CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  ptsd, depression, anxiety Short term: dizziness,nausea,confusion, and headaches for about 10 days or so. Long term: extremely graphic nightmares, night sweats(especially in winter), 30 lb. weight gain, sexual side effects, extremely unhappy with all of these side effects. I feel somewhat more stable than when off of this type of medicine, but I am also so unhappy with the long term side effects. Also, I am still experiencing some major depressive episodes and invasive thoughts, which makes me question if the cure is worse than the disease. I want to get off of it, but I fear feeling the way I did prior to taking any antidepressant, which was horrible. Others taken include Paxil and Lexapro. I am at a real crossroad right now and don't know what to do. Help??? F 45 2 years
4/12/2009
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 5  anxiety depression social phobia Major lack of appetite during the first 4 or 5 weeks of taking Cymbalta. Slight headache during the first week as I worked up from 30 mgs to 60 mgs. Lighter sleep pattern and some tooth grinding. I never had the problem of excessive sweating or dry mouth with Cymbalta. FWIW I cannot take Prozac, Effexor or Lexapro due to very bad physical side effects. This SSNRI has truly changed my life for the better. Wonderful medication for anxiety with depression and social phobia. I've battled panic attacks and anxiety since my early teens, with many different medications along the way. Cymbalta has finally shown me what "normal" feels like. I've had no weight gain with this med. in fact I've even lost some and have kept it off. Be patient it takes weeks for your body to adjust to an SSNRI but the side effects do go away and the benefits are incredible. It evened out my moods and I am able to appreciate daily life now. What an incredible gift. F 36 8 months
4/10/2009
 4  bipolar II - depression Unfortunately I can't remember exactly what they were, but I did have some. I guess they weren't too horrendous, except it severely hinders weight loss, so I finally decided I had to quit it. Worked very well for my depression; happy to report I had no complaints with that. You WILL need to discipline yourself and BE WISE with this med though: DON’T skip any doses, not even by an hour or so, or you may begin to not feel very well physically. Just follow these simple rules and you should be just fine, and in a pretty stable mood! If I’m social drinking with friends, which isn’t very often - maybe once a month - I might not take the med exactly when I’m supposed to, but I stick with it daily, and don’t recall it making me feel odd, mentally or physically as long as I'm consistent in taking it. HOWEVER, getting off of Cymbalta altogether requires following a VERY STRICT PROTOCOL. If you don’t follow it, IT CAN GET UGLY. REAL UGLY. (Quick, but necessary MY GOD (I never use that phrase - I'm atheist!), DO NOT RISK, UNDER ANY CIRCUMSTANCE, stopping this med cold turkey OR EVEN A BIT TOO QUICKLY or you may sorely regret it (no pun intended)! Husband calls it the 'heroin of antidepressants'. Make that mistake, you'd better prepare for nausea, dizziness, increasingly crappy feeling overall, & ultimately SEVERE BRAIN ZAPS. The ZAPPING is CRAZY depressing; I felt completely helpless, always in bed, didn’t want to move so zaps wouldn't start! Same reason for wanting to KILL MYSELF; just to be rid of the PHYSICAL AGONY of ZAPS! Not sure what those are? Fantastic blog: http://theblondepharmacist.wordpress.com/2007/11/17/brain-shivers-brain-zaps-brain-shocks/ - Cried & zapped while reading it. PLEASE. VERY SLOWLY wean off this if/when med change & ONLY UNDER CLOSE SUPERVISION OF DOC! PLEASE! Brain zaps are VERY COMMON & EXTREMELY DEBILITATING. For me, right after SEEMINGLY NEVER ENDING vision-screwing epileptic lightning storms FINALLY PEAKED, TAKING SEEMINGLY FOREVER to decr in intensity after several UTTERLY HELLISH days, I literally felt I had been repeatedly struck in the head for 24 hrs straight w/metal bats covered w/protruding nails. Scalp burned in pain the following AM. You know ‘head tenderness’ after a severe migraine or bout of flu? That’s what it’s like & and only when the zaps are BEGINNING to cease. One week later: FINALLY, zaps very mild, 99.7% gone; yet still frightenin F 40 3 years
4/10/2009
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 4  Anxiety Nausea, night sweats, severe chapped lips My anxiety has been 100 percent better since taking Cymbalta. It was a life saver for me. I was having severe anxiety and a lot of sleepless nights. About 2months after taking it I started getting my life back together and getting some good sleep. I still feel really sick to my stomach though and thinking of coming off of it. I tried taking it @ night but it keeps me awake. My next step is to cut my dose from 60mg to 30 mg per day. Has anyone else experienced this complete sickness to there stomach. It is especially worse if I drink caffeine. F 32 10 months
