CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2744 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Major depression No effect on libido, it was as strong as ever, but it killed my ability to orgasm...It felt like I would be climaxing and then just never happen. This MAJORLY SUCKED. This drug is also approved/prescribed for physical pain symptoms. For people posting they were lied to regarding its "antidepressant" status--this is not true. Read your insert, fools. Also-- DO NOT STOP THIS MED COLD TURKEY, YOU WILL FEEL LIKE SH*T! Read your instructions!! I used to take Wellbutrin XL but it stopped working during a very difficult period in my life after a few years. I started going to counseling and professional hypnotherapy, but it wasn't enough on its own after 3 months, so I started Cymbalta. This drug was successful combined with therapy to assist me in fully recovering from this depressive episode and I discontinued it 5 or 6 months later. A year and half later I still feel normal and stable! However, my ability to orgasm never seemed to come back the way it was pre-Cymbalta. It is not as intense and doesn't last as long as before. I don't know if this is something being affected only within my brain/mental processes or if the actual nervous system process to complete orgasm got its "firing pattern" mixed up slightly and hasn't re-educated itself like before (a neuromuscular phenomenom). Has anyone else had this problem? F 29 6 months
11/15/2006
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 1  Fibromyalgia, depression, insomnia Diarrhoea, strong nausea, insomnia, disconnected from myself, muggy, shaky feeling and unclear thinking. I'm so glad I found this webpage and decided not to put up with the horrible side effects and withdrawal symptoms. My God! I agree that such violent reactions from your body cannot lead to anything good! Great if it works for somebody, however I'd personally be very worried all the time thinking which of my symptoms are side-effects due to the drug. I have an instinct about anti-depressants that they really screw with your mind and body in a sly way. I thought Cymbalta seemed like a good idea because the indication was similar to Lyrica (neuropathic painrelief), but I didn't know about the side effects. They sound like a waking nightmare. After 24 hrs from taking it I still feel queasy and weird, really drugged. I have severe insomnia and don't want to risk getting worse. I also have chronic diarrhoea already as it is. I'm also not sure I'm depressed, probably more in pain, distressed and stressed out than anything. Tranquillizers work better for me. This drug seems to speed you up. Al F 40 1 days
11/14/2006
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 1  Fibromyalgia, fatigue, insomnia,dep Diarrhoea, strong nausea, insomnia, disconnected from myself, muggy, shaky feeling and unclear thinking. This is defenitely a DRUG, I'm not even sure it's a medication in the real sense. It causes more upheaval in the body than anything I've tried. I'm so glad I found this webpage and decided not to put up with the horrible side effects and/or withdrawal symptoms.I agree that such violent reactions from your body cannot lead to anything good!I'd also be worried all the time wondering which of my symptoms are side-effects due to the drug.I have an instinct about anti-depressants that they screw with your mind and body in a sly way.I thought Cymbalta seemed like a good idea because the indication was similar to Lyrica (neuropathic painrelief),but I didn't know about the side effects.They sound like a waking nightmare. After 24 hrs from taking it I still feel queasy and drugged.I have severe insomnia and don't want to risk getting worse. I also have chronic diarrhoea already as it is. I'm not sure I'm depressed, probably more in pain and distressed than anything.Lyrica and tranquillizers work better for me. This drug seems to speed you up. Although I'm very fatigued I also tend to get wound up, so taking something that stresses the F 40 1 days
11/14/2006
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 3  Depression, pain from neuropathy Extreme sedation, inability to move, excessive sleeping. Digestive tract discomfort which has lead to a flare up of IBS. May be a good drug, but I can't take it anymore because of the sedation and stomach problems. F 28 2 months
11/13/2006
 1  Anxiety/Fibromyalgie Awful! Only took one 20mg pill in the morning. Had strong, persistent agitation that lasted the day. Nausea and chills too. At night is when it got worse. Twelves hours after I took it I started getting spasms, twitches and uncontrolable shakes. I woke every 3 hours to these waves of ... terrible sensations. It's hard to describe but that was one of the longest nights I've had in a long time. Seriously considered going to the ER. Only reason I "weathered" the night is because I've had much worse days from my CFS/Fibro. I can't believe people actually take this medication. M 35 1 days
