CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2744 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Depression/Anxiety Vivid dreams, odd bowel movements, decrease in sweating, weight gain, insomnia, electric shocks in neck, no sex drive. I have been on Cymbalta for about 2 months now. The first 2 weeks were ok, I was on 30mg, with only minor sleep pattern changes which I expected. When I was upped to 60 mg, everything started. I began having really vivid dreams, not scary, just odd. I began to have diarrhea one day and constipation the next. I am normally a sweaty person, but I rarely sweat at all, but when I do, it is profuse. I have gained 10 pounds, which I can deal with, but it isn't good for my wallet by having to buy new clothes. I now cannot sleep, either from the dreams or just not feeling tired, but may fall asleep during the day. The worst thing is the electric shocks going from my head through my neck and the lack of libido. M 24 2 months
7/27/2009
 1  Mild Anxiety Extreme sweating & insomnia, suicidal thoughts, racing heartbeat, panic attacks, aggressiveness. I went to my doctor several months ago in search of something to calm me down after my life sort of exploded with all sorts of issues at once- cut in pay (economic downturn with company), barely affording massive mortgage, family member sent to prison for her drug addition/possession, and now dealing with lawyers and massive bills in addition to everything else. I first started out on Paxil, which ended horrifically. I became incredibly numb to emotion all the time coupled with extreme nausea and lost interest in just about everything and became depressed even though I wasn't depressed in the first place. After 2 months, I couldn't take it anymore and went back to the doc hoping for something else. He then switched me to prozac. This is when sweating really started happening: Non-stop, day and night, regardless of my movement I sweated profusely. I had to stand in front of a fan in the morning with every window open in the house while getting ready for work after my shower, even though it was 50 degrees outside in San Francisco fog. Two months after prozac, I felt significantly more anxious, more aggressive, started fights with co-workers over nothing, barely slept... basically way worse then before I took any damn pills in the first place. Finally, I went back to the doc again and he switched me to cymbalta. Having been on this for a few weeks I am now convinced there is not a single anti-depressant my body can handle. Cymbalta not only increased my already inces M 24 4 weeks
7/27/2009
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 3  Fibromyalgia Numbness in the head, like brain was in a vise grip (30 mg), numbness in face and traveling numbness through the body (20mg) I was really bummed because the cymbalta acutally helped my fibromyalgia pain from day 1. And unlike other people, it cut my appetite, which was a blessing because of weight gain from taking meds for pain. But I oould not put up with the numbness in my head. At the lower dosage and the numbness in the head was lessened but then I developed numbness in the face and then it started traveling throughout the body like the fibromyalgia pain did. If it weren't for the numbness, cymbalta would have been an answer to my fibromyalgia pain. :( F 48 2 weeks
7/24/2009
 3  Depression and Anxiety Insomnia. Mentally alert (no more need for caffeine in the a.m.). Short term memory is crap. My sweat smells differently (someone else mentioned this too). Better mood in general, like a mild cocaine buzz, but no euphoria - just good mood and awake. Not helping with anxiety yet. Really hard for me to sleep. Conscience about my body odor now. Waiting for the anit-anxiety effect to kick in. Appetite decreased. I read lots of reviews mentioning hair loss. the second I see any hairloss, I'm OFF Cymbalta and on to next antidepressant. This is my first one. F 32 5 days
7/24/2009
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 1  Depression and anxiety So tired I felt like I had the flu, foggy, severe pain in one eye, horrible stomach ache, hedache I only took this for two days and was unable to continue due to the side effects. I felt so ill I had to call in sick to work and I never do that. I hear it does help some people though, it is just how it reacts within your particular system. F 35 2 days
7/24/2009
 3  severe depression started on 60mg first week,then to 90mg from there.Bp up,sweating,very nauseated with vomiting first week,itching to hands and feet,very dizzy, no sleep, no appetite, feeling more down than i've ever been(thoughts of suicide with plans). Am into 9th week.Still on 90mg plus valpro 200mg 3times a day.Vomiting has stopped but still very nauseated,itching not as bad but neck/face hot flushes on/off.Still very dizzy and am not sleeping(approx 1.5hrs a night but not quality)Blood pressure slowly rising despite taking meds for bp after heart attack.Have lost just over 9 kilos in 7 weeks from loss of appetite(not complaining there).Also noticed reduction in penis size?Will continue cymbalta for a few more weeks in hope that all will come good.Am very concerned after reading other posts as to ceasing medication.HAVE tried all types of drugs over last 2 years without too much success.If this doesn't work my next treatment will be a course of E.C.T. To the people this drug is helping i say cherish it as some of us are doing it hard to get results and maybe someday we will all get our lives back.I live in Australia and would appreciate emails from other patients. M 45 9 weeks
