CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Depression, anxiety/OCD Bloating, constipation, slight weight gain, even though my appetite is decreased and I have begun to exercise. The Good News-- it helped my depression. By the time I had been on 30mg for a month and went up to 60mg, I had more energy and was noticeably more cheerful. I was finally getting out of bed every day, cooking sometimes, even doing the dishes, watering the lawn. I even started exercising every other day. The Bad News-- I experience very severe bloating, especially premenstrually. However, having crohn's disease, I could not yet be certain that it was from the Cymbalta. But then we raised the dose to 60mg and the bloating has gotten even worse-- before when I got bloated, at some point my belly would finally go back down to its normal size. Now it never does. This is making me feel more depressed and anxious. Some of my depression and anxiety is due to the effects the crohn's has on my body-- I feel ugly and hopeless, don't want to leave the house, and obsess about it. So being bloated is very bad news for my emotions. I am tempted to go off of it, but I have already been on F 33 2.5 months
5/18/2006
Email
 1  PN + dep IMPORTANT MSG to F 44 email adr withheld taking Cymbalta 5 days with ongoing GI problem: I feel your pain !! PLEASE TRY ORAL ALOE VERA (Herbalife) 1 tsp in glass of juice once per day.. should clear your problem within days but continue treatment for 2 weeks. I experienced severe GI, digestive, upper stomach pain for 3 months after initiating Elavil (amitryptline for only 5 days). Prilosec et al inneffective. Rating 1 ONLY to gain attention / Help offered to F 44 if you know her Plse fwd...... I started Cymbalta 5/17/6 for PN pain + dep. with no perceived +or- affect. Dale. Torrance, CA M 61 1 days
5/18/2006
 4  Scizo-Effective Disorder This Is My Second Day On Cymbalta, But Yesterday I Could Not Go To Work Because I Was So Tired And Sick. I Have Not Had Any Mood-Swings, Depression, Or Stress Though. I Would Reccomend It M 24 2 days
5/17/2006
 4  chronic depression I'm new to it (2 weeks) but am already experiencing clarity and weight loss (app. 5 lbs). I switched from 225 mgs Effexor to 60 mgs Cymbalta, and the difference is striking. Feel much more upbeat and motivated. Some difficulty with orgasm and dryness, but very minor. Very happy about the weight loss -- still trying to lose the 15 pounds I gained with Celexa 3 years ago. Very hopeful this will work. I've tried Prozac, Celexa, and Effexor -- all with happy initial results but eventual dissatisfaction. F 30 14 days
5/17/2006
 2  Sciatica, nerve pain EXTREME sleepiness, weakness, fatigue. Some balance loss and dizzy. Craved sweests. Most times, not enough energy to pick up the phone while in bed. Itchy on chest, back, underarms, back of knees. Went from 30-60-90mg/day w/ long/equal trials of each dose. Took w/ food and at bedtime (when possible ie, at 30mg and tried w/ 60mg instead of 30 twice a day also tried 30 twice a day). Did Work WONDERS for 1-2 mths - more energy, less nerve and back pain. Once increased it went downhill - cannot get that same good result at the lower dose. Might try going off completely, wait, then go back on just at 30. More than that and you're sleeping for life. Not sure how long good parts will last at 30 though... we'll see.... (Total took for 5 mths about). I think Neurontin might be better. (had similar reaction to Lyrica as Cymbalta - but much sleepier w/ cymbalta than w/ Lyrica). F 38
5/17/2006
 5  DEPRESSION AND MENTAL FOG Weightloss, dry mouth, some insomnia but a peaceful insomnia. I feel calm and worry less. I have more energy and can think straight in the afternoons which I couldn't do before. CYMBALTA GIVES ME MENTAL CLARITY NO MORE THINKING THROUGH A FOG. My neurotransmitters function the way they are supposed to when my stomach is full, my brain gets the message and I feel full!!! M 60 4 months
5/15/2006
 5  FIBROMYALGIA AND DEPRESSION I LOVE IT!! I do get dry mouth and some insomnia but my overall mood is so much nicer. I don't hurt near as bad and don't mind the insomia. I had insommia anyway. I have some great nights of sleep and others I am awake but in a peaceful state that doesn't seem to bother me. I dont' feel drugged just better with more energy like I felt at 30 years old. F 59 4 months
5/15/2006
 5  Depression Muscle Pain Dry mouth and weightloss. I feel full much sooner when eating than I used to. Much less pain, a little headache now and then. I'm more upbeat and can think more clearly. A GODSEND. M 48 3 months
5/15/2006
 5   Weightloss, dry mouth, some insomnia but a peaceful insomnia. I feel calm and worry less. I have more energy and can think straight in the afternoons which I couldn't do before. CYMBALTA GIVES ME MENTAL CLARITY NO MORE THINKING THROUGH A FOG. My neurotransmitters function the way they are supposed to when my stomach is full, my brain gets the message and I feel full!!! M 60 4 months
5/15/2006
 5  Depression Muscle Pain Dry mouth and weightloss. I feel full much sooner when eating than I used to. Much less pain, a little headache now and then. I'm more upbeat and can think more clearly. A GODSEND. M 48 3 months
5/15/2006