4/10/2009
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 4  anxiety I LOVED Cymbalta. I had energy for the first time in 10 years, my anxiety was gone. I would have rated it a '5', but exactly at the six weeks' mark...I started with severe diarrhea and it lasted until I finally quit taking Cymbalta a month later. I've tried to gradually re-introduce the Cymbalta at a lower dose twice since then, after 1 month rest for my 'gut'...but the diarrhea starts back immediately. I would love to know if anyone else has had experience with this & if the diarrhea finally went away. I felt so good on it, I'd gladly suffer the diarrhea if I knew it would pass in time. If you can tolerate it, hang in there! It worked better than anything else I've tried. F 49 6 weeks
4/8/2009
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 4  depression night sweats, dry mouth, dizziness, constipation (decreased over time) It's certainly not perfect, but Cymbalta has worked pretty well for me. Imporant to note that almost all of the side effects started off as severe, then very gradually tapered off to a minimal or acceptable level. I was doubtful that the side effects would significantly diminish, but, over time, they did. For those who feel extremely sleepy when taking this drug, I experienced that too--until I underwent two sleep studies and found out I have narcolepsy. It's my understanding that often the Cymbalta lifts depression enough that people become aware of other medical and/or psych problems they may be having. One other note: on the very first day that I took the Cymbalta I did have a brief episode of anxiety. Nothing that caused a change in my actions, but for three or four hours I had increased feelings of self-doubt, anxiousness, paranoia, etc. However, after the first day, this never recurred. M 47 9 months
4/8/2009
 3  depression, fibromyalgia increased sesitivity to cold weather, tired, yawning, foggy mind, confused, no worry even when I should be. I have been on Cymbalta for three weeks and my mood is better and I am happier. I take 30Mg in the morning and will increase if I stay with this med. At night I sleep well now and waking up is extremely difficult. It has not improved on the fibro fog or pain. Pain in my legs is worse than before. I am also taking 10mg of Amitripline at night. M 49 20 days
4/7/2009
 5  depression and fybromyalgia i was sleepy had alot of stomach problems first week. it caused some insominia, i also felt like i was haviing brain buzz and ringing in my ears. I have hung in there and now the side effect have gone. I am feeling wonderful now. I have not felt like this in years. I am playing with my kids and smiling and laughing everyone can tell. I am cleaning and organizing my house now. I feel like a person. I have to take alot of meds. I have no insurance and my cymbalta is $185.00 a month. I am also on neurotin, tramadol, benazapril for my blood pressure and glyberide for my diabetes. They have not caused any problems yet with the cymbalta. My meds cost about $800.00 all togther. It is hard to buy sometimes. I am a homemaker and i have four little girls. I have been so depressed for the past 2 years and have not been myslef at sll. but now with the cymbalta I have started acting like my old self. i love it. My happy pill. Some of the other meds I take also effects and raises serotonin levels so that may make a difference. But whatever is going on in my brain is wonderful. Everyone who reads this if you have any suggestions on how to get samples or discount on meds please email me at [email protected] Pray for me and everyone in that can not afford there meds. It is a big problem i think in the economy. Lets all remeber to pray for our country and the economy. There is power in numbers and all our prayers can make a difference. F 28 2 weeks
4/6/2009
 5  Anxiety due to health problem No real significant side effects in the beginning. Just sleep problems after 4 yrs of taking the drug. Wean myself off slowly! Long process but better outcome. I posted a message on 12/22/08 about weaning myself off. Well, as of now 04/06/09 I finished my last dosage this week. Feel pretty good. Sleep problems are minimal. I sleep a deeper sleep instead of feeling disrupted. I have minimal "brain zapping or twitching" that you may call it and I know from the last few months that it will be gone within the week. What I did to wean off the drug is I started out with every other day for 1 month. Then I went every two days for another month. Again every 3 days for next month. And every 4 days for the last month. I did this on my own terms and decided this was the best way for me to handle it. Don't get me wrong, in between each month or sometimes a day out of the month I had some dizziness and twitchng, etc., but I kept going. It got frustrating some days and I felt like I couldn't do it, but each week and month got easier. I am so glad I did it this way. It takes alot of patience and will to tough it out. I would highly suggest doing this for anyone wishing to wean themselves off. DO NOT CUT OFF COLD_TURKEY. YOU WILL REGRET IT & HAVE A TOUGH TIME! I tried that way before this and couldn't handle it and just stayed on it. Good luck to all. I am getting much better as the days go on now. M 42 4 years
