CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Neuropathic pain /spondylolisthesis Nausea & vomiting for first week at 30 mg then mild nausea for first few days at 60 mg. At 60 mg. I now have hot flashes, night sweats, and increased sweating during exertion Started at 30 mg which provided excellent pain reduction for 3 months. Increased to 60 mg. when it stopped working and it's working well again. Despite the hot flashes and sweating, it's well worth it for pain reduction. I have missed the occasional dose with absolutely no problems. I have a friend who's been on Cymbalta for over a year for diabetic neuropathy and he's had no problems at all. F 47 6 months
6/2/2007
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 5  Depression None I took zoloft for years but was having a lot of depression and felt really spacy. Switched to Cybalta and I am 100% better. Few episodes of depression and I don't feel so spacy and numb. It gives me hope that one day I can get off these drugs all together. F 55 8 months
6/1/2007
 2  depression F 20
5/31/2007
 4  depression, hypomania sleepiness, constipation I've been taking Cymbalta for 3 weeks, and by the 3rd week it started to help. Usually I get very depressed on Sundays, but this past 3 day weekend I was fine all the time. No more feeling in a "black" mood, and sadness. Knock on wood, hope it continues. I've taken Zoloft, Wellbutrin, Lexapro, Lamictal, and Adderall. The Lexapro was great at first; almost felt high,it made my mind race, then it failed me. My psychiatrist called that partial recovery. On Cymbalta by the 3rd week I felt more optimistic, and calm. I sure hope it continues. My Dr. started me at 60mg. I just hope the fatigue is a side effect that will wear off in time as my body adust to the drug. F 55 3 weeks
5/30/2007
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 4  Depression & Anxiety Intially I felt more energetic like I had been given a dose of adrenaline. Even if I didn't sleep well, I still had energy. As I adjusted to the medication, I began to feel normal. It made me feel wonderful and for the first time in years I felt "normal". Unfortunately in week 5 I began to have dizziness from it but kept taking it a few more weeks to see what would happen. The dizziness got worse so I was lowered to 20 mg. The dizziness got a little better but the depression and anxiety began to worsen so I had to stop taking Cymbalta. It worked really well for me but the dizziness was worse than the benefits. F 36 10 weeks
5/30/2007
 2  Depression/MS Depersonalization(felt detached from whatever situation I was in), insomnia, worsening depression, zombie like state all day, alcohol intolerance, digestive issues MY PDOC finally pushed this drug on me, never again! I was a zombie all day, even getting into a car accident. One day, I sat on the couch all day watching TV. My personality completly changed, i wouldn't socialize with my friends, I just sat there. I would have one glass of wine and feel like I drank the whole bottle. Did nothing for my pain and numbness. I am going back on Zoloft..stat!!!!! F 34 10 days
5/30/2007
 1   sweating,sleepy,manic moodswings do not take for any reason! F 31 6 months
5/30/2007
 5  Fibromyalgia Good Side effects -- Weight loss(reduced desire to snack), reduced inflamation in ankle, increased sex drive, Bad Side effects -- nausea and insomnia, started taking pill in morning instead of at night I took Cymbalta about 1 1/2 months, went off of it due to nausea, THEN I noticed decrease in appetite, especially for snacks, and increased sex drive. Have gone back on Cymbalta taking it every other day, because of the weight loss benefit. :-) F 50 3 months
5/29/2007
 2  yes vivid dreams,decreased sex drive,night sweats with chills,hot flashes (feels like early menopause or something),excessive sweating,very bloated and swollen feeling,higher blood pressure,all over not feel good,weight gain of 4 pounds in four weeks,always hungry.sleeping difficulty either can't sleep or can't wake up. I have tried Lexapro and had side effects that were not good, so the doctor changed me to 30mg of cymbalta and the new side effects of cymbalta were worse this med may or not be for you it was'nt for me. I say stop taking it if you have too many side effects don't wait more than 6 weeks and just think it will get better if you keep taking it. F 32 4 weeks
5/29/2007
 2  manic depression fatigue,irritability,lack of appetite(without weight loss) Started at 30mg and increased to 60mg. Very bad fatigue Week#1 then a little less during Week#2, especially in afternoons. No impressive mood benefits, just drawbacks: the most notable was irritability everyday with a general negative outlook and being easily angered. Need a different drug. F 47 2 weeks
5/29/2007
 3   weight gain-27 lbs. so far, dry mouth, sleeping problems F 48 16 days
5/26/2007
 5  pain from Rheumatoid Arthritis headaches, drowsiness, vivid dreams, dry mouth and eyes This drug really helped me with my pain. A positive side effect is that my family says I'm easier to get along with now, too. The side effects in the beginning were very discouraging, and I considered stopping treatment, but I pushed through it and I'm so glad I did. I don't have the headaches anymore, the dreaming has normalized, the dry mouth and dry eyes has gone away. It took about 3 months to stabilize on this drug, but I'm very glad I persisted thru the tough times. This drug is amazing. F 51 9 months
