CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  Depression Cymbalta has cured my life-long depression, and eliminated my constant fatigue and irritability. Prozac did nothing for me, and I could only tolerate Wellbutrin for 1-2 weeks. Cymbalta increases norepinephrine (along with serotonin), and I started having greater energy after only a day or two. I started at 20 mg for the first 2 months, and just increased to 30 mg 2 weeks ago. The only side effects I notice are a dry mouth (have to be more careful with dental hygene--I had 2 cavities while on Prozac), and that lately someone remarked (twice) that I am smiling a lot. :-) I have felt almost "too happy" the last week or so. But after a lifetime of depression, there's nothing wrong with that. Cymbalta has changed my life, as my doctor and my counselor would agree, and my best friend tells me. I'm apparently growing new neurons in my hippocampus, and it has given me the mental focus and clear-headedness that I so desperately needed working on my Master's degree. I've read some negative comments about coming off of it, but with the overwhelmingly positive changes it's made in my life, I would be willing to stay on it for the rest of my life if I needed to. But maybe with my lower dose (30 mg instead of 60 mg), it won't be as bad. I'm not worried about it. I hardly worry about anything anymore. ;-) My life is going just great now, the way it was always supposed to. M 49 3 months
5/9/2007
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 4  depression, physical pain nausea, after a few days mild diarrhea, mild insomnia, the calves of my legs are COLD and it is summer, so far the side effects are tolerable. I'm told the nausea will go away as I get used to the med. I can't tolerate any anti-depressant at normal doses. I lack the necessary enzymes to metabolize them (this is genetic, some of us are born with low ability to metabolize many drugs). Fortunately I found a Dr. who understands this. He has me opening the capsule and taking only five of the tiny beads inside per day. Sounds absurd, but the improvement in my depression has been DRAMATIC. I feel glad to be alive again! F 51 8 days
5/9/2007
 2  major depression disorder serious insomnia bloating, gas, serious diarrhea after chnaging to 60mg. No dperession change, almost three weeks in. 1 week at 30 mg, weeks 2-3 60 mg. Insomnia and diarrehea have made me so tired I'm going backwards. Cymbalta was added for the "black cloud" after Adderall actually fixed adult ADD. Dr. says to keep taking. M 60 20 days
5/9/2007
 1  major depression nausea, sleeping too much, inability to orgasm, near complete loss of sex drive, random irritability, food and drink taste different, weight loss, no appetite, dizziness and feelings of hypoglycemia STAY AWAY i am afraid to wean off of it :( M 28 45 days
5/9/2007
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 5  fibromyalgia and depression nausea about 4 hours after taking the med lasting rest of the day,sweating in the face, severe constipation Ihave only taken cympalta for 5 days and already I feel like a new person. My mood and energy are better than they have been in months. I feel like i have found my light at the end of the tunnel. 1st week taking 30 mg will be going up to 60mg in 2 days. I take this in addition to 150mg per day of wellbutrin and this has helped every aspect of my life already!!!!!! I LOVE IT! F 34 5 days
5/8/2007
 5  major depression nausea at first, but that went away. Lost some weight, keeps me from eating like I was. I was already taking Wellbutrin but the depression was the worst I had ever had and doctor added the cymbalta 30 mg a day. I had high blood pressure and migraines so Inderal was added. I feel like a different person, feel so much better. Am afraid now the doctor will take me off this combination. Blood pressure is back to normal, cut down on the inderal to 20 mg a day. I have read the side effects of coming off the cymbalta, sounds really scary. Doctor mentioned me being on the cymbalta for about a year. Has anyone been on the cymbalta longer and with the combination of other meds that I am taking. F 55 4 months
5/7/2007
 1  depression i took cymbalta for 6 weeks and it reversed on me i didnt not want to be around anyone started fights with my family,had very very bad mood swings, dry mouth and quit taking it. i recently started taking st johns wort and it has helped me out a lot i have no side effects and im in a pleasent mood!!!!!!!! F 25 6 weeks
5/5/2007
 4  Anxiety/depression Vivid dreams, Horrible nights sweats(drenched but cold), occasional clenching of jaw initially I was on Lexapro which worked really well except I gained a lot of weight so I switched to Cymbalta. I have lost the weight. I initially had a decrease in my appetite but it came back. My only complaint is the night sweats. It is very irritating. I have very vivid dreams but those don't bother me. F 26 5 months
5/4/2007
 3  Fibromyalgia After initially feeling "out of it" for a time, my body adjusted and I felt fine. The side effects I've experienced include frequent stools, sweats, delayed orgasm (took forever), loss of libido, and....major weight gain. I have gained over 30 pounds in nine months, and have not changed my diet or routine. Don't much like these changes to my life. It did seem to lessen my fibro aches and pains somewhat. I have decided that I am going to the MD tomorrow and start weaning off this med. I wish I would have researched this drug more when I first started. I have never been heavy in my life and I'm sure that added weight is not doing my fibro any good. I am a little worried about the weaning process...it seems that it is not so nice. I wish that my doctor had been more forthcoming about the fact that getting off this drug can be hell. F 55 9 months
5/4/2007
 2  generalized anxiety disorder Extreme sleepiness during the day. Falling asleep on the sofa each night by 8:00 pm, then after getting up and getting into bed, waking up after an hour or so of sleep and having extreme difficulty returning to sleep, with frequent wakings. Problems focusing at work...loss of productivity. Vivid dreams. I am in the process of going off this med. Trading anxiety for exhaustion and sleep problems is not worth it. I think I would rather be anxious and sleep well. I will say that I did not cry (out of frustration, anger, anxiety) once while I was on this med, and did have more patience with my small children, which is nice, but again...the exhaustion and listlessness is not worth it. So far, I have been off of the drug for almost 3 days. Feel "herky-jerky", some small mind "zaps" but so far it hasn't been long enough to know the extend of withdrawal symptoms. I tried once before to get off the drug and felt bad and wierd enough to go back on. This time I am better prepared for what may happen and plan on sticking with it. Will report more later... F 40 6 weeks
