CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  depression and diabetic nerve damag weakness to the point of just falling down numbness and tingling in arms and legs difficulty swallowing sleeplessness, nightmares when I do get an hour of sleep. exhausted, pain, wanting to give up on life unable to think, headaches restrict use and perhaps remove from market F 53 8 weeks
12/29/2008
 1  depression The depression got worse and became debilitating after starting the medication. Increased sadness, suicidal thoughts, insomnia, constant urinating during the night. I was taing 60mg for 6 weeks and abruptly stopped it. I figured stopping could not be any worse than what I was feeling on it. The withdraw symptoms were difficult. Crazy nightmares everytime i closed my eyes. F 39 6 weeks
12/28/2008
 1  depression and chronic pain brain zaps when a dose was forgotten. Vivid dreams, memory problems, no desire to do anything but sit & watch TV. Waaaayyyy to expensive This is a very expensive med. I am currently on day 5 after every other day of weaning off. OoffDuh, it's horrible. I feel like I'm going to fall over every time I move my head or my eyes. I have panic feelings and paranoia. Hope this ends soon. Hope I get my memory back and my sleep. Do not recommend F 39 7 months
12/28/2008
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 1  Depression and pain Constipation, brain zaps like what the heck just happened to me? Could not wake up from sleeping when I did get to sleep. If I did get to sleep it was a daydream type of sleep. Weight gain. Mood swings. If you have any enemies that you want to get revenge recommend this medication. I was only on this medication for about 2 months I had severe homicidal idealation. Spoke to my doc and she told me that it would go away. It didnt. I thought I was going to loose my mind. I told her I needed to stop the medication and she said ok just stop taking it. I learned later that this medication should not be stopped abruptly. I should have been weaned off. However while I was on the medication it did make me feel better for the first week after that it was down hill. I went through hell. F 42 2 months
12/26/2008
 5  Rheumatoid Arthritis and Fibromyalg I experienced many of the side effects others have written about here. I read the comments of others who had pressed thru the adjustment stage and found that my side effects subsided just as they said it would. Had I not been encouraged by others' comments to keep taking the drug I would have given up. I would highly encourage you to keep taking the medication and don't give up. I now have no side effects whatsoever and this drug has improved my pain dramatically. I think this drug is wonderful and it has helped with the pain of RA and fibromyalgia. After a few weeks, the dreams went away, the headaches went away, and the other side effects are a distant memory now. I've been on Cymbalta for over a year now and highly recommend it. F 53 18 months
12/24/2008
 4  chronic pain relief from pain F 32
12/24/2008
 5  depression Only increased sweating. No other side effects I really like this drug. I'm not big on drugs but needed something to help with depression. Other drugs did nothing for me. F 48 13 months
12/22/2008
 5  Anxiety due to Chronic Pain (RA) Have been taking this drug for about 4 years. I have had no side effects until recently-last 3 months. Can't sleep or sleep too much. Little bit of blurred vision. Otherwise drug helped me tremendously through those rough earlier years. I think everyone's body is different. It has a different chemistry for each drug we put into our body. I have to say that I started out with 60mg for the first 1yr and then dropped down to 30mg and this drug really helped me. I actually handled my pain better and life was more manageable for me. However, the last 3-6 months I have noticed sleep problems that I can't relate to anything else other than this drug. I feel I am ready to wean off this drug anyways as I am dealing well with my disease alot better, but am afraid of the side effects of withdrawls. I noticed before that if I missed a dose, my body recognized it by the dizziness or the brain zap, so I hope it goes well. My doctor says to try taking every other day to start with. I pray it works well! F 42 4 years
12/22/2008
 4  Chronic pain; depression I gained thirty pounds. Definitely made me sleepy while driving at first, but that dissipated after two months. Sex drive plummeted. Super sweaty (especially my back). I read the boards and tapered very, very slowly to get it out of my system. It took a few months to finally get back to normal. I loved Cymbalta. It helped somewhat with my pain -- Fibromyalgia and vulvar vestibulitis -- though pain definitely still existed. More important, it was the best antidepressant I've been on and I've tried Wellbutrin, Prozac, and Paxil. I was positively cheerful and unbothered while on it. No inappropriate anger. I was sorry to have to go off it. F 41 1 years
12/22/2008
 4  Depression No side effects other than the "zap" feeling after skipping a dose (60mg per day) and minor sweating at night. I did not have any of the flu-like symptoms when starting this med, no headaches, changes in behavior or weight changes. Overall, this medicine worked great for my depression. Effexor was horrible when it came to "zap" feeling after skipping a dose...far worse than Cymbalta. Everybody has a different chemical make-up when it comes to how drugs affect you. Lexapro works great for my husband and other family members, but only made me sleepy and cranky. Sertraline (zoloft generic) worked great for me, but after having my 2nd child didn't work as well as it once did. Cymbalta works well for me. F 33 2 months
