CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Depression Shaky hands depression worse, sexual side effects M 50 1 years
3/7/2007
 5  panic disorder, depression sudden sweats particularly between my legs? (kinda gross but tolerable, 1-2/day), occasional hot flashes (~15 minutes each, 1-2/day), no change in sex drive, slightly delayed orgasms, amazingly powerful orgasms, increased thirst, occasional middle insomnia, ocassional muscle twitches (particularly at night), amazingly vivid dreams, and bizarreness warning--> I occasionally ejaculate (4-5 times) while having a bowel movement (without orgasm, freaky!) This drug cured my depression and eliminated the panic attacks I was suffering with. Certainly an interesting set of side effects, I don't mind at all, I feel and act so much better, my wife is much happier. I am scheduled to stay on cymbalta for 26 weeks than taper off (slowly). Warning: one day I missed a dose and the evil symptoms returned within 12-16 hours, this was early in the treatment cycle but indicates that some people will have trouble coming off this quickly. Good luck to all. M 44 12 weeks
3/6/2007
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 1  Muscle Pain, bruising nausea, stomach pain, loss of appetite, restlessness, overactive reflexes, hallucinations, loss of coordination, fainting, nausea, vomiting, diarrhea, fast heartbeat, dizziness, headache, insomnia, anxiety so bad you can't stand it, panic, nervous, increased sweating, violent tremors My doctor prescribed Cymbalta for me against my better judgment, Oh my god! This is poison, poison, poison!! The first hour the sweating and disorientation began, next came the panic, anxiety, nausea, IBS. At first I thought it's ok I'm just adjusting to it. Two hours later I am on the phone shaking violently, trying to form a thought so I can call my doctor and my poor husband. So here is the picture. I am laying over a trash can in the kitchen throwing up uncontrollably, can't focus, cannot form a solid thought, trying to chant my abc’s since it's the only thing I can grasp. Shaking so violently the trash can is bouncing off the floor with my tremors. Constant panic and anxiety overwhelming me, wired out of my mind. I can barely open my jaw to throw up it keeps clenching so tightly. I lost all feeling and control of my bladder for an undetermined amount of time. Now, it is 2 days later. I finally slept for a few hours last night. I still have the anxiety/panic in my chest and m F 40 1 days
3/5/2007
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 5  Diabetic Neuropathy & Depression Difficult to orgasm, sleepiness Cymbalta started relieving the pain almost immediately, I am much more functional and need less opiods for 'breakthrough' pain. I've been on Cymbalt for 4 weeks now and it has been my 'cure'. I got my life back! M 37 4 weeks
3/3/2007
 5  GAD, Panic Disorder Diarrhea, Upset Stomach (occasionally) After being prescribed this medication (that I had only heard about briefly on commercials though paid little to no attention to) I went ahead and researched it extensively. I went to reputable medical websites, message boards and just plain googled the med. At first, I was dead set against taking it as a majority of the reviews on the message boards were extremely negative. People were talking about terrible side effects that were often developing within hours of taking their first dose. I was appalled that such a medication would even be prescribed. Then I found this website, which seemed to include the good and the bad. I read hundreds of posts from those who swore by the med to those who felt it was the root of all evil. I had made up my mind that I was not going to try Cymbalta- no way! I thought I'd rather suffer through all my anxiety and panic attacks, than deal with the crazy side effects that people were going through. But then, my dad said something- he said that a F 27 1.5 weeks
3/1/2007
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 1  Fibromyalgia, depression Acute diarrhea, nausea, blurred vision, restless energy. I'd taken this drug for 5 days total (20mgs), suffered through adverse reactions for 4 days, then stopped. Withdrawal difficulty very real even after 4 days: shakes, disorientation, nausea, blurred vision. Couldn't wean off the drug since I was already at lowest dosage. But, I had felt some reduction of fibro pain and a week later, with some sense of desperation, decided to try it again. This is my 1st day back, and it will be my last. Acute diarrhea again. After reading this web site, I'm certain that effort is NOT WORTH THE RISK! F 53 5 days
3/1/2007
 3  Depression and Anxiety Nighttime sweats some sleepiness during day I have taken many antidepressents over the years (prozac, paxil, wellbutrin, lexapro). Am currently on 60mg cmbalta (up from 30mg first two weeks) and am weening off 40 mg prozac). No major effects yet. Am hoping this will address my ongoing depression and anxiety (since October). M 39 14 days
2/28/2007
 5  CHRONIC PMS, ANXIETY AND DEPRESSION MODERATE LOSS OF APPETITE. INITIAL INABILITY TO ORGASM, BUT THAT HAS PASSED. CYMBALTA IS THE BEST MEDICATION FOR DEPRESSION THAT I HAVE TRIED - AND I HAVE BEEN ON THEM ALL. I AM NOW ON 60 MGS OF CYMBALTA AND 300 MGS OF WELLBUTRIN - FOR 3 MONTHS. I HAVE CHRONIC PMS - WHICH HAS GREATLY IMPROVED. AROUND THANKSGIVING, I WAS CRYING CONSTANTLY AND VERY DOWN. I AM A NEW PERSON ON CYMBALTA - BETTER THAN GOOD. THE COMBINATION WITH WELLBUTRIN IS A WINNER! PLEASE TRY IT. F 38 3 months
2/27/2007