4/6/2009
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 5  Depression and Anxiety None I have been taking Cymbalta for a few days now. I am loving it. I have no side effects. I feel alert, focused, and happy. I haven't felt this way in a while. I am very pleased. F 25 1 weeks
4/5/2009
 2  Fibromyalgia fatigue, headache, yawning, general stupidity I've had fibromyalgia for 6 years, used to take Effexor, which worked well for me (with no side effects while taking it) but was horrible to get off of (lost my health insurance, and it was too expensive). Just got health insurance again, doctor put me on Cymbalta 3 days ago, and I think someone stole my brain...all I want to do is sit and stare or sleep, can't think clearly, yawning all the time, no motivation...and I have a TON of work to do this weekend! I need my brain back! I think I'm going to stop taking this and just take my clonazepam for sleep and see how that goes...it doesn't seem to be helping my fibro pain much, and I am taking tramadol with it (which they say you shouldn't do, but my doctor prescribed both, so I'm hoping she knows...couldn't function at all without the tramadol right now...). After reading about some of the weight gain issues, I'm concerned about that, since I gained 30 lbs. on Lyrica and have just now worked off 12 lbs. of that...not looking forward to gaining it back. F 45 3 days
4/4/2009
 1  Anxiety disorder/depression One dose 60 MG before bed. Woke at 1 AM with panic attack/heart pounding. Get up and immediately feel faint. Collapse in a cold sweat and put feet up- intense dizziness, disoriented, nausea, tingling- seemed like it would never end- and recurred repeatedly through the night- alternating chills and sweats- diarhea (GI evacuation) - dry heaving- exhaustion- zombie headed and anxious next day- looked in the mirror at one point and my eyes were totally dialated and bugging out of my head! Very freaky! AWFUL! AWFUL! AWFUL! I was on Effexor with great success for my AD and depression, but it made me SO sleepy all the time. Dr. said cymbalta is closely related to Effexor but has less incidence of SE in most people - but HOLY MOLY! My first dose almost had me calling 911 in the middle of the night! I thought I was going to have an aneurism or a heart attack! I can't remember when I've felt so terrible- it seemed like it would never end! F 36 1 times
4/3/2009
 3  anxiety IBS At first just head tingling in my right side. Jaw clenching made worse. IBS better but terrible smelling gas at times and Belching. First two weeks nausea not hungry. Sweet cravings. I have lost 8 pounds in 4 weeks. I take it in the morning 60mg and have energy all day. Restless leg type jitters. No outburst on hudband or kids anymore. Feel Well and calm but take ativan in the late afternoon to relax. Oh I also crave beer sometimes is weird. Oh ya really sucky thing is hard to have orgasms. I am going to try to stick with the drug at least for 6 months it really seems to help. Hopfully then I can go off and keep the ativan for daily use. F 33 5 weeks
3/29/2009
 5  Depression Night sweats but oddly enough only on my lower body Cymbalta has helped me greatly. I tried 3 other antidepressants which actually made me worse (I had severe social anxiety while on the generic form of Wellbutrin which I never had before) and Cymbalta is the only medication that has worked for me. The night sweats can be severe but since the medication seems to be working it's a small price I am willing to pay. Unlike some of the other medications Cymbalta worked slowly; each day I felt a little bit better. While on the some of the others it almost felt like I was on speed as I was full of energy yet still didn't feel quite right. After a few weeks on them I crashed and was actually more depressed than before I started taking them. I am very thankful for Cymbalta! F 41 5 weeks
3/28/2009
 4  Fibromyalgia Dizzy, foggy brain, eyes tired, blurry, dry mouth,low sex drive, etc., however, off it, I hurt too much. A year ago was on 60mg day for months.Was having terrible decided to stop cymbalta,stopped cold turkey,OMG!it was awful,but I made it thru.I started feeling better,then aches & pains came back big time.I also have a problem with veins & phlebitis in my rt lower leg.It swelled up bad, which it had before, but this time didn't go down.I had all kind of tests & they couldn't figure out what was causing it so sent me to a Rhumatologist.They ran more tests, but still nothing to say what was causing phlebitis.Just before I saw the Rhumatologist,I asked my doc for an Rx of celebrex to see if that would help with pains,it did some, but not the