CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Depression/anxiety Initially: extreme drowsiness, decreased sex drive, extreme yawning, increased appetite, very light sleep, and abnormal dreams. Currently: Dry mouth, increased appetite, night sweats, gas, abnormal dreams, confusion/difficulty waking from sleep, and occasional stoned/numb feeling. After missing a dose: all symptoms increase severely, and I also get extreme nausea and headaches. Around the time of starting Cymbalta I also made many other changes in my life to try to overcome my depression and anxiety such as healthy appetite, decreased stress, consistently taken vitamins (Omega3, multi-vitamins ex.) and I began taking amino acids for anxiety so I am still to this day unsure of how much the Cymbalta actually helped me. But the combination of all these changes helped me immensely to get rid of my depression and decrease my anxiety. I only side effect that has really been effecting my life is the strange vivid dreams, because I will often wake in the morning completely confused thinking that the dream was real or thinking that my dream life was my real life or I will have difficulty waking because the dream is so fascinating that I forget I'm sleeping and think its an awesome movie. I have had dreams that go on for over 6 hours in which I can remember every little detail which really creeps me out. Other than that the side effects are nothing I can't deal with. F 18 2 months
90mg 1X day
3/31/2010
 5  GAD, panic attack None compared to the SE of anxiety I had my first experience with anxiety and a full blown panic attack in Jan. of this year. Ringing in my ears, couldn't breath, muscles tense,nausea, feeling hopeless, helpless, guilty and hadn't slept all night in weeks. I lost 12 pounds from the anxiety. Tried Welbutrin, and Lexapro and no relief, some worse. Was irritable and had tremors.I have been on Cymbalta for 11 days and today is the first day I did not need my Ativan.I am smiling and optimistic. Some nausea but I had that before. I will report back in a few weeks. F 52 10 days
1X day
3/29/2010
 1  depression Worked great at first. Now I feel naseous, get bad headaches, anxiety is worse, I'm meaner, irritable, feel like I have pms all the time. I have horrible gas and have at least 3-5 bms a day. Makes me more hungry. Don't take it. F 31 4 months
60 mg 1X day
3/28/2010
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 2  Fibromyalgia Took 20mg at 8:30pm. Went to bed at 10:30 and woke up at 3pm with stomache ache. At 8:30am got out of bed but did not feel rested and pain about the same. I will skip a day of Cymbalta and take Sunday nt before bed. My directions on side of bottle say may take with food to lessen stomach upset. Also state to take cap whole do not chew or crush Also two weeks ago tried Nortriptylin 10mg. Took it at night for a week and sleep was ok. Very good for pain but made me very tired next day and all day until 6 or 7pm. F 45 1 days
20 1X day
3/27/2010
 2  Depression/anxiety Brain shocks in the beginning with insomnia. Loss of appetite, and more thirsty than usual. Decrease in Libido. I went on Cymbalta for my Depression/Fibromyalgia. I also have Chronic Fatigue Syndrome so my Dr. was hoping it would lift my depression and help me to regulate my sleep cycle and get up earlier in the morning. Ever since I have been on it, I have not had one good night sleep. I wake up about every two hours and am very restless throughout the night. I have also had night sweats on a few occasions. There were times where it made me feel even more anxious than I already was. The one thing I did notice is it controlled my ruminating which was a bit of a relief. However, I felt no better in regards to my depression. Now I have to go through the hell of withdrawl for another two weeks. I would not recommend this medication for anyone who has a sensitive system like me. Unfortunately, I did not find much benefit!!! F 43 2 weeks
20 MG 1X day
3/27/2010
 3  depression spaced out feeling, emotionally numb, jaw clenching, nausea, indigestion, muscle pain, weight gain, weird scary dreams, inability to concentrate, shakiness, EXTREME yawning, restlessness, severe mood swings, paranoia, anxiety-not wanting to leave the house i am very glad that i found this site. i thought i was starting to go crazy when it came to the side effects from this med. i sometimes wonder if the side effects out weigh the benefits. i have been on cymbalta for close to 5 years. they have futzed around with my dosage several times. considering looking into alternatives to this med. it is frustrating trying to find a meds combo that works and does not give me so many side effects that i can't function in daily life. F 36 5 years
30mg 3X day
3/26/2010
