CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  mild depression/chronic pain Occasional acid reflux. Mild insomnia but that subsides when I take it in the early AM. Inability to achieve orgasm. This medication has worked wonders for me. I don't have stress headaches anymore. I'm finally loving life again and can cope with the chronic pain that I used to have. F 32 32 days
8/2/2006
 4  fibromyalgia & mild depression first week. On first day, burning down legs and feet so hot on bottom felt like fire. Nervous feeling in heart/chest area or upper stomach like getting ready for a navy jet launch. mood elevated. energy elevated. pain in gut on taking for an hour. i hope that pain is less, it seems so. M 60 7 days
8/2/2006
 1  Peripheral neuropathy; SCI Severe headaches, dizziness, nausea, vomiting. Night sweats so bad I had to sleep with a towel. Insomnia - maybe due to waking up in puddles of sweat. Never felt well enough to think of sex - I hope everything still works. Quit cold turkey last week and am still experiencing withdrawal effects. This is BAD medicine. This dangerous drug needs to go back to the FDA for more study. I've been bedridden for the last 2 weeks because of the severe flu-like symptoms it causes. Never noticed any reduction in my pain level. After reading this forum I wonder why Cymbalta should ever have been prescribed for pain. M 57 13 days
8/2/2006
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 1  Nerve Pain First several months helped with the pain, then noticed, No energy, no feelings, no sex drive, panic, irregular heartbeat-very pronounced, high blood pressure, bloating, skin rash, weight gain throughout the midsection 25lbs in 4 months, feeling dead inside--no emotion. After NO warning from physician, or pharmacy on quitting this posion--the withdrawals are scary, high pitch ringing in ears, dizziness, crying spells for no reason, sweating, anxiety, restlessness, sick--throwing up violently, brain zaps, numbness in face, hands, feet, wrists--tingling and pain. THIS IS A SCARY DRUG. F 45 4 months
8/1/2006
 4  fibromyalgia, depression, pain increased blood pressure, initial bouts of insomnia/somnelence Took for one month and quit. I then tried it a few months later when I had time to "deal with" the sleep issues. Once it got in my system I was Ok. Most of my pain is gone thanks to Cymbalta. Hot flashes b/c of high blood pressure are still a bother. Paxil did nothing for my pain. F 24 8 months
7/30/2006
 4  Anxiety, Mild Depression Decreased Libido, difficulty in achieving an orgasm. Other than those two, much better than any anti-anxiety/depression medication I've tried in last 15 years. Cymbalta is by far the best the best of the medications I've tried, and I've tried them all. It's also has the least amount of withdrawl symptoms when tapering off as suggested. Paxil is the worst for withdrawl and I had a very hard time getting off of it. With Cymbalta, I can taper down for two weeks and the only side-effect I have is mild dizziness and "zaps", which all of these medications cause when discontinuing them. All in all, a very good medication. M 46 1.5 years
7/30/2006
 1  Bipolar - Depression At first weeks dose, it was great. Then was increased to theraputic level of 60 mg. Major insomnia. Instructed to take in morning instead of at night - was completely opposite. It made me very tired. Switched to taking at night again. Sweats, nausea, tightening of muscles for no reason, tooth grinding resulting in horrible jaw pain, the feeling of high blood pressure (hot headed, restless). I missed 4 doses in a row and began experiencing the 'zaps' -- mini zap like feeling in the head, similar to my withdrawal from Peroxetene. So now I know this is something I'll have to wean myself off of once again. I'm currently on lithium and alprazolam. Overall, this drug is beginning to scare me as the side effects seem to be getting worse rather than getting better. F 36 4 months
7/28/2006
 5  long term depression-over 10 years Terrible night sweating (I need a towel in the middle of the night) has caused loss of sleep problems for me and my spouse. Also, problems with acid reflux that sometimes feels like chest pain. No information on whether these side effects will go away. This is the best antidepressant I have ever used--and I have used dozens alone and in combinations concurrent with psychotherapy. Currently, I take 40 mg Cymbalta plus 300mg Wellbutrin daily. Inability to orgasm on all other drugs is less of a problem on Cymbalta, although still usually happens. Unfortunately, I have not lost the 15 extra pounds from Lexapro! F 54 3 months
7/27/2006
 1  CRPS Extremely tired, bloating, confusion, blurry eyes, depression worse than before taking. Terrible drug Made me more depressed after 4 day than before. Could not think straight. This drug should be taken off the market F 4 days
