CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2744 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  fibromyalgia weight gain, brain zaps if I miss a dose Cymbalta has been tremendously helpful for fibromyalgia. I've been on 60 mg per day for about 2 years and still experience the benefits of the medicine. My only complaints are weight gain (20 pounds in 2 years) and how I feel if I miss even one dose. F 36 2 years
2/11/2009
 2  Minor chronic depression Extreme drowsiness. Dizziness. Some nausea I've been on a very lose dose of Prozac (5 mg/day) for many years. Wanted to change because of low libido. Tried Welbutrin and although I liked it I started having heart palpitations and would lose my temper pretty easily. Doc gave me some samples of Cymbalta to try. I took one 30 mg dose in the a.m. on way work because I had read that it could keep you awake at night. Whoa! I got so woozy and dizzy I left work at 10 a.m. and then laid on the couch the rest of the day alternately sleeping and staring at the TV. Couldn't even work on my laptop. Slept like a log last night and am still feeling somewhat disoriented today. Everyone is different in their reactions it's plain to see by this board. That one isn't for me though. The cure is much worse than the malady in this case. Going to try nothing for awhile and if I start getting crabby and depressed again I'll go back to my little bit of Prozac. F 54 1 times
2/11/2009
 1  PTSD FROM IRAQ WAR ***ZOMBIE, LACK OF MOTIVATION AND WORK ETHIC. NO LOVE FOR ANYTHING IN LIFE...WORSE OFF THEN BEFORE THE DRUG**** (((WITHDRAWL))) THIS IS BY FAR THE WORST DRUG TO COME OFF OF. WAY TO MANY SYMPTOMS TO LIST BUT THE BIGGEST ONE IS SUICIDAL THOUGHTS AND HURTING OTHER PEOPLE....DO NOT EVER, EVER , EVER TAKE THIS DRUG...THERE BETTER OPTIONS OUT THERE..DO YOUR RESEARCH M 29 3 years
2/11/2009
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 3  Fibromyalgia Reduced my daily pain pretty well. However I started having pain in my right side all the time. I could not tell when I needed to urinate except my side would ache more and thats how I knew. Lose of appetite (lost 7 pounds, yay!). Withdrawl is HORRIBLE!!! I've never had suicidal thoughts until I tried to wean myself off this drug. Headaches, vomiting, insomnia, bouts of crying for NO reason. I'm taking Zoloft now which is really helping to get me off Cymbalta. I've always been a happy person. My friends say its impossible to be sad around me. Not on this... F 26 6 months
2/10/2009
 3  anger, mood swings, fybromyalgia dry mouth, blurred vision,tired, constipated this is my 7th day, I started with 30mg, now on 60mg I don't feel angry anymore, actually feel calmer than I did before. I think I feel better with the pain. It just makes me feel different. Will write again in another week F 48 7 days
2/10/2009
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 2  chronic fatigue, fibromyalgia very tired, eyes feel heavy and burn, cannot fall asleep even though I feel tired. lack of sex drive. will try to stop taking this drug F 55 6 months
2/10/2009
 1  depression Extreme fatige,sweating,nightmares and that was just the beginning.The thoughts of suicide were overwhelming and it made me feel a horrible despair.Mood swings,extreme anger,leg pain just to name a few. I didnt take cymbalta for long because it was turning me into a worse basket case than I already was. One thing I did experience when trying to get off it was mood swings. Some of which were very angry outbursts,an anger I never felt before.Lost the love of my life because of it. Now taking 100 mg. of Zoloft and feeling so much better. I would not recommend cymbalta to anyone. F 46 2 months
2/9/2009
 3  Nerve Pain, Fatigue CTD Extreme weight loss, chronic fatigue, frequent night urination, no appetite, sleeplessness,nausea, headaches, constipation, difficulty swallowing, night sweats,wouth sores. Have taken Cymbalta about about 5 months,has helped with nerve pain associated with cdt, cant go to sleep or stay asleep problems with frequent urination 4-5 times a night, when I do go to sleep cant wake up, or could sleep for ever, feel exhasted no energy 24x7 , no appetite lost 10 lbs that I couldnt afford to lose. Its possible the weight lose is attrubuting to the fatigue but dont think so. M 52 5 months
2/8/2009
 1  anxiety/depression This is day 5 since I stopped the 30mg cymbalta and i must say..i feel TERRIBLE! feel like i have the flu..horrible headache, can't sleep..body is aching something terrible..but i will ride it out..i will NEVER take another pill!! F 31 1.5 years
2/6/2009
 5  depression/mood swings Initially dry mouth, extreme sleepiness, some nausea READ THIS!!! Guess I am the ideal patient. LOVE this drug. After 7 weeks side effects are GONE. My life has been transformed. No more crying jags, or self-involvement. Best part of this is my self-esteem problems disappeared. No longer hate myself and because of my attitude change I have stuck with my diet/exercise program and have lost almost 10 pounds. Life-changing. F 48 7 weeks
2/4/2009
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 3  fibromyalgia Weight gain, periods of anxiety, did I say weight gain? severe dry mouth, hot all of the time I have been taking 30mg. Cymbalta for 13 months. Dr. first gave me 60 mg. and I felt horrible. Flat, zombie-like. No sex drive. Reduced dosage did better. Sleep better, ache less but now have gained over 10 lbs. Never had weight problem before. It seems the benefits are decreasing and the side effects are increasing. Made a dr.'s appointment to check my options. F 55 13 months
2/4/2009