7/23/2009
 1  depression/pain brain freezes, brain shivers i took it for about 4 months and at first it was WONDERFUL, then the brain shivers started to happen, i was grateful that i read a lot about the drug before taking it so when they started i knew it was the cymbalta and i wasnt loosing my mind. i would suggest that anyone considering taking this drug to be really sure they read about it, Ive been in several different meds for depression and pain and this one was a HORROR to get off of. I didnt think I would ever be normal again, but after about a month it finally let up and I started to feel normal again (depressed still but at least no brain freezes) i am not on wellbutrin and tolerate that just fine, cymbalta to me is junk F 34 4 months
7/23/2009
 4  nerve pain/CRPS Hair loss It took a few weeks to get used the "fuzzy" feeling in my head and decreased appetite, but then no problems..that's until the hair loss ! I first noticed it a few weeks ago, didn't think much of it as it was just strands in the shower, sink, etc. Now I can actually feel that my hair is thinner, guess all those little strands add up :< I'm really stuck on what to do, it's the only rx that helped the neuropathy pain in my tongue which was horrible for 2 years. Frustrating that it's working so well, I've e-mailed my neuro. for advice. F 56 2 months
7/22/2009
 1  neuralgia/chronic pain sweating at first, then tapering off. Strange dreams(but not nightmares). Good control of pain. After 1 year began depression never had before, confusion, lost concentration, and thought I was going to have to check into a mental hospital and leave work. When saw doctor, she immediately switched me off Cymbalta to Effexor to stabilize the depression. Dr. mentioned had 5 patients had to do the same thing for. Long term use was not studied enough, in her opinion. Once again I'm looking for relief for control chronic pain. F 43 1.5 years
7/22/2009
 5  depression/chronic pain (lupus) started on 30mg X 1 week, and took first dose before bed, and i felt a little bit buzzed and kinda nauseated. The next day had really no side effects except feeling a bit sweaty at night and not sleeping as well,which only lasted for about 2-3 weeks. I decided to switch the medication to the daytime and then i had no more sweating and no more sleeping difficulties. I can honestly say that i really didnt haven any major side effects with this medications, not even the fatigue you can experience when you start the other types of antidressants/SSRI's. I do however feel a bit more figidity, but not really bothersome and is getting less as teh weeks go by By week 2 on 60mg my pain has "dramatically" reduced. I am a nurse and seen it work on another patient were we had tried everything for pain control with no success but this worked for her, so i decided to give it a try and i cant believe it. It has also helped with the depression but has not fully resolved it. I did lose about 6 lbs on it and after about 6 weeks, my ablity for orgasm returned. I think anyone with pain issues or both painand depression should try this med. F 39 5 weeks
7/21/2009
 4  depression delayed orgasm so far so good. delayed orgasm, but unlike paxil, still functional. overall, feeling much better depression-wise. i have tried many medications over the past 20 years, and so far this is the most optimal in terms of dealing with the problem, but with manageable side effects. this was going to be my last attempt at medication. i'm glad it has worked as well as it has. i am going to stay on it for the long haul if it is continues as well as it now. hope it comes out in generic soon because it is expensive. but it is worth it if it can help keep me employed. able to function at work and with family much better. has also helped me cut way back on booze. i just hope it keeps on working as well as it does now. i feel almost like a complete person. M 56 2 months
7/21/2009
 4  GAD all the usuals First off anyone who posts here should wait at least a month as to really get the effects of this med. You are not special and we all experience the side effects. BUCK-UP and give it a real try or live with your problems. I do understand it does not work for everyone and effects everyone differently. OK, so, as for me it is not a magic bullet but has improved my life. Coping with work and stress has surely improved. I do recommend trying everything else first then when you need give it a whirl be prepared to stick it out for the chance at the full benefit . It just maybe worth it. So far I am glad I did , Good luck all. If I can help anyone my email is listed. America is for the people by the people. Obama/socialism is the wrong direction M 45 3 months
7/21/2009
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 1  nerve pain snored alot more, extreme sweating, felt like i was in the clouds, violent rage against family this is the worst drug i have ever taken. hard time getting to sleep at night. had this weird feeling about myself. thought it was just from the back pain. then one day i dont remember anything that happened. i went into a violent rage and went after my girlfriend and her son. i will not go into detail but will say that cymbalta turned me into a monster. i stopped taking it cold turkey. the side effects from stopping was not that bad only for 3 days for me M 35 2 months
7/21/2009
