CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  atypical depression Intense anger, manic episodes, paranoid and grandiose delusions, change in mannerisms. I experienced a real "activating" effect early on, which I enjoyed until others starting commenting on my change in demeanor. The change continued gradually and finally became extreme enough that others began to ask me whether I was abusing "uppers." All the while, I was feeling energetic and confident, and was unable to see my actions as erratic or strange. Now after having quit, I am amazed that I could not see how different I really was on Cymbalta. The memories I have from that time period seem like the memories of another person. M 4 months
12/11/2008
 4  anxiety/depression loss of appitite/different types of on and off insomnia deffinitly helps the depression and i highly recomend it, but don't miss a dose, you'll be sorry. F 16 10 months
12/9/2008
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 5   Horrible constipation, sleepnessness and stomach problems for the first 3 weeks. It was well worth it. I feel so much better 6 weeks in. I feel like i have a new attempt at happiness. M 36 6 weeks
12/8/2008
 2  severe depression none, that I have noticed, nothing out of the ordinary it works ok, good, maybe for some depression, for me it has been more temporary, as if my body became immune and the effects are weakening I have highs and lows but not as drastic as I was with out it. everyone has different chemistry... F 37 7 months
12/6/2008
 3  Depression, GAD, fibromyalgia vivid dreams, decreased sexual function, muscle and joint pain After taking Prozac for almost 3 years, I switched to Cymbalta 3 weeks ago. it was an easy transition. I stopped the prozac and immediately started on 30mg cymbalta for 1 week and now 60mg everyday. I noticed within a few days I was sleeping better, despite the vidid dreams. During the day, I feel more happy and excited. I still have muscle and joint pain and it may actually be worse since starting the cymbalta. The pain does slow me down, but I feel so good mentally that I don't think about it. Maybe after a while the pains will lessen. There are definitely frustrating sexual side effects (worse than prozac). After 3 years of prozac not working for my anxiety and depression, I'm pleased with cymbalta. M 28 3 weeks
12/4/2008
 1  Anxiety/Depression Nauseau, profuse sweating, dry mouth, can't sleep. The side effects are too much to take. I was on 60mg. per day butwhen I complained the doctor put me on 30mg. per day but I still feel awful. I throw up alot. F 37 2 months
12/4/2008
 1  depression-bi polar 2 blurry vision, then double vision, nausea, nightmares depression went away but it was not worth the severe vision problems & extreme nightmares. F 66 75 days
12/4/2008
 5  Depression Back Pain and Knee Pain When I started treatment for depression I remember being a bit tired for 2 or 3 weeks. It has since passed and I have had no other side effects. I love the impact this has had on my life! Being put on this medication for depression and having the pain reduction has changed my life. I am now able to do things that my pain was keeping me from doing. I am getting two products for the price of one. M 25 2 years
12/3/2008
 2  Myositis,depression My blood pressure has skyrocketed!! I thought the Cymbalta was causing the headaches and blurred vision...till I started checking my BP--170/100's!!As a nurse that does disease management I have heard of many side effects from pts...headaches,tremors,vivid dreams,decreased libido..Helps tremendously with muscle pain but the BP goes up to STROKE range..Beware! I am weaning myself off! When I first started on the med I felt wonderful..less pain..better mood..more energy. But then the side effects really showed up. I question whether MD's are aware os the actual side effects or just believe the drug reps! I'm headed to GNC for a more natural cure. F 45 2 months
11/28/2008
 1  severe depression suicidal migraines, stress headaches, confusion, no sex interest, slept up to 12+ hours, chronic fatigue ^, delayed processing of information, apathetic, flat, first thought of suicide 6:57 am Do not recommend to anyone. Remember, drug companies are first and foremost out to make big bucks; cannot explain scientifically how C. works, or any other antidepressant IS NOT KNOWN. MD.s heavily use Reps. to promote their "poison" pills and the shrinks listen to them, get their "education" from them. Good luck and be careful, my dear experimenter. I am off the "stuff." F 51 5 days
11/26/2008
 5  neuropathic pain Initially, I experienced anhedonia, but it passed with time. Excellent results, minimal and bearable side effects. Noticable difference in pain level by mid-afternoon if I forget the morning dose. F 55 2 years
11/25/2008
 2  depression/anxiety mainly weight gain 10 lbs and nausia...but i stopped taking 60mg dose (no doctor orders) because I thought I felt much better, then about 5 days later i had severe joint and muscle pain that lasted 48hrs...not going to touch the stuff again... it did help with my anxiety and hyperhidrosis (palms) but the severe withdrawal pains are not worth it...I will just have to carry a hanky to dry the hands... M 33 90 days
11/24/2008
 5  Depression None - maybe more tired Simply put all AD's work - If you have the patience to hang in there through the adjustment period you will improve and get better. I have been on this for two weeks and little things each day improve. The problem for me and most people is we quit to soon. You ahve to be on them quite awhile to get them to work! M 37 2 weeks
