CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  muscle and back pain I took only one caps on monday dinner time. The day after early morning I was really sicks with high blood pressure, watering a lot, cold fever, stomach cramps, very pale, in resume having the full list of side effects. My family was afraid, thinking that I was ready to pass. A doctor came in emergency and was able to reduce only few effects. I was exhaust all the day and very tired the days after. It happend 6 days ago but every morning I am still feeling few side effects. For myself this medecine is very dangerous and never I will take it again. Sorry for my comments but I am French. M 73 1 days
1X day
12/17/2011
Email
 1  pinched sciatic nerve&L.B.P. NAUSEA NIGHT TERRORS WHEN I COULD SLEEP SUICIDAL AND HOMICIDAL THOUGHTS HORRIBLE WITHDRAWLS WORSE THAN TOLD. DOCTORS LIE LIKE HELL.ELI LILLY PAYS WELL DO NOT TAKE THIS DRUG DANGER !DANGER! DANGER! M 56 10 days
30 1X day
12/16/2011
 4  depression anxiety PTSD OCD none but nausea very good med but very very expensive M 45 2 months
60 1X day
12/15/2011
 5  Anxiety/Depression First three months: Reduced libido, dizzy spells, nausea, hot spells. After three months: hot spells, last longer sexually, don't realize how drunk or full of food you are. If I miss a pill I have insane dreams and some withdrawal. I think going off these meds will be very difficult. This medication has changed my life. My depression and anxiety were at time paralyzing. I now enjoy life! My wife says that I am a changed person and our relationship is 1000% better. I can think clearly and focus more on what is important. I feel like I did 20 years ago! M 38 15 months
120 MG 1X day
12/14/2011
 4  Depression, prereferal neuropothy, Racing brain, not sleep well, dry mouth, sexual disfunction, bad memory, bad dreams, endless energy. All medicines have side effects!! it is how it effects the individual in different ways. Up until now I have been taking Endep for the pain and neuropathy and Citropalapram for depression. These drugs both had similar side effects to Cymbalta and hard to withdraw from with bad withdrawal symptoms the only difference is the Endep knocked me out at night and I slept well, only very drousy and tired during the day, sexual disfunction just the same. So I figure in my mind that having one tablet to take and only pay for just one lot of medication ($34.20Aud) has to have a plus and only one set of side effects and withdrawal symptoms to cope with is even more a plus. By the way, with Citropalapram had endless energy for the first year or so then just felt worn out and tired after that. Having said that also, it saved my life as I was so bad before taking the drugs all I wanted to do was die to stop the dark depression and pain, so I think I have done well. F 57 3 months
30mg 1X day
12/13/2011
 3  Clinical Depression - PTSD Nausea, brain-zaps, ED, extreme malaise and apathy, debilitating tiredness, muscle and joint pain, memory and concentration issues... Traded the dreaded Effexor for alleged wonder drug, Cymbalta. Since they of the same ilk, the transfer wasn't too bad. Actually worked okay for the first 9 months (hey, doctors don't have a clue how all these drugs work but they dole them out to millions of us guinea pigs every day) , then everything turned bad: I became so depressed that I wrote my goodbye letters and picked out a spot to park my car where I wouldn't be disturbed once I stuck the hose from the exhaust into the window; I had trouble concentrating on driving and had a rear-end collision; having never been a great sleeper, I began waking up 30-50 times per night so I was constantly exhausted; lost the little that was left of my libido; experienced extreme pain in my muscles and joints... Tried changing the dosage and experienced the worst depression in years... I was looking forward to ending the pain through suicide, I experienced fits of rage at nothing in particular (except my desperation)... it was a full on Dr. Jekyll and Mr. Hyde transformation and very, very scary... I'm now at 120 MG A DAY OF THIS S%*T... THIS STUFF IS EVIL... but so are all the other dozen AD's I've tried over the last 30 years.... is the cure worse than the disease... that is something each of us has to decide for ourselves… M 60 1 years
60MG 2X day
12/12/2011
Email
 1  Bipolar I Very sick the first days taking it. Continued with erectile dysfunction and weight loss due to lack of apetite. STAY AWAY M 22 1 months
30mg 1X day
12/12/2011
 5  Fibromyalgia I have tried all the fibro drugs on the market - Cymbalta being the first from a drug study 5yrs ago, Gabapentin at night for sleep issues, then when Savella came out it was touted as the wonder drug. Couldn't stay on it as it wasn't taking the edge off pain and my BP was 160/110, so dr wouldn't increase dosage, infact she took me off. Just now getting off of Effexor XR today as it is not doing the trick, and going back to Cymbalta. I am hoping that it will address my osteoarthritis as well as my fibro. I liked Cymbalta and felt it managed my situation. Those in chronic pain are always looking for the new fix and I think this is the med I need to stick to. Hope this helps others out there. F 55 3 years
30 mg 1X day
12/9/2011
 4  started for depression None really. Some aches and pains that I never related to fibro went awat or have gotten more mild or disappeared depending on how stressed I get. One problem right now is ready to get off because the things causing my depression are better but I am getting muscle cramps in my legs, feet and toes real bad as I taper to every other day instead of every day. Not sure if it is the Cymbalta or not. Such a puzzle. If I have to stay on the biggest problem would be cost..but it is most important to me to feel better. I did not have problems with sleep but take a sleep aid anyway. Did not get constipated or diarrhea but I also came up with a severe case of lymphatic colitis AT LEAST 5 months before the cymbalta was started and took meds for that with regularity. Sine I have tapered off with that maybe that is the cause of the sever cramping. God only knows. Drugs are such a pain in the ass of confusion. F 58 6 months
