CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  depression, chronic pain initially, I was very tired for the first few weeks; no side effects after that It has really helped with my depression. I had tried St. John's Wort and Wellbutrin, but my doctors switched me to Cymbalta after a back injury. It doesn't really reduce the pain at all, but it helps make it easier to bear the pain. F 49 3 years
60mg 1X day
12/20/2010
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 3  Fibromylgia & Depression Twitching, Loss of ablilty to speak correctly, night sweats, severe nausea, loss of appetite, loss of sleep, increases fatigue, light headedness,random muscle spasims, inablilty to wake in the morning, headaches, loss of concentration... etc. etc. etc My FB pain and depression have been reduced but I'm not sure if the benefits outweight the side effects... The withdrawls are God awful. Cymbalta has also casued the loss of two pregnancies which added to the depression. F 29 2 months
60mg 1X day
12/20/2010
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 2  Depression Anxiety to the point of panic (had to start taking Ativan to counteract this effect). Bruxism, racing thoughts, loss of appetite (but no weight loss), excessive thirst. Use caution on Cymbalta, I was on 20mg, the lowest dose possible as I am med sensitive and starting having severe anxiety to the point I needed Ativan to stop my anxiety. When I stopped Cymbalta, my panic, anxiety and bruxism was gone within 3 days, though after only taking the medication for a month, I suffered some serious withdrawal symptoms. F 37 1 months
20 mg 1X day
12/10/2010
 1  Depression Massive weight gain, Diverticulosis, Breathing problems, No Libido, Extremely dry skin,Swollen thyroid, Swollen feet and hands, Rigid muscles, Very tired, Apathetic, Skin rashes & blisters, Bruises, Fingernails peeling, Abdominal pain. Every time I eat, I experience many food intolerances, nausea and my abdomen swells massively. Constant diarrhea. Extremely thirsty. Very dry eyes. There are many more side effects I experience. I have always been healthy, always naturally very slim, then I took Cymbalta. I am now 40 lbs heavier, I have been eating less food but very healthy food. I dont eat junk food. My weight is still increasing My body skin is loose,very thick, wrinkly, with masses of cellulite, I look about 80. My Doctor has done every test imaginable to find out what is wrong with me. The only possible conclusion, has been that, my major problem is Cymbalta. F 55 12 months
60mg 1X day
12/8/2010
 1  Fibro/depression I have told my Doctor for the full 2 years that I don't think this stuff works. I have none of the side effects other than feeling depressed. I have switched to Lyrica a few times which helps but packed on some weight. Not worth it. F 59 2 years
60 2X day
12/7/2010
 3  Anxiety; depression Mental haze, loss of words, mental bluntness. Absolutely helped but only take this medication when others has failed. It is hell to stop. F 36 5 years
60mg 1X day
12/5/2010
 4  Depression Dry Mouth, chronic forgetfulness, a mental 'haze', it feels like I am peeing every liquid out of my body. Overall, I really feel positive about this drug, at least for myself. It has been powerful at curing anxiety, depression and mental clutter. I feel as if my mind is constantly a cool calm pond. I do however feel a blunting of my emotional life and I wish that were not the case. I also take trazadone with the cymbalta, does anyone have experience with these two drugs together? if you do, please email me! I hope everyone is finding healing even if it is not through this particular drug. F 23 6 months
60 MG 1X day
12/3/2010
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 5  OCD, depression. dizziness, slight delayed eiaculation. Cymbalta is saving my life. it controls my OCD in a way that i do not think about. it is very useful in depression, attention and especially in GAD too. Give it a try. I take it with Zyprexa Zydis 2,5 mg in augmentation. M 24 1 months
120 mg 1X day
11/29/2010
 1  depression This drug made me a zombie. I couldn't think. Had to get off of it. F 51 1 months
30 mg 1X day
11/29/2010
 3  Fibromyalgia Lost 10 pounds, no other side effects The weight loss was great, however Cymbalta only slightly reduced my daily pain level F 19 3 weeks
30 MG 1X day
11/25/2010
 1  Depression/anxiety Severe hot flashes, blackouts, tremoring, increased heart rate, stomach pains, numbness, nausea, dizziness!! 7 hrs after taking my FIRST pill, I thought I was going to call 911. THIS DRUG IS AWFUL!! The horrible side effects lasted more than 24 hrs!! Lexapro never did this to me but after 3 yrs, it didn't seem to be effective anymore. I stopped it 6 mos ago, cold turkey! After weeks withdrawal symptoms, it seemed ok. But recently my depression was worse than ever. Dr prescribed cymbalta 30 mg once daily, without explaining about side effects! Stupid me. I shouldve read up on it before taking my first pill. What a mistake!! F 38 1 days
30 mg 1X day
11/25/2010
 1  depression and chronic pain Severe nausea, severe constipation, fatigue, apathy, yellow coat on tongue, dry mouth, hair loss, excessive sweating, suicidal ideation. Withdrawal caused hallucination, confusion, muscle spasms, agitation, severe asthma, esophageal spasms, chest pain. F 58 2 years
60 mg 1X day
11/22/2010
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 4  depression, paranoia nausea/ weight loss the first month After the first month, it is the the best thing that has ever happened to me. I feel like i did before the depression ever happened. F 25 18 months
1X day
11/17/2010
 1  Firbomyalgia I was a total zambee.(sp) Walking around with no emotion at all. Felt like I wanted to just lay down and stare at the walls. Wanted to cry, but didn't have it in me. Only one pill and I was out of it for 4 days. Not a good drug!!! Through all of the samples I received in the trash!! M 50 1 days
30mg 1X day
11/16/2010
