CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Depression & Anxiety On 30mg, none. On 60mg, mild constipation and delayed orgasm. The delayed orgasm was similar to Effexor, but without impotance. Effexor 150mg was effective but pooped out. I switched to Pristiq which was not effective so I stopped it. I then commenced 30mg Cymbalta for two weeks and then increased to 60mg for three weeks. Being an SNRI like Effexor, I was expecting it to be effective, but it's been underwhelming. Nortriptyline is next on the menu. Wish me luck. M 33 5 weeks
7/2/2009
 3  Depression/Anxiety Experienced dry mouth, excess mucous production, cough, numbness in my hands and arms, blurred vision, dizzyness, weight gain, slight elevation in blood pressure from my norm, constant diarrhea and totally NO libido. It helped with my depression and anxiety some, but for me this didn't offset the negative side effects. If I got into any stressful situation I felt more suicidal than I had before I began taking Cymbalta. From what I have been reading Cymbalta obviously helps a lot of people. But I seem to be reading many more negative comments about it than positive ones. M 58 9 days
7/1/2009
 5  nerve pain in feet For the first 3 days (and at 30 mg), nausea, fatigue, dizziness. Had much trouble sleeping. Felt worse with caffeine. All that is passing now. Upping to 60 mg soon. Already I feel markedly better. Haven't had to take a percocet in 4 days. I'm not pain-free, but the pain level is reduced to a tolerable level. Also feel calmer and more even-tempered. So far this is a "yes" for me. F 45 7 days
6/29/2009
 4  Anxiety/Panic Attacks So far the only real side effect is sometimes a I experience abdominal pains, like I ate to much. Upon a rare occasion, I have trouble sleeping. I have been treated for anxiety/panic attacks for 14 years now. From Paxil to Prozac, sleep aids and tranqs., but this medicine has provided the most relief. I liked the paxil CR, but for now I am going to continue to try this drug. No more attacks, mood swings, or anxiety, but from reading on here, I will keep an eye on things. Oh do not drink, the alcohol hits harder, trust me on this one. M 44 3 months
6/26/2009
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 2  Seizures / Anxiety / Migraines In March 2009 I woke up paralyzed on the left side of my body after going to bed with a migraine. I was first put on 30mg of Cymbalta back in November of 2008, upped to 60mg & now 120mg per day. Since then I have been having seizures, numbness on the left side of my entire body, I feel like I am shaking all over, I have daily panic attacks, all my joints are killing me, especially my hands. I cant sleep, although I feel as though I want to sleep constantly, I have bouts of diarrhea & constipation. I have constant dry mouth, SEVERE chapped lips & thirst. I cant think straight, & I have no emotions other than wanting to be left alone. I have pushed everyone out of my life. My doctor added Lamictal to the mix and now I am having more seizures than ever before and I cant stop throwing up. He seemed to think upping the Cymbalta would help but I don't know if I can take any more of this. I cant stop crying & I can barely stand to care for my children. They keep upping my dosage thinking it will help, but I think its going to be the death of me... M 37 8 months
6/26/2009
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 1  Generalized Anxiety Disorder Dizziness both the spinning kind and the getting up to quick/low blood pressure kind. Blurred Vision. Overwhelming tiredness. Periods of depression probably due to the tiredness. Loss of appetite. Mild Weight Loss. Dry Mouth. Feeling Hot. Sweating. My psych nurse switched me to Cymbalta from Lexapro about a month ago because I was a little tired on the Lexapro. The Cymbalta was horrible for me. The first side effects noticed were mild dizziness upon standing - the kind you get if you have low blood pressure and get up too quickly from a seated or lying down position. I thought I could stick it out because many times the side effects will disappear as your body adjusts to the new medication. That didn't happen. After about two and a half weeks on Cymbalta, the side effects began getting worse. The extreme "crashing" fatigue was awful. Then the spinning type of dizziness began. And when I began feeling depressed and hopeless, I said that's it. But, of course that was on a Saturday and I had to wait until Monday to get ahold of my nurse practitioner. Well, I was very close to going to the ER on Saturday night because of the depressed mood. Fortunately, I was able to "stick it out" until Monday when my psych. nurse practitioner took me off of it completely and switched me back to Lexapro. That was four days ago and I still feel horrid. The dizziness is bad - withdrawal? - worse than before and now I feel anxious and jittery. Ugh. Tomorrow I am going to pick up a prescription for a medication to help with the dizziness. Hopefully it will help. Luckily I have a "stand by" prescription of Xanax for the anxiety. F 41 24 days
6/26/2009
 2  depression chronic diarrhea as cipramil was no longer working after several years of use, I was perscribed cymbalta, which worked fine except after a month I began having chronic diarrhea - total water! and running to the loo every five minutes... quite awful! F 40 4 months
6/25/2009