5/4/2007
 1  Anxiety & mild depression Sleep...its all I want to do, however, unable to rest for more than an hour at a time...so sleepy on 60mg 1x/day. I lost 25 lbs in 3 wks. Had to be put on valium so I could eat. 5'3" - was 125 now 100 even....not good. (It put me to sleep for an hour, then I would wake up and eat a little) Don't want to eat, had to force myself. Hazy, do not care attitude. Felt like I was sitting in a chair watching the world go by. I'm amazed that I have not been fired from my job. DO NOT TAKE THIS MEDICINE! IT IS HORRIBLE! I simply don't understand how the FDA could allow this medicine on the market. The withdrawal symptoms are nothing sort of a nightmare. Electrical shocks, headaches, tremors, frequent urination, nausea, major anxiety. Cannot get straight answer from anyone regarding how long these withdrawal symptoms will last. F 45 6 months
5/3/2007
 4  nerve damage low back ,foot pain very hard to wake up in the morning no sex drive 30 Mg is all I take per day has help me with my feet they do not burn are feel like pins sticking me I sleep sound but very hard to wake up I also sweat much more but worth it to me because my feet feel almost normal M 57 2 months
5/2/2007
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 5  Depression/Neuropathic Pain Sick at stomach first week. Ongoing insomnia, blurred vision, headaches, initial weight loss but back to normal, increased libido, "lump in throat" Starting feeling better in about five days. I am a different person. Side effects are mostly minor and wouldn't make me quit. Insomnia is getting old. Can go to sleep fine but wake up in 2-3 hours and several more times during the night. Seem to have a constant "lump in my throat". Some indigestion, but minor. Mild headaches. Has made a huge difference in my mood. People say "I'm my old self again." F 40 1 months
5/1/2007
 1  depression flu-like symptoms, body aches, nausea, extreme fatigue, dry mouth (60 mg), couldn't function and do basic living Weaning is a nightmare, please read up on internet about weaning. One Psychiatrist only puts a person on if they are to be on for life as the weaning is awful. I am still going through it after 1 month (9 days completely off). M 16 2 months
5/1/2007
 4  Nerve Transduction Issues NA Has worked with Lyrica in prevention of problems. M 38 6 months
4/27/2007
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 2  Severe Depression/Moderate Anxiety Severe dry mouth, minor weight loss (no complaint there), extreme bowel irritation, blood in stool, fatigue. I used to be on 40 mg of Lexapro, but that left me feeling empty, so my therapist prescribed Cymbalta, in hopes that the norepinephrine would give me a mood boost. It doesn't. I started on 30 mg and am now up to 120 mg of Cymbalta a day. It is doing very little to help the depression. F 19 3 months
4/26/2007
 1  depression weight gain, acne, nightmares, heartburn, dizziness, confusion I had a horrible time getting off this drug. I slowly tapered like my docter said,but still had a terrible withdrawal. I was constantly dizzy and felt suicidal when coming off the drug. The reason I wanted to stop taking it was the rapid weight gain and the extreme dizziness I went through. Since getting off, all the side effects have stopped but my depression is back. F 33 10 months
4/26/2007
 3  chronic atypical depression I've only taken it for two days but I have a VERY heightened sex drive, feel like I'm having an orgasm every time I urinate! I don't know if this is good or bad, as I was on Effexor before and it killed my libido. Also feel jittery, headachy. Have tried every drug imaginable in my life and this is the first that INCREASES my sex drive. Will re-post after a week or so to see if this changes. Effexor worked well for me for years, then lost its efficacy. Of course everyone should be aware of the withdrawal problems with this and Effexor - I tapered off Effexor VERY slowly, then took 37.5 mg for 6 months, just to have some in my system. Be very careful when discontinuing. F 41 2 days
4/25/2007
 5  3 months Very Minor: Moderate Rate of weight loss(stopped "nervous" eating), slight cases of diarrhea, minor incidents of visual disturbance experiences for the first few days of treatment only(sort of a visual delay or hesitation in brain-eye movement coordination). I feel 100% better now that I am taking this medication. I was suffering from chronic depression for more than 15 years. The last 10 years, I contemplated suicide every day. Family history of suicide and depression. I also have Lupus, with the accompanying physical pain and fatigue. After I came to an emotional crisis point, I sought medical help and started with 30 mg Cymbalta for 2 weeks. After carefully monitoring my progress and drug tolerance, my dosage was increased to 60 mg. I have tolerated the drug well, and am able to funtion at a higher level. I have had no thoughts of suicide for many weeks now. My chronic pain from Lupus is much improved. F 54 3 months
4/24/2007
 1  MDD & Anxiety. Extreme hot & cold sensations,Extreme sweating, Extreme apathy Extreme daytime sleepiness with insomnia, Extreme, extreme, extreme depression,Confusion & disorientation, Memory loss, Nausea, Severe mood swings, Suicidal ideations THIS DRUG IS A DISASTER!! PLEASE DON'T TRY CYMBALTA!! I have been treated for MDD on and off for over 20 years. Have tried just about every SSRI out there and have never, ever, experienced "side effects" anything like this. Cymbalta may work well for some people. But when it doesn't work, well, I firmly believe it will cause many suicides before the FDA wakes up. Had it not been for my extremely understanding and supportive husband, and finding another site (check out healtdiaries.com for more Cymbalta info.), I might not be here. I have never felt this mentally "ill" in my life. F 44 1 months
4/24/2007

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