CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  Fibromalgya/Scholiosis/back problem I, think cymbalta is a real good medicine. But maybe will not work the same for everybody. In my case, i have been taking cymbalta for almost one year, i suffer from scholiosis that become in a hard fibromalgya pain. I have been feeling almost completely relieved from the pain i suffer during more than 5 years. I couldn't walk well, carryng my babies and I suffer from pain 24 hours per day, i wanted to die, since i begin taking cymbalta i have improve my quality of life, i feel almost normal. But i worried about side effects. My doctor prescribe to take 60 mg daily until 1 year, however i didn't follow up, the first 3 months i take daily, then 3 or days per week, now just maybe 1 or twice per week, (depending on how i feel), i feel better and better, and what i think is the side effects just appears when you take it daily. I just take when i need and i have been doing that for one year. Right now i feel great, and i have recover my life. During five years i taked a lot of drugs, a F 32 10 months
12/18/2009
 5  Severe Depression, Social Phobia Possibly tiredness/sleepiness (though I've felt that way long before starting Cymbalta). By far the best antidepressant/antianxiety medication I've tried. Both my depression and anxiety have abated significantly, though there is some of both left (plus the tiredness, which I suspect could be depression-related). I'm already at 120mg and would like to go even higher. My sexual performance has improved greatly, as has my concentration and even driving skills! It's really interesting how the same compound affects different people in so many different ways. I definitely recommend at least trying Cymbalta. M 41 1 years
12/15/2009
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 2  Depression and Anxiety In a constant fog, inability to concentrate, no libido, memory loss, night sweats and vivid nightmares(in the first month, stopped eventually). This particular drug did not work for me. I have been on 60mg. I just dropped to 30mg today and will be coming off of it to switch to welbutrin. I am a full time graduate student who works full time. I have never in my life had such a hard time getting motivated (even with anxiety and depression). I am constantly forgetting words and always feel like I'm in a fog. I barely remember the last 3.5 months. I would sit down to study for class and forget what I just read. I would suggest if you are starting this drug to do so when you have no important engagements going on, so that you can see how this drug effects your memory and concentration. F 26 3.5 months
12/15/2009
 3  Depression & Nerve Pain I've only been taking Cymbalta for 3 days, but I'm already not sure about it. I took the first 2 doses at night, and I wasn't able to fall asleep for 4 hours. Then, when I finally did, I woke up within 2 hours with a massive headache. So, I decided not to take it last night and took it this morning, instead. The headache hit quicker and more intensely. Also, my mouth feels like sandpaper and I have absolutely no appetite, but that part is ok! I have lost 6 lbs already, so I can't complain about that! The headaches and insomnia are almost too much, tho. Will talk to my dr soon. I don't think I can wait to see if the side effects go away. F 33 3 days
12/14/2009
 1  Depression At first things were great, then about 6 weeks into the treatment I experienced electric shocks that would shoot from the front of my head, down my spine and out both hands. This would typically happen early in the day, right after I took my daily dose. If I missed a day, then the shocks would occur throughout the day. I also found that it was difficult to urinate completely and when I tried to force a greater flow, it would not increase. My level of agression had greatly increased and I was very intolerant of minor irritations, with explosive outbursts. I decided to stop the medication to make sure that my prostate wasn't in trouble and to make things better for those that were living with me, and the week of withdrawl was horrible. I was not able to concentrate, I don't remember much of what I did, nor why I did it. It was pretty much a lost week, but things are back to "normal". I have been taking Welbutrin for 3 months with no side effects and things are back on an even keel. M 54 8 weeks
12/13/2009
