CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  fibromyalgia I took ONE PILL and the side effects were horrendous. Severe heart palpitations, seriously elevated pulse, horrible dry mouth, restless legs, woke up multiple times during the night in pools of sweat, and my mental state was bad. Being it was time released, it lasted 24 hours. It was the worst 24 hours of my life. I know a few people who have taken this drug and have done well, I recommend if you are considering using this drug to read ALL of the side effects, and if you experience the heart problems I did go to the ER immediately. The side effects will not stop for 24 hours and its not worth the risk. F 37 1 days
5/21/2012
 1  depression and generalized anxiety Not many until I stopped taking the drug. Then is horrible. Brain zaps and dizziness are the worst. This drug is great as long as you don't mind brain zaps, weight gain, a sweet tooth, and muscle pain during withdrawals. F 37 6 years
60 mg
5/19/2012
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 1  Depression and Anxiety I took 30mg of Cymbalta and 300mg of Wellbutrin in an effort to reduce my Wellubutrin and increase the Cymbalta. I only did this for two days. The second day I had a very very very bad stutter. My dr had me stop the Cymbalta and it took 6 days for the stutter to go away. F 49 2 days
30mg 1X day
5/12/2012
 3  Fibromyalgia Excess sweating, muscle tension, head pressure/headaches, jaw clenching. I would have stayed on it if these weren't so bad. F 40 6 months
60mg
5/9/2012
 5  Fibrimyalgia After two days started feeling better. When the pain gets worse I take Tramadol 50 Mg. an it works great when needed. No bad side effects. Slightly dry mouth. The good effects made me do this review. Do not mix with Dicyclomine for IBS It will cause you more pain than you could ever imagine, I would rather have had my legs sawed off with a chain saw; but when I stopped taking the Dicyclomine it took two days to get it out of my system I was fine. I would not stop taking the Cymbalta it has made my life so much better and I am better able to handle the problems of the Fibro. I give the drug and A+ so far F 52 3 weeks
30mg 1X day
5/6/2012
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 4  chronic lowback pain I started on 30mg 1x per day and felt very tired at first. After I got used to it I went to 60mg.Had some sexual side effects at first but they subsided. After 2 lower back surgeries for herniated discs I was in constant pain. Cymbalta helps take the edge off and reduces any nerve pain.Also makes me less afraid to go out and live my life and to stop focusing on my back so much. M 41 3 months
60mg 1X day
5/3/2012
 3  depression feels like my throat is burning, like i have a glob os note sitting there and have to constainly clear my throat. it is driving me crazy i know it's the meds because i was forgot to take it for a few days and i didn't have this throat thing during that time.i think is allergic reaction F 51 6 months
60 mg 1X day
5/3/2012
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 1  GAD, dysthymia OMG! This stuff made me almost kill myself after two days! I had to have a friend look after me for a few days because I honestly thought I was going to kill myself. Withdrawal was INTENSE after only 3 doses. I will never touch another anti-depressant after this and other horrible experiences. I personally think that SSRI's and other similar drugs are the cause of the increasing incidences of people snapping and killing friends and family for no apparent reason. Look it up, almost every school shooter was on them. M 29 3 days
10 1X day
5/2/2012
 2  Bi-polar Depression I am so tired. All the time. I can have nightmares. Sweat dripping off me in the morning. if i miss a dose I am in a daze. I can get cold alot. Body jerks, My body can feel bruised all over. I got dizzy and feel over once. lowering my dose also. i am suppose to go down. 30 mg. but.. dam I don't wanna hurt or get sick. driving sometimes when going up or down off this is not smart. I would never had agreed to be on this if i knew how painful and sick I would get if i missed a dose or going up or down on this med. Due i feel any better Hmmm... no not so much! F 38
90 1X day
4/28/2012
 1  depression Feeling of a type of dizziness back sides of head to front sides of head, like a fish was swimming in head, sometimes it started from backbone up to neck to head Really did not do nothing for depression M 55 1 years
1X day
4/28/2012
 3  Back Pain And anxiety If I missed a dose day 1 my mouth would be numb And would have a severe headache.The SWEATING is horrible!!!! I gained 40 lbs in a year (i am very active and dont eat junk food). I finaly had my dr ween me from it because i was concerned about my weight and i wasnt really feeling a difference in anxiety. The Dr. took me down to 30mg for two weeks. I just took the last pill on Wed. night and am having bad dizzy spells. Anyone else have the problems? If you dont mind gaining weight and sweating. It helps with the pain and anxiety F 29 2 years
60 1X day
4/27/2012
