CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Depression Morning fog, oversleeping Helped my depression very much (I was taking Celexa before but still experiencing depression). However I now have problem of morning fog. F 30 2 months
60 mg 1X day
3/29/2013
 5  Depression and Pain from Fibromyalg Cymbalta has had No Side effects that I know of for Fibromyalgia. - Lyrica is different, but is also FDA approved for Fibro and I had to lower my dose to alleviate the side effects of sweating at weird times profusely. - Savella is the 3rd drug approved for Fibromyalgia & this drug I could not tolerate as I sweat constantly with this medication & woke up to a soaking wet bed every morning. I did try this earlier in my life when needing a Depression drug to combat the Constant Pain from Lumbar Stenosis in my lower back, that caused pain down the sides of both legs. However, I only gave this med 2 weeks to work & I did not notice improvement and stopped taking it. I was not having Fibromyalgia symptoms at the time. - Now that I have been diagnosed with Fibromyalgia for the past 4 + years, my beloved Pain & Physiatrist Dr. Cathy Gao, recommended that I see a Psychologist to see what was causing my Depression & if he thought that my problem was in fact related to the Fibro & he ultimately prescribed the Cymbalta again, but had me stay on it for 4 weeks this time. He filled me in about Cymbalta & how it is designed to work for Depression and as a Pain Blocker & that it is only 1 of 3 drugs approved for Fibromyalgia. - After 4 weeks, I had fantastic results to complement the Lyrica that I had already been taking. I am happy to say that I have been able to continue working since that time. With this being said and my having 3 Surgeries to alleviate Lumbar Stenosis from L3~S-1, my Surgeon told me that I am the only Patient he has that still has a Job. Dr. Paul McAfee is one of the Best in the Business of Orthopedic Surgeons & he did a Fantastic job of inserting 2 Prosthetic Disks, 3 rods & 6 screws over the 3 Surgeries, with my last being about 1.1/2 years ago, and he had a new way of entering that was far less invasive, called an X M 46 2 years
60 1X day
3/24/2013
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 1  Depression started on 30 and felt a little weird but doc increased me to 60 and i felt miserable.. like it was going to jump out of my skin, reduced back but killed my sex drive, freezing cold all the time, vertigo/ dizzy spells, emotionally dead / not feeling anything, woke me up early but i would tire out again halfway through the day, became very easy to startle .. sudden movements or loud noises made me jump out of my skin, started having so many aches and pains that I began to be treated as though I may have Fibromyalgia... one of the very conditions it's supposed to treat!! I was apparently lucky, i quit cold turkey about 9 months ago and didn't have the horrible withdrawals people seem to, then again i already felt so horrible i just may not have noticed. I'm just beginning to get some of my sex drive back now, but the constant aching all over is gone as are the chills and the episodes of vertigo. Every time i complained to my dr he just told me to drink more water or added another drug. At one point i was on three additional medications just to treat the side effects of this one! F 38 1 years
30-60mg 1X day
3/23/2013
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 1   If you are wondering why you so quickly feel better (pain free) ask a chemist to explain to you just how close to "ecstasy"the notorious date rape drug this actually is! and the reason that it "quits working" and you have to go up in dosage after awhile is because your brain craves MORE. THIS is not a medication it is a drug, the withdrawal is worse than from heroine a DEA agent told me ! BWARE!!!! Dangerous Drug !!!! F 64 6 months
60mg 1X day
3/20/2013
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 3  anxioty Sikness agitation insomnaa dizzy F 55 8 days
20mg
3/19/2013
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 2  Migraine prevention I have bipolar II and when I was on 60 mg it caused me to have thoughts of hurting other people. I went down to 40 mg and that side effect went away, but the medicine didn't help me very much with my migraines so I went to Tizanidine which has helped a lot. F 42 60 days
40 mg 1X day
3/16/2013
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 1  Depression Post Partum Out of body experience; flat affect (had to literally tell myself to smile or laugh or show affection), felt disconnected, sweating, weight gain. Felt like I was STONED on this med - a horrible, disconnected feeling. Felt no pleasure whatsoever when interacting with loved ones. Was just going through the motions of life. No conflicts but no joy. Just there. F 43 1 years
1X day
3/16/2013
 5  depression side effects ONLY when missed a dose. mild brain zaps I have read so much about withdrawal symptoms, I hope I can always afford this medication. It works so well for me, and I don't want to get off it. F 58 4 years
60 mg 2X day
3/14/2013
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 1  depression, back=neck pain Extreem sleep loss, pain was worse, confusion, dizziness, nausea, sweating, freezing and NIGHT TERORS! Only on this drug for 2weeks, started at 30mg then 60mg, quit takeing it at two weeks! The affects for me were instant and in a 7 day time I only got 25hours of sleep, pure Hell! F 54 2 weeks
30/60mg 1X day
2/28/2013