 3  Depression and herpes nerve pain Adrenalin Rushes, lost 3 lbs in 2 months, nightmares (these ones really top zoloft even as I've been on all SSRI's and I had a dream about a decapitated head in my pillow, nice :)...complete loss of interest in sex and can't orgasm, pain in the left side of my body and muscle aches...on the plus side I've got more energy and I'm not panicky or depressed, just a little jittery when drinking coffee and eating too much sugar. I like this drug, other then the sexual effects and nightmares I'm only taking 30 mg a day right now of the brand name. Waiting for Canada to bring the generic over so I can drop down to 20mg as I'm a little too speedy for my liking sometimes, but at least I'm AWAKE and alert which I havent been in years. F 31 60 days
12/12/2009
 2  depression/anxiety Felt like I had taken speed - anxiety, restlessness, insomnia, loss of appetite, felt "worked up", increased depression, probably because of sleep deprivation from the insomnia. Obviously not the drug for me! I was not willing to wait around to see whether the side effects would decrease after a while, as I have 2 young kids, a house and a job and I need to function in the mean time. F 33 5 days
12/12/2009
 4  Depession/constant pain in thigh First day i felt a little nauseated but not since, dry mouth, some headaches for a couple weeks, now after 3 mo I'm getting a bad pain in my neck. My pain is gone! My depression is much better, woo hoo! I am concerned about my neck pain because I might have to stop taking the drug, going to make an appointment with doc, we'll see. P.S. The symptoms I had were worse when I felt dehydrated, and improved much when I drank more water. F 44 91 days
12/11/2009
 2  Fibro/Myofascial pain syndrome Unable to achieve orgasm or get sexually aroused. Some mild headaches, nausea & sleeplessness initially which went away but sexual side effects were intolerable. Worked great for the pain but discontinued due to sexual side effects. I really wish companies provided more info and did more research on sexual side effects of medications on women. F 37 3.5 weeks
12/11/2009
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 5  migraines No side effects, unless you can consider feeling awesome a side effect... I tried Paxil and Amiltryptaline (sp)for my migraines, and even tried inderal. My neurologist suggested Cymbalta over and over again and I kept refusing it because of the cost. Once I got my prescription deductable met, I gave in. Got a lot of samples, and after two and a half weeks, I feel fantastic! I was dealing with an addiction to opiates and with prayer for a miracle, which as it turns out was in the form of Cymbalta, I am over it! Today, I realized that I am ready to quit smoking. F 42 18 days
12/9/2009
 4  Mild depression/Generalized Anxiety I'm now almost 3 weeks in and have still only experienced positive side effects...more energy, more focus, less moody, etc. Only negative was in the first couple of days...feeling a bit foggy and some tension through my neck and shoulders. I follow-up with my doctor this week to determine if we need to add or take away anything and I pretty sure we'll keep things just as they are. I feel human again and I can only hope this feeling will last. F 28 3 weeks
12/9/2009
 3  ulcerative colitis diziness, foggy head, sweats, difficulty accessing feelings and making good decisions. The drug woked well to supress my uc. Totally experimental. My doctor felt it was worth a try and so did I. After 5 months on cybalta I am now having trouble in my relationship with my wife. I have become very detached and have not been able to react to feelings of saddness or happiness or discontentment with a situation. I am going to stop taking cymbalta and try to UC meds again. I will be trying to wean off the drug slowly. The withdrawls sound awful. M 40 5 months
12/8/2009
 4  Anxiety & Depression Started immediatly on 60mg per day to deal with depression and anxiety - Key negative side effect is LOSS..... Loss of focus and attention (got into 2 small accidents after 35 years with clean driving record); lose stuff like keys, pens and stuff, loss of memory, ideas and words; Loss of sex drive (no desire for it anymore). Most of the loss is quite mild but does cause a concern - I don't and to be on ths forever - HOWEVER..... on the positive side, I sleep well don't cry at the drop of a hat, I can work full time again and my relationships are back on track again. Cymbalta and 3 month rest have helped me greatly. I've just dropped to 30mg per day - I can say I am feeling a lot better since being on Cymbalta - I'm not anxious and I'm able to put things behind me that would really set me off before. It's not a wonder drug (just read at some of the other comments) but it has done an amazing job with me. I'm looking to be off Cymbalta soon and hopefully the effect lasts, and I'm worried about withdrawl. M 52 6 months
12/6/2009