 3  depression floating/numb feeling on skin and in movement, not wanting to be touched/have anything move against skin, confusion, nausea, uncomfortably dry mouth or thick saliva at back of throat, odd feeling in throat like a knot, loss of appetite, severe nighttime insomnia if med taken after 10am, confusion, trouble thinking and concentrating, excessive yawning, floating feeling increases just after yawning/sneezing, diarrhea (first day), constipation (no movements for 4 days thereafter), loss of libido Only 5 days into it, not having much fun so far. Started on 60mg. Would really recommend taking it right after waking up, as the sleeplessness is really weird. F 25 4 days
6/24/2009
 3  Fibromyalgia Increasing nausea, insomnia, blurred vision, headaches It has really helped with the fibro pain, but after a month I can't take the side effects anymore and am awaiting an answer as to how I get off this drug. F 55 1 months
6/23/2009
 2  depression insomnia, hard time falling asleep and staying asleep, also I seem to get dizzy really easily getting up from crouching down outside. Sometimes out of breath for no particular reason. I have been wondering if this is for me. If the side effects go away soon, it might be worth it. F 62 6 days
6/22/2009
 1  Nerve Pain Sleep Apnea, constant sweating, constant thirst, intense dreams, psychadelic feelings at night, emotionless person now. I am on 60mg of cymbalta which I am taking for nerve pain. This is my second rating now that I have been on this medicine a little longer. I am dropping my rating from a 3 to 1. If I am lucky I can keep my marriage. I wont go into all the problems since these can be found in my other entry. Just my latest problem which is sleep apnea. For those not in the know this is when you stop breathing at night. You never get into a deep REM sleep. You brain is starved of oxygen, you get no rest, and you go through life exhausted. This is a new problem for me and I suspect the cymbalta. I have never snored in my life and my wife of 13 years now is constantly awakened by me. After being hooked up to sensors I found out that I stop breathing up to 51 times per hour. I cannot make it through the day without napping... which does not go over well at work. I am trying to get off cymbalta now. I realize now I am an emotionless zombie and this has brought great strain on my marriage. My wife wishes to file for a seperation. :( M 40 11 months
6/22/2009
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 1  Mild depression Confussion, inactivated, nausia, dizziness, eventually increased depression, unfocused, not able to concentrate. Nasty withdrawal brain zaps going on and on! Headaches. Loss of appetite Dont ever think about taking this drug unless perhaps you are ready to kill yourself! In any case, try everything else first. This drug may ruin your ability to maintain your friends, familiy, and work. It is difficult to understand that this drug is legal. At first it seemed to work VERY well for me but eventually dragged me down into a much deeper depression from all the inactivating depression-like side effects. Very sneaky bastard! M 34 1 years
6/21/2009
 4  Depression/anxiety Chronic pain Only been on it 3 days at 30 mg before moving up to 60 mg tomorrow. So far a bit sweating at night, tired and yawning, a bit of stomach upset and some buzzing type feeling in my arms and legs that comes and goes. Too early to say much about Cymbalta either way. It really either seems to work really well for people or very poorly. I have bad depression anxiety and somatization disorder and have developed recent chronic pain in my mid chest & back with a tight chest feeling. So far all the detailed blood and diagnostic tests/scans have been negative as to a cause of the chronic mid chest and back pain pain, which included a body ct scan with dye, bone scan, ecg's, thoracic spine MRI, heart echo, nuclear stress test and gastrocopy, chest x ray and Ultrasound. I am really hoping this drug works for reducing my chronic pain and eventually elevates my mood because I am so down :( M 40
6/20/2009
 3  Depression, Anxiety My main side effect is cold chills and just feeling cold all the time unless I am outside in the 90 degree weather we are having. Feeling a little bit sleepier than usual. This is day 5. If the tiredness does not go away, I will have to stop it. I cannot afford to be tired with an 18 month old running around. I was on zoloft for 7 years with no side effects at all and it just completely stopped working. I have been in a depressive state for a year and a half now after having my last baby and have not been able to come out of it. It has gotten progressively worse. I got a 2 weeks supply from my DR and I am gonna take it the whole 2 weeks and see if there is improvement. I have found out over the years you have to at least give meds a 2 week trial. I thought about not taking it after day 2, day 3, day 4 but decided to finsih the 14 days. I sure hope it helps because I can't stand being in the state ive been in for the past year and a half. I have 4 kids to take care of and they keep me very busy. Good luck to everyone F 39 5 days
6/20/2009
