CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  Depression/Anxiety HIGH BLOOD PRESSURE!! Lack of emotions (neither happy or sad), heart palpatations, very little sex drive, VERY tired! Cannot get enough sleep!!!!! F 28 2 months
8/21/2006
 3  anxiety upset stomach, shaking of hands.. difficulty sleeping, felt a bit more anxious at first through out the course of the day began to feel very happy, but I am only going on my first week F 27 7 days
8/19/2006
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 5  Panic/anxiety ncreased sex drive, weight loss, delayed and intensified orgasm, increased sex drive. All these "side effects" are welcomed. I've tried a variety of SSRIs, and now I'm wondering why my doc had me bother with them. I take 40mg a day in the morning. Cymbalta is far and away a much, much more effective drug than any other antidepressant. It's like the difference between a Model T and a Lexus. I don't have a down day ever. I don't feel in a haze, zombie-like. I have energy and motivation. I think more clearly. I'm enjoying life like I haven't before. I'm constantly happy, getting along much better with friends, relatives, and coworkers. Yet I'm not emotionally dead like with the other SSRIs - I can feel anger, and sadness, and all the other human emotions. I can't say enough about how great I think Cymbalta is. I'm stunned and dumbfounded, especially after having experienced the other comparitively primitive drugs in its class on the market. Way to go, Eli Lilly! M 42 3 months
8/17/2006
 4  60 MG I have gone from 30 to 60 mg in the last two weeks; I think it helps pain, depression and anxiety. My BIGGEST complaint, is overheating; sweating.l Will that get better! F 62 60 days
8/17/2006
 2  Anxiety, Depression Several sexual side effects (40 mg+) Completely ineffective anti-depressant/anti-anxiety medication, I had to be tapered immediately down from 60 mg to about 30 mg, very soon thereafter to almost none. I do not intend on continuing taking cymbalta. Other than its complete lack of effectiveness, the sexual side effects (similar to ones experienced with Effexor XR, also a popular "SSNRI") were absolutely severe and intolerable. I've been on many SSRI's and other meds with a high chance of sexual side effects, and only, possibly, effexor, was worse than cymbalta in this area. M 22 5 months
8/17/2006
 4  Depression, Anxiety Nausea, rash (may or may not be from medicine), loss of appetite, constipation, some dizziness, lack of sex drive; nausea and dizziness went away after 1.5 weeks on 20mg, came back for a few days when I moved up to 40mg. Still have everything else. It's worked for me so far. I'm willing to deal with itchy skin and not eat if it will get rid of the depression. I was on Paxil throughout high school, took a break from meds and then couldn't stand it anymore. On Cymbalta, I'm more comfortable in social environments, not as anxious about everything, have more get up and go. I don't space out like I used to, it's easier to pay attention to what's going on around me, I don't stay in bed all day anymore, I can do things like a normal person. After reading other comments, I'd say it's definately not for everyone, but no medicine is. Also, stopping a medication without consulting your doctor first is dangerous, not to mention dumb. I tried it with Paxil, and the first day I didn't take it I passed out during a volleyball game. It wasn't the drug's fault, it was mine. F 21 3 weeks
8/16/2006
 4  Depression If I miss a dose I get dizzy. Sexual Side effect. Difficulty getting / keeping an erection. Dificlty obtaining orgasm. Worst symtom is hot flashes and night sweats. Has helped me better than Wellbutrin, Paxil, or Lexapro. Sexual Side effects are tolerable but the hot flashes and night sweats are REALLY annoying! But I tolerate because it helps the most with depression. M 40 1.5 years
8/16/2006
 3  vulvodynia insomnia and tiredness, initially dieharea (sp?) and slight headache and wide eyes in the morning, lots of wild dreams instead of deep sleep I was only on it maybe 6 -8 weeks and cannot say whether it would help long-term with vuvlodynia, but it did not combine well with Trazodone which I had to go off (sleep inducing, for FMS) - I switched to Lyrica for the vulvodynia and it is much easier to go on, plus it helps me sleep without the trazodone. I don't feel it is as much of a stress on my body as the Cymbalta was. Whew, it whacked me out at first and the sleep never improved! F 57 7 weeks
8/16/2006