11/23/2008
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 2  depession and stress and jus sadnes The headaches were so bad after taking this drug for a month and a half, I stopped taking it before consulting with my doctor! Had no desire for sexual contact with my partner at all and I had to fake orgasm just so he would get off me!! I continued to have the VERY BAD headaches for about two weeks. If you have NEVER had a migrain headache (which I have)...please do not take this drug. YES, YOU WILL GAIN WEIGHT WITH THIS DRUG>>>> I work as a Personal Trainer and workout daily with my clients, however, in the month and a half I was taking this drug, I had no appitite, yet I gained 10.5 pounds!!!!??????????? F 35 2 months
11/22/2008
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 2  depression Extremely tired, low motivation and energy. NO LIBIDO, anxiety, s/s of OCD ie biting nails and lips, lightheadedness/dizzy, occasional nausea. I was on wellbutrin and prozac combo, but I had decided to take myself off as I was getting alot of severe headaches. I was not sure if meds were contributing to this. However, the depression and moodiness quickly returned and my psychiatrist decided to try Cymbalta. Started out on 30 which did nothing. Eventually increasing dose to 90. I have actually felt more tired during day and difficulty with sleeping. I have a tendency toward seasonal affect disorder and cymbalta has not done anything to improve this. In fact, I feel worse this year as compared to last year when I was on Welbutrin and Prozac. Further, I suffer from PMS and Prozac was highly effective for relieving those symptoms. I am now back on Wellbutrin to start and will see how it goes. 47 4 months
11/22/2008
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 1  depression, back pain, fibromyalgia agitation; hostility; suicidial thoughts; increased pain; increased depression; muscle spasams in legs and feet; dry eye; increased blood pressure; heart palpitations; increased anxiety, etc. Switched to Cymbalta because of claims that it helps with pain. Side effects were terrible. My prescribing MD assured that a second increase in dosage was needed. He believed the drug rep but not me. Finally, was able to see a board certified psychiatrist and switched to Lexapro. Huge improvement and almost instant end to leg spasams. The industry needs more honesty about Cymbalta side effects-it made my liffe a livng hell for 2 years. Wonder how much those drug reps make per year in bonuses. F 60 2 years
11/21/2008
 1  depression and anxiety I took 15 mg and fell asleep. Woke up 4 days later. Had constipation, racing heart, nausea which lasted 2 weeeks and all this from a single dose. Just had a liver function test and enzymes have doubled. Psychiatrist is a lovely man but believes the drug reps when they say there are no side effects. F 48 1 days
11/17/2008
 3  Depression Profuse sweating, dry mouth, constipation, migraines, weight gain of 40 lbs in 6 months, severe acne on face, and top back. This really helped with my depression and getting my life back but the side effects are becoming very bothersome as my weight and acne increase so...I will be asking the doctor to change my med. therapy. F 36 6 months
11/16/2008
 4  Depression, BiPolar Disorder Unbearable night sweats, then chills. Horrific nightmares so graphic I didn't want to fall asleep. My boyfriend suggested I try a holistic approach to my side effects. I figured "why not, it can't hurt?" I don't know what was worse, the sweats or nightmares. (changing the sheets every other night) He already had the stuff so I popped a couple of them and LOW AND BEHOLD the next morning, I had slept through the entire night no sweats or nightmares! I wanted to run outside and shout to anyone that would listen. "IT WORKED!" Go get you some GNC GABA 750. It's $16 for 90 capsules and take two before bed. I sure hope it works for you, I'm on cloud nine. Judy F 52 3 months
11/15/2008
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 3  longtermdepression/dysthymia,anxiet nausea & dizziness at first, then, headaches, night sweats, excessive sweating overall, constipation, no sex drive, inability to orgasm, weight gain, incredibly vivid dreams, ability to sleep for up to 12 hours or more without feeling rested, chronic fatigue I have been on the maximum approved dose of Wellbutrin for two years. About a year ago, my psychiatrist decided to add the Cymbalta. The first day I took it was a complete nightmare. I felt like I was drugged. I could not eat without throwing up, my head felt like it was detached from my body, and it felt like I had tunnel vision and what I could see was "floating". Those symptoms only lasted 1-2 days, but they come back if I ever miss a day and then take it again the next day. I am not sure if the Cymbalta has actually helped my depression or not, and my doctor is switching me to Abilify starting within the next several weeks. What I do know is that the side effects of Cymbalta have been awful, and I've finally decided I can't deal with them any more. I am currently still taking the maximum dose of Wellbutrin, plus 90 mg/day of the Cymbalta. Soon after starting the Cymbalta, I started noticing that I was getting headaches every day, around the same time. In f F 27 11 months
11/14/2008

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