 4  FIBROMYALGIA AND DEPRESSION I LOVE IT!! I do get dry mouth and some insomnia but my overall mood is so much nicer. I don't hurt near as bad and don't mind the insomia. I had insommia anyway. I have some great nights of sleep and others I am awake but in a peaceful state that doesn't seem to bother me. I dont' feel drugged just better with more energy like I felt at 30 years old. F 59 4 months
5/15/2006
 4  FIBROMYALGIA AND DEPRESSION I LOVE IT!! I do get dry mouth and some insomnia but my overall mood is so much nicer. I don't hurt near as bad and don't mind the insomia. I had insommia anyway. I have some great nights of sleep and others I am awake but in a peaceful state that doesn't seem to bother me. I dont' feel drugged just better with more energy like I felt at 30 years old. F 59 4 months
5/15/2006
 4  Depression and Muscle Pain Works like a charm. Occasional nausea if I don't eat before taking it in the morning. A little insomnia but in a pleasant relaxed way. Less appetite, more energy. Nothing had worked before. Tried Zoloft and many other meds. I still have some muscle pain but it has improved along with my overall attitude while using Cymbalta. I worry less and it gives me a little energy boost all day long which I did not have before. F 58 3 months
5/15/2006
 4  Depression AND FIBROMYALGIA I have fibromyalgia and it has helped some with the muscles in my back and neck. Don't eat near as much and in a better mood. Some insomnia but I had that problem anyway. CYMBALTA IS A GODSEND!!! A little upset stomach sometimes but not if I eat first. Dry mouth. F 62 5 months
5/15/2006
 2  Chronic Severe Depression, PTSD Extreme fatigue, nausea, flatulance, feeling of pressure inside my head, extreme lethargy, loss of interest in sex, diahrea, my limbs feel like they're made of lead. All I want to do is sleep. Oddly, despite the side effects, my mood seems to be very stable, my anxiety is down, my back pain is down. I would not, however, say that my mood has lifted, just that the mood swings are less severe. After reading other people's experiences on here, I'm going to stick it out and see if the side effects go away. M 42 10 days
5/15/2006
 4  Depression and Anxiety The first day I took the drug I had insomnia, and couldn't sleep due to brain activity taking place and body adjustment. Experienced some pressure in head, nausea, butterflies in stomach feeling, and headache. Side effects are going away second day. Think this drug is great for low side effects Great drug for depression, anxiety and OCD. The first day I took the drug I was amazed at how fast it started working. I was suddenly happy about everything and smiling all day. It was almost difficult to be sad about anything. This drug works wonders. For those who don't know about cymbalta, it is a great anti-depressant with low side effects, at least for me. I recommend this drug to anyone suffering from depression. THANKS CYMBALTA! F 27 2 days
5/11/2006
 4  Depression Mild dizziness and diarrhea the first few days. Vivid dreams. Oddly warm hands. Sometimes I get a cool, "menthol" feeling up my spine and down my arms. Inability to reach orgasm. Has reduced my depression a great deal. I've tried many medications over the past 10 years or so and never gotten this much relief. I'm not all the way where I'd like to be, but for the first time I feel that I'm better and making progress. I can tell a big difference from the drug. F 44 7 weeks
5/9/2006
 1  Depression Severe sweating;Severely sleepy at 30-mg, which improved slightly at 60-mg; Vivid and realistic hallucinations and dreams; I will wake up smelling things from dreams; it's weird; as cerrebryl as LSD, but not as flashy. Sex drive is in the high want to category, but my tool has been chemically castrated by this stuff. I am tired all the time, and pass out on the job, then have weird dreams. For me to benefit from Cymbalta, I would need some dextroamphetamine to keep me from falling asleep at work, and I would need viagra or that 36-hour pill to have sex, cause Cymbolta cheets you out of your sensitive tissue nerve endings. May as well take depro provera to get the same result. M 47 43 days
5/9/2006
Email
 5  muscle pain / depression at first had some anxiety and still have insomnia, usually after sleeping only 4 hrs. in the past two months have had three severe colds that start with flu-like symptoms and then have severe congestion lasting a couple of weeks. Cymbalta has definately helped me with nerve/muscle pain and with depression. Concerned about the colds (3 in 2 month) and severe congestion. I have rarely gotten any colds in the past and having 3 this Spring (06) is alarming. Please contact me if you also have cold symptoms and you think it's from the cymbalta. Thanks. F 53 4 months
5/8/2006
 3  osteoarthritis pain in hips A little nausea, some insomnia, inability to orgasm. Cymbalta worked on my hip pain almost immediately. I felt great. The only thing that i didn't like was my inability to orgasm. I'm going to do like one suggested, take it at night and every other night. Hopefully this will help the orgasm issue. I hope so as this drug was great in relieving my hip pain. F 52 4 days
5/8/2006

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