5/25/2007
 3  Fibromyalgia After 3 weeks on 30mg/day. Sleep improved. Daily nausea and horrible diarrhea. Significant weight loss. Dry mouth. Sweating. Have not noticed any significant improvement in pain. Was really hoping this was an answer to pain. Not sure I can tolerate a "therapeutic" dose. Diarrhea is tough to deal with every day. F 34 30 days
5/25/2007
 2  fibro, irritation, fatigue, mood so far, dry mouth, jaw clenching(during sleep)which causes major jaw pain the next day, jittery at times, fatigue during the day. started on 30mg for one week. felt ok, but still really irritated. been on 60 mg since 5-21-07. it works great for my irritation, but i'm still tired during the day. and now on top of my headaches, i have this uncontrolable jaw pain. i don't think i like this one very much. F 34 2 weeks
5/25/2007
 3  Depression Kind of like a lsd trip so far, dilated pupils, confusion, sensitivity to noises, light trails, sleep loss, Jaw clenching, short attention span, sweating, small hallucinations M 20 3 days
5/24/2007
 3  Migraines, Anxiety Initially, loss of appetite, sleepiness, trouble swallowing Too soon to tell if it's working but I do feel a bit calmer and my PMS headache was milder and more easily treatable. F 42 10 days
5/24/2007
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 5  Depression/Anxiety A little bit of sleeplessness. Up early. At first, dry mouth, drink alot of water now(which is a good thing!), I've noticed perspiration, but have to wonder if that isn't about the water too and being more active. And oh yeah, I potty alot more.And I get the yawns in the afternoons, yawns from the toes I would like to offer myself up to the "Cymbalta Gods". I have tried other anti-depressants in the past....nothing....ever....Cymbalta works. I don't hurt. My body feels better and I can actually move around and do things. Want to do things. I've lost 15 lbs. Food is not a crutch. Thoughts flow rather than sit and stew. It has been like having a black hood removed from my head. Amazing. Problem: Insurance.....made me pay for two prescriptions because I'm on 90 mgs. That's not right. Could someone tell Cymbalta to make a 90 mg? It gets my vote for best dosage. Why jump from 60 to 120??? There is room in there for 90, because it works. F 40 2 months
5/23/2007
 4  Fibromyalgia & Severe Depression SEVERE, SEVERE SWEATING, hand tremors, bloated stomach, weight gain, gas, thoughts of suicide, I sleep 12 to 17 hours at a time and still am sleepy and lethargic, loss of interest in doing anything, tired all the time, can't get motivated to do anything except go to work and come home, no energy, constipation, some stomach cramps, still depressed, lack of concentration, can't keep focused, short term memory, increased urinaation, some headaches, dry mouth, increased dreams, feelings of worthlessness, anti-social, nothing really seems to matter Cymbalta helped me in the beginning. Started at 30 then to 60, and now 90 mg daily with Wellbutrin SR. Doctor says the Wellbutrin (150 mg) is suppose to help with my loss of energy and lethargy. I am seriously wanting to discuss with my Doctor, & considering coming off Cymbalta because of the SEVERE SWEATING (my face, head, hair, under garmets) all stay wet about 90% of the time, day, and night, and with summer here, I am scared the severe sweating will even increase with the heat. I am not able to play and enjoy my granddaughters because of the sweating and being tired and wanting to sleep all the time! I am afraid to stop though because I don't know what other meds. are out there that can help me with the combination of fibromyalgia and depression. Surely there is something that can address these issues without the severe sweating and other major side effects. I have A-Fib and am on some heart meds. & other meds too, so I might be limited! Anyone know of anything that mig F 60 2 years
5/23/2007
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 1  Excessive Sleeping. Loss in family Complete loss of sleep, panic attacks, racing heart beat. Throat closed and had to go to ER. I have never felt more out of my head then on this medicene! Initally, I felt great- totally in control of my life. But the more that I took it the worse I got. I had horrible rage where I wanted to just lash out and break something. Sometimes I feel the desire to pull at my skin (altough I dont do it, it is constantly racing through my head). I was off of it for two days and even though never have cotemplated suicide, I was suddenly overwhelmed with sadness to the point where suicide seemed like a very logical and normal answer. I immediatly called my doctor. This stuff is BAD NEWS. I am working quickly to get it out of my system. F 36 6 weeks
5/22/2007
 3  Anxiety/Depression Blurred vision, intense headaches (which I've never had previously), insomnia, and vivid dreams (when I do manage to sleep). The headaches are nearly unbearable. I never had that result with Lexapro. 60 MG daily. F 20 8 days
5/21/2007

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