7/27/2006
 5  depression and chronic pain initially: sweating, tiredness, foggy thinking, lost 8 pounds, slow to orgasm; after two months, just slow to orgasm. This is the SEVENTH antidepressant I've tried in the last 16 years and the FIRST that has truly alleviated my depression and chronic pain. In a nutshell: I'm much happier, far more productive, and a better wife, mother, sister, daughter, and friend. I want to live life rather than retreat from it. (Posted Summer 2006) F 41 3 months
7/26/2006
 3  
7/26/2006
 5  gad, mild depression nausea and fatigue the first week at 30mg, but went away during next week of 60mg. Nervous energy. Worked great on depression. Waiting for it to kick in fully for anxiety. F 38 3 months
7/24/2006
 5  post-partum anxiety jittery, dry mouth, feels like a 24-hour steady rush of energy, wake up several times a night, yawning that causes a tightness in my throat and makes my ears need to pop. after 1st baby had to take effexor, worked great, but husband didn't like me on it...i am not a worrisome person, very laid back, but the physical feelings of panic or "weird feelings" in my head/dizziness would make me worry...especially when driving. Now listening to attacking anxiety program, works great! Cymbalta is for short term, hope to be off of it by December! F 27 9 days
7/23/2006
 5  mild depression I was a bit spacy my first few days, felt like I was walking on a cloud. Some constipation. Had insomnia the first week, but then started taking it in the morning and can now sleep fine. The mood lift is worth any of these slight effects. I have lost seven pounds, (great for me) while i have been on this. I lost my desire to drink alcohol as much. Also, it has helped me tremendously with my urinary incontinence problem. All in all, a miracle drug. I felt myself being more patient with my kids and a lot happier. F 40 5 weeks
7/22/2006
 3  Depression Horrible loss of libido. I find that keeping an extra pair of underwear in the car a benefit. Never take for granted that it’s gas. I probably have 10 pit stops to the bathroom a day. Horrible diarrhea. My depression went away but my relationships and my laundry suffered. M 32 1.5 years
7/21/2006
 4  Chronic Back Pain/Mild Depression Extreme sweating, sleepiness, lack of appetite It has helped considerably with my back pain, I'm hoping with more time it will aleviate the majority of the pain in my back. My kids have told me I'm not so grouchy. So, that is a good thing. I'm just hoping this sweating will go away. Plus the 100+ temps. are killing me. I started taking it at nite and now I am having trouble sleeping at night. Hopefully it will taper off when I get use to the dosage. 60mg, just bumped up to that after starting on 30mg. F 33 2 weeks
7/19/2006
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 3  OCD, depression Sweating more than usual, light-headedness, lowered libido, inorgasmia, increased energy, can't sit still, decreased appetite, dizziness, unable to concentrate for long periods of time, waking up earlier, constipation, difficulty urinating although i've enjoyed having more energy/ feeling less lethargic and depressed, it hasn't impressed me in terms of improving my ocd tendencies. in fact i think they've gotten worse. the sexual side effects are MISERABLE. not sure that the good outweigh the bad... and the amount of comments i've read about the drug causing suicidal thoughts is a bit disconcerting. F 23 7 days
7/18/2006
 4  anxiety/depression yawning, major increase in sweating, and constantly hot, very difficult to achieve orgasm if at all; has helped anxiety, much more energy, hasn't effected my sleeping negatively, don't feel 100% better, but definitely better... Trying this after many other anxiety/dep meds... I'd say it's one of the best F 27 3 weeks
7/17/2006
 3  PMDD I've only been taking this medication for four days now. I've had severe heartburn/acid reflux and mild insomnia. Other than that I feel pretty good. I'm taking 30mg but will increase my dosage to 60mg in three days. F 32 4 days
7/17/2006
 1  depression sleep all the time, paranoid, antisocial just a matter of finding the right thing for right person but as a precaution this is not one you quit easily. I got empty gel caps from vitamin store and broke the 60's down into halves for about 2 weeks, then another 2 to 4 weeks broke (like in pour!) down into quarters, etc. until I seemed neutral. Still a little zappy but the upshot is that best thing is have doc help you taper off. I read somewhere that switching to prozac is helpful cause quitting prozac is easier due it lasting longer in the body. Good luck. F 54 4 months
7/15/2006

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