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 2  depression & anxiety Fatique, lethargy, night-sweats and uncontrollable muscle jerks. Cymbalta works to reduce my anxiety, but has done nothing at all for my depression. My physician says I should be doing things that mimic being "normal," but I do not have any energy or enthusiasm. Physicians do not have a clue...unless they've experienced extreme depression, they have no basis for advice-giving. So now I'm quite addicted to this drug. I have the alarm on my phone set to alert me to take the capsule, but if I miss one dose, the following day I have brain zaps and audible buzzes, very disconcerting and I do not look forward to quitting this drug. I've also gained weight with no change in my normal eating habits, which are quite healthy. Another example of the pharmaceutical companies pushing a drug into the market and the medical profession pouncing upon it. I am quite confused with the variety of conditions Cymbalta is prescribed for. F 63 9 months
60 1X day
4/27/2012
 4  trigeminal neuralgia/fibromyalgia None that I can tell, but am on a lot of medications. I have had a loss of apetite for a long time, but can't tell which drug has caused it. Felt an immediate decrease in pain. F 56 5 months
30 2X day
4/23/2012
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 3  Depression. Interstitial Cystitis. I found Duloxetine helped my depression, not so much with my chronic pain unfortunately. When I first started it I felt euphoric and it was amazing! I wished it would last as then life would have been amazing and joyous! It didn't last so I went from euphoric and high to depressed and low. My mood plummeted and I felt worse than prior to starting it. My pupils were dilated and people thought I was high on illegal drugs. I felt alot of pressure in my eyes which was painfull. I was sensitive to light and had to wear sunglasses alot even indoors. My pupils went back to normal after a few weeks, maybe even smaller than usual. My eyes have continued to feel pressure and hurt the entire 2 years I've been on Duloxetine. My mood is fairly good but I don't have bursts of laughter like I used to before I went on it. I'm very disappointed that it doesn't really reduce my chronic pain. I still feel anxious, sweaty and paranoid on Duloxetine. It does give me lots of energy and keeps me awake. Initially it made me lose my appetite then when that wore off my appetite increased. I am always craving sugar. My blood pressure is normally low but it decreased my blood pressure even more. I know people who have claimed it doesn't help with depression. I would say its better than being on nothing. F 27 2 years
120
4/22/2012
 1  depression and pain suicidal thoughts The first month I took Cymbalta was great! No pain in my legs for awhile. Then the pain came back, but depression stayed away. Third month I had suicidal thoughts for the first time in my life. I quit cold turkey and had withdrawl that felt like the flu~~severe body aches and nausea~~couldn't even get out of bed. Took it again, but started weaning myself off Cymbalta by opening the capsules and taking some out each day. Suicidal thoughts the whole last 7 months! What a nightmare drug for me! I'm off now, and no suicidal thoughts. I DO NOT recommend this drug! F 51 10 months
1X day
4/21/2012
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 5  fibromyalgia Fatigue, weakness in legs, appetite loss With my very first capsule, I slept like a baby. By the third capsule I could roll over in bed without pain. I felt an aversion to sweet food, and still had loss of appetite. I had 1 day of a bad case of anxiety but controlled it with Xanax. I still sleep very well. I am able to clean my house with more endurance and less pain. Overall the pain is much reduced. F 79 45 days
60mg 1X day
4/19/2012
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 3  Fibromaylgia Nausea,dry mouth,severe headaches,dizziness,high blood pressure,dark urine.fuzzy thinking,constipation,wanting sweets when before I never ate them....fatigue and extreme sleepiness during the day..because I don't sleep much anymore. F 50 2 months
60MG 1X day
4/14/2012
 4  major depressive disorder minimal shaking in hands I'm pretty pleased with Cymbalta. I was previously taking Lexapro for my depression, which wasn't helping at all. I started taking Cymbalta and after two weeks, I was feeling much better. Only problem, that I quickly adapted to, was the shaking in the hands. I still have it at this point, but it's not so horrible that I can't do my job (cosmetology!). F 23 2 years
60 1X day
4/12/2012
 1  RLS I felt very spaced out and lost track of where I was and what I was doing. . It made the RLS worse. I was clenching my jaws and yawning all the time. I felt cold all the time and was constantly jittery and shaking and my legs couldn't stop moving. This is one of the most awful things I've ever tried. Also my sexual appetite was 0. I see everyone has different side effects, but there are many common thread. In my estimation I would never recommend it to my worst enemy. The stuff is awful. M 62 7 days
30 mg 1X day
4/12/2012
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 5  Depressoin and Fibromyalgia Sometimes it interferes with my sleep cycle by keeping me awake long into the night. When this happens, I have had to reduce my dosage for a day or two (ie: skip pills), which is a drag, because then the positive effects go away, too. This has been a miracle drug for me in many ways. My FMS pain is significantly reduced on days when I am taking my full 60 mg dosage. It also helps amazingly with my life-long depression and SAD. F 49 4 years
60 Mg 1X day
4/9/2012

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