CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  Anxiety, fatigue, headaches Significant brain fog, memory loss in short term, trouble ejaculating, dry mouth I tried taking Cymbalta after Effexor had worked but had major sexual side effects. Cymbalta lowered my libido, and caused me to have problems not being able to ejaculate, but unlike Effexor, I guess at least I could get an erection. The biggest problem was brain fog. While on this drug, I forgot a breakfast I was supposed to go to, started driving to work when I was supposed to go the doctor, left my wallet in the car, and numerous times started sentences only to lose my train of thought. Really not confident speaking in public. Had to take this medicine at about dinnertime, then took Clonazepam to sleep. Not an awful medicine, just didn't work for me as I wasn't mentally sharp like with Effexor. M 35 16 days
2/9/2008
 3  Fibromyalgia Gained 20 pounds I can't lose and forget about trying to stop taking it. Before Cymbalta I was on Effexor which took several months to wean myself off of once all the aches and pains were under control. With the Cymbalta if I miss a dose within 4 - 6 hours my lips are tingling and I can't concentrate on anything. At this point I would love to get off it to see how I do drug free, but the physical side-effects almost guarantee that it's going to be a really long road to do that. So it works for the fibro pain, but I don't think the withdrawal problem is worth it - had I known it'd be this bad I never would have started it. F 37 3 years
2/8/2008
 3  depression - slight ocd feeling like you were in a lucid dream if you skipped a dose, weight gain after stopping i was on cymbalta for about 2.5 years, since college, to deal with my depression and slight ocd (assumed to be caused as a reaction to depression, i would have manic periods where i would obsess). the first time i forgot to refill my rx, i went 4 days without it, and turned into a monster. irritable, brain wouldn't function. that was only on 60mg. now, after getting off 90 mg because i could no longer afford it (ATTENTION ANYONE WITH UNITED HEALTHCARE: they WILL NOT allow you to take 3 pills of the 30mg a day for this dosage, therefore you are forced to get one prescription for 60mg, and one for 30, which meant for me my rx copay of $40 TWICE! almost $80 a month for this rx!) and knew very well what i had in stage with my withdrawal. the packet is extremely right, tingling, but not in my hands, in my brain. literally. it was like i could feel the synapses not connecting right, and i would get huge jolting headaches, feeling like stabbing pains in my temples. also, if i would be si F 22 2.5 years
2/8/2008
 2  GAD, Panic Disorder, OCD Extreme sleepiness, no appetite, mild nausea Granted I was only on this medicine for 1 1/2 weeks, I began with 30mg and was fine for a couple of days. Then the sleepiness hit me like a ton of bricks. Would go to sleep at 7pm, not wake up til the next day even with husband trying to wake me. I was sleeping my life away---Had to stop before it got out of hand. I have 2 little ones and was very dangerous being that tired constantly---didn't matter how little/much sleep I got. I would say if I continued with Cymbalta, I would've lost a drastic amount of weight because I had little/no appetite. Worked on my issues, definitely. Doctor had me stop the Cymbalta and am switching to effexor. We'll see how that goes. Not on it long enough for withdrawal symptoms other than headache. F 29 10 days
2/8/2008
 1  pain, depression withdrawal has been a NIGHTMARE!! My doctor titrated me off of Cymbalta WAY too quickly and my life has been turned up-side-down! I'm so angry and irritable that I can't stand it. Nauseated 24 hours a day. I now have bouts of liquid diarrhea. In the first 2 weeks off of Cymbalta my sleep was totally wrecked. The sleep got better. But then I've had episodes of sleep paralysis and screaming waking from nightmares. I have an odd tinnitis that's driving me crazy. I'm miserable ... and my doctors are dumb as dirt about Cymbalta and how to deal with coming off of it. I've never had a problem stopping any other medication. F 51 2 years
2/6/2008
 1  Depression F 41 6 months
2/5/2008
 3  Depression Yawn, diarrhea for a about a month, apathy, withdrawal on missed dose, vivid dreams, night sweats, weight loss. Started at 20mg and felt awesome for a week. Went away so dose was increased rapidly to 60. This caused diarrhea for about a month which went away. I feel happier, laughing and all but no motivation to work or do much of anything. Missed tons of work, about to lose my job. I wake up nightly drenched in sweat and can recall every bit of my dreams. F 29 4 months
2/4/2008
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 5  Depression A little tiredness at first but went away eventually. I have been on Zoloft then Paxil for about 4 years. My doctor told me about Cymbalta and I decided to try it. I really like it. It makes any worry go away where you basically "Don't Care." Where some things used to bother me I now say..."So What!" I noticed this as a few weeks went by on Cymbalta. If you decide to try Cymbalta give it a little time to work. It is a powerful med more so than Zoloft or Paxil. I am looking to be on Cymbalta for a long time. It's one medication that I actually could tell it was working correctly. M 34 2 months
2/2/2008
 5  depression was on this before and had weight loss i was on cymbalta a couple of years ago and thought i could live without it boy was i wrong. my moods changed i didn't care if i ever got out of bed and i was down right miserable! if you stop taking this the withdrawal is awful. my doctor decided to put me on lexapro because when i get feeling better i think that i don't need anything and lexapro didn't have withdrawal effects, but i gained 35 pounds on it. when i was on cymbalta before i was able to lose weight and not feel hungry all the time. i don't think i will ever stop using cymbalta again. looking back when i was on cymbalta before it was the happiest i have been in about 10 years. in the past i have been on several medications and nothing worked as well as cymbalta F 43 2 days
