CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  moderate depression & anxiety the first 2 weeks I was fatigued & constipated. Less sexual side effects than effexor or zoloft and I feel great! Less mood swings. F 49 30 days
9/4/2007
 2  depression and headaches Dizziness, difficulty sleeping (I wake up numerous times throughout the night), dry mouth, feeling like walking through fog I absolutely HATE this medication. I took it on Saturday night and had trouble sleeping, so I took it midday Sunday, then wanted to do nothing but sleep, took it around 7 pm Monday evening, had trouble sleeping, then felt like I was in a fog on Tuesday morning. I had to drive to work and only vaguely recall getting there! I looked around at a stop light trying to figure out how I got there. I'll be asking to switch to something else. I can't live like this! F 27 3 days
9/4/2007
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 1  Depression Nausea, Insomnia, Constipation, Crying, Dry Mouth, Sexual, "Speeding", Worsening Depression, Thoughts of Suicide, Jaw Clenching, Heart Racing This is the most frightening experience I have ever had with an anti-depressant. I have a very high tolerance for drugs, and I have been on meds almost consistently for thirteen years, trying almost everything possible. Never have I had such side effects, nor have I ever felt as "drugged" as I did on Cymbalta: nervous and speeding. The side effects were almost immediate. Rarely do I ever think of suicide, but after two days the thought was almost constant. I woke up after three hours sleep each of the four nights, and could not get back to sleep. I was "speeding" the whole time, but felt no relief or, for that matter, a single positive effect. I would rather be depressed than feel like this--at least depression is predictable and I know it will end. I see that it worked well for some, but I would never take this drug again. The user comments for withdrawal were enough to stop me after four days. M 46 4 days
9/3/2007
 5  Depression, GAD nausea, diarrhea, constipation, agitation, sexual side effects (only the first 3 weeks) Immediately after I took the first dose I noticed that this is a STRONG drug. I tried many antidepressants (SSRIs, tricyclics, NaSSA, MAOI) but none of them killed the depression and especially the anxiety like Cymbalta did. After 10 years of suffering, I am free of any anxiety finally! I experience life like I did before I got the illness. I feel JOY again in my everyday tasks. But I understand why this drug has so many negative ratings. That’s due to its potency. I dosed in VERY slowly, by opening 60mg capsules and splitting the pellets in six parts, being careful not to damage the pellets. Even with 10mg I needed a sleep aid for the initial 3 days. Starting with 60mg is definately too hard in side effects concerns. That's too much in the beginning. Now after 30 days I am at my final dose of 60mg, feeling so good like I never did before and side effects free. They subsided pretty fast. M 30 30 days
9/2/2007
 4  anxiety/depression/lack of patience Helped with my mood and patience TREMENDOUSLY, 30mg a day for about 3 mos, but some of the side effects are bumming me out. Really tired alot of the time, real vivid crazy dreams, and I have a REALLY hard time waking up in the morning no matter how much sleep I get. Sweat alot while sleeping too. Am going to try 30mg every other day and see if that helps. F 40 3 months
8/30/2007
 4  Major Depression Some sleepiness, but not as bad as before the pill. Some lowered sex drive. Slight constipation. Night sweats...tending to occur 3-4 times a week with more vivid dreams. I have gained about 30 lbs. Started on 30 and went to 60 mg. Dropped back to 30 mg, because of side effects. Just went back to 60mg/day (30mg in morn, 30 mg after dinner). Decided the benefits out weighed the side effects. For myself, there is a 2 week "crazy time" (named by my husband) whenever I changed dosages and when I started. If you can get past those 2 weeks, you will notice a fantastic change. I actually get up and go out of the house. I will do laundry and wash the dishes again. My husband did notice that I tend to twitch for the first hour or so that I sleep. After reading all of this, the drug sounds horrific, but it has done wonders for me as well. F 31 18 months
8/30/2007
 4  Depression and Anxiety I have been taking Cymbalta for about a year. Any side effects I have had have eventually gone away except for occasional excessive sweating of my scalp. Cymbalta is the only thing that has ever helped me. F 64 12 months