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 1  fibromyalgia Caused muscle damage to my leg. The withdrawal was horrific! I had atrial fib, intense itching with blistering, diarrhea, mood swings, with a suicide attempt, vertigo, brain zaps, headache, dizziness,joint pain,the list goes on. The drug should be taken off the market. This lasted for over four months and put my family and myself through torture! F 63 2 years
120 mg 1X day
3/25/2010
 3  depresion weight gain,itchy skin bad,doesnt work for my anxity deppresion is gone i can go threw the day without crying at stupid stuff like movies ect. F 35 6 months
60 1X day
3/24/2010
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 5  depression been great for depression. I know that I cannot quit "cold turkey" as withdrawals are severe. It is a trade off that I am satisfied with. 3 years. No longer on an emotional rollercoaster. When I wake up sad, I don't spiral into a full blown depression. If I get depressed now, it is a legitimate reason.ie. death of a friend or loved one. I will continue on Cymbalta. No sexual side effects! F 53 3 years
60 1X day
3/22/2010
 1  Fibromyalgia, back pain, depression I thought I had come down with the flu... felt hot and sweaty like I had a fever, bad headache, no energy, irritable, frequent bms, pain like IBS. Also, such deep sleep that urinated while dreaming. It got worse and I just assumed I was sick with a virus for 4 days. No interest in people, felt like I had PMS. Then I realized it all began when I started the new medicine. I stopped two days ago and feel fine. I'd been on Lexapro, low dose, for years but still had back pain and some fibromyalgia so hoped Celexa would be better. But I felt terrible on it and will go back to the Lexapro and get more regular exercise, stretching, and try cumin capsules for anti-inflammatory effect as recommended by my physical therapist. F 64 6 days
30 1X day
3/20/2010
 5  Migraines Nausea, heartburn, dizziness, "feeling as though a switch has been turned off in my head and has stopped my headaches", slight drowsiness during the day and jittery at night with insomnia Since starting Cymbalta 7 days ago I have had only 1 severe migraine due to a virus and it lasted only a few hours otherwise I have felt great. I was having 28-30 migraines a month, rebound in nature. My nurse practioner also ordered a muscle relaxant to help me rest at night and it made me jittery instead of helping me sleep. She has also taken me off of all my other migraine meds. I am hoping I can achieve a happy medium here tonight and get some much needed sleep. I feel great during the day. I eat something in the morning before taking my capsule and that avoids the nausea I first had with Cymbalta. Can someone explain the "brain zap" I keep reading about? I hope others have the success I feel I am having because right now I feel great! F 52
30 MG 1X day
3/19/2010
Patient History
 4  Depression and Anxiety Some nausea, loose stools, feeling like I had the stomach flu, skin very itchy Feel like it is working for my anxiety and depression. I am bumping up to 60mg starting tomorrow. F 34 7 days
30 1X day
3/18/2010
 4  depression/anxiety/pain downside:brief nausea,constipation upside:less pain, more energy, less appetite, lifted mood, brighter outlook, laughing, vivid dreams, singing, writing poetry again! will closely monitor; keeping a journal..... so far it's the best drug i've taken.... F 48 3 weeks
30 1X day
3/17/2010
 1  depression symptoms increased anxiety/panic attacks which I never had before, sleepy all the time, still. Inability to concentrate at work due to anxiety or tiredness. Had to start taking .5 mg Xanax at least twice a day for the feeling of heart racing/anxiety. Started on low dose and increased dosage about every 2 weeks until I got to 120 mg. Increased dose would only help a few days and then I would go back to same symptoms and just have a good day every once in a while. Did not like taking Xanax, but "had" to take it for the feeling of heart racing. Fincally came to my senses that Cymbalta is not working and only made things worse. Back to square 1 with my doctor to slowly switch to Wellbutrin. Wish me luck. I am so sick of not feeling myself. I miss me! F 43 2 months
120 1X day
3/17/2010
 5  depression and fibromyalgia pain I have not experienced any major side effects. It has decreased my appetite some and that is a good thing. This medicine has been a life saver to me. I was in really bad shape a week ago and it has already started to help me in just a week's time. I am so happy my Doctor recommended it! I was having deep depression and chronic pain and had lost my joy in life and didn't know what to do. I pray this continues to help me to improve. I was so scared to take this medicine due to all of the bad reviews I had read about it. I am feeling so much better day by day! F 51
30 mg 1X day
3/15/2010
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Patient History
