CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  depression It works fine with depression but the withdrawl is horrible. If I go one day without it I feel completely out of it. Almost like an out of body experience or drunk( but not in a good way). I cry, get irratable easily and will sleep all day with the withdrawl. I go through bad withdrawl with any med but with cymbalta it is bad. Also very vivid dreams and sweating Good with depression but with me personally the withdrawl comes hard and fast! F 22 1 weeks
4/10/2008
 4  fibromyalgia chronic depression Very briefly a little nausea, headache. Now a lot of involuntary muscle twitching, ringing in my ears, tremor, blurred vision on occasion. Felt a little jumpy and edged-out, cranky. Cough and lose my voice toward the end of the day since I've been on it. It helped my depression a lot (I had been on Lexapro). For the jumpiness my psychopharm. added in a little bit of Lexapro. That helped,but the twitchiness is getting worse. Depression is still much better. I'm also on Wellbutrin, and I take GHB for fibromyalgia. With the cymbalta, all these side effects started. I can certainly live with all of them and the depression is so much better. But the withdrawal symptoms I've read about are unsettling and it makes me wonder what this drug really does to your body in the long term. If anyone has any info on this, I'd love to hear about it. Some drugs -- like this one -- are too new to be able to project that but SSRIs have been around long enough to get a sense of what has happened to people in the wake of taking them. F 48 4 months
4/9/2008
 3  depression Made me gain a quick 15 pounds. I work out daily and did not change my calorie intake. Switched to wellbutrin and have allread lost 8 pnds with out trying. It works well for some but not me M 31 6 months
4/8/2008
 3  Anxiety Heartburn this med is ok...I am in much better mood...Benefits outweight any side effects in my opinion. M 43 6 months
4/8/2008
 3  fibro possible weigh gain F 62 3 days
4/8/2008
 4   less libido but did not eliminate it completely (Viagra can offset) I have been on quite a few anti-depressants over the last ten years or so. Some made me emotionally flat-line but this one doesn't and I felt more relaxed. More side effects going OFF Cymbalta or even missing one dose, though not terrible for me personally unlikely others here described. For me just dreaming constantly and more significantly do feel quite dizzy/light-headed, but then any time I have tried to stop any other anti-depressant I have had same reactions. I have been off Cymbalta for a few days and other than one crying episode I don't feel bad emotionally, just dizzy/light-headed. Unfortunately cost is very high and was just laid off due to merger at my company so no insurance for now, but think I will have to go back on in the short term as dizzyness/light-headedness is too strong to quit cold turkey. Next time will try tapering dose off and see if that works better... M 36 2 years
4/2/2008
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 3  Anxiety and Depression Light Headedness, constipation, slight bloating, slight sexual decrease--but much less than SSRIs. I was taking 40 mg total (2 x 20mg) in the AM. I had come off of 100mg. of Zoloft. I found the cymbalta effective for my depression. I'm currently reducing dose to 20mg and then off Cymbalta as I've been on antidepressants for about 4 years and have lost insurance coverage, so the cost of a psychiatratist and paying out of pocket will only generate anxiety and depression --($240/month!) I would return to the medication immediately, if my health insurance status stabilizes or if I show marked symptomology. 20mg (lower dose) for titrating off is not effective for depression. Noting withdrawal syndrome, anxiety --, increased in the am and going away post dose by around 2pm. So 7am to 2pm is the killer time (5 hours of zaps and such). The manufacturer should consider dosages that are in 10mg and/or 5mg capsules. Titration 40 to 20 to ? is not possible in current forms. As most people are noting withdrawal symptoms that are equal to or worse than Zoloft, Paxil, Prozac etc, the "gett M 42 120 days
4/2/2008
 2  depression no side effects, in fact no weight gain which was wonderful. it only worked for 11 days then stopped. was only on 30 ml. and had feelings of deep depression while going off of med. what everyone has written about withdrawal is true. effexor xl is the same way. zoloft worked excellently but weight gain was very depressing....can't win! F 51 4 weeks