8/30/2007
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 4   Was on Paxil for 4 years and the past 3 months it hasn't helped the depression at all. My sister went from Zoloft to Cymbalta and told me to speak to my doctor. I went in for an appointment 2 days ago. I see the doc every 6 weeks for medication mgmt. We spoke about the Cymbalta. He is weaning me off the Paxil while on 30mg of the Cymbalta. After I am totally off the Paxil, I will take 60mg a day. I am looking forward to seeing how this medicine will help the depression, my irritable bowel syndrome, fibromyalgia and anxiety. As far as side effects- I already sweat and dry mouth all the time anyway. Any one of my 10 medications could be the cause. I am hoping the Cymbalta will work and the idea of losing weight, is an answer to my prayers. Once I start the 60mg, I will update my comments. F 54 3 days
8/30/2007
 5  Depression, Panic, Fibromyalgia small amount of nausea, sweating, weight loss, loss of appetite After years of Paxil this drug has done wonders for my depression, panic and somewhat helpful with fibro. I am currently taking 90 mg. Have had horrible withdrawls from trying to stop Paxil before but was able to just "switch" to Cymbalta with no problems at all. It is amazing to me. I also take Depakote which causes weight "gain" so the Cymbalta evens out that problem. Doc suggest I go up to 120 mg. I dont see anyone here taking such a high dose?? I have had very little side effects and no problems with sleep disturbance or anxiety at ALL. I love this drug and dont intend to stop taking it! F 37 4 months
8/29/2007
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 4  peripherial neuropathy I have been taking this drug in conjunction with Lyrica and lexapro for 4 months now. I am now able to see thru the nighyt comfortably and have had only one noticeable side effect - loss of libido. The pain was gone almost immediately. I am now wondering what if any withdrawals i will have when i get off of it. After reading the postings i wonder. But then again drugs effect everyone differently has gave my life back to me. My neuroligist made sure i took it with lyrica. Tried lyrica alone and the effects were not the same M 51 4 months
8/29/2007
 4  Depression, anxiety, back pain None really. I have been tired a lot lately, but that could be from the depression. I am not really sure. I honestly have not had any of the major side effects others have mentioned. Taking 30 mg for chronic back pain, and depression. It has helped take the edge off my depression. Not a "cure" but it does help. I have been fatigued quite a bit, however, I am not sure if the drug is causing it or just the depression. If I miss a day, I do have weird withdrawals though. Dizziness, brain zaps (look this up if you don't know what I mean) and just an out of body feeling. Taking an Omega 3, 6 supplement helps with these effects. If I didn't take this drug, I would be in my pj's all day sleeping on the couch. Depression makes me unmotivated to do anything at all, even socialize. Cymbalta will help you. F 30 5 months
8/27/2007
 5  Depression Absolutely None!! But I am loosing weight.. The first night that I took the 30mg I was very sick...but I had to do something. I didn't take another dose for two days. I am now taking 60mg and things are great. It seemed like everything was unraveling quickly and I had to make a change fast. It worked..I feel like I can deal with stress; I can focus and concentrate again. I am also loosing weight!! F 37 2 months
8/26/2007
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 5  Fibro Constipation, but since I have IBS, better than the alternative! Brain Zaps if I forget to take it Had been in pain for 15 years prior to drug trial and I have never felt better in my life. my only problem is the high cost of the medication F 38 2 years
8/25/2007
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 4  ansiedad y depresion la primera semana leve somnolencia y poca ansiedad y eso si, problemas con el estomago y disminuyo la libido y retarda la eyaculación. LLevo 24 días de tomarlo, en México es muy caro el antidepresivo pero es con el que he notado mejores beneficios, me quito la fatiga el desgano y el desanimo, aunque aveces tengo poca ansiedad esta si disminuyo, espero que en otro par de semanas ya note un efecto al 100%. Por el momento puedo decir que vale la pena tomarlo, pocos efectos secundarios comparados con otros que tome, mi autoestima y seguridad volvieron y sobre todo la fatiga que era lo que mas problemas me causaba esta desapareciendo, M 27 24 days
