CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Depression I have experience the following list of symptoms, thus am no longer taking Cymbalta. o Orthostatic hypotension o Fatigue o Vivid nightmares o Increased sweating o Decreased appetite o Blurred vision o Paresthesia o Disturbances of the gut, such as nausea, constipation, diarrhea, indigestion o Shakiness (tremors) o Anxiety, nervousness, agitation o Palpitations o Hot flashes o Taste disturbances o Difficulty passing urine o Cold hands or feet o Inflammation of the liver On January 9, 2009 my doctor prescribed Cymbalta for excessive depression that my other anti-depressent, Celexa, was not taking card of. The first 4 weeks I felt great. Sadly February the side effects were beginning to take hold. By May 7th they were at their worst. May 8th I saw my doctor who took me off Cymbalta that day and was placed back on Celexa which is helping just fine now. I feel no depression. 4 months
8/24/2009
 1  depression, anxiety, body aches. Huge fits of anger, mood swings, extreme fatigue, extreme depression, impossible to sleep, vertigo, stomach problems, unable to interact with people. THIS DRUG IS A NIGHTMARE AND SHOULD NOT BE ON THE MARKET! I am currently phasing cymbalta out. Getting off it alone has been hellish not to mention being on it for 6 months. The longer I was on it the worse I got. On many occasions I thought I was losing my mind, and have been unable to function. Ive missed months of work this year because of it. Im lucky I own my own business with my parents and was able to still get paid. I feel sorry for those who aren't so lucky, as I would be without a job and friends thanks to this. THIS DRUG CAN SERIOUSLY RUIN YOUR LIFE! What really gets me is that I was taking it for general depression and anxiety, not the end of the world stuff, I could function fine. It completely turned my life on end and nearly sunk me! I am considering contacting an attorney to see if there are any lawsuits going on this. If not I may start my own. Looking at the forum shows Im not the only one having serious trouble with it. My family and I are very worried about any long term harm it can do... M 39 6 months
8/24/2009
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 2  Depression I have been on it only 3 weeks so this may be too early but wanted to look up other's results. I have had only 2 full nights sleep since and once I wake cannot get back to sleep other than a nap shortly after waking. I did not get it for joint pain but it appears lessened. Crawly, tingling skin, short term within an hour of taking it. Sweats and change in body odour. Had Tinitus before but was very low and is louder now. *TREMENDOUS lack of energy which is getting slightly better with time. M 59 20 days
8/23/2009
 2  CFIDS/Fibromyalgia Chills, sweating without fever. Severe worsening fatigue than I experience with Chronic Fatigue Syndrome. Feel like I can barely move about. Zombie-like feeling with a crawly feeling on my skin. In just 3 doses I have had a huge reduction in pain BUT it is not worth the distress for me to take another pill. I was hoping for pain control and a boost in my energy as I have read that it can help with both. Since developing Chronic Fatigue it has been frustrating looking for something that can help me regain my level of functioning. Perhaps there is no magic bullet. F 60 3 days
8/22/2009
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 5  depression Trouble ejaculating, some weight loss. I really need a good eight to nine hours sleep a night on this medication, otherwise I hit a wall in the afternoon. I've been on it for two weeks now, so the full anti-depressive effects haven't kicked in yet. I'm pleased with the generally low side effects. M 43 13 days
8/19/2009
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 3  depression Lower sex drive to almost none. 58 yrs old wife and I used to have sex 1-2times/week.anger happens instantly and I act on it before I can stop myself. Dry mouth,yawning. Dont feel conected to the world, Prefer to not socialize. Has helped with depression. I want to get off it. I want to feel more like me and to desire my wife again. I know about tapering but would it be OK for me to be by myself so I wouldnt lash out to my family when the anger intensifies? M 58 5 months
8/19/2009
 2  depression/anxiety worst diarrhea of my entire life, dilated pupils, insomnia, restlessness, exhaustion, nausea, zombie-like i've only been on for two days, but i feel completely out of it. someone else described it as similar to coming down from drug trips, and they're right. this is the worst part of every drug trip. i'm so so so tired but i can't sleep F 24 2 days
8/18/2009
 4  Depression The primary "side effect" for me is a CONSTANT ringing (buzz) in the ears. In reviewing others comments, I seem to be the only one experiencing this side effect. Overall, I am very pleased with the effect it's had on my outlook and interaction with family and friends. My daily dosage is 60mg. M 56 3 months
8/13/2009
 3  Dysthymia/Fibromyalgia Headaches, severe sugar cravings, increased appetite, gained over 60 lbs. Nausea, light-headed and sweating more than I ever have in my LIFE. Fatigue worse than before going on it. While it has helped somewhat with my depression, I am starting to doubt that I will be able to continue on the medication. It has worked better for me than Zoloft did, but I feel so ill most of the time that my quality of life has gone down, though my depression has leveled out. My doc added Wellbutrin, 300 mg to see if that would help more. I do feel that my mood swings have also leveled out, but I just dont know that I can handle much more of the Cymbalta side effects. Started out on 30 mg, am now on 60 and doc wants to up it to 90. Dont think I will do that. F 38 6 months
8/13/2009
