CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  DepressionOCD Headaches. Cymbalta stopped working for me after I had taken 60mg for approximately 5 months. I am withdrawing cold turkey from the drug at this point, and the withdrawl symptoms are awful. Brain zaps, diahreah, headaches, dizziness and numbness are common still, 8 days after going off the drug. F 26 5 months
11/14/2005
 2  depression, possible fibro I changed from effexor, which solved my depression and anxiety, because I started sleeping all of the time after being on it for about 10 months. Cymbalta did not solve my sleepiness and just added many uncomfortable side effects. I have intense sweating, sleep disturbances, feeling spacey and dizzy, sleeping 2-3 hours during the day because of "brain fuzz". Getting off of Cymbalta has been very difficult. I have been tapering from 60 mg. per day, to 40, and now to 20. I feel dizzy whether I take it or not. I read that taking benadryl or clariton helps with the withdrawal - and it really does. F 44 8 months
11/14/2005
 1  Depression At 90mg, increased depression, impotence, exhaustion. At 30mg, no effect. Waste of time and money. Manufacturer's claims are false. MD's who prescribe this medication don't know what they're doing. M 54 3 years
11/10/2005
 5  Nurrapathy/depression Dry Mouth, trouble sleeping, first days were drowsy I have to say this med is a godsent. I wake each day ready to take it on with a happy feel. I nejoy my coffee again. Before I wanted to hide under the cover all day. My moods are cheery, I enjoy people and the results only took about 2-3 weeks. Plus, nuralgia is improved however the nereve damage is there and I can hardly manuver without a cane support system. This is the best med I have taken and sends a message of hope to one who felt helpless. I live near the beach and instead of cursing it, I tend to enjoy it now. Odd how a med can make one feel real again M 45 3 weeks
11/5/2005
 4  major depression/anxiety headaches (which have gone away), bruxism (teeth grinding/jaw clenching), loss of appitite, weight loss, heartburn started taking 30mg about 3 weeks ago after being on wellbutrin for close to a year. wellbutrin was great at first, but i noticed a decline in it effectiveness even with an increase in doseage. in addition, i gained more than 25 lbs while on it. since taking cymbalta, i actually feel normal again, despite the few side effects, which are going away. some days i have heartburn (which i've never had before!), dry mouth, diarhea or constipation on a daily basis, gas, and had terrible headaches the first 2 weeks. the side effect that has been by far the worse has been grinding my teeth at night and clenching my jaw during the day. i did not have this problem prior to taking this. in my third week now, the headaches are gone or at least more manageable when i have them, my teeth grinding/jaw clenching is getting better, i actually HAVE energy to do things again (!!), i'm not as irritable, don't get angry or panic over the 'small stuff', and best yet, i am losing the weight i gained on wellbu F 35 3 weeks
11/4/2005
 3  
11/4/2005
 1  PTSD, insomnia While on the drug: 25lb weight gain, insomnia, sleep myoclonus, akathisia, RLS, anxiety, mania (inability to concentrate, racing thoughts), painful muscle spasms (paricularly in piriformis, causing severe sciatica), paresthesia, constant diarrhea, pounding heart. After slowly taping off drug over 6 weeks - SEVERE DRUG WITHDRAWAL. Intermittent but severe "brain shivers", vivid horrific nightmares, severe muscle spasms and cramps (some causing excrutiating sciatica), worse akathisia, worse paresthesia, hypermania. Was switched to Cymbalta from Zoloft which had same side effects but worse. All the manic side effects had to be countered with an anti-anxiety medication (Xanax). While taking Cymbalta, Ambien no longer worked for insomnia, had to be switched to Seroquel which helped insomnia but then I was a zombie 24/7. Have found out that I may have permanent brain damage from taking Cymbalta (inability to make any serotonin). Would reserve this drug for only my worst enemies. M 53 9 months
11/1/2005
 5  depression,could't make decisions in the beginning headaches may have been worse but they went away. I do have hot flashes but I had them before the drug that I attributedto menopausal symptoms, the only bothersome one is 2weight gain and increased appetite. I've never felt better. I have very little explosive mood swings and pms behaviors,I can function as a productive human being even while i'm on my period and the week before. I was sleeping for a week during pms, since cymbalta I have a life even though I am disgusted with my body and I exercise reguarly F 49 8 months
10/27/2005
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 4  Depression/Interstitial Cystitis I'm having headaches almost every day and some nausea (not sure if it's from the CYmbalta or the Elmiron). My head feels a little funny once in a while. Sometimes my legs and arms feel funny, not tingly, but hard to get them moving sometimes is the only way to describe it. Someone mentioned weird surges like sticking your finger in a light socket, that's what Lexapro did for me, I was so scared to shut my eyes for days until I figured out that's what it was from. However Cymbalta doesn't do that to me. F 24 1 months
10/25/2005
 5  bipolar none just yet, took first dose this evening. however, slight pressurized feeling in the head can't rate this drug just yet so stay tuned. took my first dose this evening. slight pressure in head tonight is all i feel. i'm hoping this will help with my depression and fibro issues. i took lexapro 2years ago and stopped because of the side effects and crappy health insurance. i'm glad i ran across this sight as i've become aware of what i may experience. i've suffered insomnia for years due to my depression so i did get a script for ambien which has helped greatly in the past except by nature i'm a vivid dreamer and ambien hinders that a bit but for more rest i can't complain. so i'm hoping the insomnia due to this drug will be combatted with the ambien. i will keep zantac close by and the advil for headaches. i'm so tired of laying around not living my life. i've considered suicide when the rainbow is NEVER enough. i have a son and i don't want to leave him here alone on this planet but suicidal thoughts are hoovering hence the visit to the doc for some relief. for the first F 35 1 days