3/31/2008
 4  depression hesitation to urinate(2nd week),weight loss(5-8 lbs),late period,increase in sex drive. I like the way I feel as compared to other depression meds I've tried,and my husband can see a difference in me in only a month. a few of the side affects are a pain in the rear end, but others are great! F 31 6 weeks
3/29/2008
 5  ocd, anxiety, mild depression First three days nausea, mild trembling feeling, no appetite. After about five days all of these completely disappeared. I have been on every anti-anxiety drug available over the last 12 years and I NEVER stay on them because I usually always gain A LOT of weight within a couple of months, and two, I am unable to orgasm. I workout 4 - 5 times a week hard, watch my diet, and every other drug has always made me gain. Paxcil was the worst. Cymbalta has been literally a miracle drug for me. For the first two weeks I had to take xanax every now and then until the cymbalta built up in my system to fight the anxiety. I have been on it now for five weeks and feel great. My mood is better, the anxiety is gone. I have my appetite back, but have not gained any weight at all. For the first two weeks I could not orgasm, but that has also gone away. I could not be happier. I am on a drug that makes me feel great, my moods are evened out, no weight gain, and I can enjoy sex! Good luck to you all! F 36 6 weeks
3/28/2008
 1  Anxiety At first, I felt great, then I gradually started getting brain zaps, shooting pain in my legs, a headache that progressively got worse. I became suicidal, had major fatigue and generally felt like I had the flu. If I try to stop taking it, I am completely debilatated. The symptoms of taking Cymbalta are much worse than the anxiety that started me taking it. I am afraid I will never get off of it. Please research Cymbalta withdrawal symptoms before starting this drug. I would have never started taking it if I knew that my life would be so tragically affected. I haven't had a day of happiness or comfort since about a month after starting to take it. F 42 12 months
3/28/2008
 5  Peripheral Neuropathy Initial side effect were "racing thoughts," restless legs, vivid dreams (no nightmares) and frequent urination. All side effects completely resolved in 2 or 3 weeks! This med is the only med that relieves the pain & numbness of neuropathy for me. I've tried Trileptal, Elavil, Lyrica, Neurontin & a couple others which never helped me at all. It's a really expensive med (over $300.00 a month), but I purchase Cymbalta overseas for a lot less & write it off as a deduction on my taxes at the end of the year. I'm sorry to hear so many folks have such a problem with this med....it's been a Godsend to me! F 60 4 months
3/25/2008
 5  Intractible Depression Dry mouth Was finally prescribed this after many years of depression. In that time I had been prescribed: Seroxat, Efexor, Prosac, Prothiadin, and another whose's name I no longer recall. For me this had the lowest side effect profile of any medication I have ever had. I realize this will not be the same for everyone, but it has worked very effectivley for me for some years now. M 36 3 years
3/25/2008
 2  anxiety/depression Nauseated the first week, then went away.Cymbalta makes me very tired and listless,which in turn made me gain weight, which in turn made me feel more depressed...I can't concentrate well,foggy thoughts,poor memory,and don't want to socialize much.Not suicidal anymore, but I don't think Cymbalta had anything to do with that. That has always come and left on its own without meds.I have a subtle ringing in my ears. No real benefit from this med, So I am now weaning myself off. I've tried many kinds of anxiety/dep. med. and nothing works for me,every one so far has been just a "sleeping pill" and I dont want to sleep my life away. Not impressed with Cymbalta. I dont think I'll ever find something that makes me feel content and happy and help me stop worrying so much, without the sleepy zombie feeling... F 36 3 days
3/25/2008
 3   My eyebrows started to fall out after two months of being on this drug (60 mg daily)and hairline beginning to recede. Have been on various SSRI's. This drug has helped depression but the side effects of hair loss are not helping my mental well being. F 51 3 months
3/23/2008
 5  Depression Less appetite, but unfortunately that side effect subsided after about 1 year. I love this med! My depression is fairly mild overall, but it allows me to function while not becoming an emotional drone. Just wish it wasn't so expensive...can't wait for a generic to come out. F 35 2 years
