CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  fibromyalgia, generalized anxiety none. nausea and loss of appetite during the first few weeks, sleepiness if i take it at night vs taking it in the daytime. cymbalta has been a miracle drug for me. i lived in a fog of extreme, paralyzing anxiety for 20+ years and no other drug has ever worked. it changed my life. also reduces fibro pain by about 40%. F 34 3 years
90mg 1X day
5/24/2016
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 3  Fibromyalgia 30# weight gain fatigued all the time was not social flat personality Do not take this drug withdrawal is horrible weaned down to 30 2wks then ever other day day my muscle pain is 10x worse now that I am off get agitated quickly cry a lot brain dizziness or zaps F 62 3 years
60mg
5/20/2016
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 1  Severe Depression EXTREME lower leg & foot swelling, EXTREMELY itchy red rash lower extremities, profuse sweating, zombie state - extreme sleepiness shortly after taking and without any warning, lower extremity cramping, mouth sores, extreme weight gain, NO libedo what so ever, very bad memory. For the past 9 months I have been on Prednisone to keep the swelling and itching at bay. After seeing every type of doctor AND having every type of blood test/urine test/a fat biopsy about the swelling and itching rash on the inside of my knees and what started on the inside of my ankles. I have FINALLY figured out that I am having an extreme allergic reaction to Cymbalta. It also landed me into the ER as my upper lip swelled up after a nap one day. I was then put on Prednisone 20 mg a day to subdue the swelling and rash/itching. After putting on even a lot more weight because of the combination of the Cymbalta AND Prednisone, I have plans for stomach surgery within the next 2 months. I started investigating/researching Cymbalta and I noticed a common denominator. EVERY site I went to mentioned as a "Severe reaction to Cymbalta" ALL of my symptoms. I had an appt today with my doctor that prescribed the Cymbalta and I tried multiple times to advise him of all of the websites I checked, EVEN THE FDA.GOV, they all said the same symptoms. HE ACTUALLY TOLD ME THAT I WAS NOT ALLERGIC TO THE ACTUAL MEDICINE, IT WAS THE DYE IN THE CAPSULES I WAS ALLERGIC TO! After going through the entire endocrine system, ie: do you have diabetes, etc. He decided to change me back to Pristiq. i quit taking the Cymbalta 3 days ago and I was able to titer myself off the Prednisone and my rash,itching and swelling is so much worse than ever! F 47 1 years
120mg 1X day
5/13/2016
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 1  Depression, anxiety, Hypoglycemia, shaking, sweating, Do not take it. Read the treatment emergent effect from National library of medicine. M 32 2 years
60
5/8/2016
 1  toronto nausea, depression, suicidal thoughts, weight gain Do not take cymbalta. Do special exercise accordingly to your health condition (Low/high blood pressure, blood sugar). Avoid negative sources. Eat properly with good supplement. I am fibromyalgia free. Thanks God. F 50 1 days
1X day
5/6/2016
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 1  Fibromyalgia Significant but creeping weight gain, I've gained 30 pounds in two years regardless of exercise and trying to eat less. I was constantly craving carbs and had no willpower. Walking 3 miles per day didn't help stop the weight gain. I've never weighed this much in my life. I recently stopped taking it, I did a quick reduction time of taking half for one week then reducing pellets the next week, and stopped completely and have been off for three weeks. I can no longer tolerate being fat. I'm having withdrawal symptoms of brain zaps, foggy brain, crying spells/sensitivity, dizziness and diarrhea. I don't think my withdrawal symptoms are as severe as some. My appetite has dismissed significantly and I think I've dropped some weight which is encouraging. F 35 2 years
120
5/4/2016
 1  chronic pain F 51 6 years
90 mg
5/2/2016
 1  Pain and depression No side effects. Has never really affected me at all positive or negative. Was off of it for a while, but never suffered side effects. I don't know why it doesn't help. It's like taken a baby aspirin. Never helped initially or current. Was off of it for a while, but never suffered side effects. I don't know why it doesn't help. It's like taking a baby aspirin. Never helped initially or current. M 3 years