 3  Depression, I am a recluse. Wasn't hungry for days, then was SUPER hungry and it wont stop, yet I enjoy food less. Clenched jaw until my teeth are sore. Hard to orgasm but when I do it is earth shattering with noticeable afterglow. Everything is numbed, not just fear. Headaches. Focus problems. Jolty peeing (urinary incontinence). Stoned feeling. Tired. Vivid bad dreams that don't scare me much so I don't wake up. Weight gain (from eating). I seriously just stared at the floor for about 40 seconds, see focus problems. More insecure. More lonely. Need loads of sleep. My day before the pills went like this: I woke up afraid in general and went to the bathroom, then sat on the computer bored of everything. Crying almost every day. Now I get up and I'm dizzy. I take a pee that takes several minutes (starting and stopping uncontrollably, also staring at nothing when I am finished) and go back to bed. After some messed up dreams and about 12 hours later I am up and excited about the 12 things I plan to do (badly) at once. Still can't leave the house. F 29 60 days
60mg 1X day
3/13/2010
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 4  depression Begining: helped immediately with my depression symptoms but felt a weird/ relaxed/ buzzed/ kind of numb yet not sad sort of feeling. During: weight gain and very extreme loss of libido. Getting off cymbalta: headaches, mood swings, severe dizzy spells. It definitely helped my depression. No question. I was started on the 30 MG then after two weeks went up to the 60 MG. It gave me a weird/ relaxed/ slight drunk/ numb yet happy feeling when I began taking them, but my body adjusted rather quickly and those feelings didn't last too long. I have now been on cymbalta for 8 months and do not feel like I need them anymore, so I stopped taking them. Also, I have put on a significant amount of weight but I do not know if I can fully contribute the weight gain to Cymbalta. I tend to not be able to eat much if I am servery anxious or mentally unstable, like during this depression I experienced. My life has drastically changed (for the better) within the last few months and I feel that I am eating more stable. Plus, I changed my birth control around the same time as I got on cymbalta therefore I feel like my weight gain might be a number of contributing factors. My weight has always fluctuated my entire life. Going off cymbalta, I have experienced awful headaches, sever mood swings but those have seem to pass. I am now experiencing random dizzy spells, some relatively severe. I run and workout and it makes me slightly concerned to continue with these dizzy spells. F 25 8 months
60 MG 1X day
3/12/2010
Patient History
 1  depression and anxiety episodes PROFUSE sweating, dryness in mouth, increase in irritability, insomnia, vivid dreams, sharp pain right side of body (liver?), muscle pain and increase in reflux pain, constipation Doctor suggested cymbalta, as I began to become more anxious on lexapro. Some nausea in early days. In second week, the sweating started...unbelievable! Totally drenched at times throughout day and night, withour rhyme or reason ie just relaxing and sweating would start...sweated through pillows, clothes...very embarrassing at times. I had to carry paper towels in bag to dry my wet hair, especially around neck and face. I am being weaned off cymbalts, then doc will try something new. Look, I don't expect anti d's to be totally side effect free...but the excessive perspiration was unbearable. F 60 3 months
60 1X day
3/12/2010
Email
 5  Fibromylagia/ depression The first day I had an upset stomach, fever, trouble sleeping. I have lost my appitite and if I eat too much I feel sick, also I feel a little buzzed most of the time- but not enough to slow me down (worth it) I was given 30 MG to take daily but the first day I felt so over medicated that I decided to open the pills and empty out half - this has worked great for me. My depression is gone, I can walk and drive with no pain at all- I have ben suffereing from fibro for years and NOTHING has worked as well as this medication. I was scared to take it after reading so many reviews about aweful side effects, but I finally broke down and took it- my advice is that if you feel over medicated or super ill after the first 24hrs, take less (Im not a Dr so I dont know if that is safe but it seems reasonable to me) I am so happy with the results so far- I really wish I had been on this years ago- it would have saved me alot of pain. F 25 4 days
15 MG 1X day
3/11/2010
 3  depression initially some nausea, dizziness, but subsided after a few weeks I truly feel happier esp taking 30 in the am and 30 at dinner time. I have noticed waking up every nite around 3-4 am and have a hard time going back to sleep, hoping that will improve. Dont want to go back to 60 in the am and then feel miserable later in the day. F 38 2 months
30 2X day
3/10/2010
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