12/21/2008
 2  depression I wrote back on 11/20. Everything was good then. Things have changed. I am quickly gaining weight now,I sit and accomplish nothing when I’m not at work. My head often feels fuzzy and my memory has not gotten better. I don’t want to be on this drug anymore. I am afraid of getting off so I am going to start taking my Prozac again and try to wean off Cymbalta. Prozac is the best thing to use to wean off with. My hair continues to fall out. There is no longer any benefit to it at all. F 57
12/20/2008
 1  Anxiety and Depression agitation, anger, anxiety, panic attacks/panic disorder This drug was great at first, but after the first year on 60mg it seemed to not have as great an effect. The last 6 months on the drug was when these side effects were experienced, eventually leading to the panic disorder (which I now know was caused by interdose withdrawal.) After a miserable experience with discontinuation syndrome, even with slow tapering, I would strongly encourage anyone considering this drug to do a lot of research first. I'm not one to post my opinion on the internet but since this drug is currently being agressively advertised, I was strongly moved to report my experience. F 33 1.5 years
12/20/2008
 1  Depression-Chronic Pain Horrible migraine, and worst physical pain of my life. Could barely move a muscle (all of which were ridgid) after just one dose of 30 mg. All because my doctor did not read the prescribing information! Do NOT take this drug if you are using Ultram/Tramadol, St. John's Wort, HTP-5 or ANY Serotonin altering drug or 'natural' suppliment. You will get a Serotonin Syndrome. This was first given to me while I was inpaitent, even though I was on a high dose of Tramdol AND also taking an OTC suppliment called HTP...Read about Serotonin Syndrome, it can be fatal. It is scary to think doctors do NOT always do their homework or really look at a paitents meds! (I am on 13 because I have an autoimmune disease). Cymbalta is bad news! Stay away if you can or at least research it very thoroughly before putting it in your mouth. F 44 1 days
12/20/2008
 1  Depression WEIGHT GAIN DESPITE REDUCED CALORIE INTAKE, frequent nausea, vivid dreams to the point that is difficult to wake from them, head rush that made me think I was having a stroke, disassociation, spaciness, horrible withdrawal symptoms--so NOT quit suddenly or on your own. Withdrawal similar to heroin withdrawal. THIS MEDICATION IS GOD AWFUL AND IT SHOULD BE BANNED. F 42 6 months
12/20/2008
 1  depression confused mental state,inability to organize thoughts,helpless frightening emotional state,seratonin syndrome like condition,terrible dreams side effects occured quickly after starting 30mg time release capsules, capsules very hard to taper off,I don't recommend it to anyone my mental state before Cymbalta was normal, a little depressed,never had these expierences with Zoloft. F 59 3 weeks
12/20/2008
 4  Bipolar Type 2 Lower sex drive. Tiredness. While cymbalta is not the best anti-depressant I have taken, it is the best in terms of benefits outweighing side effects. I wish it was better at relieving physical symptoms, but the emotional relief is amazing. F 21 2 years
12/19/2008
 2  Chronic Pain, Depression Increased Sweating and then some!! Fluctuating Levels of Antiexy - Confusion. Mood swings, Irritability. Severe constipation. Virtually lost it when increasing the daily dose from 30 to 60mg daily - stayed there for 1 week then dropped back. Still on 30mg/daily. I swear that I am worse off then before taking this. Extremely stressed over everything, quite hyper but little or no real focus ;-( Makes the job quite difficult. F 50 60 days
12/18/2008
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 1  depression,anxiety,ocd profuse sweating, suicidal thoughts when withdrawing. took for 2 years.helped with depression. had to wean off due to profuse abnormal sweating. weaned off and 4 months later had serious relapse causing suicidal tendencies which required hospitalization. definitely caused by stopping usage of cymbalta M 2 years
12/15/2008
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 2  depression / anxiety yawning, fatigue, itchy mouth, harder to breathe, tingling sensation in limbs, sexual weirdness (not in a good way) I think perhaps I was having a allergic reaction. If anything, it made my mood worse. Definitely not for me. M 37 1 months
12/14/2008
 1  depression/anxiety Increased sweating, numbness from my tongue to my extremities, can't sleep, swollen all over, and if you look up hypothyroidism you will find everything I am going through since I have been on this horrible. It helps with the constant thoughts of worry playing over and over but it's not worth it when you wake up and you have missed some days and you are having zaps so bad if feel like your head is going to explode. I take it and I get so swollen all over and the weight gain within 6 months is amazing. I wish we could get a petition to this company who said take this drug and you will feel wonderful. They should provide everyone who is having a tough time to get off this medicine with something to help you get off from it especially with the extreme side effects that effect your day to day life. I hate it. If your doctor says to get on it please look up hypothyroidism and if you still want to take it then you have been warned. Believe me this is my second time trying to get off from it. The first time I thought I was having a heart attack so I took one and my Klonipin and within 4 hours my symptoms went away. F 39 3 years
12/14/2008

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