phlebitis. Rhumatologist put me back on Cymbalta 30mg day.I take it & 1 celebrex & the first couple days the swelling went down completely.I have felt so much better for the last 8 months.I still have lots of fatigue & just hate that meds seem to keep me that way.I still want off the cymbalta.Several yrs ago someone told me about a site & supplement that helped her daughter who is bipolar. I thought about it again recently & I looked up the site & called to asked if they have evidence that it helps with fibromyalgia & they said yes,so I started it myself.I have been on it a week & starting to wean off the cymbalta so we will see how it goes.The site is www.truehope.com,product EmpowerPlus.I take EmpowerPlus,Inositol & Total Amino Solution.I am already sleeping better & anxious to see what this F 47 8 months
3/28/2009
 1  Deperssion sweats, weigh gain, cotton mouth, make me into sugar junkie,never cared about sweets before. the sweats!!! trying to get off this stuff. F 42 2.5 years
3/28/2009
 1  
3/27/2009
 1  Panic disorder/depression Anger, feeling of sudden energy, burning feeling in my chest, uncontrollable of my body, thoughts of suicide I started this pill two days ago 30mg. The first day I was completly fine felt pretty good on it except when I went to sleep I felt a little sick. I took my 2nd dose yesterday(30mg) and had a horrible reaction ! I am 19 years old, female and I am not a very depressed person, I dont have any anger problems I'm very easy going person, I just have bad panic disorder/anxiety. I basically went crazy on this pill I had no control over my body. I had thoughts of killing my parents and had to hold myself to my bed so I wouldnt hurt them. In my mind I knew it was wrong but I kept getting the adrenal feeling in me and burning feeling in my chest like I was going crazy. Luckily I had the will not to do it. This drug seriously needs to be taking off the market ! Im appauld and disgusted that my doctor prescribed me this and after many times asking if theirs any other solution besides antidepressent she basicalyl yellled at me. All I can say is if your thinking about taking this drug its really not worth it ! I never thought that I would be the one to have a bad reaction to this drug I just thought the people were crazy that did, and trust me their not ! This drug needs to be taking off the market and believe me with anough people getting bad reactions it will soon ! With someone with panic disorder like me where I'm fearful to even leave my house well this drug did it for me, my panic attacks are much worst for me ! If you decide to try this medication please make sure someones their to F 19 2 days
3/26/2009
 1  Pain dry eyes, dry mouth, feel like a zombie, cannot think as clearly From the first day taking Cymbalta I have experiences abdominal pain, and constipation, sleeplessness but the stomach pain and gas has been the worst. I thought I was having a appendicitis or a gall bladder attack. I tried 15 mlg and the nausea and stomach pain were just as bad. After reading the problems others are having I have decided to quit using this medication. It has helped me with the pain but the other side effects are just not worth it. I can not sleep it is 2:00 am right now and I cannot function very well at work due to stomach pain. F 49 3 days
3/26/2009
 2  depression at first could sleep night sweats change time i took then could not wake up in the morning head in a fog could not focus Weight Gain extremly tiered cant function at work I have tried all kinds of Meds in the last year I have had a really bad year almost lost my marriage Crazy outburst could not control. My Great Nephew like a nephew past at 17 month from lukimeia, lost Great Grand mother, precancer cells just not a good year. started take Cymbalta from the Family Doctor worked For the depression good days then after a couple of days of not sleeping the doctor told me to take it at night then i was unable to get up in the morning and I would have CRAZY dreams started Talking in my sleep a lot, I never did this before. Night sweats in the winter when it was really cold I should have been freezing. Got to the point I could not keep focused to work all i wanted to do was sleep when i got home that would be all I would do Work and Sleep I talked with my doctor tried to change time I took again got worse. I told her I wanted to come off. I am still struggleing to do so. This was the worse experience ever. Then first day I skipped a dose I thought I was going to lose my mind, stomach pain headache could not move my arms and legs. I have slowly lowered my dose but I still have foggy days and headaches when I get off I will NEVER go back and I will never recommend to any one I also will urgy my doctor to stop recommending this medicine the Side effects are not worth it. And as soon as I started to get off the old feeling started coming back slowly. DO NOT TAKE THIS MEDICINE F 26 4 months
3/23/2009

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