3/21/2008
 5  depression I take cymbalta in combination with wellbutrin. I had insomnia only when I was taking cymbalta in the evening before bed. I later switched to mornings and then I no longer suffered from insomnia. After one year of cymbalta I started having regular severe constipation (5-8 days). I endured for most of a year and tried lots of things that didn't help on a consistent basis, only temporary relief. However, now my family doctor suggested I try a combination of stool softener AND fiber supplement together and this combination seems to work. Taken on their own was not helping. The only side effect that I haven't been able to change is the sexual side effect. Orgasms just don't happen. The desire is there but no physical arrousal. There doesn't seem to be any engorgement of my clitoris and it doesn't care to be touched. It's even smaller (less engorgement). These side effects were not so present at the beginning of taking cymbalta. It took about 8-12 months to really interfere. How After 5-6 months this medicine really helped my depression AND helped my other physical symptoms like muscle pain, fatigue, and muscle spasms/over-tightning to responses that I had suffered at different levels for many years. I had no idea at the time that this medicine has been known to help these kinds of symptoms. I told my doctor the big change I experienced in these symptoms and he said that it was probably because of cymbalta. For the first 5 months or so I took cymbalta at night. I had lots of new insomnia at that time. My doctor then had me change and to take the cymbalta and wellbutrin in the morning. After doing that for a 4 weeks, that is when all the positive effects started happening. When changing doses, do it very gradually and don't have alot of other stressful things going on. I know this from experience. I found it took a while to smooth things out (like a month or more) after altering. M 40 3 years
3/20/2008
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 3  depression, anxiety, pain I think it is making me extremely tired during the day. I am also on morphine, and klonopin at night. But I really didnt notice the extreme fatigue until I started cymbalta. I also had no idea that it would be so difficult to taper down when/if I have to ever. I have constipation but that is also cause from my morphine, my vision seems to have changed to more of a blurry vision, other that that I dont think I have any other side effects yet. I have been on 60mg for almost 1 month but have forgotten to take it several times and I didnt feel any improvement with my depression and especially sensitivity to little things, crying jags, and lack of energy. So my doc increased me to 90mg daily, but after reading some of the other comments I am a little scared to increase it. I am wondering if anyone has found the best time of the day to take it to avoid the daytime fatigue? I cannot stand it, I cant even drive when the fatigue sets in, I cant live that way. I am worried that this is not a safe medication. Not sure if I should continue or not. I am in the process of tapering down my morphine very slowly and also the klonopin slowly. I take the klon. at night and the morphine is a smaller does in a.m. and a larger in p.m. I am thinking maybe it is best to stay on the cymbalta to help me through the hell of withdrawal from morphine and klonopin, and work on tapering down from cymbalta last. My goal is to get off all this crap and try acupuncture, prayer, exercise, meditation, positive thinking, etc. I am sick and tired of medication, I have been on everything, just sick of it all. F 30 1 months
3/18/2008
 1  Anxiety 1st day-cramps/diarrhea/felt wired -hyper alert 2nd day after 2nd and final dose-paranoia,sore jaw and joints, fatigue, tingling head, enlarged pupils,nausea,unable to think clearly or concentrate I asked for a mild drug for anxiety that was preventing me from going to sleep. My doctor prescribed this. It is way too strong for me. It has been over 24 hrs since my 2nd and last dose and I still feel like I'm living in a dream. It's surreal. Probably shouldn't have driven to work even. F 34 2 days
3/18/2008
 1  depression It just stopped working for me. What I didn't expect, and wasn't warned about, were the suicidal feelings I experienced after stopping. I'd never felt suicidal before. Very Scary. Be very careful tapering off and watch for suicidality. F 46 18 days
3/18/2008

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