CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Social Anxiety First few days, I was mentally not here, zombie kinda, after a few weeks I noticed that my anxiety wasnt as bad, not even close actually, lots of yawning, appetite suppressed a bit, but not near as bad as others like lexapro. Sex drive was not here, this bad bad bad side effect went away after 2-3 weeks. Extremely impressed with cymbalta. Doc started me out on 60mg (not sure why not 30mg since im a first time user) but after a few days of my body getting used to it I was okay. I was also put on 10mg valium, these two combined have taken me from wanting to stay inside the house every day to actually wanting to be productive. I always thought everyone was staring at me, now I really dont much care if they were or werent staring. Also I had extreme intensified dreams. Never had this before, very vivid, almost beleivable dreams when I wake up. This is a side effect I enjoy. Wondering if anyone else had this same effect? M 23 30 days
10/8/2006
 4  severe anixiety/panic disorder/ocd loss of appetite, sleepy a lot (especially afternoons...usually after eating), some difficulty sleeping, vivid dreams or nightmares, inability to orgasm through intercourse, slow orgasm time otherwise, night sweats, headaches started taking cymbalta 30mg june 15, 2006, had dosage increased to 60mg july 29. so, been on cymbalta for total of about 4 mo, but 60mg dose for 2 mo. was prescribed for severe anixiety/panic disorder/ocd by my GP (general practitioner). had increased gag reflex & loss of appetite for first wk starting both dosages, but then went away thank goodness. most of my current side effects are not everyday, but enough. Not sure if headaches are from this, could be from tmd (teeth grinding), pillow not fluffy enough or glasses prescription. don't wanna go back to 30mg cuz still experienced occasional panic/anxiety attacks. right now, benefits far outweigh negative, cuz i function w/no attacks at all, YAY FINALLY! only anxiety/nervousness i get now only affects my appetite (every once in a while)…not as hungry. any help or recommendations w/sexual side effects, headaches & night sweats would be great! F 25 4 months
10/7/2006
 1  moderate to severe depression My hair is falling out like crazy. Now I am very, very worried. My doctor took me off of it. Iniatially I thought this was a answer to a prayer. This medicine made me feel terrific and I dropped 54 lbs. I emotionally felt like a new person. Finally I felt hope in my life. It also helped with my pain from my osteoarthritis. I would've been a spokesperson for the product. Now, my hair is falling out at a rapid pace. I want to know will this ever stop, or will I be a bald female? Does anyone know? Has anyone's hair come back after they stop taking it? I'd love to have my mind eased on that question. My doctor took me off it cold turkey to absolutely make sure this is my affliction. I have taken Effexor and had terrible nightmares and gained weight. I tried Welllbutrin and got a terrible case of hives. Does anyone know if the hair loss would've eventually stopped? I loved Cymbalta and everyone noticed my happiness, but I'm not quite willing to be a bald woman. I am single and the bald thing wouldn't really work for me since guys seems to be partial to women with h F 46 4 months
10/7/2006
 5  Depression/Anxiety Dry Mouth, Severe Drowsiness, Loose Stoole, Headache, Loss of Appetite, and Urges to Yawn a lot. I feel great for the first time in a long time. I've lost 4lbs. so far of the 25lbs. that I gained with the depression which is wonderful! My head started to ache the last day of 30mg of the medicine. Hopefully now that I've moved to 60mg this will stop. The side effects are well worth the benefit of this drug. It's great! Even though Cymbalta makes me drowsy and sleepy it's a different kind of sleepy and drowsy. It's definately not depressed exhaustion. Depressed exhastion is PAINFUL! Drowsy and sleepy I can deal with. F 29 8 days
10/6/2006