11/12/2006
 1  Fibromyalsia & Depression Insomnia, can't reach organsm. All my hair is falling out. I don't feel depressed anymore (except for my hair loss) F 51 3 months
11/11/2006
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 2  depression Severe and extreme nausea I only took one 30mg dose and had an extreme adverse reaction; it knocked me off my feet F 55 1 days
11/10/2006
 2  depression Severe and extreme nausea I only took one 30mg dose and had an extreme adverse reaction; it knocked me off my feet F 55 1 days
11/10/2006
 5  Major Depression None Worked the best of any medication, including Effexor. I have just begun taking 300mg Wellbutrin to suppliment the 60 mg Cymbalta; due to quitting tobacco and increased emotional stresses. M 43 16 months
11/8/2006
 4  Nerve pain in Back (Trigger Point) Loss of sex drive was the most pronounced side effect. Tired in the first 2 weeks, insomnia and dizzyness. Otherwise felt great. Have gone on/off the drug 3 times and not experienced significant problems. Very positive impact on pain - I have had chronic back pain for over 10years, this is the only thing that has worked. Positive change in overall attitude and stress. Only downside is the sex drive. M 33 3 weeks
11/7/2006
 5  bipolar II Fairly chronic gastrointestinal discomfort (gas/bloating), rapid pulse, panic attacks, sweating/feeling feverish, emotional numbing. Cymbalta has been by far the best anti-depressant I've ever taken. It put a spring back into my step. Like all these drugs, though, it is nearing the end of its usefulness. I've been on it close to 2 years and am now having more side effects than benefits. I think what 'killed' it for me was when I was raised to 90 mg. Family doc said psychiatrists like to get people to that dose, but that's where the heart problems begin. If it works for you, enjoy it for as long as it lasts, and don't worry too much about getting off of it. Just do a slow taper and you should be fine. F 32 2 years
11/5/2006
 1  Depression I had other-wordly out of body experiences like I was watching myself. I felt like I was buzzing and physically hyped all the time.Also, more importantly I felt very angry, had more dark thoughts than ever. It was the first time in the history of my depression I considered suicide-or hurting someone else. It only took a week for me to realize I needed to STOP this med-before I hurt myself or someone else. I have been on Zoloft, Celexa and Lexapro without any side effects except drowsiness and nausea. Still looking for the best solution for me. F 59 7 days
11/5/2006
 1  Depression I had other-wordly out of body experiences like I was watching myself. I felt like I was buzzing and physically hyped all the time.Also, more importantly I felt very angry, had more dark thoughts than ever. It was the first time in the history of my depression I considered suicide-or hurting someone else. It only took a week for me to realize I needed to STOP this med-before I hurt myself or someone else. I have been on Zoloft, Celexa and Lexapro without any side effects except drowsiness and nausea. Still looking for the best solution for me. F 59 7 days
11/5/2006
 1  Neuropathy Wired or Tired depending on dose. Lightheadeness, dizziness. Extremely high blood pressure upon discontinuation. Duloxetine (brand name cymbalta) causes autonomic and endocrine changes due to the reuptake inhibition of norepinepherine. Upon cessation of the drug it causes autonomic disregulation do to the extreme decrease of norepinepherine on the 5-HT neurotransmitter. Since cymbalta has an extremely short half life it can make you extremly sick upon cessation. If necessary for MDD (major deppresive disorder) take a non-SSNRI tricylic, though they can have the same side effects. 99% of doctors are unaware of the autonomic disturbances caused by duloxetine, and 100% of the Eli Lilly reps have no inkling of it. M 29 7 months
11/4/2006
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 5  Depression Mild loss of appetite, more intense orgasms. Lost 5lbs in 3 weeks. I was on Prozac for 3 years prior. I can feel the difference after only 3 weeks. Nothing really specific, just better at handling stress and I don't "mope around" as much. Don't feel as blue. M 37 3 weeks
11/2/2006