60MG 2X day
4/20/2016
 1  depression/anxiety Pill "hits" like an illegal narcotic after so many minutes, felt silly and goofy the first two daysm extremely fidgety, more so than normal. Terrible tremors, up for two days straight, remembering hours later what I set out to do. Passed out cold, awoke third day to ringing ears, nausea, blurry vision, severe mood swings, as if I didn’t have enough already, and my favorite, little itchy patches that fill with seepy water and pop almost instantly while removing the entire patch of skin it was covering leaving a raw open red uncovered blister that NEOSPORIN burns if touching them ! Picture chickenpox before they scab, but pop immediately when they appear. And I HATE to tell you where some of these blisters are. Maybe about six or seven large ones around body,. No goody feeling anymore, agitated quickly, "whatever" attitude, confusion, lack of wanting to do anything, narcoleptic "fall asleep anywhwe without notice" type effects, don’t realize amount of time , sometime couple seconds once fifteen min. Doc said blisters were an allergic reaction to stop immediatelY. It's amazing how many of the posts I read the people that say it's done wonders for me and I don't care if it's addictive but these are the same people that will turn around and call a Street addict "degenerate bastards" it is amazing what Society does. The effect of alcohol is The Most Dangerous Drug according to the FDA still…because of what it does to your body and in the am HEY DOC THOSE PILLS MADE ME WAKE UP IN SOMEONES HOUSE AFTER DRIVING THATBI DONT REMEMBER, CAUSED JAUNDICE WAS HOSPITALIZED BECAUSE MY HEART VALVES EXPLODED AND ATTACHED THEMSELVES TO MY BRAIN AND IM MOTE DEPRESSED THAN EVER.....OK PATIENT, HERES AN ATTORNEY REPRESENTINF THAT DRUG, YOU DONT EVEN HAVE TO GO TO COURT THERES A SETTLEMENT FUND AVAILABLE. IT SEEMS WELL JUST HAVE TO UP YOUR DOSES. NOW ARENT YOU GLAD YOU STOPPED THOSE ILLEGAL STEEET DEMONS? amazing how more and more ailments are being treated with antidepressants so instead of actually curing the problem they're making your brain stop functioning properly for that area so you don't feel the problem. Hmm like a form of mind control? just take this pill it'll stop that feeling of guilt when we ask you to kill these people...like cattle? Think about it... M 49 4 days
60
4/20/2016
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 3  Fibromyalgia Brain fog, weight loss So far no real help with the depression, anxiety, or pain, but no real annoying side effects to speak of (brain fog trends to happen with my pain anyway) so I'm hoping a larger dose will come with my next appointment and success will come then. Fingers crossed! F 29 2 months
30 mg
4/18/2016
 1  Neuropathy Started at 30 mg for a month. Minimal effects Doctor increased dosage to 60 mg seemed to help foot pain. After 6 months prescription was not refilled due to error at doctor's office, I was not informed of withdrawel issues of this med. After 48 hours I experienced extreme dizziness, brain zaps and vision problems I had no idea it was due to withdrawel from the med at the time. I realized I had best head to the emergency room that evening. Thankfully my exwife got in touch with the docotr's emergency servive a prescription was called in. I had to go to an optometrist a couple days later due to seeing color bands out of the corner of my eyes when looking to either side and floaters appeared also. The optometrist and the prescribing doctor said the visual problems were just a coincidence. I still see the floaters 24 months later. I'm trying to get off this stuff by dose reduction but every day is a challenge and very uncomfortable. I feel like my cognitive abilities have been permanently impaired. My reading and mathematical comprehension have been are degraded and I don't feel like I'm the same person I was before I started the medication. My fingers jitter so much when I write that my writing is scribbled. I experience frequent dizziness and brain zaps. My dreams are crazy and depressing and I wake up 2 or more times each night and feel tired all day. And lots of unusual sensations and frequent headaches and hand tremors. I pray I can get completely off this medication soon and get my life back on track. M 66 2 years
