CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  depression Been on lots of anti-depressant meds and cannot find one that does not have the sexual side effects! It is so frustrating! Plus on this I wake up at 1am every day after going to bed at 9pm and cannot go back to sleep. Plus I have the constipation side effect too. I am gonna stop taking it cuz the side effects are actually worse than being depressed! F 38 25 days
30 MG 1X day
4/15/2010
 5   I have always been constipated, so I do not associate that with Cymbalta. No side effects of any kind. My RA doctor suggested Cymbalta because of my pain with Osteoarthritis. I was also living through an extremely difficult time with serious personal issues. Not sure if I were depressed because I could function and quite well. I did however feel sad a lot and cried easily. I tried several anti depressents with my family doctor and my therapist, and all make me feel brain dead. But with Cymbalta I just felt level. No mood swings, just level. I would stay on it forever, but now that I am retired I can not afford it. Can anyone comment on "getting off" the pill? F 66 5 years
30 1X day
4/14/2010
 3  Depression/Thyroid/Fibromyalgia Anxiety; increased depression seeing grey skies (weird); paranoia; nightmares; itchy feet; disturbed menstrual cycle I've been on SSRIs in the past but, they've never helped. Started on 30mg Cymbalta for 2 weeks and then up to 60mg for the last 6 months. I feel a bit better in terms of handling my problems better and it has increased motivation (I didn't have any before). It's also been good for my Fibromyalgia (muscle pain). But, my menstrual cycle is lasting up to 2 weeks in which 7 days is a really heavy period!! Mentioned this to the Psychiatrist and she said it's nothing to do with the medicine. I've started to miss a dose to try and bring the medicine down gradually. So far I've been alright as I'm only missing one dose a week. I'll start to miss 2 doses a week and see what happens. I don't know what to do and am trying so hard to be 'normal' - whatever that means!! I wish there was more help out there. F 38 6 months
60mg 1X day
4/14/2010
 4  Social anxiety, small depression Fatigue (sleepy in the afternoon), decrease in appetite, delayed ejaculation Helps with social anxiety, doesn't really help depression. M 18 2 weeks
60 mg 1X day
4/13/2010
 3  Major Depression, Bipolar DO At most, have slept for 4 hours per night. I'm a walking Zombie. Also, I have NO appetite and am forcing myself to eat. I don't notice a taste change, but the food I DO eat is not enjoyable. No noted change in depression as of yet, but I don't anticipate marked improvement for approx 4 weeks. I have sufferred for years with my illness, tried multiple meds. Cymbalta is one of the last ones I have tried so I'm staying hopeful the side effects will wear off and my illness will be better managed. F 40 5 days
30 1X day
4/13/2010
 3  depression major constipation, weight gain, night sweats, excessive sweating (mostly face and head) I started on this and immediately noticed the constipation and sweating. My hair would be drenched by the time I got to work in the morning - even with the AC on in the car. Doc put me on something for that and it worked during the day but I wake up nightly with soaked clothes. I thought I could deal with it but after 4 months, I am feeling the exhaustion of not getting full nights' sleep. I like the overall way I feel - not too pumped up but not depressed, but the lack of sleep has led me to yet another failed medication. F 30 4 months
90 1X day
4/12/2010
 3  Anxiety and Depression tiredness and lethargy, stomach upsets, occasional strange taste with food. This drug helped with my anxiety and depression, but I very often had tummy troubles with were not very nice at all. I was sleeping a lot more than usual and slept during the day. For me it was better than Paxil which I was taking before but still not ideal. F 24 1 years
60 1X day
4/12/2010
 4  dysphoria, depression initial side effects lasted a week or so - bug eyed, dizzy, nausea - just like with any anti-Dep. The lasting ones: decrease in appetite, change in food cravings - from carbs to sugar - down 2 sizes :) this is a weird one...when i would find insects and spiders in the house, i would kill them. now i either leave them alone, or take them outside to a spot i think they would like - i said it was weird! when i forget to eat, i get the shakes - low blood sugar. my finger pads seem wrinkly - like a person forty years older than me. I have gone the fruit route - i will eat 4-5 apples/oranges/pears in one sitting, no diarrhea or constipation. Takes care of the sugar craving - i used to eat vegies lots and hardly any fruit, now it's reversed. Also eat less meat - kind of grosses me out now - but i crave pecans, almonds etc...Increased mood SUBSTANTIALLY - although still very reactive around menstruation. Sometimes feel JOY - dancing around the house, energetic, feel good about myself, most times just feel balanced, calm. Much improvement from the suicidal ideation, dysphoria, depression..bit borderline too, and obsessive negative self thoughts...it's the FIRST antiDep i've tried where there's a POSITIVE difference! From the sounds of the other posts, it doesn't have this effect on everyone. I would encourage you to speak to your doctor right away if some of those really bad side effects occur - this drug is so new, there's no long term studies on it, so we don't know how it reacts with different symptoms, different physiology. For me, i noticed within 2 days that the rumination was all but ceased. I've never noticed any previous AntiDep's effect until well over a month (prozac, effexor, celexa and wellbutrin combo)and none of them has actually made me feel GOOD about myself. 35 9 months
60mg 1X day
4/11/2010
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 2  Bipolar depression Loss of libido, difficulty orgasming, increased appetite, weight gain, extreme sleepiness, diminished energy I don't think this medicine has helped my depression at all so I am not taking it any more. I have also gained 40 pounds, which has probably helped make my depression worse (went from a 4/6 to a 14). I have no desire to do anything. Fortunately, my husband has been quite supportive. F 38 7 months
