CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Pain/Nerve Damage Weight Loss (40lbs.). Loss of appetite. Abdominal pain. Diariaha. Headaches. Dizziness. Nausa. Very recluse. No social life. Pain/Nerve damage symptoms reduced. Very calm/mello. M 49 2 months
11/8/2007
 5  leg pain, insomnia, depression mild nausea, loss of appetite, rare occasions of slight dizziness, clenching of teeth & related headaches, sleeplessness at first I LOVE Cymbalta! Within an hour of taking the very first pill, I felt 1000 times better! Since then I've started dieting and exercising which I'd never cared to do before - resulting in weight loss of 10 lbs so far. I'm much more able to deal with my emotions, and can communicate more effectively. I'm able to put things into perspective better, and have really seen a difference in myself lately. I don't know how I ever lived without this drug - it's amazing! F 28 6 weeks
11/7/2007
 1  Fibromyalgia It tore my stomach up. The pains were terrible and for 6 weeks you would most likely find me in the bathroom! F 59 4 weeks
11/7/2007
 4  Depression/Anxiety naseated in beginning, loss of appetite (first few weeks), sleepiness (never really went away), vivid dreams, loss of libido, weight gain Cymbalta made me feel "normal" again. It was a very good drug for me in the beginning, helped me focus, make decisions After several months doc increased dosage. Did gain weight (about 15 lbs while on it and 30lbs when I went off - Yikes!) Had to go off when i lost my insurance. Withdrawal wasn't too bad, I cut down slowly. A few brain zaps and a general feeling of "unwell" for a few weeks. Not nearly as dramatic as many people have described. F 35 8 months
11/6/2007
 4  depression, anxiety, stress loss of apetite, weight loss My crying stopped, less headaches, less stress and so I think this also helped improve my overall blood sugar control(type 1 diabetes with pump), can deal with things better. If I take it with food at night, it puts me to sleep in 20-30 minutes. Lost 12 lbs. in two weeks, but also taking Symlin. F 26 3 weeks
11/6/2007
 2  Dpression a little sleepy the first week i've been taking 60mg of cymbalta for about two months, and am surprised by all the very negatvie and very poitive comments. So far i have felt nothing, i had been smoking pot for awhile, and i think that could be a reason i'm not feeling any affects, i've stopped smoking for about two weeks now, and am going to wait to see if i feel anything yet. I don't see how so many people could be impacted by it, while i feel absolutley nothing. If anyone has any similar experiences or suggestions i would love an email, cause i'm not sure what to do here. M 17 2 months
11/6/2007
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 1  Fibromyalia / depression Extreme exhaustion, feeling like I am not in life but out of body looking out. constipation, sleeping 18 hours a day and just depressed. PLEASE THINK TWICE BEFORE YOU TAKE THIS MED!!! I have had Fibromyalia and Neuropathy for 25 years and heard that Cymbalta is a life saver because it helps with the nerve pain and the depression that goes along with have the pain 24/7 so I thought what the hell I'll give it a shot. The first 2-3 weeks were heaven. I can't tell you how good I felt for those few weeks. Then one day I woke up with no energy and just felt tired, really tired. I chalked it up to the fibro and the doc told me to go up from 20mg to 40mg. I was also taking it with Elavil which I have been told you should never do. Anyway it has been 2 months and I have never felt worse in my life. My pain is all over my body and it takes every single cell in my body to get up in the morning. I HATE THIS DRUG AND I WILL GET OFF OF IT NO MATTER WHAT THE WITHDRAWALS BRING. I have a trip to HA to plan and I still don't have the energy to do that so you know it must be bad. F 3 days
11/6/2007
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 1  Anxiety 1st 2 nights I slept and didnt get up for only about an hour, vivid dreams of falling, dry mouth, constipation, trouble urinating, sweats, tremors of body and eyes and now that I stopped taking it I have a massive headache... Dont take this medication! Horrible. I wouldnt recommend it to anyone. Ive tried paxil, lexapro and now this and nothing is helping me. I am also on xanax its the only thing that keeps me sane... F 35 3 days
11/5/2007
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 1  Fibromyalgia Incredible yawning nonstop. Tongue, throat swelling. Weird.....Constant yawning with my throat closing at the end of the yawn. VERY SCARY! Also, noted that when trying to talk or "sing" my tongue felt very thick and my spouse said that I didn't "sound" right. Finally, took benedryl after the third dose and woke up with all those bad symptoms gone. Only took three doses and NO MORE for me. Doctor said, Yes, that is from cymbalta. Stop taking it! F 40 3 days
11/5/2007
 2  Depression, OCD Constant gas, foul deadly smelling gas, continual stomach problems, cramping, stomach pain, night sweats. Was on 40 mg Prozac for years, Dr. advised changing to tackle OCD issues. After two days of being on Cymbalta, I noticed an increase in flatulance and the worst smelling gas I've ever smelled. I truly could not BELIEVE that smell was coming from me, it was as if something had died inside of me. Worse though was the stomach trouble; when I ate or drank anything, I was racing to the bathroom with cramps and threat of diarrhea. Usually it was alot of pain and very little production, I can't stress enough how irregular I became. I found myself in the bathroom eight times a day or more for two months, soft messy stools. Switched back to Prozac 40mg, after about 4 days off of Cymbalta the gas went away, however my stomach is still cramping and digestion very poor (9 days off). No side effects from withdrawal, however I switched back to Prozac, so maybe this is why? F 38 2 months
11/4/2007
