CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2744 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Clinical depression, anxiety Withdrawal symptoms within 12 hours of missing dose: Vivid dreams, lucid dreams, nightmares, spontaneous nocturnal orgasm, brain zaps, nausea, vomiting I have a hypersensitivity to psychoactive/therapeutic drugs. These are some of the reactions I have within 12 hours of missing a dose. I also experience brain fog and minor emotional blunting. F 26 6 years
60mg 1X day
6/7/2015
 4  Pelvic pain,anxiety Raised by blood pressure 10 points, but nothing major Really stopped my pelvic pain and helped the anxiety . It is a hard drup to get off of though...must do it very gradually to not have bad feeling symptoms. I was off for a while but after my pelvic nerve troubles I went back on it because a specialist recommended cymbalta again to me. I have no long term affects from this drug that I know of, this time over 5 years, last time, maybe 1 year F 64 5 years
30 mg 1X day
6/6/2015
 1  Bipolar disorder i was so dizzy any time I stood up I almost passed out couldnt drive on this medication due to severe dizziness F 57 1 months
60
6/5/2015
 5  Depression/Fibromyalgia Have some minor brain fog at times and short term memory issues at times, but these could be due to age or taking Ambien for insomnia. I couldn't honestly blame it on Cymbalta Have had life-long low to mid grade depression (familial) and was put on antidepressant 19 years ago after a major depressive episode. I intended to take for a short time but felt the best I had in years mentally, so didn't want to give them up. Talk therapy wasn't effective at all. Also developed extreme body pain/exhaustion a few years earlier and was diagnosed with fibro. About 8 years ago my doctor asked if I would switch to Cymbalta after she said she had several fibro patients responding well to it. It has helped with the pain and depression. My quality of life much better and minor side effects. I am medication averse and always go to the alternative/holistic approach before resorting to any meds. I have a very healthy lifestyle, exercise, eat well, maintain BMI 19/20, etc. Recently I wanted to try to go off Cymbalta to try to be medication free. Knew about possible severe side effects with going cold turkey, so just reduced dose to 15 mg/day for 3 or 4 weeks, with no issues. Then tried reducing to 10 mg. After a few days I was back to having circuitous negative thoughts/mental stress over very minor issues. This was what I was so relieved to have end when I started on antidepressants. I had a sense of wellbeing for the first time I could remember. I decided to try to stay on 15 mg. Cymbalta or would go back to 30mg. if necessary, but my life is unquestionably better with Cymbalta. F 66 8 years
30 mg 1X day
5/30/2015
 1  Depression Anxiety At first i thought that this was a wonder drug. Then I found that if i was a little as an hour past time to take my next dose i started feeling horrible. The brain zaps would start and lets not even start with the nausea. I ran out of meds about 3 days ago with no way to refill so I said ill just have to tough it out. My god ive never felt so terrible in my life. I haveterrible sweats, headaches, stomach discomfort, dizziness, brain fog, vertigo, fatigue, lethargy, body aches, elevated blood pressure, shakiness, weakness, blurred vision, cant hold a conversation for more than a couple of minutes, anger, and this one is more my fault than anythimg, after 2 years of no smoking, i picked it back up a day or so ago, and am smoking more now than i did before i quit. This crap is a curse more than anything else. Sure, it does what it is supposed to, but at what cost? M 30 4 years
60 mg 1x a
5/27/2015
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 4  depression fibromyalgia Heart arrhythmia (skipping beats) Insomnia Was amazed and delighted how quickly my symptoms disappeared in the first week. I have not felt this good for a many years and also noticed that I am no longer anxious or obsessed about things. I have found it very easy to lose the extra few kilos I have struggled to lose since menopause. The only annoying symptom was a slight worsening of my insomnia until I started noticing that my heart was regularly missing beats. I have not felt dizzy even with exertion and exercise and my blood pressure has remained normal . I'm now really worried that I will have to go off Cymbalta when I see my doctor tomorrow. F 59 6 weeks