 1  PTSD anxiety and Bi-polar nausea, vomiting, fainting, dizziness, fatigue, rash, phantom smells, loss of all motivation, loss of appetite, irritable, extreme sweats and hot flushes quickly changing to shivering flu like symptoms, My illness made my life uncomfortable. the drug made it intolerable. coming off the drug made my life not worth living and was close to ending it. the withdrawal (even when reducing gradually) is a living hell and hell visits you in your sleep in a bloody horror movie way. I hate this drug with a passion. after being off of it for just 2 days and despite the horrifying withdrawal symptoms, my spirit and will to live returned and i actually got out of bed for the first time in 8 weeks and cooked a meal. F 50 9 weeks
60mg 1X day
2/22/2013
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 3  Chronic pain Side effects include - Periodic sweats Severe muscle twitches - 200 - 500 +/day-night 24/7 Did not help with pain...helped with depression feelings very well but side effects were too much. M 50 90 days
3o mg 1X day
2/20/2013
 3  Depression, Anxiety, fibromyalgia M 52 3 weeks
30mg 1X day
2/20/2013
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Patient History
 4  Major depressive episode (Bipolar) Stoned feeling initially, unsteady, hallucinated, anxiety. All within the first six weeks. Decreased to nothing but weight gain a pain in the bum. Despite the nasty side effects, I am very PLEASED with this drug. My depression has resolved and the weight gain I can deal with. I am currently decreasing dosage under doc supervision as the pill has done it's work. I am relaxed, and feel normal for the first time in around two years. This drug, like all mood effecting pills, needs time to work and also you have to give it time to settle in initially, and that means tolerating a little discomfort. If people educated themselves on what they were likely to expect and didn't freak out after one day of sweating I am sure a few more people would benefit. My only gripe is the weight gain. And I can deal with that when the pills is out of my system. F 39 6 months
60 1X day
2/12/2013
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 1  diabetic neuropthy pain absolutly the worst med ive ever taken,,i was a zombie,,in pain constanly,,could not get off a chair or raise to my feet,walked with a cane,,couldnt roll over in bed,,had to get out and back in,my hubby had to lift my legs onto bed,,i was ready for a psyc hospital,,it was terrible,,,, F 77 5 months
30 1X day
2/8/2013
 2  anxiety, depression Hitting the wall with too many life problems resulted in the discontinuation of Effexor and immediately on to Cymbalta. At 60 mg. 1x day for a month I felt fine. Doubling the I felt emotionally flat, no emotion. I had impulsivity, I think just to see if I could get some feeling. Constipation was awful with a large weight gain that put me out of all clothes save sweats. I had balance issues, and would get the shakes before my second dose. I did get permission to cut the dose to 60 mg 1x a day, but it has been pure hell going down as I have a whole set of new side effects. I am exhausted and sleep with vivid dreams such as I never had before, I am a step away from a migraine daily. I have sweats and then freeze. My heart races at rest and I am getting moody, even losing my patience with my dog. I have joint pain and can hardly move. Originally at 60 mg I felt great, and until 2 days ago, I didn't know I was on the highest dose. In hindsight, I would have never started it. I also had a sudden hearing loss experience and am now totally deaf in my left ear; it is sensioneural and will never return. I don't know if it is related but I lost my job because of it. I would like to know if anyone else experienced a hearing loss as my brother-in-law is a doctor in an unrelated field and he has never heard of such a thing. If you did, please contact me. Thanks. F 56 5 months
60 mg 2X day
1/22/2013
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 5  Major Depressive Disorder,Fibro Sweats,shakey I was having suicidal thoughts constantly. I cried all the time. Finally I have hope! I feel so much better. I think positive thoughts and have been able to get out of my house and actually see people. This medicine so far is a miracle drug for me. My appetite has dropped down to hardly nothing..which is good because I gained weight from Seroquel. I might need a higher dose for my anxiety though. F 43 2 weeks
30 mg 1X day
1/21/2013
 4   Suffering major depression and severe insomnia. Within a week I was sleeping well again as it reduced my anxiety and panic attacks and took the edge off the depression.Side effects were low libido and uncontrollable body twitches at night and when resting. The Cymbalta really helped.It took me from wanting to die, or thinking that I would cut my legs off if it would ease my depression. I have now gone pretty much cold turkey after 5 years on it because I am not sure if I am still in a depressive frame of mind.Unfortunately issues causing the depression are still there.Withdrawal symptoms are headaches, dizziness, and crying at the drop of a hat. M 50 5 years
60 1X day
1/13/2013
 2  Anxiety & Depression Insomnia, Nightmares, Exhaustion, Initial Appetite Loss, Severe agitation Started 30 MG - 1st night, horrible nausea. Things were fine, increased my dosage. Stopped being able to fall asleep, stay asleep, constantly exhausted, vivid dreams and nightmares, extreme agitation with everyone and everything F 20 3 weeks
60 MG 1X day
1/7/2013
 3  Chronic pain Headaches, dizzyness and sleepiness Very difficult to come off- lots of unpleasant withdrawal effects even when reducing by 10% every 2 weeks M 25 12 months
60mg 1X day
1/3/2013
 1  serotonin syndrome My blood pressure went up to 165, I could not breath and I could not see clearly. Horrible drug. I do not understand why doctor gave me this poison after diagnosing me with high serotonin. Cymbalta raised serotonin even more. Stay away from this drug, it can kill you. M 52 1 days
30 1X day
1/3/2013

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