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 1  generalized anxiety Terrible nausea, Tremors, extreme dry mouth, felt like I have the flu alternating with chills, hot flashes, sore throat, blurred vision, ear ringing, tachycardia, inability to sleep past 3 am, Took two days but agree with the comment, I wonder if this is what chemotherapy is like. F 49 2 days
8/13/2009
 4  Depression/Anxiety Little bit of nausea. I've previously posted on the Paxil board because I started with that. The 1st 3 weeks of Paxil were HORRIFIC!! I have never felt so sick, with the exception of the worst flu I'd ever had. Then 2 weeks, I felt much better and then BAM, right back to those HORRIFIC side effects. This time, a specialist switched me to Cymbalta, and I really don't think I feel anything. Just... normal. That's what I'm supposed to feel, right? Not necessarily euphoric, but NORMAL. Perhaps because I suffered so with Paxil, that exempted me from any side effects this time. F 47 7 days
8/10/2009
 1  minor depression and arthritis Severe nausea and Severe muscle pain over entire body. Unable to walk or eat. Only with help was I able to use a porta potty. I became hot then cold , then hot again. Room was spinning and could not even get out of bed. Doctor wanted me to continue . I could not. M 89 2 days
8/10/2009
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 4  depression and pain sweating and dizzeness that does not last long It helped me to feel better andhelped my pain a lot F 78 1 days
8/9/2009
 4  anxiety/severe depression vertigo, sweating, vivid dreams(though at times quite entertaining) I wanted to add some comments that I forgot.....My weight has been the same during the entire time I have been on Cymbalta. I have had no sexual side effects. I feel that it IS still working for the joint pain and somewhat for the depression, however, not as well as it was and I'd rather not increase the dosage. Instead my doctor has added Prozac, 10mg. I can't offer any feedback on that yet, because today is the first day I have taken it. I have been on Prozac in the past, Lexapro---which worked great for a year then nothing, and coming off of it was horrible. I choose to stay on Cymbalta because of it's wonderful help with my joint pain. I honestly could not function as I do without it. I had no idea that it was used for fibromyalgia patients and the lack of pain was noticed before the help with the depression. I wish it didn't make me sweat more but it's a side effect I'll live with. To anyone that is trying it and experiencing some of the dizziness and nausea, I encourage you to stick it out...It DOES get better! F 44 1 years
8/9/2009
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 4  depression insomnia, dry mouth, teeth clenching/jaw ache Have been on cymbalta for about three weeks now and am lucky to have not had some of the more severe side effects others have experienced. The worst thing for me is the insomnia. I have no trouble falling asleep initially at night, but I wake up at 2 or 3 in the morning and CANNOT fall back asleep. Hoping this goes away. Also experiencing an ache in the left side of my jaw, and realized I've been clenching my teeth a lot, which I noticed a few other people have experienced as well. Not unbearable, more annoying than anything, but I'm not sure how to stop myself from clenching when I don't even realize I'm doing it. As far as the depression goes, it's definitely helped. I wouldn't describe myself as happy, but I'm definitely not in the black hole I felt like I was in a few weeks ago. F 29 21 days
8/9/2009
 5  suicidal thoughts and joint pain some sweating and difficulty urinating.. somewhat more tired relieved most of my suicidal thoughts and voices.. and my pain is 99% gone. its a fine medication M 57 25 days
8/5/2009
 4  Depression, GAD, BPD some blurred vision, stomach pain if I don't eat with it. increased perspiration. severe headaches when I miss a dose. I do like this medication. It seems to make me very even tempered most of the time. (except when I'm having a psychotic episode) I had very few noticiable side effects to begin with. I am happy with the performance of the drug for my depression, though when I am having large amounts of anxiety this medicine does not calm me. F 25 10 months
8/5/2009
 3  Manic Depression, Anxiety Constipation, Weight Gain, Severe Fatigue, Body Aches, Dry Mouth. Cymbalta worked quickly for my depression and anxiety. The consipation made me feel horrible, Im finally getting over that. I have gained 30 pounds, I am always hungry. About once a week I have severe Muscle aches, mainly in my back. Cymbalta will help with depression and anxiety....But the weight gain is causing even more sadness. F 17 4 months
8/1/2009
 5  Depression/Chronic Daily Headache Severe gastrointestinal bloating with painful gas - 1st week. Have been taking 30 mg for 12 days, will titrate to 40 on day 14. GOD willing, no increased dosages, because the gastro effects are hard on me. Gas-x/zantac/mylanta are as important - if not more - than lipstick. Was close to suicide with 24/7 headaches x 8 months when my neurologist prescribed Cymbalta for. After 8 mos of anti-depressants/pain meds/brain scans/mri's/lumbar punctures, and numerous money-grubbing MD's telling me that I was NUTS, I went on 5 weeks MEDICAL LEAVE from my Federal job!!! My NEW neuro (headache specialist) recommended the one drug that I feared worse than death - CYMBALTA. Within 3 days my mood brightened; within 2 wks the headaches have subsided. Many of the comments here fueled my fear of Cymbalta, so I did a LOT of praying before that first dose! F 44 12 days
7/31/2009
 4  Nerve Pain I was taking Lyrica after back surgery that brought on nerve pain and gained 40 lbs. I asked to be switched to Cymbalta. I have lost 10 lbs. but am very tired. Then at night I wake up 2-4 times. I have an appointment in 2 weeks and we will see. I take it at night maybe that is why I wake up so much. F 61 3 months
7/29/2009

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