 5  Depression and anxiety Loss of libido for first few months; excessive sweating Started with 60mg/day, major loss of libido. Tried reducing to 30mg/day, depression returned. Combined with Wellbutrin (buproprion) 300mg/day, slight improvement in libido. Dropped Cymbalta back to 30mg/day + Wellbutrin 300mg/day; depression returned. Back to Cymbalta 60mg/day and Wellbutril 300mg/day. Libido has improved over time (maybe 9 months from starting Cymbalta to nearly-full return). Sweating is a problem, but I have always sweated excessively, the Cymbalta has just increased it. About once/month I have to sleep on a couple of towels, otherwise I just sweat if I walk to work. This is a *very* small price to pay for having my life back, the joy I get from my family, and reduced stress in my wife and kids. With all these drugs, YMMV. I am happy enough with Cymbalta that I will not try switching -- I know from trying various reductions that I will get depressed and suicidal if I come off for more than a day or two. Cymbalta has saved my life, the side-effects are a small price to pay. Maybe something else would have done a better job with fewer side-effects, but I doubt it. And I am not going to take the risk of trying to find out. M 51 11 months
7/19/2009
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 4  depression & muscle pain Dry mouth, light headed - 30 mgs, went away after a couple of weeks. Sinking back into depression upped dose to 60, sweat more, body odor changed, sank again, upped dose to 90 mg. Seems to be okay. Lost 6 pounds (Yeah!) Using mouth guard at night, clenching jaw. I like Cymbalta, I have emotions again, which I didn't have with prozac. Also tried Lexapro for a while, gave me horrifying nightmares. I have better impulse control with Cymbalta, which may be why I lost some weight. The most startling side effect was the change in body odor. I have a very sensitive nose, was never able to use perfumes - I noticed soon after beginning the 60 mg regimen that my sweat smelled different, I noticed sweat stains on my clothing that didn't wash out. Also, I am now able to tolerate perfumes (certain ones) without headache or sneezing. Sense of smell is not as sensitive as it was before 60 mg. Seems odd to me, but that's the only change that has occurred, so I think it must be the drug. F 57 5 months
7/19/2009
 3  severe depression complete loss of appetite; nightmares; yawning; diarrhea I feel better emotionally already. I've lost a lot of weight and have a lot of self confidence. But I also have clear vivid nightmares every night at the same time. F 15 2 weeks
7/19/2009
 5  depression, anxiety nausea, constipation, weight gain I urge everyone who's just started taking Cymbalta and is experiencing side effects to hang in there. It takes a while for the body to adjust to this drug, but it really works, and the side effects go away or at least improve significantly. Good luck to all! F 50 9 months
7/18/2009
 2  anxiety, depression, sleep, pain None that I can see I have been on 30mg for 5 days now and I feel a little better and sleep a some now but but not what I expected I have called my doctor to see what is next since I am in no way happy with the results so far M 49 5 days
7/17/2009
 2  depression; post-traumatic stress GOIN ON: Insomnia, nausea, dizziness STAYING ON: Bladder pain, increased hunger, sugar cravings GOING OFF: Mood swings, flulike symptoms--nausea, vomiting, fever, chills I first thought this drug was a Godsend despite severe insomnia which lasted the first 3 months (I had never suffered from it before and then I was waking up around 3 AM every night). I had increased energy and a noticably more positive attitude. I even started to lose weight as the increased energy helped me to exercise more. However, as the insomnia decreased unfortunately so did the positive changes that had initially come with taking Cymbalta. My energy started to plummet back to my previous low levels. I was getting tired, moody, anxious--all signs of my depression returning even though I was taking the 60 mg a day without fail (upon waking each morning). Two physical side effects worsened over time--pain in my bladder that was horrible (I thought I had a bladder infection but I didn't) and increased hunger. With the hunger came INTENSE sugar cravings. I mean INSANE. The candy at the checkout stand never tempted me before, and now I was loading up on KitKat and the like. I HAD to have a milkshake everyday or something from Dairy Queen made with chocolate and drenched with extra chocolate (the people working there thought I was nutty for all the extra fudge I requested). Not surprisingly, I started to pack on weight from the sugary stuff and not having any energy to work out anymore. So I choose to discontinue the Cymbalta, decreasing the amount over a period of 3 weeks. Even doing that I had suffered the worst flu symptoms of my LIFE and I am still not over it. F 31 180 days
7/17/2009
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 5  Depression/Anxiety/Fibromyalgia Temporary decreased libido, decreased appetite, dry mouth, mild dizziness I LOVE Cymbalta. Like many others before me have stated, I have tried many anti-depressants over the years. Cymbalta is the first one to TRULY change my life. I was very irritable, couldn't concentrate, was always overwhelmed by work and stressed out at home. I felt I could never find any peace. I started out on 30mg for 30 days and then increased dosage to 60mg which I am still taking. I noticed an IMMEDIATE improvement within the first couple of days. I was happier, my moods were more stable, I could concentrate better than I had been able to in years. I am SO grateful for this medication and pray that it continues to work as well as it has for me so far. F 43 4 months
7/16/2009

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