming off it. F 45 4 years
60/30 mg 2X day
6/20/2010
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 1  Anxiety Jittery--my hands are shaky. I feel like a zombie. Detached. Talk monotone. No expression-flat effect. No Anxiety but cannot feel anything. --Numb-- Sleeping alot-10 hours. I am not going to take this anymore b/c I don't want to be a zombie and cannot be for job. I have moderate fluctuating anxiety. I think this is for more severe anxiety. F 38 2 days
30 mg 1X day
6/20/2010
 5  Chronic pain, anxiety Night sweats, insomnia, constipation After suffering from several herniated discs in my neck and spending over a year living on narcotic pain relievers, I began suffering from anxiety. My doc prescribed Cymbalta and told me it would also help with the chronic pain. At first the only side effect I had was the night sweats. I had surgery for the discs and wanted off the Cymbalta because I was no longer on the pain meds. My doctor advised against it but I weaned myself off anyway. Did not have any problems weaning myself off although I had run out at an earlier point and had a severe anxiety attack. I weaned myself off very slowly. Night sweats and insomnia disappeared but my neck pain returned within days. I had lost my insurance and could no longer affford the Cymbalta but I was able to get assistance through LilyCares and made the decision to go back on the Cymbalta for the pain. It is worth the side effects to me. I have found that taking fiber helps with the constipation although I take double the suggested dose. Have not found anything to help with the night sweats. I have tried several things to help with the insomnia but no luck so far. I am considering cutting my Cymbalta back to every other day to see how that works. M 42 1.5 years
60mg 1X day
6/19/2010
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 4  Depression I was fine on Cymbalta and it worked for the depression but then recently after 4 years I discovered and my doctor agreed that it was producing severe constipation and then gastroinstestinal issues. When weaned off cymbalta to see if the side effects would stop and didnt these past two months I mentally crashed and so I am back on it but at the 30mg and I don't want to go higher this is a happy medium for me. Cymbalta is very expensive also and most insurances wont pay for it. I had to go thru LillyCares.com to get assistance to cover it. In addition to taking the Cymbalta again, I discovered and my doctor agrees with me taking 1 probiotic, 1 stool softner, 1 colon cleanse tablet, and digestive enzymes when eating per day immensely helps my digestive disorder and severe constipation I developed while being on Cymbalta. I don't know how long it would take for Cymbalta to leave my system after being on it so long but the digestive issues are a done deal now and since my wedding is 2 mont F 44 4 years
60mg 1X day
6/17/2010
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 5  Premature Ovarian Failure None the first time around. 4 yrs later - and 7 hours ago. 1st dose at 30mg. Belching and a very gurggly stomach. A little sleepy, too. 5 years ago I began to rage. I was angry, agressive, ready for and looking for a fight. I oozed hate. Severe night sweats, severe daily hot flashes, crazy 2 week + migraines, drastic mood swings. If I wasn't pissed, I was crying. No in between. I was diagnoised with POF (early menopause). I was given 60mg of Cymbalta by my Nurse Prac. B/c she wanted me to start slow, I was advised to take one every OTHER day for two weeks then one a day. One every other worked so well, I was scared to mess with it. No night sweats, no hot flashes, no rage, no mood swings, no hate, just me, myself and I. It was THE MIRACLE PILL. I took it for a year, every other day with absolutely no side effects and then quit. Cold turkey without any withdrawl symptoms. So I'm kinda shocked to see how everyone here has had such a hard time getting off it. Now I'm on it for anxiety and depression. Today was my first 30mg dose in 4 yrs and Dr. wants me to take it every day. I have suffered from severe optical migraines since I was 10 years old. I'm pretty good at medicating before pain, but I'm a little hopeful here as I didn't know it was also a treatment for migraine suffers. Will keep you posted. (O: F 41 12 months
30 mg 1X O
6/16/2010
Email
 3  Neuropathy Acute loss of interest in sex, inability to reach climax - no sensitivity, mild constipation, dry mouth, uncontrollable yawning Seems to help some with neuropathy, although it doesn't completely ease the pain and burning sensation. The first time I tried it, I got very nauseated and stopped taking it, but decided months later to take it with food and didn't have that problem again. Will probably stop taking it and go back to neurontin because of sexual side effects. M 65 3 weeks
30 mg 1X day
6/16/2010
 3  Anxiety & Depression Euphoria, decrease anxiety, stable & calm mood, increase in confidence, loss of short-term memory. I would rank this higher, but it absolutely affected my memory & it is still not quite what it used to be. Also, when I was weaning off of it, it made me feel SO SICK and miserable. DON'T MISS A DOSE OR YOU WILL FEEL IT, and I was only on the minimum dosage! I must say, though, it did help me at a time when I really needed it! I'm not on anything now and I feel fine. F 27 2 years
20 mg 1X day
6/13/2010
 2  Dysthymia This has been no cake walk. The side effects that this medication has should make the manufacturer (Lilly) blush with shame. Anyone prescribing it should be required to take it for a minimum of six months. Each capsule has many SIDE dishes that have meant, SLEEPINESS, LACKING MOTIVATION, INSOMNIA, VIVID DREAMS OF A GARISH NATURE, EXCESSIVE SWEATING, ANTISOCIAL TENDENCIES, IRRITABILITY, DRY MOUTH, MEDICINE BREATH, WEIGHT GAIN, SERIOUS MENTAL MISTAKES WHEN DRIVING, CONFUSION, and others that I don't remember at the moment. With all of the nastiness that this horrible drug represents I have attempted to come off of it twice only to come back on to it because of brain popping severity that one could only connect to as being in HELL!!! This garbage should be administered with a RED FLAG. In order to fall asleep I require additional drugs including TRAZODONE and TEMAZAPAM to help enhance sleep. I am now HOOKED on TEMAZAPAM as I am on the Cymbalta. My next order of business is to once again come off Cymbalta and hopefully the Trazodone and Temazapam later on. I will pull the devil capsules apart and take some of the time release grains out. I will carefully log each week as I do this to mark my progress and side affects. I expect this will take many months. What a shame (or is a SHAM!). If I have any problems with this I will ask for a new Dr. since the one I have now does not care what he prescribes. I notice that most people who complain about this bastard drug do not comment on what they will then take once they get off of it. This is a good indication of how the side effects of this garbage tops everything else. This almost smacks of a class action lawsuit against Lilly for their poisoning us. I feel that strongly about this! M 49 5 years
60 1X day
6/12/2010

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