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 5  Fibromyalgia I had an little dizzy when I first started, I have changed taking my cymbalt to night before bed and works great. My only complaint is the price. My insurance only covers $30 of the price. wish to find a way to reduce the cost. I have started my second month and I have noticed so much better feeling. The pain I have experience has dramatically decreased. I am able to walk more freely. I also have arthritis, but am able to handle it better. Alot better mood without the pain F 53 45 days
12/5/2009
 4  CFS/Fibro pain, anxiety, depression No neg. side effects so far. I switched from Zoloft to Cymbalta and also continue to take 300mg. of Wellbutrin, and 5mg. of Dexedrine. I feel that it works better than Zoloft and I feel more 'naturally relaxed', if you will. I am on 60mg. and I am hoping that it will really help me cope with my pain. F 37 3 days
12/5/2009
 4  Depression/Anxiety nausea when first started. Fatigue after 3-4 months F 31 120 days
12/3/2009
 4  Maintenance for depression I tolerate Cymbalta really well. It works for anxiety much better than the SSRI's like Prozac, Paxil, and Zoloft. And I don't know what everyone is talking about, 30 days worth of the 60 milligrams is only $120, so Cymbalta is not that expensive without insurance. I guess I also get some mild sexual side effects, but not bad....the molecule that Cymbalta is based on is closely related to the molecule that Prozac is based on, and I tolerate Prozac very well so that explains why I do so well with Cymbalta. This drug has an action like Effexor but with a much more calming, soothing affect. The only thing that you have to watch is the short half-life which means that if you miss just one dose you will experience withdrawal symptoms like dizziness, nausea, and electric-shock sensations. But don't let these horror stories scare you...this drug is known for working quickly among the antidepressants and for working when many other medicines have failed. Cymbalta has really improved the quality of my sleep and the quality of my life, actually. I'm a high-anxiety kind of person by nature and this drug has really allowed me to relax and enjoy my life a lot more. Definately give this drug a try, especially if you have depression with anxiety and the SSRI's like Prozac, Paxil, and Zoloft don't really adequately treat all of your symptoms. M 27 2 months
12/3/2009
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 2  depression/anxiety Constipation that has increased to very severe over the past 3 yrs. degestive problems, memory & problems with attention. Decreased libido I changed from paxil to cymbalta after having possible TIA or mild stoke (only a small spot showed on the Brain Scan in the right frontal lobe-Overnight I had temporary slurred speach and permanently lost part of my ability to remember). I wanted to see if changing to cymbalta helped my memory. Cymbalta is great for the depression and I felt less medicated than when I took Paxil and had a little more libido, but the memory loss problem continued and the prementioned side effects now make it necessary to try something else. Has anyone else had my constipation or other problems and if so, what have you successfully changed to? I get very depressed easily and very irratible when I skip a dose (60 mg). F 61 4 years
12/2/2009
 5  Fibromyalgia & depression I have not noticed any side effects that I can necessarily contribute to the Cymbalta. WOW!!! I was told about this medication by my beautician, who suffers from fibromyalgia & depression. She said she felt like a totally new person, and that I should at least give it a try. I have been suffering from fybromyalgia & depression for several years. I asked my Dr to prescribe it, I tried it...and she's absolutely right...it makes you feel like a human being again!! Please don't let the negative remarks left by others, keep you from at least trying this medication...I'm glad I tried it! I feel so much better! Please realize, nothing is a miracle drug...but you certainly can feel good enough to function in life again! F 58 2 months
12/1/2009
 3  Neuropathic pain/RSD 35 pound weight gain, Sweating, Insomnia, Sexual indifference, Dry mouth, Nausea, Agitation, It worked great for over a year allowing me much greater comfort in my thigh area in regards to the neuropathy, but the agitation reached such a level, and changed the way I felt inside, I couldn't stand myself anymore, and asked to be taken off of it. Withdrawal was pure hell. Was surprised at the level of CNS involvement, and what a vegetable I became. Also was a complete dragon for a day. Was in bed 3 days entirely due to this process. Would NEVER do this again! Luckily am working to take off weight gain, and have 13 more pounds to go, and feel much better 2 1/2 mos later! F 45 2 years
12/1/2009

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