 3  Depression Loss of libido. Migraines and brain zaps. Inability to orgasm (exception-masturbation). Penile insensitivity. I switched to Cymbalta after I started feeling depressed again while on Zoloft (1 year). Cymbalta worked wonders for me for the first 10 months I took it. However, after around 11 months of use I started to experience brain zaps and migraines on a weekly basis, and especially if I delayed taking it (sleeping in had it's consequences). I didn't notice a loss in sexual sensitivity at first because I'd already been experiencing it on Zoloft. In the past 5 months I have gone from having trouble orgasming (unless it was masturbation) to not being able to orgasm unless I was masturbating. Now I'm having trouble even when I'm masturbating. This seems, in part, to be due to the fact that my penis is no longer very sensitive to stimulation. My libido in the past 2 months has dropped considerably as well. 18 is not the age to be losing it. I can atest to it's effectiveness as an anti-depressant. It still works as one for me, but the trade off in side-effects has become unbal M 18 1.5 years
2/4/2009
 2  anxiety dizziness, trouble with footing, blurred brain, jitters, shakes, feel like im coming down off of cocaine high and the down lasts way longer than the positive side to this med. also taking klonopin as a prn. not sure if they are messing with each other. also have a bad rash on my arm. appeared within one day. my anxiety goes away for hours and then returns with a vengeance F 35 2 days
2/4/2009
 1  Depression Zombie-fied This drug just made me feel wiped out, too weak and sleepy to keep my eyes. I wasn't as depressed but at what cost? I couldn't drive safely or perform at work. I took myself off it after about 4 weeks. I wasted a $35 co-pay on filling a prescription but it was the cost for a lesson learned. M 57 30 days
2/3/2009
 5  Anxiety Dry mouth, constipation, tiredness, dry eyes and also losing eyelashes......not sure if the eyelash loss is connected or not- but I've only noticed this happening since I've been on this medication (I lose several eyelashes daily) This drug has really helped me with my anxiety. I dont have the racing thoughts or that "racing feeling" in my chest that I constantly had. No more anxiety attacks YAY! My life has improved tremendously since I've been on this drug. I have not experienced any negative side affects.....all the side effects I have/am experiencing are tolerable. Though I am concerned about this eyelash loss.....I will be asking my DR about that! I dont want to end up with NO eyelashes! F 27 1.5 months
2/2/2009
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 1  Depression Numbness, tingling, brain "zaps", headaches, HUGE weight gain, tremors DO NOT let your doctor put you on a high dose....I was on 120 mg daily and I gained over 30 pounds in the 6 months I was on this. Numbness, tingling, and brain zaps if I missed a dose. Took myself off when my doctor suggested I go on a blood pressure med to reduce the tremors. This drug should be OFF THE MARKET F 29 6 months
2/2/2009
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 1  depression/anxiety insomnia, anxiety, racing heart, racing thoughts, headache, nausea, clouded thinking, heartburn I have been on this medication for about a year and it helped tremendously at first. Now I am having SEVERE anxiety, nausea and headaches. I am going to begin tapering off of this tonight now that I know to remove seven beads a day. Will let you know how it goes. F 31 1 years
1/31/2009
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 5  depression constipation, brain fog, slowed response, insomnia, weight loss Cymbalta has worked better for me than any other anti-depressant. Yeah, it has some crappy side effects, but you have to weigh the costs and benefits for yourself. I went off it for a few months and started feeling very, very depressed again. I started it back and had to take a higher dose than I had originally, but it is still working. F 33 2 years
1/30/2009
 4  Radicular pain Vivid trippy dream and thoughs when I begin to fall asleep and when I am waking up. During the day I do not notice. In low light I have noticed some very mild hallicinatory effects. I can't seem to lose weight. Sweating. Particularly night sweats. Very bad when I started as it was everynight. THis has diminished over time, but when I do sweat at night I get soaked. I feel a little more resistant to the cold weather as well. Sexual side effects are present. No issues with arousal, but it takes a while to orgasm. And sometimes when I do things don't happed in the order I am used to (we are all adults here!). Occasional dizziness. Nausea. If you are taking Cymbalta for depression, please review comments specific to that. It seems there is a big disparity on the ratings between taking it solely for depression or nerve pains. It is hard to ascertain the exact side effects when I started cymbalta. I had to abruptly stop taking lyrica and experienced severe gastrointestinal disturbance (kind way of putting it), huge emotion swings, weight loss. This lasted about 2 weeks and can't tell if it was the cold turkey from lyrica or starting cymbalta. The side effects with lyrica were more pronounced for me.. severe confusion, drowsiness, numb hands, extreme weight gain. There are side effects with cymbalta but they are more manageable. I think it beats having to take pain killers and muscle relaxers. M 39 6 months
1/30/2009
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 2  FIBROMYALGIA Weight gain, suicidial ideation, dry mouth, leg cramps. My rheumatologist ordered this drug for my fibromyalgia. I really didn't notice any difference in the amount of pain but did have an increased appetite. Terrible dry mouth and leg cramps at night. Decided on my own to get off the drug--not such a good idea because the first few days felt suicidal and dizzy, poor concentration and general tiredness. F 67 1 years
1/30/2009

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