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 3  Fibromyalgia Nausea, yawning, and sweating. The first two side effects went away after 2 weeks. Chronic pain from FM went away within 2 weeks. My doctor tapered me off from 90mg to 0mg within 2 weeks. The first day completely without Cymbalta was the day when hell opened up for me. I am a happy, laid-back and healthy person (besides FM), but I felt as if I was posessed by something evil and insane. It was the worst thing I ever experienced in my life. My doctor said I might get brain zaps, but what I experienced was waayy beyond that. A constant feeling of absolute horror and severe anxiety. Terrifying nightmares. If I would have known that, I would never have started taking Cymbalta. M 40 2 years
60+30mg 2X day
11/9/2010
 2  Anxiety and Depression Weight Gain, Severely Decreased Interest In Sex, Dry Mouth, Nightmares, Disturbing Dreams Leaving Me Unsure of Reality, Frequently Waking At Night, Always Tired, Sweaty, Commonly Abnormal Bowel Movements, Gas, Clenching Jaw It seems to help a bit, but is expensive. I've never had much luck with antidepressants, but this is definitely an improvement to my suicidal tendencies. I do still have mood swings, though not as often. The side effects all stink, and the things such as weight gain (I've gained at least 20 pounds!) and gas really effect my self esteem. I'm thinking about trying to switch mess again... This is not easy. Cymbalta has helped me the most, but the side effects are very significant. Plus the price is not fun for a poor, stressed out college student. F 19 1 years
1X day
11/9/2010
 3  nueropathy & depression severe bouts of short term memory loss, inability to think of words , near total loss of libido, bouts of sudden onset sweating, frequent urination the "have to go NOW! kind. recent dramatic weight gain, wired lethargy if that makes any sense, developed high blood pressure since starting cymbalta too.... plus more but that's enough, right? Cymbalta works amazingly well for my at times crippling nueropathy. It also helped greatly as I began to suffer from depression which I'm not inclined is Cymbalta induced (why would it work well in treating the same thing it caused?) I am prone to ever increasing instances of an inability to think of a word or name that in the past would have rolled off my tongue with ease (now I'm often resorting to ridiculous sounding multi word phrases in place of the word or name. I'm at this site now looking for something that might replace cymbalta before I morph totally into some pathetically forgetful, sweat drenched, morbidly obease cymbalta victim that even my wife can't love anymore! Oh and for anyone interested I am also on daily pain meds (methadone), also NSAID as needed, Provigil for years because I get so lethargic I tend to do nothing, BP med now, and the wonder cure my doc recently instructed me to try for HORRIBLE cramping (legs and feet mostly) MAGNESIUM and Calcium w/vit D suppliments. This worked immediately for not just myself but also my wife and motherlaw that also suffer from these ...try it if you have the problem! Now I don't dare forget taking it every day! Seems if I do I WILL have a major cramp episode ..did everyone but us know about this? I can't believe such a simple fix has not been common knowlege! I guess there are differnt causes for cramping so it probably does not work for squat for some ...but 3 for 3 sugggests there is a BIG percentage of suffere M 56 3.5 years
60 1X day
11/7/2010
 3  anxiety, migraine waking frequently during the night, trouble falling back to sleep, frequent urination This medication has really helped my anxiety but the insomnia is a problem. And if I don't get enough sleep that sets off a migraine. I am trying to stick with the medication but I may have to go off of it and try something different:/ I was put on this medication for migraines so helping the anxiety was just an added benefit. I am taking nortriptyline for migraines but am having a ton of bad side effects and it is making my heart beat really fast which is concerning my doctors. I was hoping this could replace the nortriptyline but this insomnia thing is not cool! F 22 30 days
2X day
11/5/2010
 3  depression So far, the same as most any other antidepressant. Though not nausea, vomiting, or sycopy Decreased libido, inability to orgasm, fatigue In the course of my recent depression I have taken a few different antidepressants. I came to this site to find tangible, objective side effects, and it saddened me that this page has become a conglomeration of people's personal opinions about meds. I endured many of the same side effects from many of the drugs in this category, but I would never say NEVER take this or that drug. People are all different, and working closely with your personal doctor is the best recommendation. If you don't feel your doctor is knowledgeable or listening to you, find a new doctor. I experienced potentially life threatening side effects from the recent use of Paxil, thus my change to cymbalta (nausea, vomiting, decreased appetite, syncopal episodes, drastically decreased BP, vomiting, and severe fatigue) and so far during the week of my wean from paxil and start on cymbalta I have felt MUCH better. As with ANY antidepressant, NEVER stop cold turkey, you WILL have terrible side effects. This is a given. Good luck to all, I know how terrible depression can be, and no one deserves to feel that way. F 26 1 weeks
1X day
11/2/2010
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 3  Fibromyalgia & depression Severe itch,jaw clenching, insomnia waking every 2 hrs, nausea,tinnitus, leg jerking, frequent nocturnal urination,flushing, cold chills, dry throat, runny nose. The good effects of this drug are that I now feel like "my old self" again and feel a lot happier and have energy. I was previously on Prothiaden which made me tired & more depressed but it did help with my pain and Cymbalta has not improved on that. My heart rate has also dropped, which is a good thing. I am undecided on this drug and wonder if the side effects are worth it. I personally know people who have had success with this drug for fibromyalgia - suppose it just depends on the individual person. F 54 7 weeks
60 mg 1X day
10/27/2010

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