CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Major depression In the very beginning I had headaches, they have subsided. Low libido. I started taking 30mg daily for a week and then increased to 60mg daily. I am also taking it with Wellbutrin XL 300mg (should eventually wean off of). So far things are good. No major problems at this point. F 44 1 months
4/30/2008
 1  Depression No relief from depression. Lethargic. Brain Fog. Weight gain. Withdrawal was awful Do your research before you start this drug. M 44 1.5 years
4/30/2008
 1  depression extreme fatigue / suicidal thoughts F 55
4/30/2008
 1  anxiety extreme weight gain, intense migraines, an aura around everything similar to begining migraine, muscle spasms. I am still not off of it everytime I try I get extreme dizziness, like being on a double loop rollercoaster all day, feeling like I just might pass out. Is is also very expensive. F 42 5 months
4/28/2008
 5  Anxiety and Depression For the first two weeks, I experienced light nausea and dizziness for 2-4 hours after I took my 30mg pill each morning. I also found myself getting sleepy about 4-6 hours after each pill, especially if I was sitting still (watching TV, at my desk, etc). Three weeks after taking Cymbalta those side effects went away but were replaced by an increased difficulty having an orgasm (can still have one about 75% of the time but it takes longer) and occasional frequent night wakings (but still getting 6-7 hours of sleep per night). Cymbalta has turned my life around. I suddenly developed panic/anxiety disorder after over 30 years of being symptom-free, and during my first month before Cymbalta I was a wreck. I no longer have anxiety attacks and therefore I'm off the daily Ativan doses I was taking. The first two weeks of side effects were annoying but definitely worth it. M 34 4 weeks
4/26/2008
 1  depression/anxiety nausea (within 30 min.) spacey, out of it, cannot even lay down to try to sleep. I literally took my first pill about 12 hours ago. within 20 minutes i was nauseas and thought i was going to thow up the whole time. that lasted about an hour or little more. then i just felt space and a little out of, thinking maybe i am just tired, i try to lay down and just feel like laying down, and now i'm here because I can't sleep. when i layed down my mind was racing way more than it ever has (and i already have trouble sleeping but this is weird) and after reading all the withdrawl symptoms, i never want to go through that. I've taken lexparo and it's given me no emotion so i stopped that and that was about almost a year ago. so i'm going to stick with the ativan that i've taken as need for about a year. F 24 1 days
4/26/2008
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 5  anxiety, migraines, depression happiness I loved it. I no longer had a negative outlook on life and actually looked forward to socializing with people (which used to make me slightly nervous).PLEASE REMEMBER THAT THIS SITE IS BIASED! READING REVIEWS HERE SHOULD NOT DISCOURAGE YOU FROM TAKING A DRUG, JUST PREPARE YOU FOR THE POSSIBLE SIDE EFFECTS! F 18 1 years
4/25/2008
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 3  Fybromyalgia I was prescribed Cymbalta by my neurologist for fybromyalgia. After about 45 days, I developed chronic diarrhea....after 3 weeks of this, I went to my GP, who referred me to a gastroenterologist. A colonoscopy revealed lymphocytic colitis, which after exhaustive research was found to be a 'rare/infrequent' side effect of Cymbalta. My neurologist is weaning me off the Cymbalta with the hope that the colitis will resolve itself. It's been 6 months since it began.....five of which were spent finding out what could be causing it. I'm really disappointed in the side effect....and rather 'bummed out' that I have to stop taking it, because it truly worked wonders on the pain aspect of the fybromyalgia. If you don't have side effects, it's a wonder drug. F 49 6 months
4/25/2008
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 4  Anixety and mild depression At first the side effects were AWFUL! Racing heart, stomach cramps, constipation, night sweats, I had it all. But after a couple of weeks things have leveled off and I feel great. All I can say is, stick with it, it will work if you give it a chance. I first satred taking it at night and it kept me awake. I now take it in the am, and I sleep like a baby. M 40 23 days
4/24/2008
 1  Depression Suicidal, zero energy, constant crying, spaced out. Fire and rescue literally had to come to my home and take me to the emergency room. I COULD NOT FUNCTION!!!!!!!!!!!! Terrible, terrible experience! F 49 3 months
4/23/2008
 3  Continued terrible working conditio Increased sweating 25+ pounds weight gain Fuzzy thinking Loss of interest in sex F 58 1.7 years
4/22/2008
 3  depression and anxiety Cymbalta works well with my Adderall - I don't notice as much when the Adderall runs off. However, due to my ADD, I tend to either forget to pick up my prescription or send it in on time before I run out of my Cymbalta so I have experienced the withdrawl symptoms. They are intense. The first day my brain gets foggy and I start to get more "emotional." The second day I started to get vertigo (intense dizziness, almost like I'm drunk) which gets worse and worse the more days I don't take it. I've only gone up to a week without taking it because I finally figured out why I was getting so dizzy..I didn't pick up my prescription haha. Stupid ADD. I've only been on it for a couple of months now at 30mg and didn't want to increase to 60mg as the doctor said I should do eventually. However, I feel like I need to increase in order to get better results because I feel like I'm not as in control with my emotions as I should be. F 20 4 months
4/21/2008
 2  Depression If I forget to take a dose, I expereince extreme dizziness, and nausea. My thought clarity and judgement are impaired. I am going to ask my Docitor to take me off of this med. I am concerned about the process of coming off and the possible long term effects. F 36 360 days
4/21/2008