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 1  Anxiety, Panic, Fibromyalgia My heart beat so hard and fast that I could actually hear it loudly all of the time and my ears pulsed on my pillow when I laid down. EXTREME nervousness, extremely tired & had terrible nausea for first seven hours after taking each morning. Sweating, panic attacks in middle of night, insomnia (though exhausted), very dry mouth, bruising, bleeding gums, "out of it" feeling and forgetful I was given 30 mg pills by doctor. I broke them open and counted 273 granules within one capsule, divided them out and re-capsuled three with 91 granules each. Then I took 81 granules in a capsule on the fourth day. By the fifth day (today)I decided to just not take this anymore because I am so freaked out- absolutely frightened, really. Even today my heart is still racing. Thank goodness I had Xanex and my husband or I'd have surely gone to the ER of the hospital.I thought starting/stopping Effexor CR was bad- oh boy! Cymbalta made Effexor look like a cake walk- no joke. F 30 4 days
8/15/2006
 5  Depression Feeling that my head would explode. Not connected to things. Unable to focus. Some feeling of panic (racing heart, nervousness). This was during first few weeks on Cymbalta, and a bit when I went from 30 to 60mg. I stayed the course, and one day realized I was quite happy again and feeling very energetic. The side effects only lasted a while. I tried Webutrin, and that hadn't done anything. However, it's now been a year, and suddenly, I'm having weight gain, NO energy, no sex drive, and difficulty in reaching orgasm when my sex drive DOES appear. At the moment, under Dr.s advice, have reduced back to 30 mg while he also does other blood work looking for another reason (thyroid?), and also back in therapy. Not sure if Cymbalta has quit working or what, but while it was, I was back on top of the world. M 47 1 years
8/13/2006
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 4  Depression Mild constipation, profuse sweating especially during exercise. Reduced interest in sex with some difficulty getting and maintaining an erection. I've taken Zoloft, Wellbutrin and Lexapro in the past. I'd rate Cymbalta an improvement over the others. Side effects have been less severe with Cymbalta than the other drugs. It has helped keep my mood positive and almost eliminated the physical pain. For me, the benefit has far outweighed the cost of dealing with the side effects. M 55 1 years
8/13/2006
 1  nerve pain HORRIBLE! NO interest in anything, never before have I been depressed but this stuff is HORRIBLE! WEIRD skin rash, bruising, lack of energy, lack of interest in life, strange nerve tingling--pins and needles, racing heartbeat, high blood pressure, wierd dreams, sweats--lots of sweats and WEIGHT GAIN throughout the mid-section. BUT none of the side effects DURING the DRUG compare with going off! THE WITHDRAWAL IS HORRIFIC. THE WITHDRAWALS FROM THIS DRUG ARE HORRIFIC! GET READY, BE PREPARED IF YOU EVER STOP TAKING IT. THE DOCTOR NOR THE PHARMACY WARNED RE: A WEANING PROCESS. I quit cold-turkey and didn't know for days it was the drug withdrawals. I thought I'd die. The worse is the BRAIN ZAPS, hundreds per day--felt like little seizures, one right after the other, dizziness, ringing in the ears, diarreha, vomiting, sweating, pain in extremities, pins and needles only worse than when on the drug. TWO months later and none of the 25 lbs is gone dispite every diet, still right here around my stomach. BRAIN ZAPS and dizziness still there but now only in the a.m. and evening. DANGEROUS DRUG--HOW IT EVER PASSED THE FDA IS BEYOND COMPREHENSION!!! F 42 4 months
8/11/2006
 1  anxiety/mild depression I have been on Cymbalta for 8 months. I have been so fatigued that standing up is too exhausting. The more exhausted I become the more depressed I became. Depression has never truly been a problem with me before. To add to my problems my blood pressure shot up during my treatment. I had been on adderal for 3 years and that didn't raise my blood pressure. Time and time again I have asked my Dr. if Cymbalta could be the cause of my problems. It really upsets me that everytime a new drug comes out the medical community basically ignores the past meds and starts writing the new drug. I wanted my Dr. to give me Luvox which has worked great for me. Reading these posts I can't believe that they are letting this RX still be written. I have had the worst 8 months of my life. The sooner I get off this horrible drug the better. F 46 8 months
8/8/2006
 1  RSD/CPRS nerve pain Felt like I was extremly drunk and sick to my stomach. Headache lasted the whole time. Stiff neck and muscles. Had bad dreams and started to panic because of the way this drug made me feel. This drug needs to be studied more. Be careful when taking this drug. I called my pain mangament doctor who gave me this drug. He said he didn't know that this drug had that many side effects. Was told by Lilly that this drug had hardly any side effects and is the best on the market. So watch out. This did help me alot with my RSD but it's not worth the side effects I had to go though. M 29 2 days