60mg 1X day
4/11/2010
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 2  Chronic Depression Urinary Retention. On a few occassions, I noticed that I Couldn't pass urine 'normally'. It took some effort.. Considering I don't have a prostate because I am female!, it was a cause for concern. My Psychiatrist took me off Cymbalta straight away and commenced my on Effexor. So far, so good! I was admitted to a Mental Health Clinic where the urinary retention became worse one night and I had to be taken by ambulance to a local hospital. They did a bladder scan and had to insert a catheter to drain off over 1000ml of urine. At 5 in the morning, I was discharged and had to walk back to the Clinic as I had no phone or money. It was about 2km, but I did it in my pyjamas which was fun... At least I was headed back to the Mental Health Clinic...hahaha F 42 6 weeks
1X day
4/11/2010
 1  depression shaking of body uncontrollably, nausea, headache, dizziness weknees , cannot walk, poor eyesight, can not think straight depression is worse. this is a horrific drug I strongly suggest NO ONE GETS ON IT. the withdrawal symptoms are magnified in what i just said. F 80 1 years
60mg 1X day
4/11/2010
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 4  Fibromyalgia Loved the side effect of no appetite; however, the constipation caused by this drug is almost debilitating. Dry mouth, some difficulty falling asleep - but once I get to sleep I can sleep 10 hours. After suffering two bowel obstructions in my life, I am obviously scared of another one, and the constipation caused by this drug makes me feel not only like I'm obstructing, but also like someone has punched me in the stomach. I also take Flexeril and Vitamin D in very high dosages. If I miss a day, I become quite anxious, so am fearful of what will happen when I eventually go off of this drug. My Doctor wants to double my dosage at the end of this month, but the colon problems I am already experiencing make me think twice about doing this. F 48 4 months
30 mg 1X day
4/9/2010
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 3  depression/panic anxiety/ptss/adhd It worked okay for a while. It never gave me energy but did make me gain weight. I was wondering if anyone has this same problem and what they did about it F 32 4 months
90 1X day
4/8/2010
 5  depression major weight gain and constipation Really has helped my depression and know that I am a much happier person taking it but I HATE the weight gain and constipation. Any suggestions? F 52 4 years
80 2X day
4/7/2010
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 5  major depression/anxiety The only major side effect i have encountered is low libido. Also if I forget to take cymbalta for a day or two I experience bad vertigo, nausea, light headedness, cant think straight kind of thing. The benefits really outweigh the side effects for me. F 24 2 years
60 mg 1X day
4/7/2010
 4  Depression expreme sleepiness, yawning, occassional (1x month) migrane, itchy skin, mild sexual side effects within 1st month only This is the first prescription I've taken for depression. I originally felt much better, but I feel like I'm fighting sleep all the time -- even after 8-10 hours of sleep a night. I may try to lessen the dose or consider going off of it because I'd like to have more energy. F 30 4 months
30 MG 1X day
4/7/2010
 2  PMDD, depression with luteal cycle. Dry mouth, nausea, decreased appetite, feeling stoned. My doc gave me some samples a couple of months ago and I didn't decide to take it until today. We think that I should be on 30mg, however the samples were 60mg and they have made me feel reaaaally strange. I'm hoping to talk to him about it tomorrow and switch me to a lower dose. F 27 1 days
60mg 1X day
4/7/2010
 2  Depression/Anxiety/Panic/Fibro Fatigue, Insomnia, Entire Body Pain, Nightmares, Waking Up Frequently, Zombie Type Mood, ZERO Libido, Inability to Orgasm, Painful Tingling in Feet For the first couple of weeks Cymbalta seemed to work. I felt in control, the panic attacks stopped, and my worry ceased. However my depression slowly crept back in. Cymbalta did manage to keep my Anxiety under control, and Panic attacks were Non-Existent but I was still sad. I didn't care about anything and I felt like an emotionless zombie. I wanted zero sex and that bothered me a lot. I thought more about the fact that I wasn't thinking about sex more often than I actually thought about sex. I was tired ALL the time, I did not want to get up or do anything and I gained almost 30 lbs within that few months. HORRIBLE withdrawal now. Brain zaps ceaselessly, I get dizzy whenever I walk, and my limbs become weak. I can't sleep more than a few hours before waking up and I'm having nightmares. I'm praying that my brain returns to normal and this stops. Every time I move too much and the dizziness and brain zaps become too much I want to break down and cry so bad. I just want it to stop. My libido is back though, and I don't feel like a complete zombie.. but that doesn't help me much since I'm suffering from the withdrawal like this. For SOME people it might be a godsend and I wouldn't turn your back on it based on ANY of these reviews (even mine) because if you need something to help you suffer less, then it's worth a try, just be prepared for the tough road to coming off of it. F 29 3 months
90 mg 1X day
4/6/2010
 1  for Bipolar Depression At first I thought it helped. I ended up gaining 20 pounds, had no interest in sex, tired all the time, body would ache all over, joints hurt daily, abnormal orgasms, became a recluse in my home, horrible anxiety. 10 days ago I decided I had enough. I stopped taking this and boy have I been sick. It feels like electrical impulses running through my brain, leg cramps, rapid thoughts, nauseous, can not sleep more than 3 hours a night, horrible nightmares, sweating, i hear sounds in my head like a radio, i am miserable. F 33 2 years
40MG 1X day
4/5/2010
Email
 5  depression, pain relief F 51 3 years
30 3X day
4/3/2010

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