 1  depression/pain Worked great at first then sucker-punched me by significantly worstening the depression; induced suicide ideation; terrible, 24/7 headache that nothing touches; sweating, sweating and more sweating all the time; induced body aches; 100's and 100's of "brain zaps" and blackouts all day long; blurred vision; anxiety x10 worse than before use of the drug; complete zombie-like state -- interested in absolutely nothing; trashed my spirituality; weight gain; no sleep in a long, long time, even with ambien. This drug robbed me of a year of my life and replaced it with intolerable sickness. Took therapeutic dose for six months and then spent another six months of pure hell weaning and withdrawing, and its still there. Never before have I have been so sick, and it has been a long time since I quit its use. I FEEL SO DECEIVED BY THIS DRUG. I WILL LET OTHERS USE THE APPROPRIATE ADJECTIVES TO CHARACTERIZE JUST HOW HORRIBLE THIS STUFF IS; THERE ARE JUST NO WORDS STRONG ENOUGH FOR ME TO EXPRESS MY DISDAIN FOR WHAT IT HAS DONE. I'VE TRIED DESCRIBING IT AS RAT POISON, BUT NOW FEEL LIKE APOLOGIZING TO THE RATS. IT IS ABSOLUTELY NOT WORTH THE GAMBLE TO TRY THIS DRUG BECAUSE YOU HAVE A GOOD CHANCE OF BECOMING ILL LIKE YOU HAVE NEVER BEFORE EXPERIENCED IF YOU QUIT USING IT, WHICH IS LIKELY, BECAUSE IT FIRST QUITS YOU AND YOU INSTINCTIVELY KNOW THAT IF YOU CONTINUE ITS USE YOU WILL SURELY DIE. M 52 6 days
10/6/2006
 5  severe clinical depression none worthy of mention I was beyond depressed due to my wife of 15 years filing for a divorce. At age 50 and with 3 kids, 4,12,14, I was devastated and almost suicidal. I tried Lexapro with no success. Switched to Cymbalta and after 3 weeks, it was almost miraculous how much better I felt. Not happy-mind you- but light years of improvement and coping with my sadness. Remarkable product, and I mean that sincerely. It was a life saver for me. M 50 4 weeks
10/5/2006
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 5  Depression, Fibromyalgia A little nausea first week I was on it, dry mouth, makes me a bit 'wired' I was first diagnosed with depression about 20 years ago, and of all the many antidepressants I've taken, this is the first one with side effects I found tolerable. Also, it doesn't 'flatten' my mood like other antidepressants have. As an added bonus, it has greatly decreased my fibromyalgia pain. It doesn't cause me sexual side effects like Zoloft did either. For me personally, Cymbalta is a godsend. F 35 1 months
10/4/2006
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 5  Major Depression Nausea and loss of appetite, sweating, blurred vision, brain fog during the first 10 days or so, weight loss, dry mouth, all of which have leveled off a bit, except the weight loss, which keeps going!!! Lost 10 lbs during first 2 weeks. Brain fog a little weird and hard to describe. No appetite much, but not complaining. This med has saved me from the cave I had let myself get into. I am more patient with my kids and tolerate stress better. F 31 15 days
10/2/2006
 2  severe long trm dep w/min bp hard transition from lexapro then noticed improved mood. But sick all the time from insomnia and also physically feel like I have the flu. Seems like the anti depressive effect was very very temporary with me and now just feel like a total mess. This drug has not been studied on nearly enough people. We are allowing ourselves to be the guinie pigs. F 46 4 weeks
10/2/2006
 4  Depression First day nausea..but started taking with a ginger capsule, now no problem with nausea. I feel happier, less "blue" I do have problems sleeping thru the night (I'm writing this at 4:30 am) but am hoping with continued dosage, that will subside. I have noticed decreased appetite and leg twitching (can't sit still). Hopefully these side effects will subside after a couple more days/weeks. One other thing is dry mouth..none of these side effects bad enough to discontinue drug so far. F 50 8 days
10/1/2006