8/24/2007
 4  Lupus Decreased ability to orgasm which corrected in about a month; now after almost a year, seems to cause restless legs and foot pain as a result. It may have to do with the time of day I take it. At first, I couldn't sleep with it, so I had to time it for earlier in the day. Oh, yeah. Increased sweating. This is the most managed my lupus has been. I can really tell if I miss it. F 37 1 years
8/23/2007
 2  Anxiety (GAD) SEVERE nausea, blurred vision, fatigue I have only been on Cymbalta for 3 days so far and the side effects are HORRIBLE! I'm constantly nauseous and feel so tired and lathargic, I keep falling asleep at my desk at work and have been in bed before 9pm the past 3 nights. I'm terribly worried about weight gain so I was googleing stuff on Cymbalta to make sure weight gain was not a common side effect (my doc. said it was not) and after reading all theis stuff, I'm scared to take it anymore! Brain zaps and weight gain...WTF!!!??? No thank you! F 25 3 days
8/23/2007
 3  Depression, Fibromyalgia At first it was wonderful. Fibromyalgia was much improved as was depression. After about 3 or 4 months it stopped working on the pain and I noticed that I was having huge problems with anxiety and anger. Similar to when I was on Prozac. Trying to go off it has been pure hell. I am suicidal and could kill my husband very easily. Absolutely no interest in sex or other activities. I've been through it before with Prozac so I'm not worried, I know it will go away. At first I thought this drug was wonderful. That was back in March. After taking it 3 or 4 months it no longer helped the fibromyalgia but continued to help the depression. I was on 30 mg twice a day. The doctor suggested upping it to 90 mg a day but I was scared to try that after reading this site. I get letters from my pharmacist whenever I haven't filled my RX on time warning me not to go off suddenly. That is not a good sign. I should have flushed it down the toilet then but it was working so well on my pain, I really hated to stop. It only worked on the pain for a couple of months. F 58 4 months
8/22/2007
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 4  Anxiety wired like I was on speed, at first constipation, now occasional diarreha. Feel "jittery" in the mornings, ( I take at night with ativan) occasional anxiety, but ativan nips that in the bud. Ive tried lexapro with lame results still had terrible anxiety, then zoloft which actually made the anxiety worse, then finally tried cymbalta. Started on 30mg for a weekthen to 60mg. So far its been OK. The best so far. Its definately not without its side effects. I cant stay still for very long, or I get "figitty" and have to move. But the anxiety is alot better. Ive only been on it about a month, 30mg one week and 60mg for three. Go back to the doc next week and see whats next. M 29 32 days
8/20/2007
 3  Headaches ocassional somnolence but what corries me really is I cant orgasm. I have a lot of sexual appetite but can't orgasm. Soes it go away?If anybody has gotten the sexual side effects and they have gone away please let me know. Or is it the only solution to change medication? M 34 3 days
8/20/2007
 2  Depression WEIGHT GAIN! 40 lbs. in 6 months. Unpleasant hallucinations when tired. Other side effects: muscle spasms, especially when trying to sleep, bizarre dreams that made me feel exhausted upon awaking, all sorts of problems associated with lack of sleep...did I mention WEIGHT GAIN?!?! Grrrr! I began with depression and now have another BIG reason for it! My doctor is usually caring and attentive, but simply would not accept that the incredibly rapid weight gain I experienced in the months after I began taking Cymbalta was caused by the drug. Went last week to a doctor who specializes in HRT and discovered that Cymbalta does indeed cause weight gain and also learned why and how. Am now on hormone replacements and being weaned off the Cymbalta. 60 mgs every other day instead of every day. Have felt overall better and far less hungry, though I don't yet dare step on a scale. Withdrawal symptoms: severe headaches, nausea, itching all over. However, I have also learned that the hormones I am taking will "plug into" the receptors that were being filled by the Cymbalta. Please see your doctor if your symptoms are similar to mine and consider HRT. It's working for me and I feel less depressed than while on the antidepressant Cymbalta. F 45 6 months
8/20/2007
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