30mg
5/23/2015
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 2  Anxiety depression & pain in neck, Terrible sweats,memory lost,confusion, mean person!!!!!! The sweats bother me the most.Help with the pain,I looked like a race horse that just lost a race !!!!!!!!!!!!!!!!!!!!!!!!!!!! M 66 2 years
60 1X day
5/21/2015
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 3  Depression, fibromyalgia, anxiety In the beginning, nausea, lightheadedness Cymbalta works, but at what cost? It makes you gain weight-there is nothing to do for this, starvation doesn't help. It fogs your mind-I felt like I was constantly losing my memory. It makes your vision blurry. It shuts down your metabolism and proper bowel function-expect to be constipated. Basically, it works-it shuts down the pain receptors, feelings, anxiety--really great....but other body systems are effected. I'm not sure it is fully clear what this medication can do to you. F 40 1 years
40mg
5/20/2015
 1  Depression I experienced horrible nausea, acid reflux, and migraine-like headaches while taking Cymbalta. I thought they would pass so I gave it a week. No improvement with the side effects and no improvement with my depression. I was sick for the next week after stopping Cymbalta and am still experiencing terrible headaches every so often after being off for two weeks. I still have nausea and no appetite/desire for food. I agree with many people--STAY AWAY from this horrible drug! I just hope I can get back to normal. It seems like it's taking forever to get over the awful side effects. F 35 7 days
30 mg
5/20/2015
 2  Depression very dizzy very frequently. light headed scared to drive or leave the house for fear I will pass out. I still cry all the time. So far it hasn't helped my depression very much. F 57 4 weeks
30
5/17/2015
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 5  anxiety depression Only side effect is withdrawal. F 52 8 years
60
5/16/2015
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 5  depression/anxiety, pain ...no side effects. ...easily tolerated. Works as described. I don't know about those other posts with all those freaky side effects and/or withdrawls? I think its mostly their imaginations? M 63 2 years
120mg
5/13/2015
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 5  depression , anxiety and back pain The only side effects I have had was a problem sleeping sometimes. Before I started talking this medication I read a lot of the reviews here and was really afraid to take it.I decided to try it anyways because of the positive reviews here and I'm so glad I did.Since taking this medicine I have more energy,better able to concentrate and it controls my appetite.I have lost 15lbs already and have started to exercise. It works wonders for my pain,but I haven't noticed a change with the anxiety as of yet. F 45 1 months
30mg
5/13/2015
 4  depression, anxiety seem to take away my depression pretty quick and I'm not having as many panic attacks F 46 1 years
60
5/6/2015
 3  Anxiety Brief initial loss of sexual function Didn't really do much for me, even though an SNRI should help with obsessive thinking and intrusive thoughts - Cymbalta never quite managed it. Effexor XR has done a much better job. No horrible side effects with Cymbalta however, and a missed dose never led to brain zaps, like Effexor XR. M 37 2 years
1X day
5/6/2015
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 5  Depression, anxiety I have taken Zoloft, Paxil, and Effexor all with awful side effects. Cymbalta is the first antidepressant I've taken that didn't kill my sex drive, or cause any other significant side effects. Those dark, depressing days I used to have are just a memory. The severe anxiety I've had since I was a child, has significantly lessened. I appreciate so much, everyone who takes the time to comment, good or bad, on the medications that have been prescribed to them, and the experiences they've had with them. We are all different, and what may be a wonder drug to one person, might be another person's hell on earth. (That would be one dose of Paxil for me...insomnia, and horrible anxiety) My sister passed away suddenly of a massive stroke, and it threw me into a depression so deep, I no longer could see anything positive and good about life. My Dr. thought upping my dose of Cymbalta to 90mg a day would be helpful. I resisted for months, because I don't like to be on any more medicine than absolutely