8/8/2006
 2  depression and fibromyalgia I experienced a completely "spaced out feeling" which was only worsened by the dizzying relentless nausea. I feel so tired I can barely function. I have only been on this drug for eight days. Please; Could anyone tell me how long the nausea lasts? I am considering quitting although I was really hopeful about this one. F 34 8 days
8/6/2006
 1  anxiety, depression blurred vision, sweating, shaking, nausea, vomiting, brief paralysis, tingling in extremities, fainting, heart palpitations, insomnia, severe abdominal pain, auditory/visual hallucinations, dizziness I was prescribed Cymbalta as a possible alternative to Klonopin, which I have taken for over ten years. I took my first and ONLY dose of Cymbalta (60 mg) at 8:00 AM yesterday after breakfast. Almost immediately I started to sweat, began to feel very ill, and proceeded to throw up all morning and into the early afternoon. I could barely move or get out of bed. At one point I was certain that I was having heart failure, because my entire body seized up and I could not move or speak. It took me a day and a half to finally sleep, and I couldn't eat or drink anything until around 9:00 this evening (juice and some crackers). I still feel dizzy and nauseated, and my hands and feet are tingling. The only reason I'm sitting up at all is so I can warn others NOT to use Cymbalta. This stuff is like rat poison!!! AVOID IT AT ANY COST!!! F 43 1 days
8/4/2006
 5  mild depression/stress Very briefly-foggy headed, very mild nausea. Excessive sweating during first few days. Some insomnia at first, but switched to AM dosage and that relieved that. I have to agree that once I got over feeling a bit 'weird' for the first few days, and sweating a bit, I feel like the old me is back! Pre-stress ME! :) I have MUCH more patience with my children. I can focus better. I feel happy again. I feel no side effects at this point, 15 days into a 30mg dose daily. I hope not to be on it long, but am thankful for something to pull me through whatever it was I was going through. F 36 15 days
8/3/2006
 1  Bipolar - Depression This is my second rating here. I will repeat my side effects - involuntary muscle movements, major insomnia, extreme jaw pain and tooth pain, extreme headaches, flu-like symptoms, feeling of high blood pressure, induced depression, brain zaps. IF YOU ARE SENSITIVE TO ANY SSRI'S - DO NOT TAKE THIS DRUG. Began my weaning plan yesterday. I expect the major withdrawals to happen any day now. Some slight effects of withdrawal are already happening. If anyone out there has any suggestions or advice...I am open to anything. I'm very scared as to what is going to happen. It took me a year and a half to withdrawal from Peroxetene. My doc and I concluded that I am intolerant to SSRI's. If anyone has any advice on holistic measures, I would appreciate anything you can share. I'm still on Lithium which is doing alright, and still on Xanax which seems to be the only thing I can outright handle without any side effects. F 36 4 months
8/3/2006
 5  depressiona and anxiety initial dizziness and nausea and inability to reach orgasm, weight loss Now- after three months still difficulty reaching orgasm but better, night sweats (soaking), and nightmares/vivid dreams. I have been happy with this medication so far. The side effects aren't fun, but overall my quality of life and modivation for life has increased- which I think is worth it! F 27 3 months
8/2/2006
 5  Osteoarthritis in hip, Depression First few days, dizziness and nausea. Subsided by third day. Some insomnia but I'm not sure it's the drug or just the way I'm made. I haven't been able to walk properly for two years because of my OA. Between exile from my sports and the chronic pain, added to a history of major depression, I spiraled down into a major depressive crisis. Doctor put me on Cymbalta about 10 days ago and the positive effects were almost instantaneous. Within three days I was able to think more clearly, control my behavior, concentrate on work and finish something, and I have been walking much, much better and in much less pain. I'm on 60 mg and have actually never felt better in my life since I'm usually more or less depressed (though with a basically good attitude). I plan to stay on it at least until after my hip surgery and perhaps longer. I can imagine for some people it's not the right drug, but it has saved my life. F 54 10 days
8/2/2006

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