60mg 1X day
12/9/2011
 1  Fibromyalgia and mild depression Extreme fatigue, drowsiness and a 5lb weight gain within the first 2 months. 15 months later I'd gained 30 lbs, had horrible withdrawal effects each time I tried to come off of it including nausea, dizziness, fatigue, etc. I finally had a dr help me wean off 7 months ago and since that time the depression has become worst than ever w/ suicidal thoughts at times, major irritability, lack of concentration, and a major loss of love and vigor for a life has dwindled. This is the worst drug ever; please find an alternative for your symptoms!!! DO NOT TAKE CYMBALTA--it has the potential to ruin the very essence of who you are. It's not worth it; trust me! F 34 15 months
30-60 mg 1X day
12/8/2011
Email
 5  menopausal depression and migraines Nausea for first four days, sleepiness during the day, difficulty sleeping through the night, vivid dreams, dry mouth, excessive thirst, reduced appetite, no menses. The nausea has gone and I'm now sleeping better at night after two months on 40mg (60mg was too much for me.) The rest of the side effects I still have, but they're not bothersome. The fact that I'm not having periods has curbed my menstrual migraines. I hope that side effect continues! As for my mood, it has never been as stable as it is now. I used to have terrible PMDD every month, which became unpredictable mood swings/depression as my cycle became more erratic in peri-menopause. Now I feel human again. Cymbalta has worked better for me than either Celexa or Lexapro. F 49 2 months
40mg 1X day
12/7/2011
Email
 1  Depression Irritability, sleeplessness. NEVER, NEVER take this drug. I made a suicide attempt while on it and it is my opinion it was the cause that pushed me over the edge. M 47 1 years
1X day
12/7/2011
Email
 5  Chronic Osteoarthritis Pain slight weight loss (a plus); loss of appetite This medication has completely taken away pain I have suffered with for years from an injury. It has worked absolute wonders for me. F 43 6 months
60 mg 1X day
12/6/2011
Email
 5  depression and anxiety i have had no symptoms other than feeling great! starting to have more anger issues and panic attacks. going to dr. this week to see if she will up the mg. and see if that will put me back in happy land!!!! F 42 4 months
60 mg 1X day
12/4/2011
Email
 1  depression/anger i'm still taking cymbalta, because i'm terrified of going through the withdrawl again. i was once weened off the medication because i wanted to see if i could do without it. wrongggg. besides having brain zaps and dry mouth while on it, without it my moods were more insane than they were before i was prescribed this medication, and i was dizzy every time i stood up or moved my head. so...i'm back on it, probably for life. WAY EXPENSIVE FOR ME. i have horizon as my insurance. with coverage its almost $600 for a 30 day supply. i can't afford that. thank god my psychiatrist stocks up on the sample bottles for me F 22 3 years
60 MG 1X day
12/3/2011
 1  depression/anxiety Numb face, brain zaps, not knowing where i was, depression, anxiety, pretty much everything in the book this stuff was poison for me, it didnt work at all what so ever and it took longer to get off of then to get on to. its a horrible drug, at least for me. M 20 3 weeks
150? 2X day
11/29/2011
Email
 1  Depression Was supposed to take 30MG for 2 weeks; then, double it. In the first two weeks I was nauseated, but that was all I really noticed. When I doubled it, I turned into a spaced out zombie. So, I cut back. While better on the lower dose, I felt so flat and "absent". I would rather experience emotional pain than to feel nothing. Withdrawal was cold turkey. Experience terrible hot flashes, drenching me in sweat and "sore" muscles for up to 10 days. Since I was on the lowest dose, I didn't know a way to taper off. I've taken Lexapro, Elavil, in the past. They did not take over my body and mind like Cymbalta did. Never Again! If you go online, you will read many horror stories about this drug. Withdrawal being the some of the worst experiences. Make sure you know the risks/side effects vs the benefits before agreeing to take this drug. I've never written a review on anything, but I felt a morale obligation to warn you about this drug. F 70 3 months
30 MG 1X day
11/26/2011
Email
 5  fibromyalgia and diabetic neruopath have not had any real side effects. maybe not eating as much so have had weight loss. F 66 3 months
30 mg 1X day
11/25/2011
Email
 3   dry mouth, total loss of appetite, drowsy, constantly moving my legs, slurring speech...inability to reach orgasm, and total loss of sex drive.but most of all I feel nothing....not happy or sad, just flat. I think i would rather have emotion. to me....id rather have feelings....I want off this drug. F 38 3 weeks
60 1X day
11/24/2011
Email
 2  depression I started have extreme sweating. I couldn't do anything without becoming soaked. I also had severe insomnia and had to take a lot of drugs to make me sleep. I didn't connect any of this to Cymbalta until I ran out and just used the Elavil I had. My sweats have gone away and then I notice that I could take half or a third of the medicine I took before and could go to sleep. My mind doesn't race like it did. I can't believe how long I suffered all due to Cymbalta.. I couldn't even go outside in the summer because I sweated so bad and would get sick and dizzy. All of it is gone now. F 56 3 years
90 1X day
11/22/2011

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