10/21/2005
 4  Generalized Anxiety Disorder Hair loss At first, Cymbalta was a dream. I got motivated to get in shape, was getting more done, and felt better than I had in my life. Last week, however, I noticed my hairline receding and general thinness in my hair. I am going to see an internalist, but I do not have much family history of hair loss (and none at my young age at all). Also, I've plateaued with the medicine and even the increased motivation and good moods have dropped off noticeably. Also, I was sleeping better than I ever had, and I'm starting to regain my insomnia. It seems like my body has adjusted and its lost its effectiveness while causing me to lose my hair. M 24 3 months
10/20/2005
 4  bipolar and borderline personality the first SE i noticed was substential sleep difficulty, then weight gain and recently an alarming hair loss, although this may also be due to Dekapote which i also take. i've been on Cymbalta for 10 weeks now, and am very very pleased with it's anti-depressant effect; this, after failure of almost all existing anti-depressants and ECT treatment to grant relief from severe depression and very poor functioning. F 53 10 weeks
10/18/2005
 1  Bipolar/Fibromyalgia/anxiety Extreme fatigue, weight gain, complete loss of interest in sex and inability to achieve orgasm Initially I was taking 20 mg in the morning (eventually increased to 60 mg) for pain and bipolar disorder and 150 mg of Topomax in the evening to promote weight loss (which did not work) and the bpd as well. I was so tired from the Cymbalta I could not even function. I switched to taking it in the evening, then couldn't sleep (go figure!). I found that taking the pill with a small amount of caffinated soda allowed me to sleep for about 4-5 hours a night. I've gained almost 25lbs which has added to my depression. However, the pain is almost completely gone. I'm not sure how I feel about stopping the med after reading horror stories of withdrawal and for fear of the pain returning, but the weight gain is ruining my life. I'm so depressed that I've considered suicide. I have an appt with a new Psych so hopefully he will be able to find something comparable w/o these terrible side effects. F 35 8 months
10/17/2005
 5  depression/bi-polar disorder After 2 days on 30mg Cymbalta once each morning, made me rather drowsy the first day, then had a pretty bad headache the 2nd day on it but I took two ibuprofen which knocked that out quickly. Seems to provide a VERY noticeable energy boost, even on this 2nd day...almost a "speedy" feeling but not overly jittery or shaky...quite tolerable when I consider that before starting Cymbalta, I had absolutely NO energy and felt no motivation whatsoever to move from the couch. I am told the headaches should subside within a week but I'm keeping my Ibuprofen close at hand for the time being to counteract that. All in all, pretty good so far. As I've said, this is only my 2nd day on 30 mg per day of Cymbalta and I feel immeasurably better already, though it remains to be seen how I will fare on it as the days go by. I'll post again after being on it awhile longer. F 42 2 days
10/14/2005
 2  depression Serious weight gain (30 lbs in less than a year) and horrible withdrawal (if I missed a day or two, I would start getting flu-like symtoms) F 28 11 months
10/14/2005
 5  anxiety and depression ACCELERATED weight gain, initial night sweats, initial sleepiness After trying all others, this drug has given me a sense of calm and feeling of contentedness that I never knew others lived with. Unfortunately, I also experienced drastic wieght gain of 25 lbs. within 6 months and it is still going. I am naturally very thin and this part is driving me crazy!! The dr. says losing all that nervous energy has slowed my metabolism(?). He has given me a prescription for Topomax to counter effects. I would hate to stop the cymbalta but have gone up 3 pant sizes!! F 43 8 months
10/11/2005
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 4  mild depression, anxiety, pain some brief spells of nausea, restless legs and vivid dreaming at first and when upping dose, low sex drive increased energy apathy Love it/hate it! Definately reduces fibro pain. energizing at first then decreases. I'm more patient, less negative, calmer but my give a darn is broken and I can't even imagine why folks would want to have sex. Makes me a bit withdrawn. F 37 10 months
10/10/2005
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 1  Depression Severe constipation, lack of appetite, bloating, difficulty concentrating, felt very spacey This drug caused terrible side effects for me. I had severe constipation and though I lacked my appetite, I actually gained some weight on the drug. I also felt like a space cadet the entire time I was taking the drug. I could not concentrate at all. I really felt pretty doped up. F 26 2 months
10/7/2005
 1  Depression Severe constipation, lack of appetite, bloating, difficulty concentrating, felt very spacey This drug caused terrible side effects for me. I had severe constipation and though I lacked my appetite, I actually gained some weight on the drug. I also felt like a space cadet the entire time I was taking the drug. I could not concentrate at all. I really felt pretty doped up. F 26 2 months
10/7/2005
 5  depression Weight gain is the only side effect I've experienced. I'm thin so the extra weight hasn't been as issue for me. I am so happy I finally decided to follow my doctor's recommendation to take Cymbalta. I've never felt better physically or mentally in my life. F 52 2 months
10/4/2005

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