 3  back/chest pain/depression/unmotiva Drymouth, Delayed Orgasm, Psycotic Rage. I didn't really have any side effects when I started taking it, but the rage started towards the end of the third month. I begane with 30mg for two weeks, then held at 60mg. The Doc wanted to up my dose to 90mg, but I felt good at 60mg. The rage started about the 11th week and I quit cold turkey once I started feeling detatched during the fits and felt as though I could only sit back and watch myself go off and had no controll. I had no side effects from quitting asside from the anger getting slightly worse for about two weeks. It's been about 10 months since I stopped taking it and I'm strongly considering taking it again because I just might need a higher dose. I've never been so happy and outgoing as I was on cymbalta. M 26 3 months
6/19/2009
 2  depression severe insomnia, loss of appetite, tingling in hands, decreased sex drive, suicidal thoughts I cannot sleep more than 4 hours a night, but I feel tired and really WANT to sleep. I am never hungry and my boyfriend has to remind me to eat every day. My right hand, particularly pinky and ring finger are tingling and numb like they are always asleep. I have no sex drive, and the worst of it has been the constant thoughts and desire to commit suicide. I just want to blow my brains out and it takes all I have not to do it. I've been on all the meds, but I've never had the suicidual thoughts with those like I have with this, I'm lucky to be alive! F 28 1 months
6/19/2009
 5  Bi-Polar / Depression Because I had previously been on Effexor and was simply switching TO... and now FROM .... Cymbalta, I had so few side effects they're not even worth mentioning. My dose of Cymbalta grew to 120 mg, stepped back to 30 mg. I HAD been on Effexor for 5 years, very successfully, but my dosage was already at 450 mg and I began reading about the withdrawl side effects of Effexor. I REQUESTED a medication change, so we ramped down slowly on the Effexor and afterwards, slowly up on the Cymbalta. It was a seamless transition. So WHY am I getting OFF Cymbalta? At 120 mg., I don't want to keep going up, up, up (due to my weight of only 123 pounds). After two years, I feel it simply has reached its peak of effectivness. I'm not getting the same "feel good" as I once did. I'm sleeping all the time again, I'm nasty to everyone, I don't want to go out of the house... the same things all over again. And it's funny, because it happened suddenly - almost like someone threw a switch or something! So, we're ramping down verrrry slowly on the Cymbalta, and so far the only thing I've experienced is a couple nights of "night sweats" and a few "brain flashes" (but they weren't HORRIBLE as some people say.) The key is to step down REALLY slow. It has taken TWO AND A HALF MONTHS to ramp down, and you DON'T start another medication while you're doing it. SLOOOOOWWWWLLLLLYYYYY. I've had absolutely no problem. Don't be afraid of Cymbalta. I think it's a great medication. It just stopped working for me after 2 years. F 47 2 years
6/18/2009
 2  anxiety and panic attack constant dry mouth, complete loss of appetite, weight loss, constipation, short-term memory loss, inabilty to REM sleep, complete loss of libido, feeling of wanting to sleep all the time, thinning of hair, lethargy, carpel tunnel -like pain in wrists and hands, odd pain or numbness in left thigh causing severe difficulty in walking, lack of interest or joy in former hobbies and activities, feeling of "eyestrain" in bright light or on computer I was prescribed cymbalta after having the first ever panic attack in my life at the age of 54. In hindsight I now realize that I was nearing the height of menopause and was hormonally imbalanced, not depressed. All of the side effects I have described have persisted and worsened over time. In the last three years I have had two major surgeries and a great deal of stress. Recently I decided to try to get off this stuff as my life has lost so much of its vitality on this drug. All I want to do is sleep and I never feel rested. I recently had my hormone levels tested, and surprisingly, my testosterone level is very high for a woman, yet I have absolutely no interest whatsoever in sex. Before cymbalta I was a bodybuilder and personal trainer for 20 years and always strong, sexually functional, and healthy. I never used any drugs at all other than "the pill" in my youth. I have been on 60 mg 2x per day of cymbalta and 2 mg per day of clonazepam for the past three years. I spoke to my psychiatrist and primary doctor about getting off this stuff, and neither was especially helpful. Just said cut back dosages over a month or two and then stop. Neither said anything about withdrawal or the misery to come. F 58 3 years
6/18/2009
 1  anxiety today is only day 1 and will probably be the last. i feel very sick to my stomach. i feel like i drank NyQuil and am forcing my self to stay awake. HUGE lack of concentration, dizzy, headache this is not fun at all!! i would rather deal with the panic attacks for a while longer then see if this gets any better. i sure hope i wouldn't get wore.. good luck all F 25 1 days
6/18/2009
 1  Fibromyalgia Confusion,impaired short-term memory,decreased sex drive,insomnia,night sweats,increased pain,severe headaches,irritable bowel,constipation,unable to focus,unable to multi-task,depression,weight gain,vertigo,stiff joints,etc... The public needs to be made aware that this drug is a poison. If you are not taking this drug, do not begin to take it. Please research discontinuation symptoms the drug manufacturer does not disclose, as well as the "common side effects" that the drug company so nonchalantly lists. BEWARE OF THIS DRUG!! F 48 4 years
6/18/2009

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