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 4  Depression, Fibromyalgia The major side effect that I am having is flatulence (increased gas) and stomach cramping especially at night after I take the medication. I have also noticed some decreased libido. However, this is not a bad side effect for me since I had an overly high libido prior to taking Cymbalta. I have also noticed a decrease in my appetite. I am hoping that will pass. The first day after I took Cymbalta I thought I thought my lung has collapsed. I have severe chest and stomach pains that took me to the ER. Where they found nothing wrong with me. I have only been on the med for about 14 days now and my dosage is currently 30 mg. I will be increasing my dose to 60 mg in the next few days. The major side effect I am having from the Cymbalta is flatulence (gas) and some stomach cramping. I have tried several different techniques to solve this problem which include taking the medication with food, taking tums before and after taking the medication and taking a stool softner before bed. I take the med at night and don't seem to have the flatulence during the day until later in the evening. If anyone knows of a solution to this problem I would love some advice. I am hoping the effects subside within the next few weeks. I have had to stop taking other medications due to the gas. Not only do I have depression and fibromyalgia but I also have Cysti F 31 14 days
2/27/2007
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 3  Depression and Anxiety Have been on it 12 days, along with 60 mg prozac (4+ years on that). Have not seen major improvements yet. Am wondering how long it takes to "kick in"? Am on 30 mg - wondering if I should be on 60 mg? 12 days
2/27/2007
 5  anxiety/panic disorder, ocd sleepy afternoons (long naps almost everyday), trouble sleeping at night (not often), some breaking out (face, back & chest but getting better on face), vivid dreams w/night sweats (1-2wk), sexual side effects: orgasm takes a long time, IF at all (not w/intercourse). I've been taking cymbalta since June 2006. I'm currently on 60mg. I can handle all the side effects w/the exception of the sexual ones. Can anyone recommend ANYTHING, but NOT a prescription?! F 25 8 months
2/25/2007
 3  Fibromyalgia, Arthritis,Depression Vivid dreams, and remember them in such great detail ! Increased sex drive, reduced appetite,neck pain. I haven't been taking this drug too long and I am stopping because of the dryness it causes in my eyes (swollen) and my scalp (scratching). I can't read or focus my eyes because of the dryness and burning, my eyelids are swollen and, although it has helped somewhat with fibro pain, it's not worth it. Also, affects sleep patterns, I'm exhausted earlier, but can't sleep well. I've been on Zoloft for years, and we tried Cymbalta because my doctor felt I had gotten too used to Zoloft and it wasn't helping as much. When I first tried Cymbalta, I stopped after a week or two because I was so angry, I was biting off everyone's head. Stopped and started again and now experienced this dryness. I won't try it again. F 66 4 months
2/23/2007
 2  General Anxiety Disorder Very delayed or inability to orgasm. However, no erection problems. Some loss of sexual desire. Dull headache all day long. Maybe some teeth grinding and sleep interference. I want to get off of these brain altering drugs and control my general anxiety by exercise, will and therapy but my wife insists I stay on it to keep our marriage intact. I'll be talking to my doctor shortly about options. M 49 5 weeks
2/22/2007
 4  depression 1 or 2 days a week I am really weepy where I feel like I need a good cry w/o anything particular occurring each week. Some marital probs may contribute. Palpitations if I have a drink or two. Previously taken Zoloft for 10+ yrs & Wellbutrin for 5. Now Cymbalta w/Wellbutrin seem to have helped my outlook & stability. F 50 1 months
2/21/2007
 4  chronic pain and mild depression I wake up in a cold sweat. Soaked. 60 mg. at night. No more negative thoughts. Happy Days instead of sad days. Better relationships with my friends and family F 78
2/19/2007
 4  anxiety/depression weight loss (good thing), nightmares, sweating. I have a new symptom and that is when I start to fall asleep I go into an instance panic attack or something. I feel I stand lay still and my stomach is crawling. Has anyone else had that problem? F 62 6 months
2/19/2007
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 1  depression nausea, vomiting, deadness to legs, hands and feet, over sensitized to touch legs. I am sorry to say that being on the drug feels normal it's when you are discontinuing use, it's HE**. F 33 1 years
2/17/2007
 5  depression A little nausea at first but took with dinner and was perfect. Take this with food and it is nearly perfect. No sexual side effects. My depression is gone and I feel wonderful!!! I have tried others in the past and had gained weight..no libido, etc. CYMBALTA IS A LIFESAVER!!!!! F 40 4 months
2/16/2007
 4  bipolar vivid dreaming, makes me feel awake...not tired (weird, huh?) was on lexapro for 2 yrs and gained 30 lbs. someone told me the cymbalta doesnt cause weight gain. so far after three weeks, i have LOST 3 pounds.........i switched right over from the lexapro. feel great. no real bad side effects. makes me feel like i have more energy. M 44 18 days
2/16/2007
 4  Major Depression / OCD Slight drymouth, but drinking more water during the day at work. Seems to be going away. The first week I found myself yawning constantly. Honestly I started feeling better about 5-7 days after I started taking it. The level of anxiety has been reduced. Little things that have bothered me before do not seem bother me any longer. My mood is better. As each day passes, I feel like I am continuing to get better. My short term memory is suffering a little, but I think it is because of occasional clonazepam that I will take in evenings. My sleep has been more even through the night. My erections are harder for some reason, but the orgasms are harder to reach. Urinating is somewhat of a chore, but I think it is worth the feeling better in my head. I seem to wake early every morning, even if I take a sleeping aid of some sort. Dreams are a very vivid. I think the drug is worth it so far. I can't wait for results down the road. M 34 3 weeks
2/14/2007

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