 3  depression first week or so, major tremors after it was taken (the first time I took it it shook uncontrollably for 3-4 hours, this effect faded after each sucessive dose), sweating, restlessness, anxiety, fatigue, nausea, harder to reach orgasm the first antidepressant I've taken that actually seems to be helping somewhat, at least in combination with other meds, after prozac, celexa, wellbutrin, etc it was a relief to have something that seemed to cause some improvement, although the side effects nearly caused me to quit before there were any beneficial effects M 20 30 days
11/2/2006
 3  leg pain due to spinal cord damage The first few weeks I had night sweats, vivid nightmares, constipation. The months brought more WEIGHT and HAIR THINING! The burning and leg pain returned after 6 months. I was not taking it for Depression, but became very blaza about life. I did not care if I died. I was not sucidial but nothing seemed important. I felt it was time to come off! F 38 6 months
11/2/2006
 1  Fibromyalgia Well I was talked into this after a year of trying something else. Read my comments and others comments. Right now, symptoms include severe night sweats, vivid dreams/nightmares, severe dizziness, stuffy head/achy/fever, chills, etc. Sometimes cannot stand and/or walk. I was grinding my teeth before this; much worse now that I'm not it. RICO and/or other class action lawsuit is in order here! Stop the ride, I want off! I was diagnosed with fybromyalgia last year and tried an experimental dosage of pregabalin (if I spelled that right). After the trial, I tried a regular dose of Pregabalin. It helped with some of the pain, but still felt like it was missing something. I was told about a Cymbalta trial, so I waited 30 days from the end of the other pills and started the trial. I only lasted a few days on this trial; the pills were MURDER on my stomach. Then I was given a 20mg dose to start; increasing to 2-20mg pills when I could tolerate it. I had a few odd aches and pains about a month into the Cymbalta, and a little sleeping difficulty. I was also afraid to take them on an empty stomach, so usually took them with food around 4pm (my wife and I are both full time students and we eat that meal before classes every day). M 40 5 weeks
11/2/2006
 1  Fibromyalgia Well I was talked into this after a year of trying something else. Read my comments and others comments. Right now, symptoms include severe night sweats, vivid dreams/nightmares, severe dizziness, stuffy head/achy/fever, chills, etc. Sometimes cannot stand and/or walk. I was grinding my teeth before this; much worse now that I'm not it. RICO and/or other class action lawsuit is in order here! Stop the ride, I want off! This week though, I had the MONSTER of headaches and stuffiness out of nowhere. Monday I was starting to feel foggy; couldn't complete simple experiments in school. Tuesday morning my head was swimming so bad I couldn't even walk. Head was stuffy, throat dry, chills, fever, it was bad. aches and pains were worse than what they previously were; back/neck were killing me besides my head throbbing. I skipped my dose Tuesday and Wednesday, then took it as early as I could this morning. I was having terrible night sweats; getting up twice at night to change clothes and go to the bathroom. I'd get the shakes/cold trembling out of nowhere. Even at times during the day I'd sweat profusely then stop. It was almost like my hypothallamus intermittently lost control of my bodily temperature. M 40 5 weeks
11/2/2006
 1  Fibromyalgia Well I was talked into this after a year of trying something else. Read my comments and others comments. Right now, symptoms include severe night sweats, vivid dreams/nightmares, severe dizziness, stuffy head/achy/fever, chills, etc. Sometimes cannot stand and/or walk. I was grinding my teeth before this; much worse now that I'm not it. RICO and/or other class action lawsuit is in order here! Stop the ride, I want off! I emailed the doctor, and am awaiting instructions. I would think it was all the Cymbalta EXCEPT that my wife has a few odd aches and pains too. Now, if Cymbalta is causing some sort of weakness in my immune system that ALLOWS normally weak viruses to grow, that could be a problem. Our bodies could normally encounter thousands of viruses and we'd never know it. But it could be that Cymbalta enables certain, normally ineffective viruses to take hold in our bodies or mutate into something that can affect normal, healthy people. I don't know. Things may change when I go to the 60mg dose here in a few days. I'm not sure. But seeing what other people have been saying for side-effects, I'd have to agree with most of them. I can't attribute all the symptoms to Cymbalta, nor can I say which ones are truly sickness related or which ones are purely Cymbalta. But I will say that I DO seem to have gotten 'sick' twice now in a relatively short time, which NEVER happens with me. And my M 40 5 weeks
11/2/2006

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