 1  DEPRESSION/FIBROMYALGIA WEIRED FEELING IN HEAD , FORGETFULLNESS /SPACEY/UNABLE TO CONSENTRATE VERY SCARY FEELING.CONFUSED THIS DRUG IS NOT ONE THAT I WOULD RECOMMEND TO ANYONE.I HAVE BEEN ON ZOLOFT 100MG FOR 8 YRS AND WAS SWITCHED TO CYMBALTA 60MG.AFTER ABOUT FIVE WEEKS I WOULD GET THIS SPACEY FEELING, UNFOCUSABLE (IF THATS A WORD) BUT THAT IS HOW I FELT.THE DR TOLD ME TO TAKE 30 MG FOR ABOUT 4 DAYS THEN STOP ALL TOGATHER , OH I THINK THAT WAS A MISTAKE.I AM AFRAID TO DRIVE I FEEL THAT MY VISION IS OFF VERY SPACEY.I HAD A MRI / MRA DONE LAST WEEK BECAUSE I WAS NOT SURE WHAT WAS WRONG BUT READING THIS BLOG IT HAS TO BE THE MEDS.I WENT TO A NEUROLOGIST YESTERDAY TOLD HIM WAS COMING OF CYMBALTA AND HE SEEMS TO THINK IT IS THE WITHDRAWLS FROM THIS MED HE TOLD ME NOT TO USE ANY ANTIDEPRESSENTS FOR A WHILE UNTIL I CAN GET THAT WEIRED FEELING GONE.I WAS VERY CONFUSED FEELING TRYING TO WORK THIS WAS VERY HARD BECAUSE I COULDN'T REMEMBER WHAT I WAS SUPPOSE TO BE DOING.THIS DRUG NEEDS TO BE REEXAMINED.09/28/06 M 35 45 years
9/29/2006
 1  Neuropathic pain Decreased libido, difficulty having orgasm, SWEATING, hot flashes, jittering, decreased apeptite Can't handle the SSRIs... the decreased sex drive is unbearable. F 26 9 days
9/29/2006
 4  depression First 3 months, night sweats, vivid dreams, reduced libido and diffuclty reaching orgasam. 4th month developed chronic diarrhea, muscle twitches/jerks and fasciculations that could be related to dehydration from the diarrhea. All other causes of diarrhea were eliminated (bloodwork and other biological tests OK). Weird thing is I feel "OK" most of the time except for being tired, twitchy and always hungry (due to the diarrhea). I was willing to tollerate the other side effects, but this has got to stop. Otherwise, the medication seemed to work great! Was first time I've been on an antidipressant that didn't just make me feel "flat." I can enjoy both the highs and lows, without getting stuck or feeling dispondent for no reason. However, I wonder if how my body is metabolising the drug has changed, causing the side effects. I'm kind of disappointed because I was so pleased with it up to this point. F 36 4 months
9/27/2006
 1  Depressive disorder Made depression worse I Had so much hope that it would work that I failed to notice my depression worsening .. F 20 5 weeks
9/27/2006
 2  Depression Tingling sensations in my hands and feet and head when it was time for another pill. Felt off. Off balance or not there for a minute type feeling. Hard to explain. F 42 9 days
9/25/2006
 4  RSD/neuropathic pain only first 4 days: nausea after 1 weeK: dry eyes, sexual dysfunction now after 5 weeks: wake up multiple times in night, intense dreams (violent) i have gained a life back after totally disabling nerve pain that was not worth living for anymore! amAZING. the relief is worth the effects on my eyes and sexual function. BUT this late-onset insomnia is going to be a dealbreaker if it continues (i have had that for 1 week) 31 40 days
9/21/2006
 1   Racing heart, heart palputations, felt like heart failure. Paranoid. Anxious. Dry mouth. Muscle twitching in leg. Was prescribed 30mg. Only took 30mg for 1 day and that was enough. Scared stupid with the heart pain and palputations that I experienced. Thought I was gonna have a heart attack. *USE WITH CAUTION* M 34 1 days
9/20/2006
 5  "classic" depression nausea and dizziness at the beginning, I went from 30 mg to the 60 mg and that works wonders - increased sweating, increased libido but difficulty achieving orgasm This drug is fabulous. I was in a whirlwind crying for no reason, angry the next and then just nothingness. It has definitely lifted my mood and helped me adjust to issues in my life. I hate the difficulty reaching orgasm that has never been a problem before. If I miss one dose, I get dizzy, if I miss 2 doses I get dizzy, nauseaus, blurred vision, headache, and moody. Don't miss your doses. 60 mg wasn't doing it altogether so now I take Wellbutrin with the Cymbalta. F 32 10 months
9/15/2006
 1  no,i was lied anout the drug the company representative never told me that this is antidepressant drug.it was recommended for diabetic neuropaty pains. but as i read the comments of others who took cymbalta,i dont think i will not take the chane on thewithdrawl sysmptom M 53 0 days
9/14/2006
 4  Depression/ Anxiety SWEATING, dizziness with missed dose, leg nervousness, weight loss initially. Slight forgetfulness or difficulty concentrating. Less side effects than Effexor but just as effective if not more. Definitely took me off the emotional roller-coaster I was on from PMS. F 42 6 months
9/12/2006

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