60mg 1X day
4/12/2016
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 1  depression nausea, vomiting, indigestion, diarrhea, constipation (which took me to the hospital with an intestinal obstruction subjected), fluid retention, weight gain (20 kg), fatigue, insomnia, lack of empathy, depression, anxiety, mood swings, aggressiveness, lack of interest, lack of ambition, my libido has disappeared (I have come to feel disgusted by any physical contact), lack of concentration, memory failures short term ... For nearly 7 years I have been taking Cymbalta. Side effects are terrible. I have tried to quit at once for 3 times and have not been able. I've been slowly lowering the dose for 3 months and now I'm taking 10mg and almost did not get withdrawal symptoms. During the 7 years of consumption of this drug I have suffered from nausea, vomiting, indigestion, diarrhea, constipation (which took me to the hospital with an intestinal obstruction subjected), fluid retention, weight gain (20 kg), fatigue, insomnia, lack of empathy, depression, anxiety, mood swings, aggressiveness, lack of interest, lack of ambition, my libido has disappeared (I have come to feel disgusted by any physical contact), lack of concentration, memory failures short term ... I have come to feel grateful to be out of work in recent years, because I believe that it would be impossible to keep a job in this way My husband is a wonderful person who bears the situation as best he can. My daughter barely knows me otherwise, is 10, and do not even know how to explain that her mother was not this human waste that now she sees. I must admit that some of these symptoms are still prevalent, but most of them have been disappearing with the gradual reduction of the drug. The times I've tried to quit abruptly have not been able to resist the withdrawal symptoms that seemed that instead of decreasing, were increasing day after day F 35 7 years
60mg 1X day
4/7/2016
Email
 1  To back up my Zoloft Gained 30 lbs in 2 weeks. It did nothing to help my depression. I still haven't taken it off. F 45 10 days
20mg
4/7/2016
 2  Depression Insomnia, exhaustion, tense (jaw clenching), spaced-out, hot-flashes, chills, headache, mild nausea, urinary hesitancy. The pharmacist told me it could take 2-4 weeks to realize the benefit of this drug. However, it took only one day to realize the collection of disturbing side-effects. With an impending family vacation, I had to stop the medication as I didn't want to be a Disneyland zombie. It took about 4 days after ceasing the med to finally feel like myself again. Trying Deplin next. M 56 2 days
30 1X day
4/5/2016
Email
 3  Depression Horrible trying to stop. Should not have taken it so long. Doctor said I would be on it the rest of my life. I don't think soooo! I'm in the process now of trying to stop. F 61 9 years
60
3/29/2016
Email
 1  Fibromyalgia nerve pain Constipation . Weight gain15 lbs immediately, tired tired brain fog crazy dreams Horrible to try to get off of!!! Nausea zaps, foggy, chills feverish , fly like symptoms anger at nothing! Devils drug!! Don't take this !! Changes yr brain completely Can't get off of it without agony! F 58 4 years
60
3/25/2016
 2  Headaches Too much pooping!!! Seemed to help with headaches initially, but not so much now. F 57 1 months
30 MG
3/22/2016
 3  Fibromyalgia I took Duloxetine (Cymbalta) 3 hours ago. So far, I am Jittery, have the chills, extreme diarrhea, super bad nausea and I felt like I needed to lie down only to toss and turn and not be able to sleep. Muscle pain has subsided. With that being said though. It's been 3 hours, I ALWAYS have many side effects happen when starting a new medicine and it also did what it was supposed to and made my pain better. I will continue to take this dose. I am supposed to increase to 40mg in two weeks but I'll see how well the 20mg does. F 28 1 times
20 Mg
3/14/2016
Email
 5  Depression, chronic pain Sweating I've suffered with suicidal depression and the pain of Cervical Dystonia. Cymbalta helps with both. My weight has been unaffected; pain flare ups are rare but can be severe. My MD and I are considering a slow down titration as a trial. F 63 10 years
90 MG
3/13/2016
Email
 1   0 Heavy diarrea M 1 days
30 1X day
3/11/2016

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