 5  chronic depression Mood swings....maybe once a week on average. Since I've suffered from Chronic Depression for 18 years, I can deal with the mood swings by talking myself out of them....or riding them out by taking a nap or being alone. I know they are temporary. Combined with monthly cognitive behavioral therapy every 4-6 weeks (or as needed), regular exercise, healthy eating, and writing in my diary, Cymbalta has improved my mood and outlook and life! F 36 5 months
4/19/2008
 5  Severe depression Extremely gassy, drowsy, vivid/violent dreams, awake while asleep. I've been on Cymbalta for over six months now, besides being overly gassy, tired all the time, odd sleeping pattern, and vivid/violent dreams, I really don't have any side effects. On my first dose, I got sick to my stomach, but the sickness could have been from something I ate, since by day three, I felt much better. For the first few weeks, I'd have muscle spasms that would go away if I ate salt, these have since gone away. The most major complaint I have, is that on it's own, Cymbalta causes me to be awake when I'm asleep. However, with 25 mg of Tradozone, this is solved. I was diagnosed with depression at five years old, and have been on three other medications besides Cymbalta. It's really the only one that has worked for me. The first I was on (can't remember the name), gave me bad nightmares. Zoloft, didn't really work, but I also couldn't go past the initial starting dosage without going manic. The 10 mg of Prozac didn't do much for me, but when I was upped to 20, I went F 20 6 months
4/18/2008
 2  Major depression and Anxiety Dizzy, light headed, foggy brain, just stoned! Exausted too! This is the 5th day of my trial with Cymbalta. I feel literally stoned! Dizzy, light headed, foggy brain, just stoned! Exausted too! I cant go on like this another day. Yes, it did take the anxiety away, but it's making mashed potatoes out of my brain. I cant take it...I am not going to take anymore. I'm stopping slowly today. I will have to try something else. I'm 54 years old and I have responsibilities. I cant stay home being stoned and exausted over this medicine. F 54 5 days
4/18/2008
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 1  Pain and depression weight gain, lethargic, night sweats. THE WITHDRAWELS ARE TERRIBLE AND COULD RUIN YOUR LIFE!!!!!! I have been withdrawing off Cybalta for 3 weeks. I used prozac to get off it, which was better than weaning or cold turket for me. I have only allowed myself to drive the past couple of day. The brain zaps, aggitation are a little less each day and I didn't cry yesterday and so far today I am free of tears. I researched the withdrawal thing and several people wrote, "I am still on it because I can't get off of it" If I had children or worked outside of the home, I would still be on this stuff. When I asked my doctor about it and told him that when I was late for my dose that I got "Paxil Head" and he wanted to change my percription to another med in the same family and did not believe me , but humored me with prozac, which I only took one . The prozac leaves your body slower and helps make the first day a little more bearable. Please read these warnings, these side effect could very easily mistaken for depression and mental illness. F 53 3 years
4/18/2008
 2  Pain Management A Pain and Spine clinic suggested Cymbalta for pain management. They directed me to take 30mg at night, which was terrible: I had insomnia, panic attacks, feelings of rage, nausea, constipation, but was told to continue taking it, that the side effects would go away. They did not abate, but I was told to increase the med to 30mg, twice a day. No improvement. The nausea worsened, as did constipation, periods of unbelievable rage, feelings of dread, suicidal ideation and terror. Hand tremors, tinnitus, and the inability to concentrate also plagued me as well as feelings of road rage, bouts of crying, and total feelings of helplessness. I also began having unbelievable night sweats and nightmares. At 60mg, I couldn't wake myself up from my dreams. One night I thought that I shit myself. It was the most terrible nighttime experience I've had. After that, I quit listening to P&S, read the Physicians' Desk Reference, looked throught the internet, and DECREASED my dose back to 30mg a d Get informed about this medication. Don't believe everything that your doctor, nurse practioner, etc., says about this medication or tells you about this medication. Read everything that you can about Cymbalta. Know thyself and learn as much as you can. Keep a pain journal to record your reactions, and above all, remember that you know your body better than anyone else does. Hindsight is 20/20, and I'm ashamed that I didn't do more research into the side effects of Cymbalta. I never would have begun taking it. After finally getting a diagnosis, which I was told by P&S I would probably never get and that I would need to take medication for the rest of my life, I'm facing sugery on my hip for a torn labrum. Once surgery is over, I'll work on discontinuing Cymbalta and never look back! F 35 2 months
4/16/2008
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 1  Depression & Fibro Apathy, mean-spirited thinking, headaches, lack of focus, couldn't care less attitude, insomnia, constipation. Second time trying this. Not for me. I was so annoyed at my dog for PANTING in the middle of the night, I actually turned him out of the house. He could have been killed or lost. I came to my senses, got dressed, went out and found him but realized that this med was driving me to very bad decisions. I never, never intentionally put my dog in danger before, or will again. End of Cymbalta for me. Watch out on this drug. Might work for some, but beware for those it doesn't help. Gotta be something better out there. I am sick and tired of suffering to make money for the drug companies. F 55 7 days
4/15/2008
 5  depression Hard to say becasue I take quite a bit of medication. I had to quit taking my Cymbalta when I got pregnant and never experienced any of the withdrawl people talk about here. It has done wonders for me and within hours of having the baby I asked to be put back on it. Depending on your chemical imbalance, this may not be the drug for you. It is for me becasue none of the other worked quite as effectively. I am more than wiling to make that $50 co-pay each month for the peace of mind that I will not suffer a major relapse into depression F 31 3 years
4/14/2008

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