2/1/2008
 4  anxiety I see so many negative side effects. I have had some minor ones, but this is my first type of medicine ever taken. Decrease of appetite( which all women im sure dont mind!), a little pukish feeling the first week . 30 mg is good but with the 60 mg I am very pleased with the results. I am much more alert and aware of whats going on. It has helped with my fiance and I. I am not worried over EVERYTHING! I recommend it. I am also taking with lamictal for depression. I was very scared and nervous all my life taking medications because of the negative way people look at those that have emotional unstability. F 26 1 months
2/1/2008
 3  Depression/Anxiety For the first 3 months I had constant diarrhea, decreased appetite, and lost quite a bit of weight. Then I switched to a higher dose and became VERY constipated and gassy despite a high fiber diet and supplements. I have gained back all of the weight I lost in addition to some more! I felt more energized on Cymbalta compared to Celexa, but I feel pretty icky otherwise. F 26 8 months
1/30/2008
 1  Depresion Horrible thoughts and night dreams. I went from depressed to nuts! This is the worst drug ever! I got off it as soon as possible. Physicians are crazy for perscribing this medication. M 21 2 weeks
1/30/2008
 2  depression NO SEX DRIVE, couldn't tell you if I could orgasm because I never had sex while on the drug. So tired all the time. I became a hermit, had no desire to do anything, especially eat (which I didn't mind, since I'm trying to lose 10 pounds) Cymbalta did lift my depression a bit, but not enough to continue. I am now on 25 mg of Lamictal and the difference is like night and day. No sexual side effects at all, just a little more hungry. Any of you having problems with cymbalta, ask your pdoc about lamictal. If you feel good on starter dose, don't let your doc move you up! F 33 1 months
1/29/2008
 5  severe depression Dizziness/disorientation when I missed a dose. It helped me a great deal along with a number of lifestyle changes, and I (thankfully) had very few or no side effects. I'm glad I took it. M 21 13 months
1/27/2008
 1  Depression associated with MS Getting off this drug is A LOT worse than the symptoms of depression! This is the drug from hell to get off of. Class action suit, anyone? 52 2 days
1/27/2008
 5  Bi-Polar rapid cycling; Severe Depr Upper ab cramps; weight gain; wake up 3 times per night I am a psychologist. I started taking anti-Depressants in the 1980's. The psychiatrist (#4) finally said all the anti-Depressants that I had taken made me become bi-polar. What I have noticed through my work as a psychologist and my history of taking this type of medication: is that psychiatrists want you to take the "normal Therapeutic" dose (e.g., 60mg of Cymbalta) right away. Caution: I recommend to everyone that when starting a new medication – Start Slow; increase slowly over a long period of time; and when it comes time to decrease or discontinue, Decrease slowly over a long period of time. Start at a very low dose (e.g., 20mg or 30mg of Cymbalta) for several months; access the effects; then increase the dose a little at a time. It took me 3 years to get to my current dose of DEPAKOTE ER. The 1st small dose (30mg) of Cymbalta: I could feel my brain actually change. I increased the dose to 40mg 5 months later. Then I increased the dose to Cy F 48 8 months
1/23/2008
 2  Major Depression Nausea, low libido, excessive tiredness. Missing a pill would cause dizziness and tingling. I have been on 60 mg of Cymbalta for the past 1.5 years. It is better than previous anti-depressants I previously taken (Celexa, Lexapro, Wellbutrin, and Effexor), but I have had my bouts w/ sadness and mainly just feel stoic now. I'm tired of trying different Rxs. I'm also tired of "reminding" myself to be affectionate w/ my husband, who I love w/ all my heart; Cymbalta has caused me to have a very low libido. I'm now also trying to evaluate my diet, etc. w/ a naturopathic doctor and have also tried acupuncture. I don't want to settle and be stoic or have "less" sadness. I want to be happy. F 25 1 years
1/23/2008
 4  Fibromyalgia Fatigue, body temperature dysfunction (i.e. always having hot flashes or always chilled to the marrow; little in between). This is a miracle drug for me, calming my anxiety and easing my fibromyalgia pain. One of the best things I've ever taken in recent years. F 44 1 years
1/22/2008
 1  treatment-resistant depression Nausea. Lots of nausea. Also, a marked reduction in sexual response and sensation. Also, spells of dizziness not associated with a change in position (randomly while sitting down or walking, not just upon standing up). No discernible effect on the depression after 8 weeks at “recommended therapeutic dosage” of 60 mg/day, at which point we decided that due to the already-present undesirable side effects, it would be a bad idea to try increasing the dose further. F 27 2 months
1/22/2008
 1  Anxiety/Depression I was so stressed out it made me feel like the anxiety i had had before with my panic attacks were welcomed. I couldn't stand up without having my whole world spin. I had done extacy in my early 20s and the side effects were similar: grining jaw, spacey feeling, feeling cold and shivering, not having any short term memory but I expected to feel bizarre because it was an illegal drug!!!! Now when I really need to feel right and straight for my very demanding job I literally had to close my door to my office and tell myself over and over it would be ok so I didn't go running screaming out of the office. I only stayed on the drug for 3 days at 30mg because I started reading about the withdrawl, that no one tells you about when they put you on it, and that seemed like it was goign to be even more traumatic. I have been on other anti depressants: Zoloft, WEllbutrin, Prozac and never ever have i had feelings of suicide, total despair and crying fits like I have for the last 2 days. The MD F 29 3 days
1/22/2008

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