 4  Depression, anxiety nausea, loss of appetite, disconnected, a lot of hair loss I work midnights and I am taking cymbalta, 30 mg so far. I work 7 in a row and get one weekend off a month. I do not get enough sleep. It seems to help some but I still get anxious. I DO NOT like the hair loss part. My appetite is horrible. I go back to the doc next week and I am interested in seeing how much weight I have lost. I hope it gets better as I am on it longer. I am still concerned about the hair loss. F 31
11/3/2007
 5  PTSD, Major Depression, Anxiety Moderate to severe dry mouth and dry eyes, occasional constipation or gastric symptoms. No longer to enjoy the occasional glass of wine or champagne (can't tolerate any alcohol since starting Cymbalta) b/c it makes me too drowsy. After discussing this drug at great length with my Pdoc, reviewing the research, looking at brain scans etc, we decided this was my best option for managing PTSD symptoms associated with childhood s*xual abuse. I'd been on Effexor for 2 years with decent depression management, however it exacerbated my anxiety, caused sleeplessness & foggy-headedness. Since switching to Cymbalta, my depression & anxiety are very well managed. I do not feel drugged or cloudy. I just feel like my self (something I never expected to return fully). I'm skeptical of some online reviews of withdrawal & SE's. The research done for med is better than most by far! Talk to your doc. In my experience, missing a dose has not caused any major issues other than headache or dizziness. I take 60 mg per day. My main SE is fairly intense dry mouth & dry eyes. I don't like it. But overall, I'm so happy with Cymbalta, that I simply treat those SE's and deal with it. Every so often I get a bout of consti F 39 2.5 years
11/2/2007
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 5  depression and anxiety initially I could not sleep while taking it. After the first week though, I improved in this area. It has raised my blood pressure, but because it helps so much it is worth taking another pill to control the bp. If you can get through the first week on it, it is worth it. F 52 8 weeks
11/2/2007
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 4  depression decreased libido (worsened as dosage increased), increased energy, jaw clenching I started at 30mg and noticed an increase in energy and elevated mood on the first day. Cymbalta helped my depression immensely, but after 5 months it started losing its effectiveness so I increased to 60mg and it worked again. After another 7 months it seemed to suddenly stop working and my depression worsened. I tried going to 90 and then 120mg but felt extremely hazy and had terrible headaches. The Cymbalta was great while it lasted, about a year, but now I am switching to Wellbutrin, specifically because of the lack of sex drive on Cymbalta. F 25 13 months
10/31/2007
 4  Bpd 1, SAD, GAD, PTSD, Depression NO SEX DRIVE! it's like the mind is there but there is no response. Often restless and have plenty of trouble sleeping. I was on Xanax for many years and had to detox. Soon I found myself on Cymbalta. It has done quite well for my anxiety and depression. M 23 4 weeks
10/31/2007
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 1  Chronic Fatigue and Depression Hot Flashes (thought I was going through menapause at 30), weight gain, insominia, axiety, zero sex drive, fatigue worse and depression seemed worse. Muscle aches and pains got much worse. I agree with everyone who says stay away. I am going on 6 days off Cymbalta and I am still having severe flu like symptoms. I can't seem to eat anything, loose stools, tired, headache. And for the first time I have felt severely depressed. I want to cry at the drop of a hat and keep crying. This drug is sooooo not worth it and at least for me did not live up to promises F 30 9 months
10/31/2007
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 1  mild depression heart symptoms, palpitations, vascular rash on extremities, etc. extreme anxiety, brain zaps, loss of thought in midsentence, or changing the subject in midsentence. wanting out of my wonderful 23 year marriage for no apparent reason. I did not want out before cymbalta and do not want out after coming off of it. grandiose ideas regardng my business and financial situation and I am usually VERY frugal. This nearly cost me my life, marriage, children, business etc. I am lucky my wife noticed that this was not the man she was married to for 23 years and had the Dr. take me off the meds whether he liked it or I liked it. I thought everything was FINE, great...just like a frat boy and I am the biggest nerd..like Fred Rogers normally. This is a bad bad drug. Do not make any life decisions on this drug as you may not be yourself on it. My 11 year old daughter asked my wife if something had inhabited my body. It was the body snatcher called Cymbalta. M 44 1 years
10/29/2007
 4  OCD, Depression I have not noticed any side effects. I have severe spinal stenosis and spend most of my life in severe pain. I take 30mg Kadian(Extended release morphine) twice a day, oxycodone 5mg every 4 hours, Elavil 50mgs at night,Baclofen 10mgs twice a day. My depression is partly situational as I am no longer able to work. I have a wonderful husband and a large loving family but I LOVED my job as a nurse on an orthopedic/neurosurgical unit. Cymbalta helps me not want to kill myself for being such a useless waste of space. F 55 11 months
10/28/2007
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 4  Depression Sweating, shaking hands,definitely "brain zaps" but only in the first few months. Weight loss F 46 10 days
10/25/2007
 1  depression I turned into a raging maniac, i had nausea, cold/hot flashes. I felt out of control, & disorientated. Also, headache,crying, insomnia, and I can't tell you all the side effects. I would never ever take this drug again, nor would I recommend this to ANYONE!! This is a BAD drug, they should have better warnings about the side effects. F 52 10 days
10/24/2007

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