necessary, but finally relented. I didn't even relate the dosage change to my increasing jaw pain and clenching, and constant migraines until I decided to look it up here. It also caused my prolactin levels to skyrocket, leading my Endocrinologist to request an MRI to rule out tumors. I am now going to reduce my dose of Cymbalta back to the 60 mg a day that's has helped me thus far, without the side effects the additional 30 mg a day caused me. I'm hoping to do that with as few side effects as possible. I'm nervous about it, because if I ever have missed a dose of my Cymbalta, I start to feel awful, my face starts to feel numb, and those electric shock feelings start in my hands. I stopped worrying about ever going through the withdrawals, because I plan to take Cymbalta for rest of my life. But now find it necessary, because the extra 30 mg are causing so many unwelcome side effects. I still am very happy with the results I've gotten from the 60 mg a day of The Cymbalta, and will stick to that dose from now on. F 48 7 years
60 mg 1X day
5/5/2015
 1  Fibromyalgia/lupus pain & Stress While taking had very little impact on pain, did reduce stress. Had dry mouth, zero libido & intestinal issues. I forgot to take with me on short vacation & by the 2nd day felt terribly ill with headache, fatigue & nausea. I started weaning off of it with my dr's guidance & have been off for approximately 6 weeks & has been torture. Dizziness, headache, suidical thoughts, indigestion, constipation, kidney pain, vision problems, floaters in eye, zero libido, sudden onset of some type of food allergy resulting in hives, sudden drop in blood pressure & I now have to carry epipens with me at all times. I have had to make 3 trips to urgent care within this time frame. I would not wish the side effects of discontinuing Cymbalta on my worst enemy. It is literally a painful withdrawal & 6 weeks plus the 4 weeks weaning off of it & I am still suffering from the effects. DO NOT start taking if you can avoid it! F 46 2 years
60 mg
4/29/2015
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 1  fibromyalgia pain Yes...it did help ease my fibro pain..BUT IT CAUSED so many more problems..some I didn't know were from it until I went off of it , as they are getting better .. I Stopped it DUE to Horrible ANGER AND AGGRESSION....... THe Withdrawals of Cymbalta are HORRENDOUS....!!!! EYE pain, to where I had to wear sunglasses in the house, dim lights, close blinds..for two weeks...Horrendous headache pain like my brains were going to explode ...nausea, jerking..brain zaps...diarrhea..itching...and then thought I was doing better and 37 days OFF of it totally...I had a panic attack and has brought out the depression issues immensely. I wanted to chuck it all to get rid of the pain of the depression and sadness. I am going to see a hollistic/psych dr next week and so praying he is good and can help me thru this journey. I WISH I HAD KNOWN more about this awful drug before I Took it...I WOULD NOT HAVE TAKEN IT. I ended up in ER...and they wanted to keep me and of course put me on drugs of the same family...NO...I want this out of my mind and body..NOW!! I can't believe they are putting people on this after a surgery...mastectomy...!!! HOW CRUEL U DRS ARE AND DRUG COMPANIES for doing this to us!! YOU TAKE IT AND THEN SEE WHAT IT DOES TO YOU!! BEFORE U GIVE TO UR PATIENTS>> F 60 6 days
60mg 1X day
4/25/2015
 5  Osteoarthritis Dry mouth 24/7 pain is gone M 64 13 days
60 MG 1X day
4/16/2015
 5  fibromyalgia and lupus chronic pain Felt hazy and weird the first dose Cymbalta is amazing!! Pain meds didn't even touch my pain. I remember just people watching and being in tears while thinking I would love to just be able to walk care free again, without pain. Literally every part of my body hurt. The first dose made me feel strange and I decided I was done with meds. But I got to a point to where I was so depressed that I gave it another try...and OMG...I feel like me again. I can shop, I can stand and walk for long periods of time again! I just pray that it continues to work. I was on plaquenil for 9 months and it was literally killing me. My dr kept saying to give it a year. I was getting worse and worse, did my research and yep..I was right. Plaquenils rare side effects cause muscle damage and worsens chronic pain....my dr said.."sorry bout that"...Thank you Cymbalta!!!! F 45 3 months
30mg 2 a d
4/8/2015
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